Abstract: Apparatus for producing a plurality of arrays of reagent regions is disclosed. A dispensing assembly in the apparatus has a plurality of heads which are spaced for depositing reagents at selected positions in different array areas in a substrate. As the heads in the assembly are advanced along array area, the regions in a row in that array are successively filled, allowing parallel deposition in several array areas at reagent regions which are closely spaced relative to the spacing between deposition heads in the assembly. Also disclosed is a method for producing a plurality of arrays using the apparatus.

Abstract: Disclosed is a method for sizing paper at a pH of about 5.0-8.5 by incorporating a sizing composition consisting essentially of (1) rosin, (2) a cationic polyamine resin at a weight ratio of rosin to cationic polyamine of about 5:1 to about 1:2, and (3) up to 0.3% alum. The cationic polyamine resin is selected from the group consisting of polyalkyleneamine-epihalohydrin resins, polyalkyleneamine-dicyandiamide-epihalohydrin resins, poly(diallylamine.HCl)-epihalohydrin resins, poly(methyldiallylamine.HCl)-epihalohydrin resins, epihalohydrin-modified polyethyleneimine resins, amine-modified poly(methyldiallylamine.HCl)-epihalohydrin resins and mixtures thereof.

Abstract: A reciprocating refrigerant compressor having a cylinder block provided with a plurality of cylinder bores in which a refrigerant gas sucked from a suction chamber is compressed to be subsequently discharged into a discharge chamber, a valve plate having suction ports through which the refrigerant gas is sucked into the respective cylinder bores and discharge ports through which the compressed refrigerant gas is discharged, a suction valve attached to one end face of the valve plate, a discharge valve attached to the other end face of the valve plate, a housing assembly attached to the cylinder block and having the suction and discharge chambers, and a sealing unit arranged in one of boundaries between the end face of the cylinder block and the suction valve, and between the suction valve and the valve plate to provide an annular sealing portions around each of the bore ends of the plurality of cylinder bores.

Abstract: An adjustable support apparatus for supporting an object, such as a keyboard. The apparatus has a rotatable arm to which a rotatable support plate is attached. Rotation of the arm allows the height of the support plate to be adjusted. Rotation of the support plate allows its inclination to be adjusted. A constant force spring applies a varying upward moment to the support arm that approximates the varying downward weight moment applied to support arm, thereby restraining downward motion of the arm and making it easier for the user to raise the arm. Ratchet and pawl mechanisms lock the angular orientation of the support arm and the inclination of the support plate. The support plate is pivoted to the support arm so that twisting of the support plate disengages both the height and the inclination locking mechanisms.

Abstract: Improved vaccines are disclosed. The improved vaccines include a nucleotide sequence that encodes a coding sequence that comprises an immunogenic target protein linked to or comprising an intracellular cellular targeting sequence, the coding sequence being operably linked to regulatory elements are disclosed. Methods of immunizing individuals are disclosed.

Abstract: A novel class of compounds, known as peptide nucleic acids, form double-stranded structures with one another and with ssDNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

Abstract: The present invention provides improved methods for tracking the biodistribution of macromolecules and carriers in cells. In accordance with one embodiment, oligonucleotides and lipid carriers are differentially fluorescently labeled and coadministered to the cells. Useful compounds and synthetic methods are also provided.

Abstract: The present invention provides a distributed software facility for tailoring an information retrieval query issued by a user based upon the position of that user within an organization of users. In a query client, the facility generates an information retrieval query on behalf of an identified user. The identified user is a member both of first logical subset of the organization and of a second logical subset of the organization. In a first proxy server corresponding to the first logical subset of the organization, the facility modifies the generated query based upon query modification criteria specified for members of the first logical subset. In a second proxy server corresponding to a second logical subset of the organization, the facility modifies the generated query based upon query modification criteria specified for members of the second logical subset. The facility then processes the query as modified by the first and second proxy servers to retrieve information responsive to the modified query.

Abstract: A portable burner has a base with an electrical lighter and a nozzle provided with an inlet and multiple outlets, a gas pipe retrievable received in the base and having a removable connector adapted to connect to a gas source, a support snugly located on top of the base to encase the electrical lighter in the base and having at least three ledges and at least three bosses oppositely formed in relation to the ledges and a cover encasing the support and the gas pipe in the base and having at least two protrusions formed to correspond to at least two keyholes in the bottom face of the base.

Abstract: A foldable mechanism for a playpen includes a connection element having substantially an U-shaped cross section with two open side faces, one front face, and one rear face, the front and rear faces being provided with a U-shaped cutout and a plurality of first openings and a plurality of second openings; a press-down block having two sides each with a side groove having a narrow portion and a enlarged open end, front and rear faces each having a groove with two closed ends, an elongated through hole passing through the front and rear faces, and a hollow center with one closed end for receiving a spring, the press-down block being attached to the connection element by a first screw passing through the through hole and pressed against the spring, such that the press-down block can be pressed down, or biased, with respect to the connection element by an external force and moved back by the spring force; and a pair of hollow rods each having therein a U-shaped reed spring with protrusions on both outer faces of t

Abstract: Conditioning of the surface of silica-based glass or ceramic by differential immersion in a serum protein-containing solution, and the resultant microporous Ca—P surface layer having serum-protein like organic molecules, as defined herein intermingled throughout, is described.

Abstract: Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.

Abstract: A can bottom having an approximately frustoconical portion extending downwardly and inwardly from the can side wall, an annular nose portion extending downwardly from the approximately frustoconical portion, and a central portion extending upwardly and inwardly from the nose. The nose is formed by inner and outer circumferentially extending frustoconical walls that are joined by a downwardly convex arcuate portion. The inner surface of the arcuate portion of the nose has a radius of curvature adjacent the nose inner wall of at least 0.060 inch. The central portion of the can bottom has a substantially flat disc-shaped central section, having a diameter of at least about 1.40 inches, and an approximately dome-shaped and downwardly concave having a radius of curvature no greater than 1.475 inches. In a preferred embodiment of the invention, the inner surface of the arcuate portion of the nose is formed by a sector of a circle and has radius of curvature is no greater than about 0.070 inch.

Abstract: A single headed piston type refrigerant compressor having a cylinder block forming therein a plurality of cylinder bores receiving a plurality of single-headed pistons for reciprocation therein, and a front housing joined to the cylinder block to define a crank chamber for receiving therein a cam plate. An extended bore-forming portion of the cylinder block having partial cylindrical guide surfaces each being continuous with the corresponding cylinder bore and capable of being in slide contact with the piston head portion of the single-headed piston and the outer circumference of a shoe-holding portion of the single-headed piston is formed by extending a peripheral portion of a front end of the cylinder block into the crank chamber. A projecting portion formed on each single head piston protrudes from a side end surface of the shoe-holding portion extending behind the piston head portion into the crank chamber.

Abstract: A computer-based method and system for digital 3-dimensional imaging of an object which allows for viewing images of the object from arbitrary vantage points. The system, referred to as the Lumigraph system, collects a complete appearance of either a synthetic or real object (or a scene), stores a representation of the appearance, and uses the representation to render images of the object from any vantage point. The appearance of an object is a collection of light rays that emanate from the object in all directions. The system stores the representation of the appearance as a set of coefficients of a 4-dimensional function, referred to as the Lumigraph function. From the Lumigraph function with these coefficients, the Lumigraph system can generate 2-dimensional images of the object from any vantage point. The Lumigraph system generates an image by evaluating the Lumigraph function to identify the intensity values of light rays that would emanate from the object to form the image.

Abstract: A communications platform for enabling the cost-effective deployment of fixed wireless local loop telephone services to residential and commercial subscribers. The platform includes at least one Independent Central Office located within a new residential or commercial development, and connected to the public switched telephone network (PSTN), at least one subscriber base station, and subscriber terminals communicating with the fixed network via a fixed wireless local loop radio path. The customer premise equipment of the telephone subscriber is connected to a switch at the Independent Central Office facility via the fixed wireless local loop radio path, and the switch at the Independent Central Office facility is connected to the incumbent local exchange carrier (LEC) switch at the LEC Central Office facility via direct inward dialing (DID) and direct outbound dialing (DOD) services provided via respective DID and DOD trunk lines.

Abstract: A header for interconnecting electrical components comprises at least one column of conductors interposed between ground planes, wherein the column of conductors comprises at least a first, second and third conductor. The first conductor is a ground line, the second and third conductors are signal lines, and the first conductor is electrically connected to one of the ground planes, wherein the second conductor is positioned in the column in interposed relation between said first and third conductor.

Abstract: Methods of identifying molecular interaction sites in eukaryotic and prokaryotic nucleic acids, especially RNA, are described. Secondary structural elements are identified from highly conserved sequences. Methods of preparing databases relating to such molecular interaction sites are also provided herein as are databases themselves. Therapeutic, agricultural, industrial, and other applicability results from interaction of such molecular interaction sites with “small” and other molecules.