Abstract: A data cartridge and method for providing a write-securable storage medium that inhibits writing. The medium comprises a write-secure-type indicator in a predefined location that indicates the medium is of a type that is susceptible to write securing. Additionally, the medium comprises a write-secure-complete indicator in a predetermined zone of the disk that is not accessible to a user. When the write-secure-complete indicator is set by a host device, the setting is irreversible and consequently the data on the medium is protected, and additional writing onto any part of the medium is permanently prevented.

Abstract: The invention provides a method, system, and computer-readable medium having computer-executable instructions for designing a PCB using both HDL design elements and schematic design elements. The inventive method comprises the steps of selecting the HDL design elements and selecting the schematic design elements. The inventive method further comprises automatically interconnecting the HDL design elements, and automatically interconnecting the schematic design elements. The PCB is then physically designed based on the interconnected HDL and schematic design elements. The method may further comprise creating a schematic version from the interconnected HDL design elements, and creating a HDL version from the interconnected schematic design elements. The inventive method also may simulate the schematic version of the HDL design elements, and simulate the HDL version of the schematic design elements.

Abstract: A physiological sensor device for attachment to a mammalian subject comprising an output transmitter, at least two physiological sensors each for sensing one of the subject's physiological parameters, and a controller operably in communication with the physiological sensors which controller communicates a signal comprising data representative of both the sensed physiological parameters to the output transmitter which operably transmits the signal to a remote location, wherein the controller comprises a multiplexer which operably switches the data from both the physiological sensors into a serial output signal. Respiration may be detected by a bend sensor including an elongate member and an electrical component mounted thereon which electrical component has an electrical property which varies in dependence on the extent of bending of the elongate member. Other parameters such as temperature and full waveform ECG may also be measured.

Abstract: A portable signal transfer unit for relaying a signal representative of physiological data of a mammalian subject from a remote physiological sensor to a remote receiver unit. The portable transfer unit includes an input device which operably receives the signal, a memory for buffering the signal, and an output device which wirelessly transmits the signal to the remote unit. The signal transfer unit also includes a signal processor for relaying the signal from the signal input to the output device, wherein the signal processor has two or more receivers each receiver adapted to handle a specified signal carrier frequency. An indicator is also provided which indicates to the subject whether the signal transfer unit is within range of the remote unit to enable effective transmission of the signal from the signal transfer unit to the remote unit.

Abstract: A rotary pump for pumping fluids through a patient having a housing with an internal region, a stator member and an impeller positioned within the housing and having impeller blades, wherein the impeller is magnetically suspended and rotated, and wherein the geometric configuration of the rotary pump is sized and proportioned to minimize stagnant and traumatic fluid flow within the rotary pump. The plurality of magnetic impeller blades are preferably rare earth, high-energy-density magnets selected from the group consisting of samarium cobalt and neodymium-iron-boron alloy.

Abstract: The present invention provides 2-aminopyridine and 2-pyridone C-nucleosides and oligonucleotides containing the subject nucleosides. The nucleosides are useful in the preparation of the subject oligonucleotides. The oligonucleotides are useful in oligonucleotide-based diagnosis and separation through triplex binding.

Abstract: Therapeutic delivery systems comprising gaseous precursor-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Therapeutic delivery systems comprising gaseous precursor-filled liposomes having encapsulated therein a contrast agent or drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.

Abstract: This invention presents novel methods for recovery of phosphoramidites from the waste products of oligonucleotide synthesis. The methods include reacting a tribromophenoxydichlorophosphorane with an H-phosphonate in the presence of an amine.

Abstract: An edible, hardenable coating composition containing microcrystalline cellulose and carrageenan and either a strengthening polymer, a plasticizer or both. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.

Abstract: A system and method for monitoring vital signs and capturing data from a patient remotely using radiotelemetry techniques. The system is characterized by a cordless, disposable sensor band with sensors form measuring full waveform ECG, full waveform respiration, skin temperature, and motion, and transmission circuitry for the detection and transmission of vital signs data of the patient. A small signal transfer unit that can either be worn by the patient, e.g., on his or her belt, or positioned nearby receives data from the sensor band, which it then forwards by e.g., radio transmission to a base station that can be located up to 60 meters away. The base station receives data transmissions from the signal transfer unit and is designed to connect to conventional phone lines for transferring the collected data to a remote monitoring station. The base station may also capture additional clinical data, such as blood pressure data, and to perform data checks.

Abstract: A method of constructing biologically active compounds which mimic the biological activity of the biologically active protein block the activity of the biologically active protein is disclosed. A method of identifying specific and discrete portions of pathogen antigens which either serve as epitopes for neutralizing antibodies or which are involved in pathogen binding to host cell receptors is disclosed. A method of constructing biologically active compounds which compete with cellular receptors for binding to either biologically active proteins or pathogen antigens is disclosed.

Abstract: Phenidate drug formulations are provided having reduced potential for drug abuse. Dosage forms for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS are provided which minimize drug hypersensitivity, toxicity, side effects, euphoric effect, and drug abuse potential. Such dosage forms comprise D-threo stereoisomer of a phenidate in the substantial absence of all other stereoisomers.

Abstract: A method for evaluating a system of interconnected electronic components is disclosed. According to the method, a library element model is generated for each electronic component in the system, in a format that can be input into an ASIC evaluation tool. A system netlist that represents the electronic components and the interconnections between them is generated, also in a format that can be input into an ASIC evaluation tool. The library element models and the system netlist are input into the ASIC evaluation tool, which is used to evaluate the system.

Abstract: Phenylalanine derivatives of formula (1) are described: in which: Ar1 is an aromatic or heteroaromatic group; L1 is a linker atom or group; R is a carboxylic acid or a derivative thereof; Ar2 is an optionally substituted aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of &agr;4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.

Abstract: The present invention is directed to novel peptidyl-2-amino-1-hydroxyalkanesulfonic acid inhibitors of cysteine proteases. Methods for the use of the protease inhibitors are also described.

Abstract: Peptides which mimic a loop on the &ggr;-chain that either interact with a cytokine or a &ggr;-chain partner receptor chain of a heterodimeric cytokine receptor are disclosed. The peptides consist of 5-25 amino acids and inhibit signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a &ggr;-chain. Pharmaceutical compositions that comprise the peptides are disclosed. Methods of inhibiting signal transduction mediated by cytokine:receptor binding of cytokines that bind to receptors that comprise a &ggr;-chain, methods of inhibiting cytokine mediated cell growth, proliferation, function or activity, methods of treating patients suffering from a disease disorder or condition characterized by cytokine mediated cell growth, proliferation, function or activity and methods of preventing a condition characterized by cytokine mediated cell growth, proliferation, function or activity are disclosed.

Abstract: A load control circuit having an overload circuit capable of protecting a switching element from overload conditions over a wide range of operating conditions. The overload circuit limits the maximum average power dissipation of the switching element in accordance with a comparison of an average voltage across the switching element over a half-cycle and a variable threshold. The variable threshold is determined based on an ON-state resistance of the switching element and the environment in which the switching elements are operating. The variable threshold accounts for the squared term (V2 or I2) in determining power dissipation and allows power to be determined based on average voltage.

Abstract: A system for tracking the lineage of data in a database. Data within the tables are tracked by attaching lineage information to the data, preferably, by adding a lineage identifier to each row in a table. Data that share a common lineage can be identified by virtue of sharing a common lineage identifier. The lineage identifier can then be used to trace the source of the data, i.e., data having a common identifier share a common history. Additionally, the lineage identifier can provide details about transformations undergone by the data. For example, the lineage identifier can act as a pointer to a detailed history files of operations that were performed on the data to transform it into its current form. Preferably, the lineage identifier tracks program modules as well as specific versions of the program modules that transformed the particular data under consideration.

Abstract: A method of inhibiting the proliferation and causing the differentiation of undifferentiated cells comprising contacting the undifferentiated cells with an effective amount of an antisense oligonucleotide having a sequence which is complementary to a region of the IGF-1 receptor RNA. The sequence of the antisense oligonucleotide is selected from an oligodeoxynucleotide sequence complementary to codons −29 to −24 of the signal sequence of the IGF-1 receptor and an oligoribodeoxynucleotide sequence complementary to codons 1 to 309 of the sequence of the IGF-1 receptor. The oligoribonucleotide sequence may be provided by an expression vector.