Patents Represented by Law Firm Yahwak & Associates
  • Melanocortin receptor antagonists and agonists
    Patent number: 6054556
    Abstract: Cyclic lactam peptides are disclosed which inhibit at various levels of antagonism the melanocortin 1 receptor (MC1R), melanocortin 3 receptor (MC3R), melanocortin 4 receptor (MC4R), and Melanocortin 4 receptor (MC5R).
    Type: Grant
    Filed: November 28, 1997
    Date of Patent: April 25, 2000
    Assignee: The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Victor J. Huby, Sejin Lim, Wei Yuan
  • Stimulating sexual response in females
    Patent number: 6051555
    Abstract: The present invention is directed to a series of peptides which may be used for stimulating sexual response in females.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: April 18, 2000
    Inventor: Mac E. Hadley
  • Methods for the manufacture and use of antimicrobial sterol conjugates
    Patent number: 5834453
    Abstract: A method of forming a pharmaceutical composition of antimicrobial sterol conjugates having the following formulae: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Y are as defined in the specification. Also disclosed is a method of inducing an antimicrobial effect by administrating these pharmaceutical compositions.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: November 10, 1998
    Assignee: Lehigh University
    Inventor: Steven L. Regen
  • 5,5-Disubstituted hydantoins
    Patent number: 5767140
    Abstract: A series of 5,5-disubstituted Hydantoin derivatives synthesized by alkylating 5,5-bis(thiomethyl)-2,4-imidazolidinedione with halomethyl aromatic or halomethyl heteroaromatic precursors or by using the Buchener-Berg procedure on the required ketone. This series of 5,5-disubstituted Hydantoin derivatives are biologically active in their ability to inhibit HIV-induced death and virus production in mammalian (human) cells.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: June 16, 1998
    Assignee: Southern Research Institute
    Inventors: Robert N. Comber, Robert C. Reynolds, Robert W. Buckheit, Jr.
  • Multifocal lens utilizing rapid power shift transition zone
    Patent number: 5754270
    Abstract: In accordance with the disclosure there is described herein a simultaneous vision lens that incorporates both continuous aspheric and concentric bifocal optics into a single optical lens that may be configured as a contact lens or an intraocular lens.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: May 19, 1998
    Assignee: Unilens Corp., USA
    Inventors: Denis Rehse, Giovanna E. Olivares
  • Polynucleotide phosphorodithioate compounds
    Patent number: 5750666
    Abstract: The present invention relates to new and useful nucleoside thiophosphoroamidites and polynucleotide phosphorodithioate compounds as well as the processes whereby these compounds may be used for synthesizing new mononucleotides and polynucleotides having phosphorothioate and phosphorodithioate internucleotide linkages.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: May 12, 1998
    Assignee: Competitve Technologies, Inc.
    Inventors: Marvin H. Caruthers, Wolfgang K.-D Brill, Eric Yau, Michael Ma, John Nielsen
  • Surgical apparatus
    Patent number: 5730153
    Abstract: A surgical drape apparatus that incorporates means to alleviate a patient's "suffocation anxiety" by providing for continued circulation of air to the patient's nose and mouth while the patient is draped for surgery, especially the field of surgery is the eye, is described.
    Type: Grant
    Filed: August 1, 1994
    Date of Patent: March 24, 1998
    Assignee: Stanley Chang
    Inventors: Stanley Chang, Nancy Cimitile, Clarice Jaget, Liebert Turner
  • Linear analogs of alpha-msh fragments
    Patent number: 5714576
    Abstract: Linear and Cyclic Alpha-MSH fragment analogues of Ac-Nle.sup.4 -Glu.sup.5 -His.sup.6 -D-Phe.sup.7 -Arg.sup.8 -Try.sup.9 -Gly.sup.10 -NH.sub.2. The method of stimulating melanocytes by the transdermal application of these biologically-active analogues and compositions comprising these analogues for use in the method are disclosed.
    Type: Grant
    Filed: April 7, 1997
    Date of Patent: February 3, 1998
    Assignee: Competitive Technologies, Inc.
    Inventors: Victor J. Hruby, Mac E. Hadley, Fahad Al-Obeidi
  • Inhibition of reverse transcriptase by phosphorodithioates
    Patent number: 5695979
    Abstract: The present invention describes a method for the inhibition of reverse transcriptase by contacting said reverse transcriptase with oligonucleotides having have at least one phosphorodithioate internucleotide linkage of the formula ##STR1## within the phosphorus backbone of the oligonucleotide.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: December 9, 1997
    Assignee: Competitive Technologies, Inc.
    Inventors: Marvin H. Caruthers, William S. Marshall, Wolfgang Brill, John Nielsen
  • Cyclic bridged analogs of .alpha.-MSH and methods thereof
    Patent number: 5683981
    Abstract: A novel class of cyclic bridged analogs of .alpha.-MSH are described herein. With the described analogs, when administered in pharmaceutical compositions, it is now possible to achieve normalization of hypopigmentation dysfunctions and to achieve darkening of the skin in the total absence of sun or UV light irradiation.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 4, 1997
    Assignee: Competitive Technologies, Inc.
    Inventors: Mac E. Hadley, Victor J. Hruby, Shubh D. Sharma
  • Nucleoside thiophosphoramidites
    Patent number: 5684148
    Abstract: The present invention relates to new and useful nucleoside thiophosphoroamidites and polynucleotide phosphorodithioate compounds as well as the processes whereby these compounds may be used for synthesizing new mononucleotides and polynucleotides having phosphorothioate and phosphorodithioate internucleotide linkages.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: November 4, 1997
    Assignee: Competitive Technologies, Inc.
    Inventors: Marvin H. Caruthers, Wolfgang K. D. Brill, Eric Yau, Michael Ma, John Nielsen
  • Cyclic analogs of alpha-MSH fragments
    Patent number: 5674839
    Abstract: Cyclic Alpha-MSH fragment analogues of Ac-Nle.sup.4 -Glu.sup.5 -His.sup.6 -D-Phe.sup.7 -Arg.sup.8 -Try.sup.9 -Gly.sup.10 -NH.sub.2. The method of stimulating melanocytes by the transdermal application of these biologically-active analogues and compositions comprising these analogues for use in the method are disclosed.
    Type: Grant
    Filed: December 6, 1994
    Date of Patent: October 7, 1997
    Assignee: Competitive Technologies, Inc.
    Inventors: Victor J. Hruby, Mac E. Hadley, Fahad Al-Obeidi
  • 2-halo-2'-fluoro ARA adenosines as antinoplastic agents
    Patent number: 5661136
    Abstract: The present invention is directed to certain 2'-fluoro, 2-substituted purine nucleosides which are toxic to cancerous cell lines.
    Type: Grant
    Filed: September 21, 1994
    Date of Patent: August 26, 1997
    Assignee: Southern Research Institute
    Inventors: John A. Montgomery, John A. Secrist, III
  • Enzyme immunoassay device
    Patent number: 5629164
    Abstract: The present invention relates to an enzyme reagent ticket for conducting diagnostic or serological tests. More particularly, the present invention relates to an enzyme reagent device which allows for a low-cost, disposable, rapid and convenient system for use in the determination of various components in test fluids, and to a diagnostic kit including the device according to the present invention for conducting certain immunochemical, diagnostic or serological testing.
    Type: Grant
    Filed: November 25, 1992
    Date of Patent: May 13, 1997
    Assignee: Southern Research Institute
    Inventor: Douglas B. Rivers
  • Apparatus and treatment for wastewater
    Patent number: 5624562
    Abstract: The present invention relates to the pretreatment and treatment of biodegradable wastewater utilizing a series of treatment modes within a single variable depth reactor apparatus to biologically reduce the biochemical oxygen and chemical oxygen demand in domestic and industrial wastewater.
    Type: Grant
    Filed: March 20, 1995
    Date of Patent: April 29, 1997
    Assignee: EV Environmental, Inc.
    Inventor: Dan Scroggins
  • Amphiphilic polyene macrolide antibiotic compounds
    Patent number: 5606038
    Abstract: Described herein is a method, and the resulting compound, for the synthesis of improved amphiphilic antibiotic agents achieved by altering the chemical structure of amphiphilic polyene macrolide compounds with an oligo(ethylene glycol) conjugate in order to raise the critical micelle concentration of the compound.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: February 25, 1997
    Assignee: Competitive Technologies, Inc.
    Inventor: Steven L. Regen
  • Polynucleotide phosphorodithioate compounds
    Patent number: 5602244
    Abstract: Dinucleoside phosphorodithioate phosphoramidite precursors useful in the synthesis of oligonucleotide phosphorodithioate which can be used as antisense inhibitors of translation.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: February 11, 1997
    Assignee: Competitive Technologies, Inc.
    Inventors: Marvin H. Caruthers, Wolfgang K.-D. Brill, Eric Yau, Michael Ma, John Nielsen
  • 2'-deoxy-4'-thioribonucleosides and their antiviral activity
    Patent number: 5591722
    Abstract: 2'-Deoxy-4'-thio-ribonucleosides, intermediates in their production, and their use as antiviral and anticancer agents are disclosed.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: January 7, 1997
    Assignee: Southern Research Institute
    Inventors: John A. Montgomery, John A. Secrist, III
  • Antimicrobial sterol conjugates
    Patent number: 5583239
    Abstract: The invention discloses steroid conjugates having the following structure: ##STR1## where Y is NHCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 NH.sub.2, NH(CH.sub.2).sub.3 NH(CH.sub.2).sub.4 NH(CH.sub.2).sub.3 NH.sub.2, or NHCH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.2 NH.sub.2, and each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is individually H, OH and OSO.sub.3 H. These conjugates posses antimicrobial properties and are, therefore, useful as antibiotics.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: December 10, 1996
    Assignee: Lehigh University
    Inventor: Steven L. Regen
  • Compositions and methods for the diagnosis and treatment of psychogenic erectile dysfunction
    Patent number: 5576290
    Abstract: The present invention is directed to a group of linear and cyclic peptides having the structures: ##STR1## These peptides, when systemically administered to animals will bring about a sexual response and are thus useful for the diagnosis and treatment of psychogenic sexual dysfunction in the male.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: November 19, 1996
    Assignee: Competitive Technologies, Inc.
    Inventor: Mac E. Hadley