Abstract: A metal borate production method is realized by the reaction, M(NO3)+Na2B4O7.10H2O?M.B2O3. nH2O+NaNO3+nH2O, between borax and perchlorate or nitrate solution comprising a metal, or another completely dissolved metal salt in stochiometric proportion and the synthesis of nano-structured metal borates having antibacterial characteristic without addition of a second. solvent or additive substance to the medium.
Type:
Application
Filed:
February 8, 2021
Publication date:
May 25, 2023
Applicant:
CELAL BAYAR UNIVERSITESI TEKN. GEL. BOL. A. S.
Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).
Type:
Application
Filed:
November 18, 2022
Publication date:
May 25, 2023
Applicant:
H. Lundbeck A/S
Inventors:
Lars Christian Biilmann Rønn, Ibrahim John Malik, Jeffrey B. Stavenhagen, Soren Christensen, Jan Egebjerg, Amout Gerritsen, Edward van den Brink, Paul Parren, Rob de Jong
Abstract: The invention relates to an oral nicotine formulation for use in the alleviation of nicotine craving, the formulation comprising a content of nicotine and a content of a pH regulating agent, wherein the formulation provides a peak saliva concentration of nicotine of more than 0.3 mg/mL and a peak saliva pH of more than 7.5 during the first 120 seconds upon oral administration.
Type:
Application
Filed:
December 7, 2018
Publication date:
May 25, 2023
Applicant:
Fertin Pharma A/S
Inventors:
Bruno Provstgaard Nielsen, Kent Albin Nielsen
Abstract: Oligonucleotides are provided herein that inhibit MARC1 expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with MARC1 expression.
Type:
Grant
Filed:
May 27, 2022
Date of Patent:
May 23, 2023
Assignees:
Novo Nordisk A/S, Dicerna Pharmaceuticals, Inc.
Inventors:
Henryk Dudek, Wen Han, Natalie Wayne Pursell, Chengjung Lai, William Geoffrey Haynes, Zhihao Ding
Abstract: Disclosed is a headset for audio transmission. The headset is configured to be worn by a user. The headset comprises a speaker for sound transmission into the users ear. The headset comprises a wireless communication unit for communication with an external device. The headset comprises a connection to a location-based service software, the location-based service software is configured for controlling at least one headset feature based on location data of the headset. The headset comprises a processing unit. The processing unit is configured for obtaining current location data of the headset. The processing unit is configured for enabling the location-based service software to detect if the current location data of the headset corresponds to a geographic region for which a first geo-fence is defined by the user.
Abstract: A multihead weigher with a collector for feeding, weighing and collecting solid food products with a sticky coating. The multihead weigher has a number of receptacles for weighing the solid food products and discharging the solid food product to the collector. Each receptacle having a scraper for scraping the surface of the receptacle when the solid food product is being discharged from the receptacle into the collector.
Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising the same. The compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the compounds and compositions are useful for the treatment of pain.
Type:
Grant
Filed:
May 22, 2018
Date of Patent:
May 23, 2023
Assignee:
H. LUNDBECK A/S
Inventors:
Cheryl A. Grice, John J. M. Wiener, Olivia D. Weber, Katharine K. Duncan
Abstract: The present invention deals with a method for improving the rollability of flat breads comprising a) adding a maltogenic alpha-amylase and a beta amylase to a flour or directly to a dough comprising a flour; b) making the dough; and c) making flat breads from the dough.
Abstract: The invention relates to a method and a cochlear implant system comprising; a microphone unit configured to receive an acoustical signal and transmit an audio signal based on the acoustical signal, a processor unit configured to receive the audio signal and process the audio signal into a plurality channels that are then used to generate a plurality of electrode pulses, an electrode array including a plurality of electrodes (M) configured to stimulate auditory nerves of a user of the cochlear implant system based on the plurality of electrode pulses, and wherein the processor unit is configured to assign an importance value to one or more electrodes of the plurality of electrodes, wherein each of the importance values is determined based on a status of an electrode pulse assigned to the respective electrode, and wherein the status of the electrode pulse of the plurality of electrode pulses is determined based on a masking model of across-electrode interferences imposed on that electrode pulse by other electro
Type:
Grant
Filed:
July 2, 2020
Date of Patent:
May 23, 2023
Assignee:
Oticon Medical A/S
Inventors:
Aswin Adris Wijetillake, Manuel Segovia Martinez
Abstract: Acidified milk product, which has a pH of between 3.0 and 5.0 and a content of lactose of at least 1.5 mg/ml, wherein the product contains a lactase, which retains its activity at a pH of 5.0 and a temperature of 37° C. at a level of at least 5% as compared to its activity at the optimum pH of the lactase.
Type:
Grant
Filed:
June 7, 2017
Date of Patent:
May 23, 2023
Assignee:
Chr. Hansen A/S
Inventors:
Soeren Ng Riis, Vojislav Vojinovic, Christian Gilleladen
Abstract: A speaker device is disclosed. The speaker device includes a speaker enclosure structure including a speaker. The speaker is an electro-mechanical component, which in operation generates sound waves by deflection of a speaker membrane and in collaboration with the speaker enclosure structure. The speaker device further includes a speaker device housing. The speaker device housing is an outer shell of the speaker device and may accommodate additional electronic components required for operation of the speaker or for other purposes. The speaker enclosure structure is mechanically coupled to the speaker device housing. The speaker device further includes at least one coupling element, wherein the speaker enclosure structure is mechanically coupled to the speaker device housing by the at least one coupling element, the coupling element having a vibration damping structure configured to inhibit mechanical vibrations being transmitted through the coupling element.
Abstract: The proposed technology relates to a method for indicating a risk for coronary artery disease. A sound recording is obtained (100) covering a plurality of heartbeats, a plurality of heart sounds are identified (200) in the sound recording, and a plurality of segments are obtained (300) from the sound recording. A frequency power measure is determined (400) based on the signal strength of a first frequency window of a period in the diastole, an amplitude of the fourth heart sound is determined (500) based on the plurality of heart sounds and the plurality of segments, and an indication of a heart rate variability is determined (600) based on the plurality of heart sounds. The indication of the risk for coronary artery disease is then determined (700) based on the frequency power measure, the amplitude of the fourth heart sound, and the indication of the heart rate variability.
Abstract: The present invention relates to Bifidobacterium breve deposited as DSM 32356 and compositions comprising said strain. The composition may further comprise at least one other bacterial strain and/or at least one compound which may be an NSAID such as acetylsalicylic acid (aspirin). In a presently preferred embodiment the invention relates to Bifidobacterium breve deposited as DSM 32356 for use in the support of the defense against intestinal tissue damage such as intestinal mucosal breaks or lesions e.g. in connection with NSAID administration such as in connection with administration of acetylsalicylic acid (aspirin). The invention further provides a method of supporting the defense against intestinal tissue damage, the method comprising administering the Bifidobacterium breve strain deposited as DSM 32356 to a subject in need thereof, e.g. to a subject in need of NSAID treatment.
Type:
Grant
Filed:
May 1, 2019
Date of Patent:
May 23, 2023
Assignee:
Chr. Hansen A/S
Inventors:
Brynjulf Mortensen, Anders Damholt, Anja Wellejus, Vibeke Westphal Stennicke, Johan E. T. Van Hycklama Vlieg
Abstract: A pressure sensor arrangement (1) for measuring a pressure of a fluid is described, the sensor arrangement (1) comprising a connector housing (2) having a fluid opening (3) and a fluid chamber (4) in connection with the fluid opening (3), at least one pressure sensitive element (5), a membrane (9) arranged between the pressure sensitive element (5) and the fluid chamber (4), and pressure attenuation means (10). Such a pressure sensor arrangement should be able to protect the measuring membrane from high frequency pressure pulsations with low costs. To this end the pressure attenuation means (10) are arranged in the fluid chamber (4) in direct contact with the membrane (9) separating the membrane (9) from the fluid in the fluid chamber and comprise a homogenous incompressible material having a mechanical loss factor of 0.1 or higher at frequencies of 200 Hz or higher.
Abstract: Disclosed is a base plate and a method for manufacturing a base plate. The method comprising: positioning a coupling part, the coupling part defining a terminal interface region; positioning an electrode assembly; positioning one or more terminal elements such that a distal part of each of the one or more terminal elements extends into the terminal interface region and a proximal part of each of the one or more terminal elements extends to the proximal side of the electrode assembly; affixing the proximal part of each of the one or more terminal elements to respective connection parts of the one or more electrodes; and securing the distal part of each of the one or more terminal elements to the coupling part.
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
May 23, 2023
Assignee:
Coloplast A/S
Inventors:
Jais Ask Hansen, Niels Hvid, Finn Speiermann
Abstract: There is provided a system and method for evacuating one or more mobile robots from a confined area. The system and method involve one or more mobile robots equipped with sensors or receivers for receiving evacuation commands directing the one or more mobile robots to leave the evacuation area and enter a location outside the evacuation area.
Abstract: A method for validating a preparation of at least one tooth in a prepared set of teeth for determining whether the prepared tooth is capable of accepting a dental restoration includes obtaining a virtual dental preparation guide configured for validating the preparation of the at least one tooth; obtaining a digital 3D representation of the prepared set of teeth; visualizing the virtual dental preparation guide together with the digital 3D representation of the prepared set of teeth; and validating from the visualization of the virtual dental preparation guide together with the digital 3D representation of the prepared set of teeth whether the prepared at least one tooth is shaped such that it can accept the dental restoration.
Inventors:
Kevin A. Batson, William J. Blank, Jr., Brian J. Cole, Brian Collins, Chris Frederick, Martin E. Granville, Benjamin Parker, Thomas F. Terrien, Jr.