Patents Represented by Law Firm Yahwak & Associates
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Patent number: 5525687Abstract: A process for producing polyolefin with a vapor-phase fluidized-bed reactor, wherein the reaction is started after filling the reactor with particles which contain moisture and/or molecular oxygen and can form a fluidized bed in order to prevent the formation of molten resin which is liable to occur at the start of the reaction and to attain a smooth operation of the reactor.Type: GrantFiled: October 24, 1994Date of Patent: June 11, 1996Assignee: Nippon Petrochemicals Company, LimitedInventors: Yoshihisa Yamaguchi, Shinjiro Suga, Masatoshi Morikawa, Kunimichi Kubo, Motokazu Watanabe, Yasuhiko Sano
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Patent number: 5487899Abstract: The present invention describes a composition derived from the Aloe plant which when used as an adjuvant for the healing of wounds exhibits increased anti-inflammatory and wound healing activity. The composition, an Aloe vera mucilage at approximately a 1:1 ratio, preferably with Aloe pulp fibers, increased open wound healing activity and increased wound tensile strength by 131% over controls.Type: GrantFiled: January 31, 1994Date of Patent: January 30, 1996Assignee: Jess Clarke & Sons, Inc.Inventor: Robert H. Davis
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Patent number: 5478785Abstract: A method for producing composite materials by introducing additional phases into a porous body wherein a liquid precursor is infiltrated into the porous body, the liquid is decomposed to produce a desired phase, the body is fired for further densification, and the decomposed liquid is allowed to remain as an additional phase or reacts with the porous body to form an additional phase is disclosed. This allows for a novel method of introducing the additional phase, and by controlling the parameters such as infiltration time, firing schedule, porous body density, etc., the size, amount, extent and distribution of the added phases may be controlled.Type: GrantFiled: November 6, 1989Date of Patent: December 26, 1995Assignee: Pennsylvania Research CorporationInventors: S. Jill Glass, David J. Green, Basil R. Marple
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Patent number: 5453496Abstract: Oligonucleotides having at least one phosphorodithioate internucleotide linkage. Phosphorodithioate oligonucleotides exhibit stronger antiviral activity than the corresponding phoshorothioate derivatives.Type: GrantFiled: October 15, 1993Date of Patent: September 26, 1995Assignee: University Patents, Inc.Inventors: Marvin H. Caruthers, William S. Marshall, Wolfgang Brill, John Nielsen
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Patent number: 5385991Abstract: A process for producing polyolefin with a vapor-phase fluidized-bed reactor, wherein the reaction is started after filling the reactor with particles which contain moisture and/or molecular oxygen and can form a fluidized bed in order to prevent the formation of molten resin which is liable to occur at the start of the reaction and to attain a smooth operation of the reactor.Type: GrantFiled: March 27, 1992Date of Patent: January 31, 1995Assignee: Nippon Petrochemicals Company, LimitedInventors: Yoshihisa Yamaguchi, Shinjiro Suga, Masatoshi Morikawa, Kunimichi Kubo, Motokazu Watanabe, Yasuhiko Sano
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Patent number: 5384310Abstract: The present invention is directed to certain 2'-fluoro, 2-substituted purine nucleosides which are toxic to cancerous cell lines.Type: GrantFiled: May 10, 1991Date of Patent: January 24, 1995Assignee: Southern Research InstituteInventors: John A. Montgomery, John A. Secrist, III
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Patent number: 5381190Abstract: A low vision lens for attachment to the front surface of an ophthalmic lens by an adhesive ring coupling carried by the lens, a method for making such a lens assembly, and a method for attaching such lens to the front surface of ophthalmic lens is described.Type: GrantFiled: December 11, 1992Date of Patent: January 10, 1995Assignee: Unilens Corp, U.S.A.Inventors: Denis Rehse, Frank Rumsey, Tim Petito, Samuel Garrett, Giovanna Olivares, David Welsh, Roger Antici, Josepha Bruno
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Patent number: 5360610Abstract: The present invention relates to polymeric microspheres as injectable, drug-delivery systems for use to deliver bioactive agents to sites within the central nervous system, and for the stimulation of nerve fiber growth by implanting such microspheres within the central nervous system of a patient.Type: GrantFiled: March 15, 1993Date of Patent: November 1, 1994Assignee: Southern Research InstituteInventors: Thomas R. Tice, Deborah L. Dillon, David W. Mason, Amanda McRae-McFarlane, Annica B. Dahlstrom
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Patent number: 5356807Abstract: A culture medium, a technique for the culture of adult diploid cells from brain and meningeal tissue, explanted diploid cells from brain tissue having neuronal antigenic markers, and the use of cultured diploid cells from brain tissue having neuronal antigenic markers for the screening of neuroactive compounds are disclosed.Type: GrantFiled: September 8, 1992Date of Patent: October 18, 1994Assignee: Cornell Research FoundationInventors: John P. Blass, Ronald S. Black
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Patent number: 5310833Abstract: A process for feeding a powder catalyst with a gas intermittently to a high-pressure fluidized bed reactor for the vapor phase polymerization of olefin, wherein the cross section of a catalyst feed pipe is reduced midway through the pipe to thereby make continual catalyst feeding possible and prevent the formation of a lump polymer.Type: GrantFiled: February 22, 1993Date of Patent: May 10, 1994Assignee: Nippon Petrochemicals Company, Ltd.Inventors: Kunimichi Kubo, Motokazu Watanabe, Mamoru Yoshikawa, Masatoshi Morikawa, Yoshihisa Yamaguchi
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Patent number: 5294537Abstract: Mouse monoclonal antibodies which will specifically recognize the pathogen Listeria monocytogenes were produced by fusion of spleen cells from an animal immunized with live L. monocytogenes to an NS-1 myeloma partner, and three hybridomas were identified upon subsequent subcloning, Mab 20-10-2, Mab 36-6-12 and Mab 56-9-16 which were preferentially reactive with L. monocytogenes in a direct binding ELISA assay. An indirect "sandwich" assay was developed and used to further confirm the reactivity of these hybridomas using four serotypes of L. monocytogenes and other common cross reacting bacteria.Type: GrantFiled: September 23, 1991Date of Patent: March 15, 1994Assignee: Cornell Research Foundation, Inc.Inventor: Carl A. Batt
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Patent number: 5288621Abstract: Disclosed for the first time is the isolation, sequence, and expression cloning of a cDNA encoding for pituitary thyrotropin-releasing hormone receptor, as well as the amino acid sequence for the receptor per se.Type: GrantFiled: December 14, 1990Date of Patent: February 22, 1994Assignee: Cornell Research Foundation, Inc.Inventors: Marvin C. Gershengorn, Richard E. Straub
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Patent number: 5278302Abstract: The present invention relates to novel oligonucleotides having phosphorodithioate internucleotide linkages which may be used for the treatment of diseases caused by viruses.Type: GrantFiled: November 18, 1991Date of Patent: January 11, 1994Assignee: University Patents, Inc.Inventors: Marvin H. Caruthers, William S. Marshall
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Patent number: 5270627Abstract: A machine tool control system in which a programmable controller operates a machine to carry out a plurality of programmable functions. The controller includes a plurality of processor means, a first one of the processor means capable of pre-processing and forwarding control information to a second of said processor means, wherein said second processor means provides control information to control machine movement. Advantageously, the second processor means operates on a periodic time based interrupt method which greatly increases the accuracy of the machine.Type: GrantFiled: June 24, 1991Date of Patent: December 14, 1993Assignee: Unilens Corp., U.S.A.Inventor: Denis Rehse
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Patent number: 5218103Abstract: The present invention relates to new and useful nucleside thiophosphoramidite, polynucleotide dithioate phosphoramidite and polynucleotide phosphorothioamidate phosphoramidite compounds as well as the process whereby these compounds can be used for synthesizing new monoucleotides and polynucleotides having phosphorodithioate, phosphorothioamidate, phosphorothiotriesters and phosphorothioate internucleotide linkages.Type: GrantFiled: January 22, 1991Date of Patent: June 8, 1993Assignee: University Patents, Inc.Inventors: Marvin H. Caruthers, Yun-Xi Ma, Eric K. Yau, John Nielsen, Wolfgang Brill
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Patent number: 5202396Abstract: A process for feeding a powder catalyst with a gas intermittently to a high-pressure fluidized bed reactor for the vapor phase polymerization of olefin, wherein the cross section of a catalyst feed pipe is reduced midway through the pipe to thereby make continual catalyst feeding possible and prevent the formation of a lump polymer.Type: GrantFiled: March 19, 1992Date of Patent: April 13, 1993Assignee: Nippon Petrochemicals Company, LimitedInventors: Kunimichi Kubo, Motokazu Watanabe, Mamoru Yoshikawa, Masatoshi Morikawa, Yoshihisa Yamaguchi
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Patent number: 5189106Abstract: A polyethylene composition which has excellent flow characteristics and mechanical properties, especially low temperature mechanical properties as well as thermal stability, elasticity and workability for molding. The polyethylene composition comprises 20 to 80 wt. % of an ethylene-.alpha.-olefin copolymer of higher molecular weight having (a) intrinsic viscosity (.eta..sub.1) of 1.2 to 9.0 dl/g, (b) density (d.sub.1) of 0.890 to 0.935 g/cm.sup.3 (c) a specific areal ratio calculated with an elution temperature-eluate volume curve in elution fractionation, and (d) a specific quantity of the content which is soluble in 25.degree. C. o-dichlorobenzene, and 80 to 20 wt. % of ethylene homopolymer or ethylene-.alpha.-olefin copolymer of lower molecular weight having (e) intrinsic viscosity (.eta..sub.2) of 0.2 to 1.6 dl/g, (f) density (d.sub.2) of 0.890 to 0.980 g/cm.sup.3 and, wherein the above (.eta..sub.1) is larger than (.eta..sub.2), and the prepared composition has an intrinsic viscosity (.eta.) of 0.Type: GrantFiled: December 30, 1991Date of Patent: February 23, 1993Assignee: Nippon Petrochemicals Company, LimitedInventors: Toshifumi Morimoto, Takaaki Hattori, Noboru Ikegami, Hirofumi Nishibu, Toshiyuki Miyauchi, Kunimichi Kubo
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Patent number: 5153319Abstract: New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic (DNA) acids, are described.Type: GrantFiled: March 31, 1986Date of Patent: October 6, 1992Assignee: University Patents, Inc.Inventors: Marvin H. Caruthers, Mark D. Matteucci
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Patent number: 5132418Abstract: This invention is a process for the production of oligonucleotides which comprises:(a) converting an inorganic polymer into a coupling agent-polymer;(b) combining the coupling agent-polymer with a blocked nucleoside to obtain a blocked nucleoside-modified support; and(c) removing the blocking group from the blocked nucleoside-modified support to provide for the coupling of nucleotides to the nucleoside-modified support.Type: GrantFiled: June 18, 1984Date of Patent: July 21, 1992Assignee: University Patents, Inc.Inventors: Marvin H. Caruthers, Mark D. Matteucci
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Patent number: PP8333Abstract: A new and distinct variety of blackberry plant which exhibits erect thorny growth, is vigorous and hardy in cold climates. The plant produces fruits which are shiny black, medium sized, slightly acidic and flavorful.Type: GrantFiled: June 6, 1991Date of Patent: August 3, 1993Assignee: Board of Trustees of the University of IllinoisInventors: Robert M. Skirvin, Alan G. Otterbacher