Abstract: The present disclosure provides a compound of general Formula (I) having c-abl kinase inhibitory activity or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound, and a method useful to treat or prevent neurodegenerative diseases using the compound.

Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.

Abstract: A picture coding and decoding method includes a picture coding method for coding an input picture and a picture decoding method for decoding coded picture data. The picture coding method includes dividing the input picture into blocks, coding the input picture on a block basis, decoding the coded data of each block on a block basis, removing coding distortion in an area disposed on both sides of a block boundary, each block being adaptively decoded either as a field structure block or a frame structure block, and storing the reconstructed picture as a reference picture. The picture decoding method includes decoding the coded picture data to obtain a reconstructed picture, removing coding distortion in an area disposed on both sides of a block boundary, each block being adaptively decoded either as a field structure block or a frame structure block, and storing the reconstructed picture as a reference picture.

Abstract: An aqueous composition comprising a cellulose ether acetate being at least partially dissolved in an aqueous liquid is produced in a process, wherein an aqueous liquid is mixed with a cellulose ether acetate having a degree of substitution of acetyl groups, DSAc, of from 0.05 to 0.75 and the temperature of the mixture of the cellulose ether acetate and the aqueous liquid is set to less than 10 C to at least partially dissolve the cellulose ether acetate in the aqueous liquid.

Abstract: A centralized cooling system for data center comprises at least one cabinet, a spray hydraulic device and a hydraulic working substance cooling equipment integrated outside the cabinet, and an outer liquid working substance tank, which are connected by a pipe, wherein the cabinet comprises an auxiliary cabinet, a server cabinet, a liquid inlet pipe, and a return pipe; wherein an inner liquid working substance tank, a main pipe and a pipe distributor are arranged inside the auxiliary cabinet; a server and a plurality of spraying mechanisms are arranged inside the server cabinet; the liquid working substance sprayed from the spraying mechanisms is returned to the outer liquid working substance tank through the return pipe, cooled down by means of the spray hydraulic device and the hydraulic circulating cooling device, and enters the inner liquid working substance tank, and the liquid working substance has no phase transition during the spraying process.

Abstract: An object of the present invention is the use of iron compounds as hydrosilylation and dehydrogenative silylation catalysts.

Abstract: Aspects of the subject disclosure may include, a system for generating a plurality of electromagnetic waves having differing signal characteristics, each electromagnetic wave of the plurality of electromagnetic waves conveying a communication signal, and the plurality of electromagnetic waves propagating along a transmission medium without radiating into free space. The system can be further configured for generating, by an antenna coupled to the transmission medium, a plurality of wireless signals according to the plurality of electromagnetic waves. The differing signal characteristics of the plurality of electromagnetic waves thereby enables a device to obtain the communication signal by combining the plurality of wireless signals. Other embodiments are disclosed.

Abstract: A core biopsy instrument for taking samples of tissue such as prostate tissue comprises a handle configured to releasably receive a cartridge that holds a core collector. In use, after loading a cartridge in the handle, a spring drives the core collector into target tissue and shortly thereafter, in less than a second, a spring drives a cannula over the core collector to cut tissue in a trough thereof from surrounding tissue. The core collector is withdrawn proximally to its initial position in the cartridge and the cartridge is removed from the handle. The cartridge, with the core collector and the tissue sample therein is treated as needed for sending as a unit to a laboratory, thus preserving the orientation and completeness of the tissue sample therein.

Abstract: An electronic cigarette includes a shell and a mouthpiece. The external wall of the shell has an air inlet. An atomizer and a liquid-supply are in contact with each other. The air inlet, atomizer, and an aerosol passage are interconnected.

Abstract: A cannula comprising a hollow tube made of a biocompatible, thermoplastic polymer, memory shape material, tipped with an injection needle at it distal end, assumes desired shapes as it distally emerges from a lumen or channel of an instrument such as an introducer or endoscope. The desires shape includes a curvature conforming to an inverse tangent function. The cannula may be supplied alone, with or without an injection needle, and in a sterile pouch, for use with a device of an user's choice that has a suitable lumen or channel to guide the cannula, of the cannula may be used without such an instrument.

Abstract: A plating system is described that uses various configurations of bone fixation implants that are configured to attach to one or more portions of a bone. An exemplary bone fixation implant includes a two-dimensional structure comprising a bone-engaging surface and a tissue-engaging surface. A plurality of openings is defined in the two-dimensional structure, and arranged across a length and a width of the bone fixation implant. At least some of openings are configured to receive an attachment member for securing the bone fixation implant to an underlying bone structure. The tissue-engaging surface is configured to engage an overlying tissue structure for encouraging incorporation of the tissue structure into the bone fixation implant to promote stabilization of the underlying bone structure during healing. In certain embodiments, at least 50% of the area defined by and/or between the length and the width of the two-dimensional structure is an opening.

Abstract: An image decoding apparatus is provided that decodes a coded image, the coded image being generated by coding an image segmented into a plurality of blocks on a block basis. The image decoding apparatus includes a quantization parameter obtaining unit that obtains a quantization parameter for each block of the plurality of blocks, a decoding unit that decodes the coded image to obtain a reconstructed image, and a pixel difference value obtaining unit that obtains a pixel difference value. The image decoding apparatus also includes a comparing unit that compares the pixel difference value with a threshold value, and a removing unit that removes a coding distortion in an area disposed on both sides of a block boundary between the first block and the second block, by applying a filter for coding distortion removal.

Abstract: The invention relates to methods for predicting the onset of extrapyramidal symptoms (EPS) induced by an antipsychotic-based treatment as well as methods for providing personalized medicine to patients based on the sequence of several SNPs associated with the onset of EPS. The invention relates as well to kits for carrying out the diagnostic and predictive medicine methods.

Abstract: A connecting rod for a variable compression internal combustion engine, the connecting rod an eccentrical element adjustment arrangement for adjusting an effective connecting rod length, the eccentrical element adjustment arrangement including a first cylinder including a first hydraulic chamber and a second cylinder including a second hydraulic chamber, a first inlet for feeding hydraulic fluid into the first cylinder from a supply and a first outlet for draining the hydraulic fluid from the first cylinder, a second inlet for feeding hydraulic fluid into the second cylinder from the supply and a second outlet for draining the hydraulic fluid from the second cylinder, a switch valve for controlling a hydraulic fluid flow, the switch valve including a piston that is movable in a housing, wherein the piston is displaceable into a first switching position or a second switching position, wherein the second outlet of the second cylinder is connected with the supply in the first switching position and the first out

Abstract: Mechanical circulatory assist systems and related methods produce a pulsatile blood flow in synchronization with heart activity. A mechanical circulatory assist system includes a continuous-flow pump and a controller. The continuous-flow pump is implantable in fluid communication with a left ventricle of a heart of a patient and an aorta of the patient to assist blood flow from the left ventricle to the aorta. The controller includes a sensor that generates a signal indicative of an activity of the heart. The controller is operatively connected to the continuous-flow pump and configured to operate the continuous-flow pump in an artificial pulse mode in synchronization with the activity of the heart.

Abstract: There is provided an electronic smoking device (10; 110; 210; 310) comprising a power supply (18), a liquid reservoir (34; 34; 234; 334) storing a liquid, and an atomizer (26). The atomizer (26) is adapted to atomize the liquid stored in the liquid reservoir (34; 34; 234; 334) when operated by the power supply (18). The liquid reservoir (34; 34; 234; 334) comprises a first chamber (40) storing the liquid, which first chamber (40) has a variable volume that is reducible and non-increasable.

Abstract: In one embodiment, a method includes receiving, by a network controller and from a first node of a network, information associated with a data stream of the network and determining, by the network controller, a segmentation for the data stream. The segmentation includes a plurality of data segments and the plurality of data segments includes a first data segment. The method further includes determining, by the network controller, a data flow path for each of the plurality of data segments and determining, by the network controller, a first wavelength to assign to the first data segment. The first wavelength is one of a plurality of wavelengths spanning between the first node and a second node of the network.

Abstract: An esterified cellulose ether is provided wherein the ester groups are phthalyl groups, the degree of substitution of phthalyl groups is from 0.02 to 0.18, the degree of neutralization of phthalyl groups is not more than 0.75, and the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2° C.

Abstract: A modular building unit for construction of a building comprises a structural frame 40 suitable for interconnection to another modular building unit in construction of the building; and a stud frame wall 80/82 internal to and fixed to the frame. The modular building unit is suitable for handling as a shipping container for transport.