Patents Represented by Attorney William H. Edgerton

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  • Dialkyl 1-(2-pyridinylthio)-1,2-hydrazinedicarboxylate, N-oxides and their use as animal growth stimulants
    Patent number: 4463009
    Abstract: Dialkyl 1-(2-pyridinylthio)-1,2-hydrazinedicarboxylate, N-oxides are prepared by reacting a 2-mercaptopyridine-N-oxide and a dialkyl azodicarboxylate. The end products are useful as antimicrobial agents and, especially, growth promotants in monogastric meat producing animals. A species of the group is diethyl 1-(2-pyridinylthio)-1,2-hydrazinecarboxylate, N-oxide.
    Type: Grant
    Filed: April 15, 1983
    Date of Patent: July 31, 1984
    Assignee: SmithKline Beckman Corporation
    Inventor: Winfred J. Sanders
  • N-Carboxyalkylproline-containing tripeptides
    Patent number: 4456594
    Abstract: Certain N-carboxyalkyl prolyl-containing tripeptides have been prepared and found to improve kidney function. A species of the group of new compounds is N-(2-carboxyethyl)-L-prolyl-L-alanyl-L-proline which has diuretic activity and increases renal blood flow. The compounds are prepared by chemical reactions which couple an amino acid with a dipeptide.
    Type: Grant
    Filed: October 21, 1982
    Date of Patent: June 26, 1984
    Assignee: SmithKline Beckman Corporation
    Inventor: Francis R. Pfeiffer
  • Oligopeptide prodrugs
    Patent number: 4454065
    Abstract: Prodrugs are described whose structures have a oligopeptide chain which is substituted by a nucleophilic chemotherapeutic residue at the .alpha.-position. The products have increased cell membrane permeability and beneficial physico-chemical properties.
    Type: Grant
    Filed: June 23, 1983
    Date of Patent: June 12, 1984
    Assignee: SmithKline Beckman Corporation
    Inventors: Charles Gilvarg, William D. Kingsbury
  • Semicarbazide intermediates for preparing 4-substituted indoles
    Patent number: 4454337
    Abstract: A new chemical sequence for preparing certain indoles is disclosed which employes certain 2-substituted-6-nitrophenylacetaldehyde semicarbazones claimed here. Said semicarbazones are cyclized to the indoles by low pressure hydrogenation.
    Type: Grant
    Filed: March 2, 1983
    Date of Patent: June 12, 1984
    Assignee: SmithKline Beckman Corporation
    Inventor: Lawrence I. Kruse
  • Feed compositions containing copper salts of 2-hydroxypyridine-N-oxides
    Patent number: 4454137
    Abstract: Copper salts of 2-hydroxypyridine-N-oxides have been demonstrated to possess an ability to alter the metabolic pattern in the digestive tract of food producing animals to make energy producing metabolic units which are more available for absorption by the animals. The copper salts, such as cupric 2-hydroxypyridine-N-oxide, are active ingredients in feed compositions and methods for increasing growth and feed efficiency of these animals.
    Type: Grant
    Filed: July 29, 1982
    Date of Patent: June 12, 1984
    Assignee: SmithKline Beckman Corporation
    Inventors: Govind K. Menon, Winfred J. Sanders
  • 4-Aminoalkyl-2(3H)-indolones
    Patent number: 4452808
    Abstract: A series of new chemical compounds which are 4-aminoalkyl-2(3H)-indolones has been demonstrated to be D.sub.2 -agonists useful for treating hypertension. A representative compound of the series is 4-di-n-propylaminoethyl-2(3H)-indolone.
    Type: Grant
    Filed: December 7, 1982
    Date of Patent: June 5, 1984
    Assignee: Smithkline Beckman Corporation
    Inventor: Gregory Gallagher, Jr.
  • Adamantyl containing intermediates
    Patent number: 4448972
    Abstract: A group of adamantyl containing intermediates is useful to prepare certain oligopeptides which improve kidney function. A representative species of this group is N-(1-adamantyl)-ethanoylproline.
    Type: Grant
    Filed: March 1, 1983
    Date of Patent: May 15, 1984
    Assignee: SmithKline Beckman Corporation
    Inventor: Francis R. Pfeiffer
  • 2(4-tert.-Butyl-2,6-dichlorophenyl-imino)imidazolidine and use as an anti-hypertension agent
    Patent number: 4444782
    Abstract: 2-(4-tert.-Butyl-2,6-dichlorophenylimino)imidazolidine is a anti-hypertensive chemical compound which has unexpected biological properties compared to those of clonidine.
    Type: Grant
    Filed: December 23, 1982
    Date of Patent: April 24, 1984
    Assignee: SmithKline Beckman Corporation
    Inventors: Robert M. DeMarinis, J. Paul Hieble
  • 1-(3,4-Bis-(3-(lower alkoxycarbonyl)-2-thioureido)-phenyl-1-phenylthylenes
    Patent number: 4438135
    Abstract: 1-(3,4-bis-(3-lower alkoxycarbonyl)-2-thioureido)-phenyl)-1-phenylethylenes, which have anthelmintic activity, are prepared by reacting various 1-(3,4-diaminophenyl)-1-phenylethylenes with an alkoxycarbonylisothiocyanate which is prepared, in turn, from an alkali metal thiocyanate and a lower alkyl haloformate.
    Type: Grant
    Filed: January 7, 1983
    Date of Patent: March 20, 1984
    Assignee: SmithKline Beckman Corporation
    Inventor: Alfred W. Chow
  • 5-Phenylethenylbenzimidazoles
    Patent number: 4435418
    Abstract: New 2-acylamino-5-phenylethenylbenzimidazoles have been prepared and found to have anthelmintic activity. A species of the invention is methyl [5-(1-phenylethenyl)-1H-benzimidazol-2-yl]carbamate.
    Type: Grant
    Filed: December 13, 1982
    Date of Patent: March 6, 1984
    Assignee: SmithKline Beckman Corporation
    Inventor: Alfred W. Chow
  • Antimicrobial disulfide prodrugs
    Patent number: 4427582
    Abstract: A series of prodrugs is described which have improved antimicrobial activity and physico-chemical properties. The structures of the biologically active ingredients are characterized by having a selected oligopeptide backbone attached, via the .alpha.-carbon of an L-alanyl unit thereof, by means of a disulfide link to the residue of an antimicrobial mercaptan.
    Type: Grant
    Filed: June 8, 1982
    Date of Patent: January 24, 1984
    Assignee: SmithKline Beckman Corporation
    Inventors: Charles Gilvarg, William D. Kingsbury
  • Pharmaceutical composition and methods for producing dopamine agonist activity
    Patent number: 4414224
    Abstract: Methods and compositions using as active ingredients 2-(3H)-indolones whose structures having an aminoalkyl substituent at position 4 and a hydroxy group at position 7 of the indolone nucleus are used to produce selective dopaminergic activity resulting in improved kidney function, relief of the symptoms of congestive heart failure, long lasting anti-hypertensive activity and anti-anginal activity. A species of the active ingredients is 4-di-n-propylaminoethyl-7-hydroxy-2(3H)-indolone or its salts.
    Type: Grant
    Filed: January 22, 1982
    Date of Patent: November 8, 1983
    Assignee: SmithKline Beckman Corporation
    Inventors: William F. Huffman, James W. Wilson
  • 3-Carboxy-2-azabicyclo[2.2.1]heptane derivatives
    Patent number: 4405787
    Abstract: 3-Carboxy-2-(.omega.-carboxyalkanoyl)-2-azabicyclo-[2.2.1]heptenes have been demonstrated to improve kidney function. 3-Carboxy-2-azabicyclo[2.2.1]heptane and its esters are important new chemical intermediates.
    Type: Grant
    Filed: April 5, 1982
    Date of Patent: September 20, 1983
    Assignee: SmithKline Beckman Corporation
    Inventors: Dimitri Gaitanopoulos, Joseph Weinstock
  • Renally active dipeptides
    Patent number: 4395401
    Abstract: A group of prolyl-.alpha.-lower alkylphenylalanine dipeptides have been found to improve kidney function especially on cumulative administration. A species is N-4-(4'-hydroxyphenyl)-butyryl-L-propyl-D,L-.alpha.-methyl-3,4-dimethoxyph enylalanyl-L-arginine.
    Type: Grant
    Filed: September 9, 1981
    Date of Patent: July 26, 1983
    Assignee: SmithKline Beckman Corporation
    Inventor: Francis R. Pfeiffer
  • Processes for preparing 4-substituted indoles
    Patent number: 4394514
    Abstract: A new chemical sequence for preparing indoles is disclosed whose key reactions are reaction of a o-nitrotoluene with tris(dimethylamino)methane to give a .beta.-dimethylamino-o-nitrostyrene which is converted into a semicarbazone and cyclized.
    Type: Grant
    Filed: June 29, 1981
    Date of Patent: July 19, 1983
    Assignee: SmithKline Beckman Corporation
    Inventor: Lawrence I. Kruse
  • 6-Chloro-7,8- dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine sulfate esters
    Patent number: 4388240
    Abstract: New 6-chloro-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzaze pine hydrogen sulfate monoesters have been prepared and found to have potent renal dopaminergic activity. The most potent compound of the series is 6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-4'-yl-h ydrogen sulfate.
    Type: Grant
    Filed: January 6, 1982
    Date of Patent: June 14, 1983
    Assignee: SmithKline Beckman Corporation
    Inventors: Richard H. Dewey, Bruce Y. Hwang, George Y. Kuo
  • Adamantyl containing peptides
    Patent number: 4387049
    Abstract: A group of adamantyl containing di- and tripeptides have been found to improve kidney function. A representative species of this group is N-(1-adamantyl)ethanoyl-L-proline-D,L-.alpha.-methylphenylalanyl-L-arginin e together with its salts.
    Type: Grant
    Filed: February 22, 1982
    Date of Patent: June 7, 1983
    Assignee: SmithKline Beckman Corporation
    Inventor: Francis R. Pfeiffer
  • Renally active tetrapeptides
    Patent number: 4386075
    Abstract: N-Acyltetrapeptides are described which are active in improving renal function. An exemplary species is N-4-(4-hydroxyphenyl)-butyryl-L-prolyl-D,L-.alpha.-methylphenylalanyl-glyc yl-L-proline.
    Type: Grant
    Filed: March 19, 1982
    Date of Patent: May 31, 1983
    Assignee: SmithKline Beckman Corporation
    Inventor: Francis R. Pfeiffer
  • Process useful for preparing 7,8-acetamido, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4382029
    Abstract: A chemical process is described for preparing 7,8-acetamido, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines which involves reacting a 7,8-quinone derivative of a 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine with a benzyl or benzhydrylamine followed by hydrolysis of the resulting imine and reaction with acetic anhydride or acetyl chloride.
    Type: Grant
    Filed: August 14, 1981
    Date of Patent: May 3, 1983
    Assignee: SmithKline Beckman Corporation
    Inventors: Kenneth G. Holden, Carl Kaiser, Joseph Weinstock
  • 3-Furylmethyl-6-halo-7,8-dihydroxy-1-p henyl-2,3,4,5-tetrahydro-1H-3-benzazepines and antihypertensive use thereof
    Patent number: 4359464
    Abstract: 3-Furylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaze pines have potent dopaminergic activity. As such they have utility as antihypertensive and especially anti-Parkinsonism agents.
    Type: Grant
    Filed: August 4, 1981
    Date of Patent: November 16, 1982
    Assignee: SmithKline Beckman Corporation
    Inventor: Joseph Weinstock