Abstract: Substituted 1,2,4-triazolo[4,3-b]-1,2,4-triazines have been found to be effective antiinflammatory and analgesic agents for warm-blooded animals. Pharmacological compositions thereof and methods of using same are described.

Abstract: A process and apparatus for the recovery of suspended solids from a liquid medium is disclosed. The liquid medium containing suspended solids is circulated through an electrolytic cell and an ultrafiltration unit, the suspended solids being removed from the liquid medium as a uniform particulate mass of low liquid content while a proportionate amount of the liquid and dissolved components such as surfactants is removed through ultrafiltration to avoid a dilution of the liquid medium in a continuous process. The recovered solids, following evaporation of a small amount of remaining liquid, offers a more uniform particle size as well as substantially lower recovery costs when compared with conventional techniques, such as spray-drying, now used in the industry. The disclosed electrolytic-ultrafiltration process offers application to the treatment of industrial products and wastes (polymeric, e.g., PVC and PVC copolymers, rubber, paint, cellulose, paper sludge, food, etc.

Abstract: Substituted 1,2,4-triazines, compositions thereof and methods of using same are described. The compounds of the invention exhibit a wide range of pharmacological activity including anti-inflammatory, analgesic, anti-pyretic, hypotensive and central nervous system effects.

Abstract: Valuable pyridazinone intermediates to pharmaceutically useful compounds can be prepared in surprisingly high yields by the reaction of the corresponding monohydrazone with diketene, preferably in the presence of a basic catalyst. In an especially preferred embodiment, p,p'-dichlorobenzil monohydrazone and diketene are reacted in a xylene solvent in the presence of triethylamine to afford 4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one, which can then be reacted with ethylene carbonate in the presence of potassium carbonate to afford the antihypertensive agent, 4-acetyl-5,6-bis(p-chlorophenyl)-2-(2'-hydroxyethyl)-2H-pyridazine-3-one.

Abstract: Valuable pyridazinone intermediates to pharmaceutically useful compounds can be prepared in surprisingly high yields by the quinoline catalyzed reaction of the corresponding monohydrazone with an appropriately substituted acetic acid ester. In an especially preferred embodiment, p,p'-dichlorobenzil monohydrazone and methyl acetoacetate are reacted in a xylene solvent in the presence of quinoline to afford 4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one, which can then be reacted with ethylene carbonate in the presence of potassium carbonate to afford the antihypertensive agent, 4-acetyl-5,6-bis(p-chlorophenyl)-2-(2'-hydroxyethyl)-2H-pyridazin-3-one.