Patents Assigned to 3-D MATRIX, LTD.
  • Patent number: 10596265
    Abstract: A nanogel comprising a self-organizing peptide, a chitosan and polyethylene glycol is described.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: March 24, 2020
    Assignees: 3-D Matrix, Ltd., Tokyo University of Science Foundation
    Inventors: Hidenori Otsuka, Daisuke Matsukuma
  • Patent number: 10576123
    Abstract: There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like. The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a ?-structure in aqueous solution in the presence of physiological pH and/or a cation.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: March 3, 2020
    Assignee: 3-D Matrix, Ltd.
    Inventors: Kentaro Takamura, Satoshi Gojo, Satoru Kobayashi
  • Patent number: 10369237
    Abstract: Methods and devices for sterilizing viscous peptide compositions which have shear thinning rheological properties at high concentrations.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: August 6, 2019
    Assignee: 3-D Matrix, LTD.
    Inventors: Eun Seok Gil, Karl Patrick Gilbert
  • Patent number: 10337012
    Abstract: The invention provides a method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: July 2, 2019
    Assignees: 3-D Matrix, Ltd., National Cancer Center
    Inventor: Takahiro Ochiya
  • Patent number: 10286200
    Abstract: A syringe and a syringe set are provided. The syringe can be readily distinguished from other syringes only by viewing a tip of the syringe. The syringe includes a tip provided at an end of a barrel body to be filled with a medicine and having an outer diameter of 4.315 mm to 6 mm, a peripheral wall provided around the tip concentrically with the tip, and a helical rib formed on an inner the of the peripheral wall or an outer face of the tip.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: May 14, 2019
    Assignees: TAISEI KAKO CO., LTD., FUSO PHARMACEUTICAL INDUSTRIES, LTD., 3-D Matrix, Ltd.
    Inventors: Taiji Horita, Ippei Matsumoto, Tomoyuki Sonoyama, Fukumitsu Nishioka, Shoujirou Tanioka, Masahiro Nohara, Kiyoshi Takano
  • Patent number: 10245299
    Abstract: Materials and methods for treatment of pulmonary bulla are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary bulla.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: April 2, 2019
    Assignee: 3-D Matrix, Ltd.
    Inventors: Manav Mehta, Hisashi Tsukada, Eun Seok Gil, Karl Gilbert, Satoru Kobayashi
  • Publication number: 20180250435
    Abstract: The present invention relates to a triblock copolymer having a polyethylene glycol-poly(D,L-lactide)-polyethylene glycol skeleton.
    Type: Application
    Filed: August 23, 2016
    Publication date: September 6, 2018
    Applicants: 3-D Matrix, Ltd., Tokyo University of Science Foundation
    Inventors: Hidenori Otsuka, Daisuke Matsukuma, Noriaki Matsuda
  • Publication number: 20170312370
    Abstract: A nanogel comprising a self-organizing peptide, a chitosan, and polyethylene glycol.
    Type: Application
    Filed: August 24, 2015
    Publication date: November 2, 2017
    Applicants: 3-D Matrix, Ltd., Tokyo University of Science Foundation
    Inventors: Hidenori Otsuka, Daisuke Matsukuma
  • Publication number: 20170240902
    Abstract: The invention provides a method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells.
    Type: Application
    Filed: January 19, 2017
    Publication date: August 24, 2017
    Applicants: 3-D MATRIX, LTD., NATIONAL CANCER CENTER
    Inventor: Takahiro Ochiya
  • Patent number: 9724448
    Abstract: Materials and methods for preventing gastrointestinal obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. The peptide may undergo self-organization under physiological conditions and/or in the presence of a cation.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 8, 2017
    Assignee: 3-D MATRIX, LTD.
    Inventors: Satoru Kobayashi, Toshio Uraoka, Naohisa Yahagi
  • Publication number: 20170173221
    Abstract: Materials and methods for forming a bronchial obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to provide a bronchial obstruction.
    Type: Application
    Filed: March 10, 2015
    Publication date: June 22, 2017
    Applicant: 3-D MATRIX, LTD.
    Inventors: Manav Mehta, Hisashi Tsukada, Eun Seok Gil, Karl Patrick Gilbert, Satoru Kobayashi
  • Patent number: 9322016
    Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: April 26, 2016
    Assignees: 3-D Matrix Ltd., National Cancer Center
    Inventors: Takahiro Ochiya, Tomohiro Fujiwara
  • Publication number: 20160030628
    Abstract: Materials and methods for treating bile leakage are disclosed. A peptide comprising between about 7 amino acids to about 32 amino acids may be introduced to a target site. The peptide may undergo self-assembly upon adjustment of a pH level of the solution to a physiological pH level.
    Type: Application
    Filed: March 13, 2014
    Publication date: February 4, 2016
    Applicant: 3-D MATRIX, LTD.
    Inventor: Satoru Kobayashi
  • Patent number: 9133484
    Abstract: A transfection agent is provided that has lower toxicity and can be applied in the clinical setting. The transfection agent comprises a peptide surfactant.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: September 15, 2015
    Assignees: 3-D MATRIX, LTD., NIPPON MEDICAL SCHOOL FOUNDATION
    Inventors: Daizo Yoshida, Jiro Takei
  • Publication number: 20140377862
    Abstract: Provided is a cell cultivation method in which the cell is cultured using a peptide hydrogel as a scaffold, for carrying out high-dimensional culture of a cell such as porcine hepatocyte, human hepatocyte, porcine pancreatic islet or human pancreatic islet for a long period under conditions where cell survival, cell morphology and cell functions are maintained. Also provided are a cell culture including a cell and a peptide hydrogel obtained by the above-described cultivation method, a bioreactor including the cell culture, and a cell preparation including the cell culture.
    Type: Application
    Filed: January 6, 2014
    Publication date: December 25, 2014
    Applicants: 3-D Matrix, Ltd., National University Corporation Okayama University
    Inventors: Naoya KOBAYASHI, Noriaki TANAKA
  • Publication number: 20140329914
    Abstract: Provided are compounds and methods useful for sealing air leaks in the thoracic cavity. Compounds and compositions of the invention comprise certain amphiphilic peptides, 8-200 amino acid residues long, that self-assemble spontaneously to form a gel in the presence of physiological pH and/or in the presence of a cation. In one embodiment, the peptide comprises a repeated sequence arginine-alanine-aspartic acid-alanine (RADA). Methods of the invention include a method of occluding a pulmonary air leak in a subject, comprising applying a compound of the invention to the site of a pulmonary air leak. The compounds and methods of the invention can be combined with other agents useful to treat cancer, inflammation, or infection.
    Type: Application
    Filed: August 31, 2012
    Publication date: November 6, 2014
    Applicant: 3-D Matrix Ltd.
    Inventors: Satoru Kobayashi, Satoshi Okada, Kentaro Takamura
  • Patent number: D731647
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: June 9, 2015
    Assignees: FUSO PHARMACEUTICAL INDUSTRIES, LTD., 3-D MATRIX, LTD.
    Inventors: Fukumitsu Nishioka, Shoujirou Tanioka, Masahiro Nohara, Kiyoshi Takano
  • Patent number: D751726
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: March 15, 2016
    Assignees: Fuso Pharmaceutical Industries, Ltd., 3-D Matrix, Ltd.
    Inventors: Fukumitsu Nishioka, Shoujirou Tanioka, Masahiro Nohara, Kiyoshi Takano
  • Patent number: D833001
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: November 6, 2018
    Assignees: ANEST IWATA CORPORATION, 3-D MATRIX, LTD.
    Inventor: Hidetoshi Ishikawa
  • Patent number: D847975
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: May 7, 2019
    Assignees: ANEST IWATA CORPORATION, 3-D MATRIX, LTD.
    Inventor: Hidetoshi Ishikawa