Patents Assigned to AB Kabi
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Patent number: 4276375Abstract: Serine proteases in a substance such as blood are determined by contacting the substance with a novel chromogenic or fluorgenic substrate for serine proteinases and spectrophotometrically measuring the quantity of a chromophore or fluorescent compound released from the substrate by serine proteases in the substance. The novel substrate has the amino acid sequence-ILe-A-Gly-Arg-wherein A is Asp or Glu substituted in the carboxylic group by esterification or amidation. The novel substrate increases sensitivity and accuracy of the determination.Type: GrantFiled: October 22, 1979Date of Patent: June 30, 1981Assignee: AB KabiInventors: Karl G. Claeson, Leif E. Aurell, Leif R. Simonsson
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Patent number: 4252715Abstract: New chromogenic substrates suitable for serine proteases, specially suitable for diagnostic determination of factor Xa, which are represented by the following formula:R.sub.1 -A.sub.1 -A.sub.2 -Gly-Arg-NH-R.sub.2or its salts, where R.sub.1 is selected from the group of hydrogen, alkanoyl having from 1 to 12 carbon atoms, cyclohexylcarbonyl, benzoyl, benzoyl substituted with one or two halogen atoms, methylamine or phenyl groups, benzene sulphonyl and toluenesulphonyl; R.sub.2 is a chromophoric group; A.sub.1 is selected from the group of a single bond, and the amino acids selected from the group of Gly, Ala, Val, Leu, Ileu, Pro, Met, Phe and Tyr; and A.sub.2 is selected from the group of the amino acids Glu, Gln, Asp, and Asn.Type: GrantFiled: July 2, 1979Date of Patent: February 24, 1981Assignee: AB KabiInventors: Leif E. Aurell, Karl G. Claeson
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Patent number: 4247454Abstract: A chromogenic substrate having the formula ##STR1## and salts thereof wherein R.sub.1 is H or OH, R.sub.2 is a chromophoric group, and n is 1, 2 or 3.Type: GrantFiled: July 9, 1979Date of Patent: January 27, 1981Assignee: AB KabiInventors: Bo T. af Ekenstam, Leif E. Aurell, Karl G. Claeson, Birgitta G. Karlsson
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Patent number: 4242329Abstract: Tripeptide derivatives of the formulaH-D-X-Phe-Arg-Yin whichX is selected from the group consisting of Pro and PheY is selected from the group consisting of O--R.sub.1 and NH--R.sub.2 in whichR.sub.1 is selected from the group consisting of straight, branched and cyclic alkyl group with 1-12 C atoms, andR.sub.2 is selected from the group consisting of H, straight, branched and cyclic alkyl group with 1-12 C atoms, and physiologically acceptable salts thereof.A process for producing said tripeptide derivatives by synthesis and purification methods which are known in the peptide chemistry.Pharmaceutical preparations comprising said tripeptide derivatives.Type: GrantFiled: July 17, 1979Date of Patent: December 30, 1980Assignee: AB KabiInventors: Karl G. Claeson, Leif R. Simonsson, Salo Arielly
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Patent number: 4235772Abstract: Described are novel growth promoting peptides of the general formula:P-Cys-Q-Cys-RwhereP is hydrogen, or Phe-Asn-Val-Asp-Lys-Lys-;Q is selected from -Gln-, or -Ser-Tyr-Tyr-Gln-Ser-Asn-, or -Tyr-Thr-Ala-Glu-; andR is selected from -Thr, -Lys-Pro-Gln-Val-Thr, or -Asp-Glu-Leu;and of the corresponding reduced linear form of any of the foregoing, as well as the corresponding pharmaceutically acceptable acid addition salts of any of the foregoing. The corresponding intermediates or intermediary compounds with amino and/or carboxyl groups protected are also covered.Type: GrantFiled: June 20, 1979Date of Patent: November 25, 1980Assignee: AB KabiInventors: Ronny-Hugo L. Lundin, Gertrud E. Westin-Sjodahl, Karin H. L. Bergendal, Linda M. Fryklund
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Patent number: 4218476Abstract: New compounds of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 each independently represent an alkyl group containing 1 to 4 carbon atoms, or an alkoxy group containing 1 to 3 carbon atoms, or halogen, R.sup.3 represents hydrogen, halogen, an alkyl group containing 1 to 4 carbon atoms, an alkoxy group containing 1 to 3 carbon atoms, an amino group or a nitro group, A represents ##STR2## which is bonded to the benzene ring by its sulphur or nitrogen atom and in which R.sup.4 is hydrogen or an alkyl group containing 1 to 4 carbon atoms; together with salts thereof with physiologically acceptable acids and, when R.sup.4 is hydrogen, with physiologically acceptable bases are described. The compounds are of use in inhibiting thrombosis formation, in treating thrombosis and in fibronolytic therapy. Various methods of producing the new compounds are described involving the building up of the --A--CH.sub.2 --CH.sub.2 --S--CH.sub.2 CH.sub.2 NH.sub.Type: GrantFiled: August 3, 1978Date of Patent: August 19, 1980Assignee: AB KabiInventors: Aake N. Joensson, Ferenc Merenyi, Pinchas Moses, Lennart E. Karlsson, Gunnar Hanshoff
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Patent number: 4218472Abstract: New geminally disubstituted indenes are of general formula I ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or R.sup.1 and R.sup.2 together form a direct bond or an alkylene group --(CH.sub.2).sub.n --, in which n is an integer from 1 to 4, R.sup.3 is hydrogen, C.sub.1-3 -alkoxy or halogen, and each of R.sup.4 and R.sup.5 is hydrogen or C.sub.1-4 -lower alkyl, or R.sup.4 and R.sup.5 together form an alkylene group --(CH.sub.2).sub.m --, in which m is an integer from 3 to 6; and the corresponding amine oxides, quaternary ammonium compounds and salts with physiologically acceptable acids.The indenes find use in treating incontinence, as a mucous membrane decongestant, as a blood pressure reducing agent, as vasocostrictor or as an anti-reserpine agent.The indenes may be prepared by processes known per se involving(a) synthesing the side chain --CH(OH)CH.sub.2 NR.sup.4 R.sup.Type: GrantFiled: August 1, 1978Date of Patent: August 19, 1980Assignee: AB KabiInventors: Aake N. Joensson, Tomas G. Kempe, Lembit Mikiver, Bengt A. Sparf
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Patent number: 4214049Abstract: Method for the quantitative determination of serine proteases which includes contacting the substance for which the determination is desired with a diagnostically active chromogenic substrate with good stability and high specificity to serine proteases having the formula: H--D--A.sub.1 --A.sub.2 --A.sub.3 --NH--R or salts thereof, wherein A.sub.1 is Gly, Ala, Val, Leu, Ile, Pip, Pro, or Aze; A.sub.2 is Gly, Ala, Val, Leu, Ile, Pip, Pro, Aze, or Phe; A.sub.3 is Arg, Lys, or Orn, and R is a chromophoric group.Type: GrantFiled: October 27, 1978Date of Patent: July 22, 1980Assignee: AB KabiInventors: Bo T. af Ekenstam, Leif E. Aurell, Karl G. Claeson, Birgitta G. Karlsson, Stig I. Gustavsson, Gun A. Olausson
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Patent number: 4207232Abstract: Chromogenic or fluorogenic enzyme substrates for serine proteases containing the amino acid sequence Ile-A-Gly-Arg wherein A is Asp or Glu substituted in the carboxylic group by esterification or amidation, a method of preparation thereof, and use thereof.Type: GrantFiled: November 16, 1977Date of Patent: June 10, 1980Assignee: AB KabiInventors: Karl G. Claeson, Leif E. Aurell, Leif R. Simonsson
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Patent number: 4172093Abstract: The present invention relates to new pharmacodynamically active compounds of the general structure ##STR1## as well as the corresponding amine oxides, quarternary ammonium compounds and salts with physiologically acceptable acids. In formula I R.sup.1 signifies hydrogen, halogen or alkoxy radicals having 1-3 carbon atoms, R.sup.2 and R.sup.3 signify alkyl radicals having 1-3 carbon atoms, which togetner with the carbon atom, to which they are connected, may form a ring, A either signifies a possibly lower alkyl substituted ethylene, trimethylene or tetramethylene group, in which case D is a group ##STR2## wherein R.sup.4 and R.sup.Type: GrantFiled: March 20, 1973Date of Patent: October 23, 1979Assignee: AB KabiInventors: Barbro K. Goransson-Dahlander, Nils A. Jonsson, Ferenc Merenyi
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Patent number: 4169015Abstract: Process for determining thrombin and thrombin-like enzymes employing a substrate having the formula: ##STR1## and salts thereof, wherein R.sub.1 is H or OH; R.sub.2 is a chromophoric group; the N-terminal amino acid is in the D configuration and n is 1, 2 or 3 provided along with the method of use.Type: GrantFiled: August 22, 1977Date of Patent: September 25, 1979Assignee: AB KabiInventors: Bo T. af Ekenstam, Leif E. Aurell, Karl G. Claeson, Birgitta G. Karlsson
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Patent number: 4168146Abstract: A test strip for carrying out immunoassays. The test strip is a bibulous carrier to which antibodies are bound. The immunoassay is carried out by wetting the test strip with the aqueous solution containing a suspected antigen. The test strip is then contacted with an aqueous solution containing labeled antibodies.Type: GrantFiled: January 15, 1976Date of Patent: September 18, 1979Assignee: AB KabiInventors: Anders O. Grubb, Ulla C. Glad
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Patent number: 4168300Abstract: Hepatitis virus is removed from a biological material contaminated with the virus by contact with a preparation. The preparation may be agarose gel or beaded polyacrylamide plastic coupled with a variety of hydrophobic ligands.Type: GrantFiled: July 6, 1976Date of Patent: September 18, 1979Assignee: AB KabiInventors: Lars-Olov Andersson, Hakan G. Borg, Gudrun M. Einarsson
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Patent number: 4162941Abstract: The proteolytic enzyme designated as factor Xa is diagnostically determined by contacting the enzyme with a chromogenic substrate represented by the formulaR.sub.1 -A.sub.1 -A.sub.2 -Gly-Arg-NH-R.sub.2or its salts, where R.sub.1 is hydrogen or alkanoyl having from 1 to 12 carbon atoms or cyclohexylcarbonyl or benzoyl or benzoyl substituted with one or two halogen atoms, methylamine or phenyl groups or benzene sulphonyl or toluenesulphonyl, R.sub.2 is nitrophenyl or naphthyl or nitronaphthyl or methoxynaphthyl or quinolyl or nitroquinolyl, A.sub.1 is a single bond or one of the amino acids Gly, Ala, Val, Leu, Ileu, Pro, Met, Phe or Tyr, and A.sub.2 is one of the amino acids Glu, Gln, Asp, or Asn and spectrophotometrically measuring the degree of enzymatic hydrolysis.Type: GrantFiled: March 4, 1977Date of Patent: July 31, 1979Assignee: AB KabiInventors: Leif E. Aurell, Karl G. Claeson
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Patent number: 4138287Abstract: Hepatitis B virus (detectable as its surface antigen HB.sub.s Ag) is produced in a purification preferably suitable for use in preparing a hepatitis vaccine, by contacting a crude biological starting material containing hepatitis B virus with a water-insoluble cross-linked sulfated polysaccharide gel matrix adsorbing agent to adsorb the hepatitis B virus thereon and then desorbing that virus therefrom by treating that hepatitis B virus carrying adsorbent with a desorbing agent.Type: GrantFiled: March 15, 1977Date of Patent: February 6, 1979Assignee: AB KabiInventors: Lars-Olov Andersson, Gudrun M. Einarsson, Lennart P. Kaplan
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Patent number: 4137225Abstract: Diagnostically active chromogenic substrate with good stability and high specificity to serine proteases having the formula: H-D-A.sub.1 -A.sub.2 -A.sub.3 -NH-R or salts thereof, wherein A.sub.1 is Gly, Ala, Val, Leu, Ile, Pip, Pro, or Aze; A.sub.2 is Gly, Ala, Val, Leu, Ile, Pip, Pro, Aze, or Phe; A.sub.3 is Arg, Lys, or Orn, and R is a chromophoric group.Type: GrantFiled: March 20, 1978Date of Patent: January 30, 1979Assignee: Ab KabiInventors: Bo T. Af Ekenstam, Leif E. Aurell, Karl G. Claeson, Birgitta G. Karlsson, Stig I. Gustavsson, Gun A. Olausson
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Patent number: 4123543Abstract: New pharmacodynamically active nitrogen-containing heterocyclic compounds of the general formula ##STR1## as well as methods of preparing the same; and pharmacodynamical compositions containing the same, preferably for treating psychiatric and psychosomatic diseases.Type: GrantFiled: March 30, 1976Date of Patent: October 31, 1978Assignee: AB KabiInventors: Nils A. Jonsson, Lembit Mikiver, Pinchas Moses
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Patent number: 4119774Abstract: Crude clinically used heparin preparations having a low specific activity, for example, about 130 heparin units per milligram are purified by contacting such liquid crude heparin preparations with a gel matrix complexed with (i.e. having linked to it) antithrombin or inter-alpha-trypsin inhibitor as a heparin-binding plasma protein, and then desorbing or eluting the heparin from the antithrombin or inter-alpha-trypsin inhibitor complexed gel matrix as with an applicable buffer, removing any salt in the solution with the heparin by gel filtration and then drying the heparin as by lyophilization.Type: GrantFiled: March 2, 1977Date of Patent: October 10, 1978Assignee: AB KabiInventors: Lars-Olov Andersson, Erik Yngve Holmer
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Patent number: 4117144Abstract: New pharmacodynamically active nitrogen-containing heterocyclic compounds of the general formula ##STR1## as well as methods of preparing the same; and pharmacodynamical compositions containing the same, preferably for treating psychiatric and psychosomatic diseases.Type: GrantFiled: March 30, 1976Date of Patent: September 26, 1978Assignee: AB KabiInventors: Nils Ake Jonsson, Lembit Mikiver, Pinchas Moses
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Patent number: RE30149Abstract: Disclosed and claimed is the preparation of the 4-aminomethyl-cyclohexane carboxylic acid isomer assaying at least about 90% antifibrinolytically active material from specific para-disubstituted cyclohexane starting material. For example, in 4-aminomethyl-cyclohexane methanol such as its isomer melting at 118.degree. C. in a series of steps its methanol group is converted to carboxyl. More specifically its amino group is blocked by reaction with benzoyl halide and the methanol group then oxidized to carboxyl, and the benzoyl group removed to yield the end product isomer.1-4-dimethyl-cyclohexane dicarboxylate melting at 69.degree.-71.degree. C., another such cyclohexane starting material, is hydrolyzed to its mono-ester which with thionyl halide is converted to the halide of the half-ester, which latter reacted with ammonia gives the corresponding ester amide.Type: GrantFiled: January 30, 1979Date of Patent: November 13, 1979Assignee: AB KabiInventors: Bengt O. Melander, Gunnar Hanshoff, Bengt R. G. Granstrand, Berit M. Olsson