Abstract: The present invention relates to a composition in the form of a powder or a viscous paste, and which includes at least one low viscosity alginate having a viscosity of less than about 100 mPaS in a 1 wt % aqueous solution, and at least one high viscosity alginate having a viscosity of more than about 100 mPaS in a 1 wt % aqueous solution. The composition can also include at least one suspending agent. The composition is readily soluble in water such that an aqueous preparation can be prepared without substantive mixing. Also, the aqueous preparation is suitable for use in the treatment and/or prevention of overweight for both therapeutic and non-therapeutic purposes.

Abstract: The present invention provides a novel therapeutic combination comprising one or more anti-androgen agents and one or more antibiotic/anti-inflammatory agents or pharmaceutically acceptable salts or hydrates thereof, useful for the treatment of a dermatological disorder.

Abstract: The invention relates to a method for preparing 5-hydroxymethylfurfural (HMF) by reacting hexose in water and in the presence of carboxylic acid. The present invention further relates to the preparation of 5-hydroxymethylfurfural (HMF) by reacting hexose in water and in the presence of carboxylic acid and of a heterogenous acid catalyst. The invention also relates to an HMF-rich carboxylic acid solution.

Abstract: The invention relates to compounds of formula (I) wherein the groups A and B represent independently from each other —CH?CH—, or —C?C—, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y1 and Y2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z1, Z2, Z3, and Z4 can represent independently from each other a chemically reactive group W, such as OH, NH2, SH, the groups Z5 and Z6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.

Abstract: A trim tab assembly for a watercraft includes a enclosure. A support structure is positioned in the enclosure. At least one trim tab is disposed in the enclosure. The trim tab includes a generally planar top, bottom, side and front surfaces linked by a curved surface defining a wedge shaped body. An actuator is linked to the trim tab pivotally moving the trim tab relative to the enclosure.

Abstract: A system for controlled release of an active principle, includes at least (a) a degradable polymer matrix which produces acid compounds and (b) at least one acid-sensitive complex of an active principle having at least one electrostatic charge and a complexing polyelectrolyte partner of opposite charge which complexes with the active principle. A method for preparation of such a system is described. The release of the active principle (7P) is prolonged over 18 days (ternary system PMLA/7P/PLAGA) in comparison to binary systems (7P/PLAGA) and (PMLA/7P).

Abstract: The present invention relates to methods for determining the prognosis of a cancer. The methods involve determining the level of expression of the ZNF217 gene in a cancer cell sample or in a tumor sample wherein over-expression of ZNF217 is correlated with likelihood of metastasis and with likelihood of relapse/recurrence of the cancer.

Abstract: The present invention provides for isolated anti-human-HER3 antibodies or fragments thereof. More particularly the present invention provides an isolated monoclonal antibody that specifically binds to the extracellular domain of HER-3 and competes for binding to the extracellular domain of human HER-3 with the antibody produced obtainable from hybridoma deposited as CNCM-I-4486. The antibodies described in the present invention are useful for the treatment of cancer.

Abstract: Disclosed herein are retroreflective audio cords. The audio cords can be coupled to an audio jack and headphones. The cords may include braided strands of a non-retroreflective material and retroreflective material. In use, the audio cords may be used to increase the visibility of the wearer. The audio cords may also be waterproof and/or configured to float.

Abstract: Embodiments disclosed herein provide an apparatus that includes a container configured to store and transport drilling waste, a lid coupled to the container, and at least one arm coupled to the lid and configured to lift or lower the lid when moved, wherein the at least one arm comprises a counterweight. Disclosed embodiments also provide a method of opening and closing an apparatus. The method includes moving at least one arm coupled to a lid of the apparatus to an open position, wherein the apparatus is configured to store and transport drilling waste, disposing drilling waste in the apparatus, and moving the at least on arm coupled to the lid of the apparatus to a closed position. Disclosed embodiments also provide a method of modifying a mud skip that includes coupling at least one arm to a lid of the mud skip configured to store and transport drilling waste, wherein the at least one arm comprises a counterweight.

Abstract: An atomizing electronic cigarette has an atomizing core component and a liquid storage component, including an electric heater. The electric heater may have a through hole aligned with a channel passing through the liquid storage component. The cigarette can heat and uniformly vaporize liquid from the liquid storage component, with the user inhaling the vaporized liquid. The vapor generated by the atomizing process may be cooled as it flows through the channel.

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, where R1 is a (C1-C6)alkyl or (C3-C6)cycloalkyl group; R2 is a (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkenyl, (C1-C6)fluoroalkyl, (C1-C3)fluoroalkoxy, or (C1-C6)alkoxy(C1-C6)alkyl group, substituted: (i) with one to three hydroxyl groups, or (ii) with an NRaRb group, where Ra and Rb are independently a hydrogen atom or a (C1-C3)alkyl group; or a pyrrolidinylmethyl group substituted with one to three hydroxyl groups; R9 is the same as R2 or hydrogen; the R2 and R9 groups independently being substitutable with an —OCOR3 group, where R3 is a natural or unnatural amino acid derivative or a piperidyl group; alternatively, R2 and R9 together form a heterocyclic compound; X and Y are independently a substitutable phenyl or heteroaryl group, the heteroaryl group being a thienyl, pyridyl, pyrimidinyl, thiazolyl, pyrrolyl, or furanyl group; and R6 is a hydrogen or a (C1-C3)alkyl group.

Abstract: The present invention relates to the compound of formula (I): in which R1 represents a hydrogen atom, an optionally labelled halogen, a radionuclide or a Sn[(C1-C4)alkyl]3 group, Ar represents an aryl group or a heteroaryl group, R9 represents a hydrogen atom, a (C1-C4)alkyl group or forms together with the group R1—Ar a ring fused with the Ar group, A represents a group of formula (?) or (?): R3 and R4 independently represent a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkenyl group or a group of formula (?): —Y—Z—W—R11??(?) wherein R11 represents an optionally labelled halogen, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen, a radionuclide, a —NO2 group, a —NR5R6 group, a —N+R5R6R7X? group, or a —OSO2R12 group, and their addition salts with pharmaceutically acceptable acids.

Abstract: The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFN? production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.

Abstract: A polychrome electrophoretic ink including at least four types of particles dispersed in a nonpolar organic medium, each particle type containing a pigment of a color which is associated therewith, having a positive or negative electrostatic charge, characterized in that at least one of the abovementioned particle types has a magnetic property (magnetic core) such that each particle type can migrate in a predetermined manner under the combined action of an electrostatic force and of a magnetic return force.

Abstract: Provided is a cooking grate for improving cooking performance on an outdoor cooking grill. The cooking grate has a metallic plate, configured to be placed over a heat source in the outdoor cooking grill, where the metallic plate has a plurality of perforation holes. The cooking grate further includes a plurality of cooking surface ribs, configured to support food during cooking and positioned above the metallic plate. Also provided are methods of providing an improved cooking grate for an outdoor cooking grill including the steps of: perforating a metallic plate, configured to be positioned above a heat source on the outdoor cooking grill; forming a plurality of cooking surface ribs, configured to receive food to be cooked thereon.

Abstract: A composition including a graft copolymer, having: a linear trunk including at least one non-aromatic vinyl polymer or an unsaturated polyolefin; and at least two grafts attached to said trunk via a chemical bond, each graft having a conjugated polymer, characterized in that said composition further includes: fullerenes and a conjugated polymer; or carbon and/or graphene nanotubes. Also, a photovoltaic module incorporating such a composition, and to the use of said composition for the same purposes. Finally, methods for synthesizing the molecules forming all or part of the composition.

Abstract: The present invention relates to compounds having the following Formula (I) for use in the prevention and/or the treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs.

Abstract: A spinal interbody fusion implant has an impact rod fitting that is configured and adapted to be connected to an impact rod during implantation of the implant. The implant also comprises one or more openings that are encircled by portions of the implant and that extend into the top of the implant and continue through to and out of the bottom of the implant. The top and bottom of the implant each have a load bearing footprint. Each of the load bearing footprints has a centroid that is closer to the leading end of the implant than to the trailing end of the implant. A method of implanting a spinal interbody fusion implant between two vertebrae of a spine comprises inserting the implant into a patient through a posterior incision and guiding the implant into a position between the two vertebrae using a pair of shims.

Abstract: A method for 3D recording of data on a medium formed from a transparent photosensitive material including at least one dopant. The method includes a first step of calibrating and checking a pulsed light source including calibrating the number of pulses, the level of fluence of each pulse emitted and the rate of the pulses and a step of inscribing an area of the material. The fluence of each pulse emitted, the number of pulses and the rate of the pulses are suitable for irradiating the material in the area so as to form fluorescent clusters stabilized from the dopant while minimizing the modification of the refractive index and the absorption coefficient of the medium in a wavelength range from visible to near infrared.