Patents Assigned to 3-D MATRIX, LTD.
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Publication number: 20230381185Abstract: Described herein is a novel nanocomposite for oral administration for treatment of gastrointestinal disease, e.g., IBD, or injury. The nanocomposite contains nanoemulsion particles (NEs), loaded with an active therapeutic agent, that are then combined with a second component containing a self-assembling peptide(s) (SAP) or peptidomimetic(s) (optionally, the second component is in a powder form). Upon administration, when hydrated at slightly acidic or near-neutral pH, the system self-assembles into a hydrogel matrix enveloping NEs, which then adheres to, and more efficiently delivers, the active agent to the intestinal tract of a treated subject. The nanocomposite can be administered in a capsule dosage form that forms a depot in the stomach or post-stomach.Type: ApplicationFiled: May 12, 2023Publication date: November 30, 2023Applicants: 3-D Matrix, Ltd., UNIVERSITE CLAUDE BERNARD LYON 1, Hôpital Lyon SudInventors: Giovanna Lollo, Marie Reveiller Buffier, Sharanya Sankar, David Kryza, Annalisa Rosso, Vanentina Andretto, Stephane Nancey, Gilles Boschetti
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Publication number: 20230365625Abstract: Endoscopic surgery targeted at the sinuses and nasal turbinates assists in managing the symptoms of chronic rhinosinusitis and other conditions. With contemporary techniques, post-operative hemorrhage, synechiae formation and poor wound healing are amongst the most common complications. The present disclosure provides the use of self-assembling peptide matrix, PuraSinus, and significantly reduces the incidence of these post-operative complications, including prevention of synechiae formation and aiding hemostasis.Type: ApplicationFiled: May 13, 2023Publication date: November 16, 2023Applicant: 3-D Matrix, Ltd.Inventors: Lisa Spirio, Michael Fook-Ho Lee, Jennifer Fong Ha, Maurice Bagot D'Arc
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Patent number: 11801281Abstract: There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like. The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a ?-structure in aqueous solution in the presence of physiological pH and/or a cation.Type: GrantFiled: January 4, 2022Date of Patent: October 31, 2023Assignee: 3-D Matrix, Ltd.Inventors: Kentaro Takamura, Satoshi Gojo, Satoru Kobayashi
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Publication number: 20230338613Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.Type: ApplicationFiled: July 5, 2023Publication date: October 26, 2023Applicant: 3-D Matrix, Ltd.Inventors: Marika G. Rioult, Eun Seok Gil, Elton Aleksi, Naoki Yamamoto
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Publication number: 20230323306Abstract: A jammed gel bioink comprises a self-assembling peptide solution comprising a self-assembling peptide, and a cell solution comprising living cells and a cell culture medium. The self-assembling peptide solution is extruded to form an object, and then the cell solution is injected into the object. Useful methods of making the jammed gel bioink are also disclosed.Type: ApplicationFiled: April 5, 2023Publication date: October 12, 2023Applicants: 3-D Matrix, Ltd., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL1), L’ECOLE SUPERIEURE DE CHIMIE, PHYSIQUE, ELECTRONIQUE DE LYON (CPE Lyon)Inventors: Christophe A. Marquette, Marie Reveiller Buffier, Marika G. Rioult, Eun Seok Gil
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Publication number: 20230323305Abstract: A bioink comprises a cell solution comprising living cells and a cell culture medium, and a self-assembling peptide solution comprising a self-assembling peptide. The bioink is formed by mixing and extruding the cell solution and the self-assembling peptide solution together, and the bioink can be continuously extruded from the mixer after mixing. Useful methods of making bioinks and are also disclosed.Type: ApplicationFiled: April 5, 2023Publication date: October 12, 2023Applicants: 3-D Matrix, Ltd., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL1), L’ECOLE SUPERIEURE DE CHIMIE, PHYSIQUE, ELECTRONIQUE DE LYON (CPE Lyon)Inventors: Christophe A. Marquette, Marie Reveiller Buffier, Marika G. Rioult, Eun Seok Gil
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Patent number: 11738113Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.Type: GrantFiled: November 6, 2022Date of Patent: August 29, 2023Assignee: 3-D Matrix, Ltd.Inventors: Marika G. Rioult, Eun Seok Gil, Elton Aleksi, Naoki Yamamoto
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Patent number: 11738114Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.Type: GrantFiled: December 2, 2022Date of Patent: August 29, 2023Assignee: 3-D Matrix, Ltd.Inventors: Marika G. Rioult, Eun Seok Gil, Elton Aleksi, Naoki Yamamoto
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Publication number: 20230241157Abstract: Provided herein are ionic self-assembling peptides, pharmaceutical compositions comprising the peptides, and methods of using and making the same.Type: ApplicationFiled: February 9, 2023Publication date: August 3, 2023Applicant: 3-D MATRIX, LTD.Inventors: Eun Seok Gil, Elton Aleksi, Naoki Yamamoto
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Publication number: 20230241294Abstract: Methods and materials for mitigating biological tissue adhesion are described herein. One method for mitigating adhesion to a biological tissue includes administering an effective amount of a self-assembling peptide solution to the biological tissue, wherein the self-assembling peptide is between about 7 amino acids and 32 amino acids in length and the self-assembling peptide solution forms a hydrogel under physiological conditions.Type: ApplicationFiled: February 12, 2023Publication date: August 3, 2023Applicant: 3-D Matrix, Ltd.Inventors: Satoru Kobayashi, Eun Seok Gil, Lisa Spirio
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Publication number: 20230226142Abstract: Provided herein are ionic self-assembling peptides, pharmaceutical compositions comprising the peptides, and methods of using and making the same.Type: ApplicationFiled: February 9, 2023Publication date: July 20, 2023Applicant: 3-D MATRIX, LTD.Inventors: Eun Seok Gil, Elton Aleksi, Naoki Yamamoto
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Publication number: 20230149599Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.Type: ApplicationFiled: December 2, 2022Publication date: May 18, 2023Applicant: 3-D Matrix, Ltd.Inventors: Marika G. Rioult, Eun Seok Gil, Elton Aleksi, Naoki Yamamoto
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Publication number: 20230149598Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.Type: ApplicationFiled: November 6, 2022Publication date: May 18, 2023Applicant: 3-D Matrix, Ltd.Inventors: Marika G. Rioult, Eun Seok Gil, Elton Aleksi, Naoki Yamamoto
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Patent number: 11617778Abstract: Provided herein are ionic self-assembling peptides, pharmaceutical compositions comprising the peptides, and methods of using and making the same.Type: GrantFiled: July 3, 2019Date of Patent: April 4, 2023Assignee: 3-D Matrix, Ltd.Inventors: Eun Seok Gil, Elton Aleksi, Naoki Yamamoto
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Patent number: 11534528Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.Type: GrantFiled: March 30, 2021Date of Patent: December 27, 2022Assignee: 3-D Matrix, Ltd.Inventors: Marika G. Rioult, Eun Seok Gil, Elton Aleksi, Naoki Yamamoto
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Patent number: 11497833Abstract: Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising, or consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.Type: GrantFiled: May 4, 2020Date of Patent: November 15, 2022Assignee: 3-D Matrix, Ltd.Inventors: Eun Seok Gil, Marika Rioult, Keiji Nagano, Karl Patrick Gilbert, Toshiro Kiyofuji, Yuya Hasegawa
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Publication number: 20220168462Abstract: Systems and methods of blocking a biological vessel 2 are provided. The systems and methods may comprise introducing to the vessel an amphiphilic peptide. The peptide may comprise at least thirteen amino acids that may alternate between a hydrophobic amino acid and a hydrophilic amino acid. The peptide may form a beta- sheet spontaneously in an aqueous solution in the presence of a cation.Type: ApplicationFiled: November 24, 2021Publication date: June 2, 2022Applicant: 3-D Matrix, Ltd.Inventors: Satoru Kobayashi, Kentaro Takamura
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Patent number: 11324703Abstract: Disclosed herein are surfactant peptide nanostructures wherein the peptides have repeating hydrophobic amino acids in an integer equal to or less than four. The peptide nanostructures are useful for therapeutic applications, including for delivery of drugs and siRNA.Type: GrantFiled: November 30, 2018Date of Patent: May 10, 2022Assignee: 3-D Matrix, Ltd.Inventors: Eun Seok Gil, Elton Aleksi, Noriaki Matsuda
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Publication number: 20220111126Abstract: Methods and materials for mitigating biological tissue adhesion are described herein. One method for mitigating adhesion to a biological tissue includes administering an effective amount of a self-assembling peptide solution to the biological tissue, wherein the self-assembling peptide is between about 7 amino acids and 32 amino acids in length and the self-assembling peptide solution forms a hydrogel under physiological conditions.Type: ApplicationFiled: November 5, 2021Publication date: April 14, 2022Applicant: 3-D Matrix, Ltd.Inventors: Satoru Kobayashi, Eun Seok Gil, Lisa Spirio
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Patent number: 11298397Abstract: [Problem] To provide a composition for hemostasis that can be applied uniformly to a bleeding site and exerts a high hemostatic effect. [Solution] Provided is a composition to be applied to the subject as a spray, wherein the composition is characterized in that the spray is for hemostasis, and the composition includes a self-assembling peptide, the self-assembling peptide gelling due to self-assembly when the composition is applied to the bleeding site of the subject, and the self-assembling peptide being included in the composition in a concentration having an improved hemostatic capacity in comparison to direct application.Type: GrantFiled: December 14, 2016Date of Patent: April 12, 2022Assignee: 3-D Matrix, Ltd.Inventors: Keiji Nagano, Satoru Kobayashi