Patents Assigned to 3-D MATRIX, LTD.
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Publication number: 20170312370Abstract: A nanogel comprising a self-organizing peptide, a chitosan, and polyethylene glycol.Type: ApplicationFiled: August 24, 2015Publication date: November 2, 2017Applicants: 3-D Matrix, Ltd., Tokyo University of Science FoundationInventors: Hidenori Otsuka, Daisuke Matsukuma
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Publication number: 20170240902Abstract: The invention provides a method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells.Type: ApplicationFiled: January 19, 2017Publication date: August 24, 2017Applicants: 3-D MATRIX, LTD., NATIONAL CANCER CENTERInventor: Takahiro Ochiya
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Patent number: 9724448Abstract: Materials and methods for preventing gastrointestinal obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. The peptide may undergo self-organization under physiological conditions and/or in the presence of a cation.Type: GrantFiled: March 13, 2014Date of Patent: August 8, 2017Assignee: 3-D MATRIX, LTD.Inventors: Satoru Kobayashi, Toshio Uraoka, Naohisa Yahagi
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Publication number: 20170173221Abstract: Materials and methods for forming a bronchial obstruction are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to provide a bronchial obstruction.Type: ApplicationFiled: March 10, 2015Publication date: June 22, 2017Applicant: 3-D MATRIX, LTD.Inventors: Manav Mehta, Hisashi Tsukada, Eun Seok Gil, Karl Patrick Gilbert, Satoru Kobayashi
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Patent number: 9322016Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.Type: GrantFiled: September 7, 2012Date of Patent: April 26, 2016Assignees: 3-D Matrix Ltd., National Cancer CenterInventors: Takahiro Ochiya, Tomohiro Fujiwara
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Publication number: 20160030628Abstract: Materials and methods for treating bile leakage are disclosed. A peptide comprising between about 7 amino acids to about 32 amino acids may be introduced to a target site. The peptide may undergo self-assembly upon adjustment of a pH level of the solution to a physiological pH level.Type: ApplicationFiled: March 13, 2014Publication date: February 4, 2016Applicant: 3-D MATRIX, LTD.Inventor: Satoru Kobayashi
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Patent number: 9133484Abstract: A transfection agent is provided that has lower toxicity and can be applied in the clinical setting. The transfection agent comprises a peptide surfactant.Type: GrantFiled: August 26, 2009Date of Patent: September 15, 2015Assignees: 3-D MATRIX, LTD., NIPPON MEDICAL SCHOOL FOUNDATIONInventors: Daizo Yoshida, Jiro Takei
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Publication number: 20140377862Abstract: Provided is a cell cultivation method in which the cell is cultured using a peptide hydrogel as a scaffold, for carrying out high-dimensional culture of a cell such as porcine hepatocyte, human hepatocyte, porcine pancreatic islet or human pancreatic islet for a long period under conditions where cell survival, cell morphology and cell functions are maintained. Also provided are a cell culture including a cell and a peptide hydrogel obtained by the above-described cultivation method, a bioreactor including the cell culture, and a cell preparation including the cell culture.Type: ApplicationFiled: January 6, 2014Publication date: December 25, 2014Applicants: 3-D Matrix, Ltd., National University Corporation Okayama UniversityInventors: Naoya KOBAYASHI, Noriaki TANAKA
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Publication number: 20140329914Abstract: Provided are compounds and methods useful for sealing air leaks in the thoracic cavity. Compounds and compositions of the invention comprise certain amphiphilic peptides, 8-200 amino acid residues long, that self-assemble spontaneously to form a gel in the presence of physiological pH and/or in the presence of a cation. In one embodiment, the peptide comprises a repeated sequence arginine-alanine-aspartic acid-alanine (RADA). Methods of the invention include a method of occluding a pulmonary air leak in a subject, comprising applying a compound of the invention to the site of a pulmonary air leak. The compounds and methods of the invention can be combined with other agents useful to treat cancer, inflammation, or infection.Type: ApplicationFiled: August 31, 2012Publication date: November 6, 2014Applicant: 3-D Matrix Ltd.Inventors: Satoru Kobayashi, Satoshi Okada, Kentaro Takamura
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Publication number: 20140243392Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.Type: ApplicationFiled: September 7, 2012Publication date: August 28, 2014Applicants: 3-D Matrix, Ltd., National Cancer CenterInventors: Takahiro Ochiya, Tomohiro Fujiwara
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Patent number: 8697438Abstract: Provided is a cell cultivation method in which the cell is cultured using a peptide hydrogel as a scaffold, for carrying out high-dimensional culture of a cell such as porcine hepatocyte, human hepatocyte, porcine pancreatic islet or human pancreatic islet for a long period under conditions where cell survival, cell morphology and cell functions are maintained. Also provided are a cell culture including a cell and a peptide hydrogel obtained by the above-described cultivation method, a bioreactor including the cell culture, and a cell preparation including the cell culture.Type: GrantFiled: December 23, 2011Date of Patent: April 15, 2014Assignees: National University Corporation Okayama University, 3-D Matrix, Ltd.Inventors: Naoya Kobayashi, Noriaki Tanaka
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Patent number: 8647867Abstract: Provided is a cell cultivation method in which the cell is cultured using a peptide hydrogel as a scaffold, for carrying out high-dimensional culture of a cell such as porcine hepatocyte, human hepatocyte, porcine pancreatic islet or human pancreatic islet for a long period under conditions where cell survival, cell morphology and cell functions are maintained. Also provided are a cell culture including a cell and a peptide hydrogel obtained by the above-described cultivation method, a bioreactor including the cell culture, and a cell preparation including the cell culture.Type: GrantFiled: September 29, 2006Date of Patent: February 11, 2014Assignees: National University Corportion Okayama University, 3-D Matrix, Ltd.Inventors: Naoya Kobayashi, Noriaki Tanaka
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Publication number: 20140038909Abstract: There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like. The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a ?-structure in aqueous solution in the presence of physiological pH and/or a cation.Type: ApplicationFiled: October 4, 2013Publication date: February 6, 2014Applicant: 3-D MATRIX, LTD.Inventors: Kentaro TAKAMURA, Satoshi GOJO, Satoru KOBAYASHI
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Publication number: 20130236891Abstract: The invention provides a method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells.Type: ApplicationFiled: January 24, 2011Publication date: September 12, 2013Applicants: 3-D MATRIX, LTD., NATIONAL CANCER CENTER RESEARCH INSTITUTEInventor: Takahiro Ochiya
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Publication number: 20110201541Abstract: There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like. The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a ?-structure in aqueous solution in the presence of physiological pH and/or a cation.Type: ApplicationFiled: October 6, 2009Publication date: August 18, 2011Applicant: 3-D MATRIX, LTD.Inventors: Kentaro Takamura, Satoshi Gojo, Satoru Kobayashi
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Publication number: 20110002880Abstract: The invention relates to a material for wound healing and skin reconstruction containing a peptide, wherein the peptide is a self-assembling peptide which is an amphiphilic peptide having 8 to 200 amino acid residues with periodic repeats of alternating hydrophilic amino acids and hydrophobic amino acids, and forms a stable ?-sheet structure in an aqueous solution in the presence of a monovalent ion. The material for wound healing and skin reconstruction of the present invention is capable of healing a wound area of mammals quicker than spontaneous recovery without leaving any scars, wherein the material has no potential risk of infectious disease such as virus transmission.Type: ApplicationFiled: December 4, 2008Publication date: January 6, 2011Applicant: 3-D MATRIX, LTD.Inventors: Kentaro Takamura, Jiro Takei
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Patent number: D714935Type: GrantFiled: July 9, 2013Date of Patent: October 7, 2014Assignees: Fuso Pharmaeutical Industries, Ltd., 3-D Matrix, Ltd.Inventors: Fukumitsu Nishioka, Shoujirou Tanioka, Masahiro Nohara, Kiyoshi Takano
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Patent number: D731647Type: GrantFiled: July 9, 2013Date of Patent: June 9, 2015Assignees: FUSO PHARMACEUTICAL INDUSTRIES, LTD., 3-D MATRIX, LTD.Inventors: Fukumitsu Nishioka, Shoujirou Tanioka, Masahiro Nohara, Kiyoshi Takano
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Patent number: D751726Type: GrantFiled: September 17, 2013Date of Patent: March 15, 2016Assignees: Fuso Pharmaceutical Industries, Ltd., 3-D Matrix, Ltd.Inventors: Fukumitsu Nishioka, Shoujirou Tanioka, Masahiro Nohara, Kiyoshi Takano