Patent number: 6838435
Abstract: The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in FIG. 1 indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for example Escherichia coli, Bacillus subtilis, Streptococcus sanguis, Streptococcus pneumoniae, Staphylococcus epidermis, and Staphylococcus aureus, and/or against fungi, for example Candida albicans, C. glabarata, Cryptococcus neoformans, Aspergillus flavus, A. fumigatus, and Pseudoallescheria spec. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in humans and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in humans and animals.
Type:
Grant
Filed:
September 25, 1998
Date of Patent:
January 4, 2005
Assignees:
Academisch Ziekenhuis bij de Universiteit van Amsterdam, Universiteit Twente, Nederlandse Organisatie Voor Wetenschappelijk Onderzoek
Inventors:
Jeroen Krijgsveld, Sebastianus Antonius Johannes Zaat, Jacob Dankert, Alma Johanna Kuijpers, Gerardus Henricus Maria Engbers, Jan Feijen