Abstract: A reliable method of illuminating and imaging an eye through eyeglasses uses a carefully selected subset of multiple monochromatic light sources, a camera with an imager that exhibits minimal blooming, and a narrow-bandwidth optical bandpass filter to filter out most of the ambient illumination while passing most of the light from the system's own illuminator.
Abstract: A cartridge for a magnetic disk drive has a rigid shell and a flexible door which covers an opening through which read/write heads engage the recording medium. The flexible door is guided outside of the shell to an open position as the cartridge is inserted into the drive. A projection on a flexible arm in the drive catches a hole in the flexible door to open it as the cartridge is inserted into the drive. The door along the outside of the cartridge conserves space so that the recording medium can be large for a given form factor drive.
Type:
Grant
Filed:
February 18, 2000
Date of Patent:
June 26, 2001
Assignee:
Iomega Corporation
Inventors:
Wayne A. Sumner, Allen T. Bracken, David W. Griffith, David E. Jones, Edward L. Rich
Abstract: The present invention provides methods for the generation of virtual libraries of compounds. These compounds are generated in silico. The present invention encompasses methods for tracking the addition of fragments, use of reagents, and transformations performed. Further, methods for interfacing the information necessary to generate libraries of compounds with instrumentation that conducts the actual synthesis of the compounds are provided. Also provided are methods for the in silico docking of the library compounds to identified target molecules of interest.
Abstract: Nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.
Type:
Grant
Filed:
July 28, 1998
Date of Patent:
June 26, 2001
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Cameron J. Koch, Alexander V. Kachur, Sydney M. Evans, Chyng-Yann Shiue, Ian R. Baird, Kirsten A. Skov, William R. Dolbier, Jr., An-Rong Li, Brian R. James
Abstract: A spiral coil design can reduce or eliminate inhomogeneities caused by finite wavelength effects at high magnetic field strength. The spiral radio frequency coil has a center axis and angled conductors in a spiral geometry about the center axis, where the phase of current within the conductors varies with axial distance along the center axis of the coil and rotation of the conductors as a function of axial distance along the center axis leads to a phase rotation of a radio frequency field generated by the radio frequency coil when current is applied to the conductors. The amount of phase rotation is determined by the tightness of the spiral of the conductors.
Type:
Grant
Filed:
April 20, 1999
Date of Patent:
June 26, 2001
Assignee:
The Trustees of the University of Pennsylvania
Abstract: A plasmid isolated from Clamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formulation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections; in particular the recombinant fusion MS2-pgp3D protein is described comprising polypeptidic sequences encoded by pCT and immunogenic in the course of infections in man. A method for preparing said protein in E. coli further described.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
June 19, 2001
Assignee:
Scalvo SpA
Inventors:
Giulio Ratti, Maurizio Comanducci, Mario F. Tecce, Marzia M. Giuliani
Abstract: A Voltage Instability Predictor (VIP) estimates the proximity of a power system to voltage collapse in real time. The VIP can be implemented in a microprocessor-based relay whose settings are changed adaptively to reflect system changes. Only local measurements (voltage and current) at the bus terminal are required. The VIP detects the proximity to collapse by monitoring the relationship between the apparent impedance {overscore (Z)}app and the Thévenin-impedance. In addition, we disclose: (1) that the VIP may be used in connection with non-radial topologies; (2) a new, more robust method to track voltage collapse in terms of impedance using rolling sums; and (3) a new method for representing distance to voltage collapse in terms of power margins.
Type:
Grant
Filed:
June 14, 1999
Date of Patent:
June 19, 2001
Assignee:
ABB Power T&D Company, Inc.
Inventors:
Khoi Tien Vu, Danny E. Julian, Jan Ove Gjerde, Murari M. Saha
Abstract: Improved vaccines are disclosed. The improved vaccines include a nucleotide sequence that encodes a coding sequence that comprises an immunogenic target protein linked to or comprising an intracellular cellular targeting sequence, the coding sequence being operably linked to regulatory elements are disclosed. Methods of immunizing individuals are disclosed.
Type:
Grant
Filed:
February 2, 2000
Date of Patent:
June 19, 2001
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
William V. Williams, Michael Madaio, David B. Weiner
Abstract: An on-line dynamic shrink facility sets an allocation fence in a file and moves data from above the fence to below the fence. The fence is based on a target size for the file. When all the data above the fence is moved below the fence, the space above the fence is freed. The target size can be a specified size, an original size for the file when it was created, or a size calculated by examining the amount of space used and adding in an amount of desired free space. Resources that are required to move the data, such as old and new allocation units for the data, or that will be impacted by movement of the data, such as index entries, are locked or latched to prevent corruption of the data while it is being moved. The operations are performed in discreet transactions which are immediately committed to minimize the impact on other users of the file.
Type:
Grant
Filed:
December 16, 1998
Date of Patent:
June 19, 2001
Assignee:
Microsoft Corporation
Inventors:
Michael Zwilling, Rande Blackman, Sameet Agarwal, Steven J. Lindell
Abstract: A mechanism for attenuating torsional vibration in a compressor is described. The compressor includes a swash plate secured to a drive shaft and pistons coupled to the swash plate. Compression of refrigerant gas by the pistons generates torsional vibrations of the drive shaft. The rear end of the drive shaft is coupled to a damper for attenuating torsional vibrations. The damper includes a frictional plate secured to the rear end of the drive shaft, a weight rotatably fitted about the drive shaft, and a coil spring. The coil spring elastically presses the weight against the frictional plate and elastically couples the weight with the drive shaft. When the drive shaft torsionally vibrates, the weight contacts the frictional plate and is vibrated about the axis of the drive shaft by the coil spring. As a result, energy of the torsional vibrations is consumed and the vibrations are attenuated. Further embodiments show similar dampers attached to the exterior of the compressor.
Abstract: The present invention is directed to wet processing methods for the manufacture of electronic component precursors, such as semiconductor wafers used in integrated circuits. More specifically, this invention relates to methods of manufacturing electronic component precursors using liquids of varying temperature.
Abstract: Compounds of general formula (1) are described:
wherein
═W— is (1) ═C(Y)— where Y is a halogen atom, or an alkyl or —XRa group where X is —O—, —S(O)m— [where m is zero or an integer of value 1 or 2], or —N(Rb)— [where Rb is a hydrogen atom or an optionally substituted alkyl group] and Ra is a hydrogen atom or an optionally substituted alkyl group or, (2) ═N—;
L is (1) a —C(R)═C(R1)(R2) or [—CH(R)]nCH(R1)(R2) group; is (2) a —(Xa)nAlk′Ar′, or Alk′XaAr′ group; or is (3) XaR1;
Z is a group (A), (B), (C) or (D):
wherein
Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms;
Z1is a group —NR12C(O)— [where R12 is a hydrogen atom or an optionally substituted alkyl or (Alk)tAr group], —C(O)NR12—, —NR12
Type:
Grant
Filed:
June 20, 1995
Date of Patent:
June 12, 2001
Assignee:
Celltech Therapeutics Limited
Inventors:
Graham John Warrellow, Ewan Campbell Boyd, Rikki Peter Alexander
Abstract: A resin molded object 1 that may be used as a sunroof has a reinforcing rib 3 around the periphery of a window body 2 that is disposed inside a car. The window body 2 is molded using a fixed die 7 and one molding surface 8a of a first movable die 8, then the reinforcing rib 3 is molded on the window body 2 using the fixed die 7 and a second molding surface 8b of a second movable die 8 to thereby to fabricate a double-molded resin window.
Abstract: A blood pump preferably has a magnetically suspended rotor that rotates within a housing. The rotor may rotate about a stator disposed within the housing. Radial magnetic bearings may be defined within the stator and the rotor in order to suspend the rotor. The radial magnetic bearings may be passive magnetic bearings that include permanent magnets disposed within the stator and the rotor or active magnetic bearings. The pump may further include an axial magnetic bearing that may be either a passive or an active magnetic bearing. A motor that drives the rotor may be disposed within the housing in order to more easily dissipate heat generated by the motor. A primary flow path is defined between the rotor and the stator, and a secondary flow path is defined between the stator and the rotor. Preferably, a substantial majority of blood passes through the primary flow path.
Type:
Grant
Filed:
July 19, 1999
Date of Patent:
June 12, 2001
Inventors:
James F. Antaki, Bradley Paden, Gregory Burgreen, Nelson J. Groom
Abstract: Processes for preparing 2′-O-alkylated guanosine, uridine, cytidine, and 2,6-diaminopurine 3′-O-phosphoramidites include the steps of alkylating nucleoside precursors, adding suitable blocking groups and phosphitylating. For the guanosine 2′-O-alkylated 3′-O-phosphoramidites, alkylation is effected on 2,6-diamino-9-(&bgr;-D-ribofuranosyl) purine followed by deamination. For uridine 2′-O-alkylated 3′-O-phosphoramidites, alkylation is effect on a dialkyl stannylene derivative of uridine. For cytidine 2′-O-alkylated 3′-O-phosphoramidites, alkylation is effected directly on cytidine. Alkylation is effected directly upon 2,6-diaminopurine.
Type:
Grant
Filed:
December 9, 1999
Date of Patent:
June 5, 2001
Assignee:
ISIS Pharmaceuticals, Inc.
Inventors:
Phillip Dan Cook, Daniel Peter Claude McGee, Charles John Guinosso
Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfuiized according to the methods of the invention with higher yields than have been previously reported.
Type:
Grant
Filed:
January 11, 2000
Date of Patent:
June 5, 2001
Assignee:
Isis Pharmaceuticals, Inc.
Inventors:
Douglas L. Cole, Vasulinga T. Ravikumar, Zacharia S. Cheruvallath
Abstract: Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds are phosphorothioate oligonucleotides wherein the 5′-terminal internucleoside linkage or the 5′- and 3′-terminal linkages are modified.
Abstract: A system for performing sequential operations on a can body, such as necking the open end of the can body, in which two or more machines, such as die necking machines are, are coupled by a transfer module. The transfer module comprises a multi-pocket wheel that receives can bodies from a multi-pocket discharge wheel of the first necking machine and discharges them to a multi-pocket input wheel of the second die necking machine. The drive motor of one of the necking machines is eliminated, while the drive motor on the other machine is enlarged. A gear on the transfer module couples the gear trains on the first and second necking machines into a common gear train. Thus, the transfer module gear train transfers power from the necking machine having the enlarged drive motor to the necking machine for which the drive motor was eliminated. This enables a single drive motor to entire drive train for both machines.
Type:
Grant
Filed:
April 25, 2000
Date of Patent:
June 5, 2001
Assignee:
Crown Cork & Seal Technologies Corporation
Inventors:
Joseph M. Heiberger, Anton A. Aschberger, Floyd Arnold Jones
Abstract: A connector device includes a housing having a slide plate with a handle. By the manual operation of the handle, the slide plate is moved by a disengageable link mechanism along the length of the housing. When a data storage medium is fully inserted in the connector device and the handle is in a first position, the link mechanism is disengaged. The link mechanism becomes engaged, and thereby operable to move the slide plate, only after the handle is moved from the first position to an extended position. In this manner, inadvertent ejection of the data storage medium is prevented.