Abstract: The present invention provides nine selective c-FLIP inhibitors that are useful in the treatment of cancer, alone or in combination with other chemotherapeutic agents, in particular with TRAIL-based chemotherapeutic agents. The present invention also relates to pharmaceutical compositions and kits comprising at least one of the nine selective c-FLIP inhibitors and their use in methods for the treatment of cancer, in particular to overcome chemoresistance or to improve sensitivity of tumors to TRAIL-based therapy.

Abstract: The present application provides an oral care composition comprising: a) one or more omega fatty acids; and one or more of the following: b) one or more emulsifying agents; c) one or more protease enzymes; d) one or more soluble calcium phosphate remineralizing agents; e) one or more amino acids.

Abstract: A height-adjustable armrest for a chair, in particular an office chair, has an arm support, which is retained by an armrest holder. The armrest holder is pivotable and a pivoting causes the armrest to be adjusted in height. An arresting device fixes the armrest holder in a height position. The arresting device is arranged at the upper, alterable-height end of the armrest holder and has a linearly movable latching element. The latching element is connected via a guide element to the armrest holder such that each pivoting movement of the armrest holder induces a linear movement of the latching element.

Abstract: Systems and methods for providing an improvement to computer security relating to electronic digital messages are provided. In an embodiment, a computing device receives an electronic digital message that is sent to a receiving account. The computing device identifies a sending account associated with the electronic digital message and from which the electronic digital message was sent. The computing device obtains metadata relating to the sending account, the metadata including received message data that is related to a number of messages that have been received by the sending account. The computing device determines that the sending account satisfies a received message criteria based, at least in part, on the received message data and, in response, performs a responsive action relating to the electronic digital message.

Abstract: A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of an L-isomer of ?-lactam effective to increase the number of CD4+ T-lymphocytes in said patient's serum.

Abstract: Systems and methods for assessing the visual acuity of person using a computerized consumer device are described.

Abstract: A moving picture coding method for coding a picture with switching between frame coding and field coding adaptively on a block-by-block basis includes: determining the maximum number of reference indices for field coding for specifying fields which are to be referred to at the time of field coding, using the maximum number of reference indices for frame coding for specifying frames which are to be referred to at the time of frame coding; and assigning to fields the reference indices for field coding for specifying fields which are to be referred to at the time of field coding, within a range of the determined maximum number thereof, using the reference indices for frame coding for specifying frames which are to be referred to at the time of frame coding.

Abstract: A device for visually scaring animal species, in particular bird species includes means for generating at least one visual signal including at least one image, varying in size over time, which simulates approach via an increase in the size of the image. For example, the visual signal includes one of the following images: eyes, a disc, and a spiral.

Abstract: A mobile terminal includes circuitry, a transmitter and a receiver. The circuitry, in operation, generates a CQI for each subcarrier (SC) group of multiple subcarrier groups, a plurality of subcarriers consecutive in a frequency domain being grouped into the multiple subcarrier groups. The transmitter, in operation, reports first respective CQIs of the multiple SC groups in inconsecutive time resources based on a first period, and reports, based on a second period, second respective CQIs of the multiple SC groups in inconsecutive time resources based on the first period, the second period being longer than the first period. The receiver, in operation, receives information indicative of the first period.

Abstract: The present disclosure can be embodied by a detachable assembly, for example a helmet and headphone assembly. A locking assembly can be configured to removably attach the headphones to the helmet in a locked position. In the locked position, the headphones can be locked horizontally onto the helmet, and a portion of ear cups of the headphones may be received at least partially through a pair of ear cup receiving apertures that extend through a shell of the helmet.

Abstract: A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.

Abstract: Hydrogen generation assemblies, hydrogen purification devices, and their components, and methods of manufacturing those assemblies, devices, and components are disclosed. In some embodiments, the devices may include an insulation base having insulating material and at least one passage that extends through the insulating material. In some embodiments, the at least one passage may be in fluid communication with a combustion region.

Abstract: A method refocuses on an optical assembly target surface, using at least one beam originating from a short-pulse optical source, having at least one optical system for focusing the beam on the surface. Refocusing occurs after learning reference conditions for which the assembly is considered as focused. A focusing signal is detected representing a time overlap of pulses between a beam reflected and a reference beam not reflected by the surface, one of the beams delayed by a delay line. The optical path on which the delay line is placed is varied, on the basis of the reference conditions, to cause the focusing signal to reach or exceed a predetermined threshold. The focus is adjusted on the basis of the path variation between the reference conditions and the conditions for which the focusing signal reaches or exceeds the threshold.

Abstract: Refining assemblies and methods for refining rich natural gas containing a first methane gas and other hydrocarbons that are heavier than methane gas are disclosed. In some embodiments, the assemblies may include a methane-producing assembly configured to receive at least one liquid-containing feed stream that includes water and rich natural gas and to produce an output stream therefrom by (a) converting at least a substantial portion of the other hydrocarbons of the rich natural gas with the water to a second methane gas, a lesser portion of the water, and other gases, and (b) allowing at least a substantial portion of the first methane gas from the rich natural gas to pass through the methane-producing assembly unconverted. The assemblies may additionally include a purification assembly configured to receive the output stream and to produce a methane-rich stream therefrom having a greater methane concentration than the output stream.

Abstract: The invention relates to a method for characterising the quality of an X-ray beam having a known profile for depositing a dose in a body, having an zone (Za1, Za2) of increasing dose rate inside said body extending between the input surface of the beam and a characteristic depth (Pmax) where the deposited dose is at a maximum, the method comprising the following steps: —providing a monolithic detector including in p-n junctions (m>3) stacked depth-wise in the detector with at least three junctions distributed in the zone of increasing dose rate; —projecting said X-ray beam onto the monolithic detector; —recovering the m signals (r) delivered by the p-n junctions of the detector; —and processing the m signals (r) in order to characterise the quality of the X-ray beam.

Abstract: An atomizing electronic cigarette has an atomizing core component and a liquid storage component. including an electric heater. The electric heater may have a through hole aligned with a channel passing through the liquid storage component. The cigarette can heat and uniformly vaporize liquid from the liquid storage component, with the user inhaling the vaporized liquid. The vapor generated by the atomizing process may be cooled as it flows through the channel.

Abstract: Methods, systems, and apparatuses are disclosed for generating a spatial audio format. An input audio source may include one or more individual channels. The one or more individual channels may be designated to be played by a corresponding one or more speakers. The one or more individual channels of the audio source may be separated. The one or more individual tracks may be input into a modeling space representing a multi-dimensional space. The modeling space may include a plurality of emitters at various locations in a vector space. Each of the one or more individual channels may be panned to one or more of the plurality of emitters. The panning may be based on a normalized proximity of the one or more individual channels in the modeling space to the plurality of emitters. The one or more of the plurality of emitters may be encoded into a single multichannel file.

Abstract: A check valve for a connecting rod for a variable compression internal combustion engine with at least one hydraulic chamber arranged in the connecting rod and connectable with a supply connection or a tank through the check valve, the check valve including a valve housing; and a valve closure element that is axially movable in the valve housing along a longitudinal valve axis, wherein the valve closure element is applicable to a valve seat and arranged in the valve housing secured against separation from the valve housing, wherein a pin shaped separation prevention element is provided which secures the valve closure element in the valve housing and limits a stroke of the valve closure element.