Abstract: A method, software, database and system for attribute partner identification and social network based attribute analysis are presented in which attribute profiles associated with individuals can be compared and potential partners identified. Connections can be formed within social networks based on analysis of genetic and non-genetic data. Degrees of attribute separation (genetic and non-genetic) can be utilized to analyze relationships and to identify individuals who might benefit from being connected.
Type:
Grant
Filed:
February 1, 2022
Date of Patent:
May 31, 2022
Assignee:
23andMe, Inc.
Inventors:
Andrew Alexander Kenedy, Charles Anthony Eldering
Abstract: Determining relative relationships of people who share a common ancestor within at least a threshold number of generations includes: receiving recombinable deoxyribonucleic acid (DNA) sequence information of a first user and recombinable DNA sequence information of a plurality of users; processing, using one or more computer processors, the recombinable DNA sequence information of the plurality of users in parallel; determining, based at least in part on a result of processing the recombinable DNA information of the plurality of users in parallel, a predicted degree of relationship between the first user and a user among the plurality of users, the predicted degree of relative relationship corresponding to a number of generations within which the first user and the second user share a common ancestor.
Type:
Grant
Filed:
June 17, 2021
Date of Patent:
May 3, 2022
Assignee:
23andMe, Inc.
Inventors:
Lawrence Hon, Serge Saxonov, Brian Thomas Naughton, Joanna Louise Mountain, Anne Wojcicki, Linda Avey
Abstract: The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human interleukin-1 receptor accessory protein (hu-IL1RAP) and fully block the IL-1, IL-33, and IL-36 intracellular signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.
Type:
Application
Filed:
September 27, 2021
Publication date:
April 7, 2022
Applicant:
23andMe, Inc.
Inventors:
Davide Foletti, Erik Karrer, Germaine Fuh-KELLY, Kristie Ibarra, Quan Zheng, Yao-ming Huang, Lindsay Deis, Christine Wolak, Dominic Samuel Berns
Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD200R1 receptor protein (hu-CD200R1) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD200R1. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD200 binding to CD200R1.
Type:
Application
Filed:
May 28, 2021
Publication date:
December 2, 2021
Applicant:
23andMe, Inc.
Inventors:
Yu CHEN, Jilean Beth FENAUX, Germaine FUH-KELLY, Yao-Ming HUANG, Wei-Jen CHUNG, Erik Edward KARRER, Cecilia LAY, Steven J. PITTS, Louise SCHARF
Abstract: Displaying a comparison of genotypic information between relatives is disclosed, including receiving an indication that a first individual is a grandparent, receiving an indication that a second individual is a grandchild of the first individual, comparing the genotypic information of the first individual and the second individual and calculating a similarity score, and displaying an indication of the similarity score graphically using colors.
Type:
Grant
Filed:
December 1, 2017
Date of Patent:
November 9, 2021
Assignee:
23andMe, Inc.
Inventors:
Linda Avey, Oleksiy Khomenko, Brian Thomas Naughton, Serge Saxonov, Anne Wojcicki, Alexander Wong
Abstract: Determining relative connections between individuals includes: obtaining identification information of a first individual and identification information of a second individual; determining, based at least in part on a relative connections graph, a relative connections path connecting the first individual, the second individual, and at least one additional individual; and outputting information pertaining to the relative connections path.
Abstract: The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human interleukin-1 receptor accessory protein (hu-IL1RAP) and fully block the IL-1, IL-33, and IL-36 intracellular signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.
Type:
Grant
Filed:
August 15, 2019
Date of Patent:
November 9, 2021
Assignee:
23andMe, Inc.
Inventors:
Davide Foletti, Erik Karrer, Germaine Fuh-Kelly, Kristie Ibarra, Quan Zheng, Yao-ming Huang, Lindsay Deis, Christine Wolak, Dominic Samuel Berns
Abstract: Sharing data is disclosed. In some cases, sharing data includes receiving a request to share data from a first account to a second account, receiving an indication of a plurality of first account profiles associated with the first account to share with the second account, and establishing sharing from the plurality of first account profiles to the second account, wherein sharing comprises the second account having read access to a subset of nonpublic data associated with the plurality of first account profiles.
Type:
Grant
Filed:
April 28, 2021
Date of Patent:
November 9, 2021
Assignee:
23andMe, Inc.
Inventors:
Brian Lee Hawthorne, Oleksiy Khomenko, Jeffrey Mellen, Marcela Miyazawa, Michael Polcari, Jack Tihon, Alexander Wong, Anne Wojcicki, Linda Avey
Abstract: Determining relative relationships of people who share a common ancestor within at least a threshold number of generations includes: receiving recombinable deoxyribonucleic acid (DNA) sequence information of a first user and recombinable DNA sequence information of a plurality of users; processing, using one or more computer processors, the recombinable DNA sequence information of the plurality of users in parallel; determining, based at least in part on a result of processing the recombinable DNA information of the plurality of users in parallel, a predicted degree of relationship between the first user and a user among the plurality of users, the predicted degree of relative relationship corresponding to a number of generations within which the first user and the second user share a common ancestor.
Type:
Grant
Filed:
October 16, 2020
Date of Patent:
June 29, 2021
Assignee:
23andMe, Inc.
Inventors:
Lawrence Hon, Serge Saxonov, Brian Thomas Naughton, Joanna Louise Mountain, Anne Wojcicki, Linda Avey
Abstract: Determining relative relationships of people who share a common ancestor within at least a threshold number of generations includes: receiving recombinable deoxyribonucleic acid (DNA) sequence information of a first user and recombinable DNA sequence information of a plurality of users; processing, using one or more computer processors, the recombinable DNA sequence information of the plurality of users in parallel; determining, based at least in part on a result of processing the recombinable DNA information of the plurality of users in parallel, a predicted degree of relationship between the first user and a user among the plurality of users, the predicted degree of relative relationship corresponding to a number of generations within which the first user and the second user share a common ancestor.
Type:
Grant
Filed:
October 16, 2020
Date of Patent:
June 8, 2021
Assignee:
23andMe, Inc.
Inventors:
Lawrence Hon, Serge Saxonov, Brian Thomas Naughton, Joanna Louise Mountain, Anne Wojcicki, Linda Avey
Abstract: Sharing data is disclosed. In some cases, sharing data includes receiving a request to share data from a first account to a second account, receiving an indication of a plurality of first account profiles associated with the first account to share with the second account, and establishing sharing from the plurality of first account profiles to the second account, wherein sharing comprises the second account having read access to a subset of nonpublic data associated with the plurality of first account profiles.
Type:
Grant
Filed:
October 23, 2020
Date of Patent:
May 4, 2021
Assignee:
23andMe, Inc.
Inventors:
Brian Lee Hawthorne, Oleksiy Khomenko, Jeffrey Mellen, Marcela Miyazawa, Michael Polcari, Jack Tihon, Alexander Wong, Anne Wojcicki, Linda Avey
Abstract: Databases and data processing systems for use with a network-based personal genetics services platform may include member information pertaining to a plurality of members of the network-based personal genetics services platform. The member information may include genetic information, family history information, environmental information, and phenotype information of the plurality of members. A data processing system may determine, based at least in part on the member information, a model for predicting a phenotype from genetic information, family history information, and environmental information, wherein determining the model includes training the model using the member information pertaining to a set of the plurality of members.
Type:
Grant
Filed:
May 14, 2020
Date of Patent:
March 2, 2021
Assignee:
23andMe, Inc.
Inventors:
Brian Thomas Naughton, Chuong Do, John Michael Macpherson
Abstract: Assembling a cohort includes: receiving genetic characteristic information pertaining to a desired genetic characteristic; using the genetic characteristic information to search a data storage comprising information of previously genotyped individuals to derive a candidate group having the desired genetic characteristic; and assembling the cohort based at least in part on the candidate group.
Type:
Grant
Filed:
October 12, 2018
Date of Patent:
January 12, 2021
Assignee:
23andMe, Inc.
Inventors:
Arnab Chowdry, Alexander Kompel, Michael Polcari