Patents Represented by Attorney, Agent or Law Firm William M. Blackstone
  • Patent number: 8309101
    Abstract: The present invention relates to live attenuated bacteria of the species Pasteurella multocida, to live attenuated vaccines comprising such live attenuated bacteria, to the use of such bacteria for the manufacture of such vaccines, to methods for the preparation of such vaccines and to diagnostic tests for the detection of such bacteria.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: November 13, 2012
    Assignee: Intervet International B.V.
    Inventors: Yugang Luo, Paul Vermeij, Antonius Arnoldus Christiaan Jacobs
  • Patent number: 8227584
    Abstract: The present invention relates to nucleic acid sequences encoding a 30 kD Brachyspira hyodysenteriae lipoprotein and to parts of such nucleic acid sequences that encode an immunogenic fragment of such lipoproteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to a 30 kD Brachyspira hyodysenteriae lipoprotein and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, lipoproteins or immunogenic parts thereof and antibodies against such lipoproteins or immunogenic parts thereof. Also, the invention relates to the use of said lipoproteins in vaccines and for the manufacture of vaccines.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: July 24, 2012
    Assignee: Universiteit Gent
    Inventors: Edwin Claerebout, Jozef Vercruysse, Peter Geldhof, Isabel Vercauteren, Veerle De Maere
  • Patent number: 8178103
    Abstract: This invention relates to two attenuated strains of porcine reproductive and respiratory syndrome virus (PRRSV) and immunogenic compositions comprising one or more strains of attenuated porcine reproductive and respiratory syndrome virus (PRRSV).
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: May 15, 2012
    Assignee: Intervet International B.V.
    Inventor: Richard A. Hesse
  • Patent number: 8163297
    Abstract: The present invention relates to live attenuated bacteria for use in a medicament. The invention also relates to vaccines based upon such bacteria useful for the prevention of microbial pathogenesis and to the use of such bacteria for the manufacture of a vaccine. Finally, the invention relates to methods for the preparation of such vaccines.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: April 24, 2012
    Assignee: Board of Governors for Higher Education, State of Rhode Island and Providence Plantations
    Inventor: Paul S. Cohen
  • Patent number: 8156755
    Abstract: The invention relates to a refrigerator for storing vials containing a (bio)pharmaceutical substance, in particular vaccines for animals, comprising a cabinet having an internal space for accommodating the vials arranged in columns, a cooling element for cooling the internal space and at least one door or dispenser for removing vials from the internal space. A plurality of guides located inside the space and adapted to slidingly accommodate columns of the vials. The invention further relates to a cartridge suitable for use in the said refrigerator.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: April 17, 2012
    Assignee: Intervet International B.V.
    Inventors: Stephen Murray, Gaynor Hillier, Philip Nigel Bordet-Stead, Tanja Langgner, David Helps
  • Patent number: 8133712
    Abstract: Embodiments of the present invention provide an inactivated chimeric virus and immunogenic compositions for the treatment or prevention of infection with West Nile virus. Further, other embodiments of the present invention relate to methods of preventing and treating West Nile virus infection with the inactivated chimera or immunogenic composition.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: March 13, 2012
    Assignee: Intervet International B.V.
    Inventors: Frank J. Sterner, Daniel Ghislena Emiel Goovaerts, Melissa Anne Lum, Mark William Mellencamp
  • Patent number: 8114409
    Abstract: The present invention relates to the structural proteins of the causative agent of Pancreatic Disease in fish, nucleotide sequences encoding said proteins, vaccines comprising said proteins or nucleotide sequences and diagnostic kits comprising said proteins or nucleotide sequences.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: February 14, 2012
    Assignee: Intervet Intenational B.V.
    Inventors: Jonathan Weston, Daniel Todd
  • Patent number: 8114977
    Abstract: Embodiments of the present invention generally relate to proteins derived from white spot syndrome virus, nucleic acid sequences encoding them, and their use in the manufacture of a vaccine for prophylaxis and/or treatment of white spot syndrome in crustaceans.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: February 14, 2012
    Assignee: Intervet International B.V.
    Inventors: Maria Cornelia Wilhelmina Van Hulten, Justinus Maria Vlak
  • Patent number: 8084445
    Abstract: Disclosed are novel formulations for the treatment of otic infections in an animal comprising a triazole anti-fungal compound, a quinolone antibiotic and a corticosteroid such as mometasone furoate monohydrate.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: December 27, 2011
    Assignee: Schering-Plough Animal Health Corporation
    Inventors: Abu S Huq, Allan J Weingarten, Robert D Simmons
  • Patent number: 8084040
    Abstract: The present invention relates to the use of live attenuated bacteria for the manufacture of a vaccine for submucosal administration.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: December 27, 2011
    Assignee: Intervet International B.V.
    Inventors: Antonius Arnoldus Christiaan Jacobs, Daniel G. E. Goovaerts
  • Patent number: 8071108
    Abstract: The present invention comprises new pestivirus mutants, characterized in that the mutants are based on a cp strain of the virus wherein part of the gene sequence encoding the Npro region is deleted, except that the deleted part does not encompass the coding sequence for the N-terminal twelve amino acids of the Npro protein. Preferably the pestivirus is the Bovine Viral Diarrhea Virus (BVDV). It was found that a mutant according to the invention is a safe and efficient vaccine candidate.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: December 6, 2011
    Assignee: Intervet International B.V.
    Inventors: Martin Beer, Ilona Reimann, Patricia Koenig
  • Patent number: 8048429
    Abstract: Embodiments of the present invention generally provide an inactivated chimeric virus vaccine and/or immunogenic composition for the treatment or prevention of viral infection. Further, various other embodiments of the present invention generally relate to methods of preventing and treating virus infection in such animals with the inactivated vaccine and/or immunogenic composition. Other embodiments comprise methods of preparing a vaccine or immunogenic composition for the treatment or prevention of viral infection in such animals.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: November 1, 2011
    Assignee: Intervet International B.V.
    Inventors: Frank Jay Sterner, Daniel Ghislena Emiel Goovaerts, Melissa Anne Lum, Mark William Mellencamp
  • Patent number: 8025884
    Abstract: The present invention relates i.a. to nucleic acids encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acids, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences and to their use for the manufacturing of vaccines. The invention also relates to vaccines for combating Lawsonia intracellularis infections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection of Lawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: September 27, 2011
    Assignee: Intervet International B.V.
    Inventor: Paul Vermeij
  • Patent number: 8021670
    Abstract: The present invention relates to the use of an immunogenic dose of immunogenic material of Mycoplasma hyopneumoniae and an immunogenic dose of live attenuated PRRS virus for the manufacture of a vaccine, and to a vaccine kit comprising such a vaccine.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: September 20, 2011
    Assignee: Intervet International B.V.
    Inventors: Christa Sibilla Drexler, Maarten Witvliet
  • Patent number: 8008001
    Abstract: The present invention relates to a vaccine and a method for protecting piglets against PCV-2 infection by administering a vaccine comprising at least 20 micrograms/dose of ORF-2 protein of porcine circovirus type 2, even when they have a relatively high titer of maternally derived antibodies against PCV-2. A vaccine according to the invention may contain a recombinant ORF-2 protein, wherein said recombinant protein is preferably produced by way of expression from a baculovirus expression vector in insect cells, said baculovirus expression vector containing the PCV-2 ORF-2 gene sequence under control of a suitable promoter.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: August 30, 2011
    Assignee: Intervet International B.V.
    Inventors: Frank Roerink, Peter Van Woensel
  • Patent number: 7951587
    Abstract: The invention relates to a recombinant Mononegavirales virus (MV) vector comprising a foreign gene that is flanked by non-coding regions of a MV virus gene.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: May 31, 2011
    Assignee: Intervet International B.V.
    Inventors: Angela Römer-Oberdörfer, Jutta Veits, Teshome Mebatsion
  • Patent number: 7939088
    Abstract: The present invention relates to the use of bacteria of the species Streptococcus phocae for the manufacture of a vaccine, to methods for the production of such vaccines, to bacteria of the species Streptococcus phocae for use in a vaccine and to methods for the combating of Streptococcus phocae infection in fish.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: May 10, 2011
    Assignee: Intervet International B.V.
    Inventors: Luc Grisez, Ruud Philip Antoon Maria Segers, Chow Yong Ng
  • Patent number: 7858100
    Abstract: The present invention relates to a novel rod-shaped pleiomorphic non-motile Gram-negative bacterium causing a new, deadly, disease in fish, to a microbiological culture comprising said bacterium, to a vaccine comprising said bacterium and methods for the preparation of such a vaccine, to antibodies reactive with said bacterium, to diagnostic test kits and to the use of said bacterium.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: December 28, 2010
    Assignee: Intervet International B.V.
    Inventor: Are Nylund
  • Patent number: 7833536
    Abstract: The present invention relates i.a. to vaccines for combating Mycoplasma infection, to mycoplasmal L-?-glycerophosphate oxidase for use in such vaccines, to the use of mycoplasmal L-?-glycerophosphate oxidase for the manufacturing of such vaccines, to methods for the preparation of such vaccines and to diagnostic tests for the discrimination of animals vaccinated with said vaccines and animals vaccinated with whole cell vaccines or animals suffering from field infection.
    Type: Grant
    Filed: July 6, 2006
    Date of Patent: November 16, 2010
    Assignee: University of Bern
    Inventors: Joachim Frey, Edy M. Vilei, Paola Pilo
  • Patent number: 7824689
    Abstract: The present invention provides a new chicken astrovirus (CAstV). This chicken astrovirus (CAstV-2) is immunologically distinct from known avian astroviruses and can be used to prepare vaccines.
    Type: Grant
    Filed: September 15, 2003
    Date of Patent: November 2, 2010
    Assignee: Intervet International B.V.
    Inventors: William Baxendale, Teshome Mebatsion