Abstract: This invention relates to a process for the preparation of Form A of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide. Also disclosed herein is Form A of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide, or pharmaceutical compositions thereof, obtainable by the process described herein.
Type:
Application
Filed:
July 13, 2017
Publication date:
November 21, 2019
Applicant:
MEREO BIOPHARMA 1 LIMITED
Inventors:
Osama SULEIMAN, Lucia Romero PEREZ, Cornelius Stephan HARLACHER, Stewart JONES
Abstract: A modular building unit for construction of a building comprises a structural frame 40 suitable for interconnection to another modular building unit in construction of the building; and a stud frame wall 80/82 internal to and fixed to the frame. The modular building unit is suitable for handling as a shipping container for transport.
Abstract: A cam phaser including a stator that is driven by a crank shaft of an internal combustion engine; and a rotor that is connectable torque proof with a cam shaft of the internal combustion engine and that includes plural blades that protrude radially outward from a rotor hub, wherein operating chambers arranged between the stator and the rotor are divided into pressure cavities by the blades, wherein the stator and the rotor are configured as sintered components, wherein displacement recesses are provided on axially configured faces of the stator and/or of the rotor wherein material is configured to flow into the displacement recesses during a deforming finishing of the faces.
Type:
Grant
Filed:
January 8, 2018
Date of Patent:
November 19, 2019
Assignee:
ECO Holding 1 GmbH
Inventors:
Markus Heilig, Florian Hentsch, Dietmar Schulze
Abstract: An atomizing electronic cigarette has an atomizing core component and a liquid storage component. including an electric heater. The electric heater may have a through hole aligned with a channel passing through the liquid storage component. The cigarette can heat and uniformly vaporize liquid from the liquid storage component, with the user inhaling the vaporized liquid. The vapor generated by the atomizing process may be cooled as it flows through the channel.
Abstract: A control method for an apparatus for ultrasonically measuring the flow rate of a fluid in a measuring channel, including a measuring channel whose one end is equipped with a first transducer and the other end is equipped with a second transducer, each transducer emitting ultrasonic waves to the other transducer, and receiving waves generated by the other transducer, where, in a first step, the first transducer emits waves to the second transducer, and in a second step, which can be simultaneous with the first one, the second transducer emits waves prior to the reception of the waves emitted by the first transducer.
Type:
Grant
Filed:
April 10, 2018
Date of Patent:
November 19, 2019
Assignees:
EFS SA, ECOLE CENTRALE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL des SCIENCES APPLIQUEES DE LYON
Abstract: A method of manufacturing a sulfide-based ceramic element, such as a transparent infrared optical element, comprises the steps of: synthesizing a sulfide powder; and sintering the powder to form the ceramic element; wherein the step of synthesizing the sulfide powder is performed by combustion in an aqueous solution, the solution comprising water as its only solvent, or containing water as its main solvent and at most 10%, and preferably at most 1% of the overall solvent mass, of one or more combustible solvents. The sulfide powder may be chosen, in particular, among ZnS, BaLa2S4, CaLa2S4.
Type:
Grant
Filed:
July 8, 2015
Date of Patent:
November 12, 2019
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE RENNES 1
Inventors:
Noha Hakmeh, Odile Merdrignac-Conanec, Xiang-Hua Zhang
Abstract: Novel hybrid nanoparticles, useful for inhibiting or slowing down the formation of sulfur deposits or minerals in a well during the extraction of gas or oil. Specifically, the nanoparticles each include (i) a polyorganosiloxane (POS) matrix; and, optionally as a coating over a lanthanide oxide core, (iii) at least one polymeric scale inhibitor during the extraction of gas or oil. The invention also relates to the method for obtaining the nano-inhibitors and the application of same.
Type:
Grant
Filed:
December 15, 2014
Date of Patent:
November 12, 2019
Assignees:
TOTAL SA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Inventors:
Christian Hurtevent, Salima Baraka-Lokmane, John-Richard Ordonez-Varela, Olivier Tillement, Arthur Marais, Albert Moussaron
Abstract: A radio communication apparatus is disclosed that enables the influence of the feedback information on the channel capacity to be kept to the minimum without reducing the transmission efficiency of information by transmission of pilot symbol. In the apparatus, a delay dispersion measuring section generates a delay profile using the received signal, and measures delay dispersion indicative of dispersion of delayed versions. A moving speed estimating section estimates moving speed of a mobile station apparatus that transmits a pilot symbol based on the variation in reception power of the pilot symbol. An other-cell interference measuring section measures other-cell interference caused by signals transmitted in cells except the cell to which the apparatus belongs.
Abstract: Disclosed is an individually accessible LED light system in which color and luminosity of the LED lights are individually controlled. Each of the LED lights can comprise an LED light bank, which can contain any number of lights. The primary colors can be used in the LED bank to create any desired color. The LED light bank can also be incorporated on a single chip with an address and control circuit.
Abstract: A method for controlling an inlet-adjustment mechanism in an air inlet for a compressor so as to switch the mechanism between open and closed positions for adjusting a flow area of the inlet. The method includes an algorithm for determining when the inlet-adjustment mechanism is in a failure mode. In accordance with the method, when the operating point on the compressor map is on the high-flow side of a threshold line at which the inlet-adjustment mechanism is switched from one position to the other, a measured speed or pressure ratio is compared to a theoretical value for the speed or pressure ratio based on a compressor map for the open position of the mechanism. If the measured value differs from the theoretical value by more than a predetermined tolerance, a failure mode is indicated.
Type:
Application
Filed:
May 7, 2018
Publication date:
November 7, 2019
Applicant:
Garrett Transportation 1 Inc.
Inventors:
Hani Mohtar, Louis Philippe de Araujo, Stephane Pees, Daniele Zecchetti, Michael Robert Uchanski
Abstract: Hydrogen generation assemblies, hydrogen purification devices, and their components, and methods of manufacturing those assemblies, devices, and components are disclosed. In some embodiments, the devices may include an insulation base having insulating material and at least one passage that extends through the insulating material. In some embodiments, the at least one passage may be in fluid communication with a combustion region.
Abstract: Disclosed is a waterproof LED light string that provides outdoor lighting in a simple and reliable manner. Waterproof bulb assemblies are used with replaceable LED light sources. The bulb assemblies are easily suspended from a rope or wire, screwed to a support, or magnetically supported from a ferrous metal support. Duplicate circuitry in the LED light source allows the LED light source to be connected in either direction.
Abstract: The present invention provides a novel therapeutic combination comprising one or more anti-androgen agents and one or more antibiotic/anti-inflammatory agents or pharmaceutically acceptable salts or hydrates thereof, useful for the treatment of a dermatological disorder.
Abstract: An incremental syringe is provided and includes a syringe barrel, a finger grip disposed at the proximal end of the syringe barrel, a tab disposed inside the syringe barrel, and a plunger body having detents, wherein the detents are configured to interact with the tab to provide audible and tactile feedback to a user when the plunger body is pushed through the syringe barrel in a distal direction.
Type:
Grant
Filed:
December 7, 2017
Date of Patent:
November 5, 2019
Assignee:
URO-1, INC.
Inventors:
Phillip Jack Snoke, Philip Morrison Allred, III, John Joseph Smith
Abstract: The present invention relates to new N1- and N7-substituted sibiriline derivatives of the following general formula (I): (I) or a pharmaceutically acceptable salt and/or solvate thereof, notably for use as drug, in particular for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising such a compound and processes to prepare such a compound. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.
Type:
Grant
Filed:
October 13, 2016
Date of Patent:
October 29, 2019
Assignees:
Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, Universite Claude Bernard Lyon 1
Inventors:
Marie-Thérèse Dimanche-Boitrel, Stéphane Bach, Claire Delehouze, Peter Goekjian, Arnaud Comte
Abstract: A medical injection assembly is provided and includes an introducer with a handle, a sheath, a scope lumen configured to receive an endoscope at a first proximal end of the handle and hold the endoscope in a desired position, a cap attached to the distal end of the scope lumen configured to isolate the scope lumen from the external environment, and a cannula lumen configured to receive a cannula at a second proximal end of the handle and hold the cannula in a desired position. The medical injection assembly includes a cannula configured such that the distance between the distal tip of the cannula and the axis defined by the sheath of the introducer increases as the cannula is moved in a distal direction and a syringe.
Type:
Grant
Filed:
October 2, 2017
Date of Patent:
October 29, 2019
Assignee:
URO-1, INC.
Inventors:
Phillip Jack Snoke, Philip Morrison Allred, III, John Joseph Smith
Abstract: A Frequency-tunable and slot-fed planar antenna is proposed. The antenna includes resonant patch, a first dielectric layer, a ground plane having a first slot for each linear polarization, a second dielectric layer and a transmission line having, for each first slot, an end strand extending beneath the first slot. The antenna is frequency tunable for each linear polarization through at least one variable capacitance element. The matching of the antenna varies, for each linear polarization, as a function of a bias voltage applied to the variable capacitance element(s). The antenna includes, for each linear polarization, at least one second slot extending along the first slot. The end strand of the transmission line extends between the first slot and second slots. The at least one second slot creates an additional resonance.
Type:
Grant
Filed:
March 17, 2015
Date of Patent:
October 22, 2019
Assignees:
UNIVERSITE DE RENNES 1, CNRS—CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE