Abstract: A method of developing an immune response to HIV using a composition of inactivated HIV. Inactivation is through psoralen and ultraviolet radiation. The composition is rendered more effective by the removal of structural features of HIV that interfere with immune response. In particular, sialic acid is removed to enhance immune recognition of the composition and to impair Complement Factor H binding. CD55 and CD59 are also removed to prevent the binding of Complement Factor H. A method of developing an immune response to HIV using a composition of inactivated HIV. Inactivation is through psoralen and ultraviolet radiation. The composition is rendered more effective by the removal of structural features of HIV that interfere with immune response. In particular, sialic acid is removed to enhance immune recognition of the composition and to impair Complement Factor H binding. CD55 and CD59 are also removed to prevent the binding of Complement factor H.
Abstract: A method of making an immunogenic composition using inactivated HIV. Inactivation of HIV is through psoralen and ultraviolet radiation. The composition is rendered more effective by the removal of structural features of HIV that interfere with immune response. In particular, sialic acid is removed to enhance immune recognition of the composition and to impair Complement Factor H binding. CD55 and CD59 are also removed to prevent the binding of Complement Factor H. A method of making an immunogenic composition using inactivated HIV. Inactivation of HIV is through psoralen and ultraviolet radiation. The composition is rendered more effective by the removal of structural features of HIV that interfere with immune response. In particular, sialic acid is removed to enhance immune recognition of the composition and to impair Complement Factor H binding. CD55 and CD59 are also removed to prevent the binding of Complement Factor H.
Abstract: A surge protector which has a metal grounding plate having holes and tubular sleeve guides, standard UL-approved ground rods that are inserted through the sleeve guides and are affixed to the sleeve guides using a durable exothermic weld, and leads attached at one end to the grounding plate also using an exothermic weld to affix any number of grounding devices, traditional ground rings, electronic equipment, structures, sites or combinations thereof. The durable exothermic weld is a permanent connection that stands in contrast to commonly used mechanical connections. The present invention also has a minimal footprint requirement allowing for placement in areas where space limitations are unsuitable for placement of conventional grounding rings. The present invention can be used in combination with or in lieu of conventional grounding rings.
Abstract: A visual messaging system and device can employ high efficiency LEDs and current driven versus voltage driven circuits to reduce power consumption and enable the device to be powered from IEEE 802.3af (Power over Ethernet (PoE)) standard based power sources. The device can be powered from a local area network (LAN) connection using PoE, and does not require a separate AC power supply. The present invention also uses a 1× yellow algorithm to create the yellow color with one half the instantaneous current of previous circuits. The device can incorporate multiple message inputs for receiving and displaying messages having different priorities, allowing higher priority messages to override lower priority messages.
Type:
Grant
Filed:
November 14, 2006
Date of Patent:
December 15, 2009
Assignee:
INOVA Solutions, Inc.
Inventors:
Laurence E. Moulis, Jr., Aaron Buchanan
Abstract: A method of building and assembling programs across computer networks that is dictated by the user to perform logical work without the user using a compiler. Users are able to assemble programs over a network by defining or re-defining which logical components are bound into the overall program without the use of a compiler. Logical components are called and bound into the program at run time, allowing dynamic programming which may be modified at any time without re-compiling the entire program. Each logical component can act independently of other logical components or work in concert with each other. This allows assembly of a program, even though some components may be created using totally different methodologies and/or are constructed by different programmers.
Abstract: The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to at least one covalent binding site of myristate (SEQ ID NOS: 1-3) on the HIV matrix protein. The present invention contemplates three categories of embodiments: protein or protein fragments (SEQ ID NO: 1), messenger RNA, or DNA/RiNA (SEQ ID NOS:2-3). DNA/RNA compositions may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.
Abstract: A frame extension device for the reduction of aerodynamic drag and for improved performance of ground vehicles by increasing the pressure on the base of the vehicle by stabilizing the wake flow. The device is particularly suited for tractor-trailers utilizing a roll-up type rear door in that it does not block any part of the door opening. The device is of sufficient thickness to support the weight of an unloading device.
Abstract: A microhollow cathode discharge assembly capable of generating a low temperature, atmospheric pressure plasma micro jet is disclosed. The microhollow assembly has at two electrodes: an anode and a cathode separated by a dielectric. A microhollow gas passage is disposed through the three layers, preferably in a taper such that the area at the anode is larger than the area at the cathode. When a potential is placed across the electrodes and a gas is directed through the gas passage into the anode and out the cathode, along the tapered direction, then a low temperature micro plasma jet can be created at atmospheric pressure.
Type:
Grant
Filed:
May 31, 2005
Date of Patent:
August 11, 2009
Inventors:
Abdel-Aleam H. Mohamed, Juergen Friedrich Kolb, Karl H. Schoenbach
Abstract: Changes in event, threat and result patterns assist in forecasting subsequent occurrences. The present invention derives signature for event-types based on a comparison of actual event data with pre-established representational surfaces. The surfaces represent functional measurements and analysis associated with elements of the geospatial boundary being considered. Comparing newly obtained event, result and threat data with previously stored signatures facilitates change detection.
Abstract: An antigenic and immunogenic composition of predetermined inactivated strains of human immunodeficiency virus (HIV) is disclosed. Inactivation is through psoralen and ultraviolet radiation; the composition is rendered more effective by the removal of structural features of HIV that interfere with immune response. In particular, sialic acid is removed to enhance immune recognition of the composition and to impair Complement Factor H binding. CD55 and CD59 are also removed to prevent the binding of Complement Factor H. Determination of strains for inactivation may be though immunotherapeutic genotyping or probabilistic assessment of risk of exposure.
Abstract: The present invention provides a progressive fact or trivia game. In one embodiment, the present invention is implemented as a series of cards, each having a unique multiple choice question as well as a unique number or other identifying indicia placed conspicuously thereon. After each possible answer to the question, another number or identifying indicia appears referencing a separate card in the series. When a player answers a question from a given card, the number or other indicia placed beside the player's answer indicates the next card to which the player should proceed. The next card holds the next question for the player to answer. The present invention can be implemented through physical cards or electronically over a network, for example.