Abstract: There is provided an improved process for producing novel compounds represented by the general formula: ##STR1## wherein the ring A represents a pyrrole ring which may be hydrogenated; X represents an amino, hydroxyl or mercapto group; R.sup.1, R.sup.2 and R.sup.3 each being the same as or different from the other, represents hydrogen or an alkyl, alkenyl or alkynyl group which may be substituted; R.sup.4 represents OR.sup.5 wherein R.sup.5 represents hydrogen or a hydrocarbon group which may be substituted or NHCH(COOR.sup.6)CH.sub.2 CH.sub.2 COOR.sup.7 wherein R.sup.6 and R.sup.7 each represents hydrogen or a hydrocarbon group which may be substituted; and n represents an integer of 1 to 4, or a salt thereof from compounds represented by the general formula: ##STR2## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n are the same as defined above; Y.sup.1 and Y.sup.2 each represents oxygen or sulfur atom; R.sup.8 and R.sup.

Abstract: There is disclosed an oral composition comprising a water-insoluble polymer having quaternary nitrogen atoms as an active component and a polyoxyethylene-polyoxypropylene block copolymer surfactant as a stabilizing agent for the polymer. This composition has high adsorbability of microorganisms in the oral cavity and removes the microorganisms to exhibit improved dental plaque control effect.

Abstract: Pyrroquinoline quinone-dependent glycerol dehydrogenase is provided which requires no surfactant for its solubilization and stabilization. The glycerol dehydrogenase has the following properties:(a) catalyzing the following reaction: glycerol+electron acceptor.dbd.glyceraldehyde+reduced electron acceptor,(b) optimum pH: pH 8-9,(c) pH stability: stable at pH 7-11,(d) optimum temperature: 20.degree.-25.degree. C.,(e) thermal stability: stable at a temperature of 30.degree. C. or less for 10 minutes at a pH of 7.0,(f) molecular weight: 70,000 by gel filtration and SDS polyacrylamide gel electrophoresis,(g) bound to pyrroloquinoline quinone as a prosthetic group,(h) soluble and stable without the need of an ionic or non-ionic surfactant.

Abstract: A beverage can end for connection with a can body having a necked-down top, and wherein the center expansion panel of the end forms a gate which is pushed downwardly into the can to open it. This provides, essentially, an open-top-can wherefrom a beverage may be drunk in the same manner as if it were a glass or a cup. The can end, of drawn metal, includes a triple fold reinforcement ring constituting a chuck panel adjacent to the chuck wall of the peripheral seaming ring of the end. The upper layer of the triple fold connects with the bottom of the chuck wall and the lower layer with the center expansion panel. A score-cut about the underside of the lower layer, with a short uncut portion forming a hinge, permits the center expansion panel to be separated from the triple fold and pushed downwardly to open the can.

Abstract: Defective portions, such as black dot defects, in an emulsion layer of an emulsion mask such as a photomask are repaired or removed by irradiating an ultraviolet laser beam from a laser oscillator, preferably an excimer laser. The laser beam is passed through an adjustable aperture for shaping and is then projected onto defective portions in dimensional alignment, whereby the defective portions are destroyed. In order to ensure that only the defective portions are destroyed, the image of the aperture projected on the emulsion layer is observed so as not to cover the emulsion mask where defective portions do not exist. Defective portions such as white defects can also be repaired by using additional procedure together with the irradiation of the laser beam.

Abstract: A trailer coupling including a housing, one wall of which forms a first part-spherical coupling surface, a movable coupling element which is movably mounted on the housing and which forms a second part-spherical coupling surface, a control lever pivotally mounted on the housing and operable by an operating handle connected with the control lever, the control lever being engageable with the movable coupling element for displacement of the movable coupling element between an open position, in which the movable coupling element is at a distance from the first coupling surface, and an engaging position, in which the movable coupling element is close to the first coupling surface, where at least one of the coupling surfaces carries friction material, and where resilient pre-loading structure is arranged for constraining the movable coupling element into the engaging position with a pre-loading towards the first coupling surface, the pre-loading structure being arranged between an engaging point on the operating ha

Abstract: A method of using saturated organic ring-containing compounds as clearing solvents for biological materials is described. The clearing solvents are equally effective or superior to conventional clearing solvents but they lack the toxic and noxious characteristics of conventional clearing solvents. The clearing solvents are used to replace the alcohol and/or other dehydrants in fixed biological materials and to remove wax from wax-imbedded biological materials.

Abstract: The present invention relates to a method of production of frozen surimi not containing polyphosphate additives, in which carbonates and/or bicarbonates in combination with an organic acid salt are added to dehydrated minced fish meat to adjust the pH value to less than 7.5. The obtained surimi and surimi based products have an excellent whiteness and good elasticity (ashi).

Abstract: The microbeads are composed of a core containing the active ingredient and a microporous membrane, insoluble in aqueous medium, consisting of a film-forming polymer, a plasticizer and a filling material.The membrane has a thickness such that diltiazem is released in vitro at an approximately constant rate for at least 6 hours after a latent period of less than one hour.The active ingredient can be intimately mixed with the core or included in a polyvinyl pyrrolidone layer coating an inert grain.The sustained-release microbeads are formed by application to the core of a dispersion of the constituents of the membrane in a solvent and evaporation of the solvent.The pharmaceutical compositions consist of capsules containing the microbeads. They are administered orally one or twice per day, depending on the dose, for the treatment of angina or hypertension.

Abstract: There is disclosed a novel phenothiazine derivative of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are a C.sub.1-6 alkyl group and at least one of them has as a substituent a group which can react with amino group, thiol group or carboxyl group, and X.sup.- is a counter ion of the phenazathionium. Their production and the intermediates used in the production are also disclosed. The compound (I) is a derivative of methylene blue and is applicable to photodynamic therapy of cancer or immunoassays utilizing chemiluminescence.

Abstract: The present invention relates to a contrast agent for NMR imaging constituted by a complex between a chelating agent and paramagnetic metal cations, wherein said complex corresponds to the formula I: ##STR1## or a physiologically acceptable salt of this complex, in which formula: n and n' are whole numbers from 1 to 4R.sub.1 -R.sub.7 are selected from among H, a halogen, alkyl, alkoxy, aryl, alkenyl, and cycloalkyl groups; with the alkyl groups being optionally substituted by halogen, alkoxy, alkyl, nitrile, nitro or amino; >C(R.sub.6, R.sub.7) can in addition represent >C=O;the three substituents Y are identical or different and represent H or an ionic equivalent of a divalent or trivalent paramagnetic metal cation or of a physiologically acceptable cation derived from an inorganic or organic base,with the condition that at least two of the substituents Y represent ionic equivalents of paramagnetic metal cations.

Abstract: A molecular weight of a polymer is measured by a process including steps of: heating a polymer portion with a heating device, measuring, with a temperature measuring device, the difference between temperatures of at least two points of the polymer portion at each of which the polymer portion is subjected to a thermally different influence from each other by the heating device, and estimating the molecular weight of the polymer which corresponds to the difference between the temperatures obtained by the measuring step according to a relationship between the temperature difference and the molecular weight of the polymer which relationship has been beforehand obtained.

Abstract: A system is provided for the preparation of a cyclic maintenance work schedule table. The system includes a display unit which can show boxes defined by dates in a desired period and the names of individual workers.

Abstract: A preload-adjustable bearing is constructed of a first rotary unit and second rotary unit. The first rotary unit has a first race and second race arranged immobile in a direction approaching toward each other. The second rotary unit has a third race and fourth race. The third race is located opposite the first race while the fourth race is located opposite the second race. The third race is fixed relative to the second rotary unit in a direction away from the fourth race. The fourth race is fitted with the second rotary unit with an interference formed therebetween movably relative to the second rotary unit. The fourth race is movable toward the third race under axial pressure applied between the fourth race and the second rotary unit.

Abstract: A rigid container for interchangeable flexible packs including an interchangeable flexible pack and a substantially parallelepiped-shaped box that includes an upper edge that includes a plurality of structures for supporting the interchangeable flexible pack and a plurality of structures for blocking the interchangeable flexible pack and a closable lid. The interchangeable flexible pack has a parallelepiped-shape that will fit in the box and includes a plurality of structures for engaging with the structure for supporting and the structure for blocking.

Abstract: An arc welder provided with a low frequency square waveform a.c. power supply as a main power supply for welding in order to improve its power of recovering an arc which may go out at the time of polarity transition of a welding load and an auxiliary d.c. power supply for super-posing its output upon the input of the main power supply to further improve the recovering power, in which a switching element is inserted in a supply path of the output of the auxiliary d.c. power supply and the switching element is put in conduction by a suitable control device only for a necessary shortest arc recovery time in order to reduce a power loss due to continuous supply of the auxiliary d.c. output.

Abstract: Cycloaminoalkoxyphenyl derivatives useful for the treatment of certain pathological syndromes of the cardiovascular system and ocular diseases of formula: in which:B represents a --S--, --SO-- or --SO.sub.2 -- group,R.sub.1 and R.sub.2, which are identical or different, each denotes hydrogen, a methyl or ethyl radical or a halogen such as chlorine, bromine or iodine,A denotes a straight or linear alkylene radical, having from 2 to 5 carbon atoms or a 2-hydroxypropylene radical in which the hydroxy is optionally substituted by a lower alkyl radical,Am denotes a group: ##STR1## in which: R.sub.3, R'.sub.3 and R".sub.3, which are identical or different, each denotes hydrogen, a halogen atom such as chlorine or bromine, a lower alkyl group or a lower alkoxy group, R.sub.4 denotes hydrogen or an alkyl radical,n and m, identical or different, each denotes 0, 1, 2 or 3,Cy represents a group of formula: ##STR2## pharmaceutically acceptable salts thereof.

Abstract: Liquid crystalline compounds having an optically active .gamma.-lactone ring of the general formula (A): ##STR1## wherein R.sup.1 is a group selected from the class consisting of ##STR2## n and e are each independently 0 or 1, R.sup.3 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 15 carbon atoms, said alkyl and alkenyl groups having each optionally one or more asymmetric carbon atoms, X and Y are each hydrogen atom, a halogen atom or a cyano group, R.sup.2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 15 carbon atoms, said alkyl and alkenyl groups having each optionally one or more asymmetric carbon atoms, and * means an asymmetric carbon atom, a liquid crystal composition Containing the same and an element for opto-electronics devices comprising the liquid crystal composition.