Abstract: The present invention is directed to a Blec plant 3′ sequence of SEQUENCE ID NO: 5. A method of transforming plants with a Blec 3′ sequence is also within the scope of the present invention. The present invention is also directed to cells comprising a Blec 3′ sequence, plasmids and vectors comprising a Blec 3′ sequence, and the Blec 3′ sequence per se. A plant extract comprising all or part of the Blec 3′ sequence and a method of transcribing nucleic acids in vitro comprising an extract having all or part of the Blec 3′ sequence are also within the scope of the present invention.

Abstract: Compounds of formula (1) are described: and the salts, solvates, hydrates and N-oxides thereof, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings given in claim 1. The compounds are selective inhibitors of protein kinases, especially src-family protein kinases and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to have a role.

Abstract: The present invention provides novel methods for preparing oligonucleotide conjugates using a novel electrophilic haloacetyl linker. Novel compounds and intermediates are also disclosed.

Abstract: Improved methods for preparation of phosphoramidite compounds are disclosed. The phosphoramidites are useful, for example, for the preparation of oligonucleotides by solid state oligonucleotide synthetic regimes.

Abstract: A de-energized tap changer is disclosed that includes a contact rail assembly, a gear assembly, a handle assembly and a transmission system that compensates for angular misalignment of the gear assembly and handle assembly. The transmission system includes two elongated members with attached blocks that fit inside a hollow tube and when the handle of the de-energized tap changer is rotated, torque is transmitted through the transmission system to the gear assembly which drives the movable contacts.

Abstract: A reach-measurement method is used in connection with a series-compensated line of a power system. The series-compensated line includes an installed series capacitance having a bus side and a line side, and a non-linear protection device parallel to the installed series capacitance. The series-compensated line has a line current, a bus side voltage, and a line side voltage. The series capacitance and the non-linear protection device have a capacitance voltage thereacross equal to the bus side voltage minus the line side voltage. In the method, a number (n) of line current samples are measured, where such samples are representative of values of a line current waveform at successive instants of time on the series-compensated line. Capacitance voltage values are computed based on the measured line current samples in accordance with an equation which takes into account the non-linear protection device parallel to the installed series capacitance.

Abstract: A bendable bookend having a first, non-operating position wherein the bendable bookend includes a substantially flat planar piece and a second, operating position wherein the bendable bookend includes a base and a support member extending upwardly from the base. In the non-operating position, the bendable bookend includes a base, a tongue extending from the base in a plane that is coplanar with a plane defined by the base, and a support member extending from the base in a plane that is coplanar with the plane defined by the base and in a direction toward the top end. In the operating position, the formed up bookend includes a base, a tongue, and an upstanding support member. The tongue extends from the base in a plane that is coplanar to a plane define by the base, and the support member extends upwardly from the base. Preferably, the bendable bookend includes a stiffening structure to help strengthen the formed up bookend.

Abstract: A shunt compensating power flow transformer implements power flow control in a transmission line of an n-phase power transmission system, where each phase of the power transmission system has a transmission voltage. The transformer has n primary windings, where each primary winding is on a core and receives the transmission voltage of a respective one of the phases of the power transmission system. The transformer also has n secondary windings on the core of each primary winding for a total of n2 secondary windings, where each secondary winding has a voltage induced thereon by the corresponding primary winding. One secondary winding from each core is assigned to each phase. For each phase, the secondary windings assigned to the phase are coupled in series for summing the induced voltages formed thereon.

Abstract: Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and internucleotide linkage sites. The folate can be attached via the &agr;- or &ggr;-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are diclosed. Also disclosed are nucleosidic and non-nucleosidic linkers conjugated to folic acid and related folates.

Abstract: An industrial vehicle has a frame and an axle swingalbly connected with the frame, wherein a cylinder interposed between the frame and the axle selectively extends and retracts so as to absorb a swinging motion of the axle. The cylinder is coupled to the frame and the axle in a rotatable manner within a plane intersecting an axis of a center about which the axle swings.

Abstract: The camera of this invention preferably includes a combined film advance/rewind mechanism for advancing film from a film cassette to a film path and to a film spool and for rewinding film into the cassette after the film has been exposed within the film path. The combined film advance mechanism preferably thrusts film from the film cassette in order to begin the loading process and then pulls the film to wind it around the film spool after the film has been thrusted to the film spool. Preferably, the combined film advance/rewind mechanism is manually operated and can be operated either to advance film or rewind film. Further the combined film advance/rewind mechanism preferably has an interlock that prevents thrusting of the film when the combined film advance/rewind mechanism is in a rewind position and rewinding film the combined film advance/rewind mechanism is in an advance position.

Abstract: An electrical connector (10) that may be surface mounted to a circuit board that includes a housing (11) having an outer shielding (40) and mounting posts (32) formed at a base of the connector. The outer shielding surrounds the housing and includes two “T-shaped” extensions (44) that are formed at a bottom of the shielding. The “T-shaped” extensions (44) are bent at approximately a 90° angle with respect to the lateral walls (16, 18) of the housing and through an opening in the mounting posts (32) such that the top of “T” is retained within a groove that is formed in the bottom of each mounting post. The top of the “T” has length that is longer than the diameter of the mounting post (32) such that the ends of the “T” extend beyond the periphery of the mounting post (32), and are longer than the diameter of a receiving hole of a printed wiring board (52) into which the mounting post is inserted.

Abstract: The present invention provides methods for the determination of the structure of biomolecular targets, as well as the site and nature of the interaction between ligands and biomolecular targets. The present invention also provides methods for the determination of the relative affinity of a ligand for the biomolecular target it interacts with. Also provided are methods for screening ligand or combinatorial libraries of compounds against one or more than one biological target molecules. The methods of the invention also allow determination of the relative binding affinity of combinatorial and other compounds for a biomolecular target. The present invention further provides methods for the use of mass modifying tags for screening multiple biomolecular targets. In a preferred embodiment, ligands which have great specificity and affinity for molecular interaction sites on biomolecules, especially RNA can be identified.

Abstract: A photonic integrated circuit (PIC) device comprising two or more vertically stacked asymmetric waveguides is provided. A photo-detector PIC device comprises a coupling waveguide for providing low-coupling loss with an external optical fiber and for guiding primarily a first mode of light, a second waveguide vertically coupled to the first waveguide for guiding primarily a second mode of light having an effective index of refraction different from the first mode, and a photo-detector vertically coupled to the second waveguide. Light received at the coupling waveguide is moved into the second waveguide via a lateral taper in the second waveguide. The photo-detector PIC device may further comprise a third waveguide having an optical amplifier therein and positioned between the coupling waveguide and the second waveguide.

Abstract: Novel compounds having the formula: wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring system. Attached to the central ring system are two linear groups having nitrogenous moieties that are derivatized with chemical functional groups. The ring system can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring, that may also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the these compounds. In accordance with certain embodiments of the invention, libraries of such compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the libraries.

Abstract: Phenylalanine derivatives of formula (1) are described: wherein R is a carboxylic acid or a derivative thereof; L1 is a linker atom or group; Het is an optionally substituted heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of alpha4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.

Abstract: Compounds of formula (1) are described: wherein L1 is a covalent bond or a linker atom or group; R is a carboxylic acid (—CO2H) or a derivative threof; R6 and R7 which may be the same or different is each an atom or group —L2(Alk2)tL3R12 in which L2, L3, Alk2 and t are as previously defined and R12 is a hydrogen or halogen atom or an —OR9, —NR9R10, —NO2, —CN, —CO2R9, —CONR9R10, —COR9, —N(R9)COR10, —N(R9)CSR10, —SO2N(R9)(R10), —N(R9)SO2R9, —N(R9)CON(R10)(R11), —N(R9)CSN(R10)(R11), —N(R9)SO2N(R10)(R11), or an optionally substituted aliphatic, heteroaliphatic, cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group provided that R6 and R7 are not both hydrogen atoms and when R7 is a hydrogen atom then R4 and R5 is each a hydrogen or halogen atom or an alkyl, alkoxy or nitro group; and the salts, solvates, hydrates and N-oxides thereof, for use in modulating cell adhesion.

Abstract: A cryostat for a superconducting transformer is provided that includes non-conducting load bearing insulation and is adapted for use with a superconducting transformer. In addition, the cryostat prevents the formation of closed loop stray currents on its outer case. The cryostat contains the winding sets and other related electrical equipment of a transformer. The cryostat generally comprises a cryogenic tank having an outer wall, a non-conducting liner, and a load bearing insulation layer disposed therebetween. The tank holds a liquid or gaseous cryogenic coolant into which the components of the transformer are immersed. A plurality of passages allow the passage of the limbs of the iron core of the transformer through the tank.

Abstract: Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds are oligonucleotides which contain at least one region of 2′-modified nucleosides connected by alternating phosphodiester and phosphorothioate linkages.

Abstract: Nucleosides and oligonucleosides functionalized to include carbamate functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleosides through the carbamate group.