Patents Assigned to 23andMe, Inc.
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Patent number: 11935628Abstract: Determining relative relationships of people who share a common ancestor within at least a threshold number of generations includes: receiving recombinable deoxyribonucleic acid (DNA) sequence information of a first user and recombinable DNA sequence information of a plurality of users; processing, using one or more computer processors, the recombinable DNA sequence information of the plurality of users in parallel; determining, based at least in part on a result of processing the recombinable DNA information of the plurality of users in parallel, a predicted degree of relationship between the first user and a user among the plurality of users, the predicted degree of relative relationship corresponding to a number of generations within which the first user and the second user share a common ancestor.Type: GrantFiled: November 2, 2022Date of Patent: March 19, 2024Assignee: 23andMe, Inc.Inventors: Lawrence Hon, Serge Saxonov, Brian Thomas Naughton, Joanna Louise Mountain, Anne Wojcicki, Linda Avey
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Patent number: 11884719Abstract: The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human IL-36 cytokines, IL-36?, IL-36?, and/or IL-36?, and block the IL-36 stimulated signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.Type: GrantFiled: December 19, 2019Date of Patent: January 30, 2024Assignee: 23andMe, Inc.Inventors: Chingwei Vivian Lee, Germaine Fuh-Kelly, Louise Scharf, Tina Thai, Ashka Bharat Patel, Shashank Bharill, Erik Edward Karrer
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Publication number: 20240018239Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD200R1 receptor protein (hu-CD200R1) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD200R1. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD200 binding to CD200R1.Type: ApplicationFiled: August 24, 2023Publication date: January 18, 2024Applicant: 23andMe, Inc.Inventors: Yu CHEN, Jilean Beth FENAUX, Germaine FUH-KELLY, Yao-Ming HUANG, Wei-Jen CHUNG, Erik KARRER, Cecilia LAY, Steven J. PITTS, Louise SCHARF
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Patent number: 11875879Abstract: Displaying a comparison of genetic data is disclosed, including receiving an indication of a first individual, receiving an indication of a second individual, retrieving the genotypic information for the first individual and the second individual, comparing the genotypic information of the first individual and the second individual, displaying an indication of the comparison of the genotypic information of the first individual and the second individual graphically. A first graphical symbol is used to display an indication of the genome regions for which the first individual and the second individual are identical. A second graphical symbol is used to display an indication of the genome regions for which the first individual and the second individual are half identical.Type: GrantFiled: May 17, 2023Date of Patent: January 16, 2024Assignee: 23andMe, Inc.Inventors: Linda Avey, Oleksiy Khomenko, Brian Thomas Naughton, Serge Saxonov, Anne Wojcicki, Alexander Wong
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Patent number: 11817176Abstract: Presenting ancestral origin information, comprising: receiving a request to display ancestry data of an individual; obtaining ancestry composition information of the individual, the ancestry composition information including information pertaining to a proportion of the individual's genotype data that is deemed to correspond to a specific ancestry; and presenting the ancestry composition information to be displayed.Type: GrantFiled: August 12, 2021Date of Patent: November 14, 2023Assignee: 23andMe, Inc.Inventors: Peter Richard Wilton, Gabriel David Poznik, Kimberly Faith McManus, Ethan Macneil Jewett, William Allen Freyman, Adam Auton
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Publication number: 20230348604Abstract: The present disclosure relates to a ULBP6 binding protein that inhibits the interaction between ULBP6 and NKG2D, and methods of treating cancer with said ULBP6 binding protein.Type: ApplicationFiled: April 28, 2023Publication date: November 2, 2023Applicants: 23andMe, Inc., GLAXOSMITHKLINE INTELLECTUAL PROPERTY (No.3) LIMITEDInventors: Joel BENJAMIN, Shashank BHARILL, I-Ling CHEN, Yu CHEN, Wei-Jen CHUNG, Zahra Bahrami DIZICHEH, Germaine FUH, Patrick KOENIG, Yujie LIU, Mauro POGGIO, Shruti YADAV, Ping-Chiao TSAI, Claus SPITZFADEN
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Patent number: 11803777Abstract: Displaying an indication of ancestral data is disclosed. An indication that a genetic interval corresponds to a reference interval that has a likelihood of having one or more ancestral origins is received. One or more graphic display parameters are determined based at least in part on the indication. An indication of the one or more ancestral origins is visually displayed using the one or more graphic display parameters.Type: GrantFiled: March 8, 2023Date of Patent: October 31, 2023Assignee: 23andMe, Inc.Inventors: John Michael Macpherson, Brian Thomas Naughton, Joanna Louise Mountain
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Patent number: 11791054Abstract: A method, software, database, and system in which a query attribute is used as the basis for accessing stored attribute combinations and their frequencies of occurrence for individuals; and tabulating, based on frequencies of occurrence, those attribute combinations that are most likely to co-occur with the query attribute.Type: GrantFiled: January 20, 2023Date of Patent: October 17, 2023Assignee: 23andMe, Inc.Inventors: Andrew Alexander Kenedy, Charles Anthony Eldering
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Patent number: 11787861Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD200R1 receptor protein (hu-CD200R1) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD200R1. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD200 binding to CD200R1.Type: GrantFiled: May 28, 2021Date of Patent: October 17, 2023Assignee: 23andMe, Inc.Inventors: Yu Chen, Jilean Beth Fenaux, Germaine Fuh-Kelly, Yao-Ming Huang, Wei-Jen Chung, Erik Edward Karrer, Cecilia Lay, Steven J. Pitts, Louise Scharf
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Patent number: 11783919Abstract: The disclosed embodiments concern methods, apparatus, systems, and computer program products for storing and retrieving genetic data for individuals. In some implementations, a storage format is provided that allows genetic data to be defined by metadata for reproduce-ability.Type: GrantFiled: October 8, 2021Date of Patent: October 10, 2023Assignee: 23andMe, Inc.Inventors: Tulasi Krishna Paradarami, Michael Polcari, Yeshwanth Bashyam Balachander, Matthew Bryan Corley, Anuved Verma, Anja Bog, Cordell T. Blakkan, Dmitry Stupakov
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Patent number: 11776662Abstract: Determining relative relationships of people who share a common ancestor within at least a threshold number of generations includes: receiving recombinable deoxyribonucleic acid (DNA) sequence information of a first user and recombinable DNA sequence information of a plurality of users; processing, using one or more computer processors, the recombinable DNA sequence information of the plurality of users in parallel; determining, based at least in part on a result of processing the recombinable DNA information of the plurality of users in parallel, a predicted degree of relationship between the first user and a user among the plurality of users, the predicted degree of relative relationship corresponding to a number of generations within which the first user and the second user share a common ancestor.Type: GrantFiled: March 28, 2023Date of Patent: October 3, 2023Assignee: 23andMe, Inc.Inventors: Lawrence Hon, Serge Saxonov, Brian Thomas Naughton, Joanna Louise Mountain, Anne Wojcicki, Linda Avey
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Patent number: 11748383Abstract: Assembling a cohort includes: receiving genetic characteristic information pertaining to a desired genetic characteristic; using the genetic characteristic information to search a data storage comprising information of previously genotyped individuals to derive a candidate group having the desired genetic characteristic; and assembling the cohort based at least in part on the candidate group.Type: GrantFiled: December 15, 2020Date of Patent: September 5, 2023Assignee: 23andMe, Inc.Inventors: Arnab Chowdry, Alexander Kompel, Michael Polcari
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Patent number: 11735323Abstract: A method, software, database and system for attribute partner identification and social network based attribute analysis are presented in which attribute profiles associated with individuals can be compared and potential partners identified. Connections can be formed within social networks based on analysis of genetic and non-genetic data. Degrees of attribute separation (genetic and non-genetic) can be utilized to analyze relationships and to identify individuals who might benefit from being connected.Type: GrantFiled: November 17, 2022Date of Patent: August 22, 2023Assignee: 23andMe, Inc.Inventors: Andrew Alexander Kenedy, Charles Anthony Eldering
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Publication number: 20230220037Abstract: The present disclosure relates to an inhibitor of human TRPM3 for use in the treatment or prevention of migraine, including in subjects whose migraines are not responsive to CGRP inhibition or whose migraines are responsive to triptans. Combination therapies are also described. In other aspects, the present disclosure provides methods for identifying suitable patients, methods for identifying inhibitors of human TRPM3, cell lines and agonists for use in such methods and a method for measuring PACAP release.Type: ApplicationFiled: July 13, 2022Publication date: July 13, 2023Applicants: GlaxoSmithKline Intellectual Property (No.3) Limited, 23andMe, Inc.Inventors: Janet Mary KUMAR, Colin Houston McPHEE, Adam Mohamed NAGUIB, Lea SAROV-BLAT, Claire Yvonne Marie TOWNSEND, Paul Bryan WREN, Clint Ernest YOUNG, Alexander George Steven PRESTON, David Andrew HALL
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Patent number: 11683315Abstract: Sharing data is disclosed. In some cases, sharing data includes receiving a request to share data from a first account to a second account, receiving an indication of a plurality of first account profiles associated with the first account to share with the second account, and establishing sharing from the plurality of first account profiles to the second account, wherein sharing comprises the second account having read access to a subset of nonpublic data associated with the plurality of first account profiles.Type: GrantFiled: October 12, 2021Date of Patent: June 20, 2023Assignee: 23andMe, Inc.Inventors: Brian Lee Hawthorne, Oleksiy Khomenko, Jeffrey Mellen, Marcela Miyazawa, Michael Polcari, Jack Tihon, Alexander Wong, Anne Wojcicki, Linda Avey
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Publication number: 20230183343Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD96 receptor protein (hu-CD96) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD96. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD96 binding to CD155, including effects arising from CD96 interactions with CD226 and/or TIGIT.Type: ApplicationFiled: November 18, 2022Publication date: June 15, 2023Applicant: 23andMe, Inc.Inventors: Yu CHEN, Chingwei Vivian LEE, Germaine FUH-KELLY, Zuoan YI, Yao-ming HUANG, Valentine YEUNG, Krista Maureen MCCUTCHEON, Samuel NALLE, Augusta Eleanor BROUGHTON, Louise SCHARF, Navneet SINGH, Tina THAI, Shouhua XIAO
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Patent number: 11657902Abstract: Determining relative relationships of people who share a common ancestor within at least a threshold number of generations includes: receiving recombinable deoxyribonucleic acid (DNA) sequence information of a first user and recombinable DNA sequence information of a plurality of users; processing, using one or more computer processors, the recombinable DNA sequence information of the plurality of users in parallel; determining, based at least in part on a result of processing the recombinable DNA information of the plurality of users in parallel, a predicted degree of relationship between the first user and a user among the plurality of users, the predicted degree of relative relationship corresponding to a number of generations within which the first user and the second user share a common ancestor.Type: GrantFiled: October 28, 2022Date of Patent: May 23, 2023Assignee: 23andMe, Inc.Inventors: Lawrence Hon, Serge Saxonov, Brian Thomas Naughton, Joanna Louise Mountain, Anne Wojcicki, Linda Avey
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Patent number: 11625139Abstract: Displaying an indication of ancestral data is disclosed. An indication that a genetic interval corresponds to a reference interval that has a likelihood of having one or more ancestral origins is received. One or more graphic display parameters are determined based at least in part on the indication. An indication of the one or more ancestral origins is visually displayed using the one or more graphic display parameters.Type: GrantFiled: November 22, 2022Date of Patent: April 11, 2023Assignee: 23andMe, Inc.Inventors: John Michael Macpherson, Brian Thomas Naughton, Joanna Louise Mountain
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Patent number: 11621089Abstract: A method, software, database, and system in which a query attribute is used as the basis for accessing stored attribute combinations and their frequencies of occurrence for individuals; and tabulating, based on frequencies of occurrence, those attribute combinations that are most likely to co-occur with the query attribute.Type: GrantFiled: October 3, 2022Date of Patent: April 4, 2023Assignee: 23andMe, Inc.Inventors: Andrew Alexander Kenedy, Charles Anthony Eldering
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Patent number: D985610Type: GrantFiled: October 18, 2022Date of Patent: May 9, 2023Assignee: 23andMe, Inc.Inventors: Peilun Shan, Jie Wei, Magdalene Misztal, Brad Kittredge, Caitlyn Elizabeth Adams, Afton Kerry Vechery, Vilia Ingriany, Timmy Chau, Claudio Guglieri Lillo, Sampo Aleksi Jalasto, Joel Parsons, Jesse Jouni Sakari Maula