Patents Represented by Attorney, Agent or Law Firm William M. Blackstone
-
Patent number: 7807184Abstract: The present invention relates to a hybrid bacterial toxin subunit, to a hybrid bipartite bacterial toxin and to nucleic acid molecules comprising a nucleotide sequence encoding such bacterial toxins. Furthermore, the invention relates to vaccines comprising bacterial toxins and to their use in vaccines. Finally, the invention relates to methods for the preparation of such vaccines and to the use of such bacterial toxins for the manufacture of such vaccines.Type: GrantFiled: July 16, 2004Date of Patent: October 5, 2010Assignee: Interuet International B.V.Inventor: Paul Vermeij
-
Patent number: 7799330Abstract: The invention relates to a Piroplasmid protein or an immunogenic fragment of the protein, and to a nucleic acid encoding the Piroplasmid protein or immunogenic fragment. Furthermore, the invention relates to cDNA fragments, recombinant DNA molecules and live recombinant carriers comprising the nucleic acid. Also the invention relates to host cells comprising the cDNA fragments, recombinant DNA molecules and live recombinant carriers. Finally, the invention relates to vaccines comprising a Piroplasmid protein or an immunogenic fragment of the protein, to methods for the preparation of such vaccines, to the use of such proteins or fragments for vaccine purposes, and to diagnostic tests.Type: GrantFiled: November 21, 2008Date of Patent: September 21, 2010Assignee: Universiteit Utrecht Holding B.V.Inventors: Erik de Vries, Fasila Razzia Gaffar, Ana Patricia Yatsuda, Theodorus Cornelis Schaap
-
Patent number: 7794724Abstract: The present invention relates to veterinary immunology, namely to the immunological response of fish to a virus. More specifically, the invention provides an epitope of salmonid alphaviruses which epitope is capable of inducing a virus neutralising immune response. In particular the invention relates to a polypeptide comprising a certain amino acid sequence, a protein comprising such polypeptide, to a carrier comprising such protein, and to a method of producing antibodies. Further the invention relates to a nucleic acid encoding such polypeptide or such protein, and to a carrier comprising such a nucleic acid. Also, the invention relates to a vaccine and a diagnostic kit comprising such a polypeptide, protein, carrier, or nucleic acid.Type: GrantFiled: September 15, 2006Date of Patent: September 14, 2010Assignee: Intervet International B.V.Inventors: Stephane Villoing, Michel Bremont, Coralie Moriette, Monique Le Berre
-
Patent number: 7790178Abstract: Embodiments of the present invention generally relate to novel multivalent vaccines and methods of vaccinating. In an embodiment, the present invention is a trivalent vaccine for canine herpesvirus (CHV), canine rotavirus (CRV), and Minute virus of canine (MVC) or other canine parvovirus delivered to pups of a whelp through colostrums and providing sufficient antibody titer to impart protection.Type: GrantFiled: December 18, 2003Date of Patent: September 7, 2010Assignee: Intervet International B.V.Inventors: Thomas Gore, Adrian Mockett
-
Patent number: 7785570Abstract: The present invention relates to a combination vaccine for the protection of poultry against Ornithobacterium rhinotracheale, to the use of a live over-attenuated Ornithobacterium rhinotracheale strain and a live attenuated poultry virus for the manufacturing of such a combination vaccine, to methods for the preparation of said combination vaccine and to vaccination kits for the immunization of poultry against Ornithobacterium rhinotracheale.Type: GrantFiled: December 21, 2004Date of Patent: August 31, 2010Assignee: Internet International B.U.Inventors: Antonius Arnoldus Christiaan Jacobs, Paul Cornelius Maria van Empel, Petrus Johannes Maria Nuijten
-
Patent number: 7749506Abstract: Embodiments of the present invention generally relate to proteins derived from white spot syndrome virus, nucleic acid sequences encoding them, and their use in the manufacture of a vaccine for prophylaxis and/or treatment of white spot syndrome in crustaceans.Type: GrantFiled: April 19, 2007Date of Patent: July 6, 2010Assignee: Intervet International B.V.Inventors: Maria Cornelia Wilhelmina van Hulten, Justinus Maria Vlak
-
Patent number: 7736847Abstract: Embodiments of the present invention generally relate to novel methods for the treatment and/or prevention of neurological symptoms caused by an avian reovirus, enteric reovirus strain (ERS), and associated characteristics. Other embodiments generally comprise an immunogenic composition or vaccine comprising an ERS for the treatment and/or prevention of neurological symptoms.Type: GrantFiled: October 9, 2003Date of Patent: June 15, 2010Assignee: Intervet International B.V.Inventors: Saskia van de Zande, Rudolf George Hein, Donald Eugene Roessler, Gwenllyan F. Slacum, Karen L. Jensen, Phyllis A. Lynch
-
Patent number: 7722879Abstract: The invention relates to Babesia proteins of a 28kDa protein family and to immunogenic fragments of such proteins, to nucleic acids encoding such proteins or fragments, to cDNA fragments, recombinant DNA molecules, live recombinant carriers, or host cells comprising such nucleic acids, to vaccines, to methods for the preparation of such vaccines, to the use of such proteins or fragments for the prophylactic or therapeutic treatment of an infection or its clinical signs caused by an organism of the family Babesiidae, and to diagnostic tests for detection of nucleic acids, antibodies or antigens of an organism of the family Babesiidae.Type: GrantFiled: July 12, 2004Date of Patent: May 25, 2010Assignee: Intervet International B.V.Inventors: Bernard Piere Dominique Carcy, Andre Francois Gorenflot, Theodorus Petrus Maria Schetters, Prisca Laetitia Cibrelus, Karina Moubri, Delphine Depoix
-
Patent number: 7722877Abstract: The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.Type: GrantFiled: November 7, 2006Date of Patent: May 25, 2010Assignee: Intervet International B.V.Inventors: Theodorus Cornelis Schaap, Catharina Maria Kuiper, Arnoldus Nicolaas Vermeulen
-
Patent number: 7718179Abstract: The present invention relates to nucleic acid sequences encoding Ostertagia ostertagi proteins and to parts of such nucleic acid sequences that encode an immunogenic fragment of such proteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to Ostertagia ostertagi proteins and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, proteins or immunogenic parts thereof and antibodies against such proteins or immunogenic parts thereof. Also, the invention relates to the use of said proteins in vaccines and for the manufacture of vaccines.Type: GrantFiled: August 2, 2007Date of Patent: May 18, 2010Assignee: Universiteit GentInventors: Edwin Claerebout, Jozef Vercruijsse, Peter Geldhof, Isabel Vercauteren, Veerle De Maere
-
Patent number: 7674469Abstract: This invention is directed to a vaccine and a method for using the vaccine to protect a feline from influenza virus infection. The vaccine comprises one or more antigens from one or more H3, N8, H7 or N7-type influenza viruses.Type: GrantFiled: October 25, 2007Date of Patent: March 9, 2010Assignee: Internet International B.V.Inventors: Nallakannu P. Lakshmanan, Melissa A. Lum, Frank J. Sterner, Frederick Randal Bethke
-
Patent number: 7662390Abstract: The present invention relates to nucleic acid sequences encoding novel Lawsonia intracelluaris proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acid sequences, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences and to their use for the manufacturing of vaccines. The invention also relates to vaccines for combating Lawsonia intracellulairs infections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection of Lawsonia intracellularis DNA, the detection of Lawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.Type: GrantFiled: September 8, 2004Date of Patent: February 16, 2010Inventor: Paul Vermeij
-
Patent number: 7638131Abstract: This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.Type: GrantFiled: May 2, 2007Date of Patent: December 29, 2009Assignee: Intervet International B.V.Inventors: Jacobus Johannes Kok, Paul van den Boogaart, Arnodus Nicolaas Vermeulen
-
Patent number: 7601500Abstract: It has been found that adequate protection against viral infection in equines can be achieved when vaccination with a live viral vaccine (prime) is followed by vaccination with an inactivated vaccine (boost) for the same virus, wherein the two shots are given no longer than 8 weeks apart. The invention therefore provides a method for vaccination of equines against infection with an equine viral pathogen, wherein an animal is first vaccinated with a (prime) vaccine comprising an attenuated form of the pathogen, followed by a vaccination with a (boost) vaccine comprising the same pathogen in inactivated form, and wherein the boost vaccine is administered no longer than eight weeks after the prime vaccine. The method of the invention is especially useful for vaccination against viral infections such as infections with EIV and/or EHV-1/EHV-4.Type: GrantFiled: May 2, 2007Date of Patent: October 13, 2009Assignee: Intervet International B.V.Inventor: Saskia van de Zande
-
Patent number: 7601804Abstract: The present invention relates to nucleic acid sequences encoding a 22.5 kD Streptococcus uberis protein and to parts of such nucleic acid sequences that encode an immunogenic fragment of such proteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to a 22.5 kD Streptococcus uberis protein and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, proteins or immunogenic parts thereof and antibodies against such proteins or immunogenic parts thereof. Also, the invention relates to the use of said proteins in vaccines and for the manufacture of vaccines.Type: GrantFiled: August 6, 2003Date of Patent: October 13, 2009Assignee: Intervet International B.V.Inventors: Petrus Johannes Maria Nuijten, Selma Marianne Hensen
-
Patent number: 7601502Abstract: The present invention is concerned with vaccinating equines against the equine influenza virus (EIV). It has now been found that adequate protection against equine influenza in equines can be achieved when vaccination with a live equine influenza vaccine (prime) is followed by vaccination with an inactivated influenza vaccine (boost), wherein the two shots are given no longer than 8 weeks apart.Type: GrantFiled: October 27, 2006Date of Patent: October 13, 2009Assignee: Intervet International B.V.Inventor: Saskia van de Zande
-
Patent number: 7601137Abstract: The invention relates to a needle-less injector having a housing comprising: a chamber defined within said injector for containing liquid to be injected; a liquid outlet for said chamber positioned at the front end of the injector, a dispensing member in contact with the liquid in said chamber and movable in a first direction to reduce the volume of said chamber to cause the liquid contained therein to be expelled through said liquid outlet; drive means for actuating said injector, wherein the dispensing member is a spring-loaded piston movable in said chamber by the spring in the first direction to a preferred position at which the volume of said chamber is at a minimum and the spring is nearly unloaded, and which piston is movable in a second direction opposite to the first direction by actuation of the drive means whilst counteracting a force from the spring and moving the piston to a non-preferred position at which the spring is loaded.Type: GrantFiled: June 5, 2003Date of Patent: October 13, 2009Assignee: Intervet International B.V.Inventors: Antonie Hendrikus Meijering, Andreas Johannes Maria Jacobs
-
Patent number: 7514547Abstract: The present invention relates to novel Helicobacter felis urease subunit polypeptides and to nucleic acid sequences encoding these subunit polypeptides, to DNA fragments and recombinant DNA molecules comprising the nucleic acid sequences encoding these subunit polypeptides, to live recombinant carriers and to host cells comprising nucleic acid sequences encoding these subunit polypeptides. Also, the invention relates to the subunit polypeptides for use in vaccines and the use in the manufacturing thereof, to vaccines comprising said subunit polypeptides and to methods for the preparation of such vaccines. Furthermore, the invention relates to diagnostic methods for the detection of Helicobacter felis specific nucleic acid sequences, Helicobacter felis antigenic material and to antibodies against Helicobacter felis.Type: GrantFiled: July 13, 2001Date of Patent: April 7, 2009Assignee: Intervet International B.V.Inventors: Johannes Gerardus Kusters, Giovanni Cattoli
-
Patent number: 7491401Abstract: The present invention relates i.a. to nucleic acid sequences encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acid sequences, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences. The invention also relates to vaccines for combating Lawsonia intracellularis infections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection of Lawsonia intracellularis DNA, the detection of Lawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.Type: GrantFiled: July 13, 2005Date of Patent: February 17, 2009Assignee: Intervet International B.V.Inventors: Antonius Arnoldus Christiaan Jacobs, Paul Vermeij
-
Patent number: 7462359Abstract: A Neospora caninum vaccine comprising tissue culture grown Neospora and methods of making and using said vaccines. Neospora caninum vaccines described include those containing whole Neospora tachyzoites, extracts of Neospora tachyzoites and protective antigen subunits of Neospora tachyzoites. The vaccines of this invention may be in a liquid or lyophilized form.Type: GrantFiled: April 28, 2005Date of Patent: December 9, 2008Assignee: Intervet International B.V.Inventors: Leszek J. Choromanski, Karen K. Brown