Abstract: Disclosed is (1) a method of resisting as well as suppressing recurrent venous thrombosis in a human susceptible to or having said thrombosis, which method comprises administering to said human a recurrent venous thrombosis-combatting effective dose of a pharmaceutical composition comprising a pharmaceutically acceptable acid addition salt of moroxydine, such as of an inorganic acid as hydrochloric or sulphuric, or an aliphatic carboxylic acid such as any of acetic, ascorbic, citric, fumaric, gluconic, glycolic, lactic, levulinic, maleic, tartaric, salicylic or nicotinic acids, and (2) pharmaceutical preparations containing such acid addition salts for the indicated use.
Abstract: Method for studying biochemical reactions in which a substance, whose activity or concentration is to be determined, affects a substrate specific for the biochemical reaction which includes providing electrodes coated with the substrate, determining as the control value, the capacitance in a measuring device containing the electrodes, introducing the substance into the measuring device, measuring the change in capacitance, and thereby obtaining a quantitative measure of the activity or concentration of the substance present in the sample and affecting the specific substrate on the electrodes.
Abstract: An analytical test, color change reagent preparation comprising peroxidase, an oxygen-oxidoreductase specific to a particular substance to be tested and a chromogen-reactive-indicator formula selected from (a) those having the general formula ##STR1## wherein X is the divalent carbonyloxy or sulfonyloxy group, W is hydrogen or another cation compatible with the aforesaid other ingredients of said reagent preparation, the subscript n is 0 or 1, and (i) when X is the carbonyloxy group, A is a divalent alkylene chain with from 2 to about 7 carbons, and (ii) when X is the sulfonyloxy group, n is 0 when A is the divalent alkylene chain of from 2 to about 7 carbons, and n is 1 when A is straight chain trimethylene or tetramethylene, and (b) the acid addition salts of said disubstituted benzidine derivative, compatible with the aforesaid ingredients of the chromogen-reactive-indicator, when X is the carbonyloxy group.
Type:
Grant
Filed:
February 9, 1977
Date of Patent:
January 3, 1978
Assignee:
AB Kabi
Inventors:
Nils Ake Jonsson, Ferenc Merenyi, Lars-Erik Westlund
Abstract: Substrate with high specificity to thrombin and thrombin-like enzymes having the formula: ##STR1## and salts thereof, wherein R.sub.1 is H or OH; R.sub.2 is nitrophenyl; and n is 1, 2 or 3 provided along with the method of use.
Type:
Grant
Filed:
June 17, 1976
Date of Patent:
December 6, 1977
Assignee:
AB Kabi
Inventors:
Bo Thuresson Af Ekenstam, Leif Eric Aurell, Karl Goran Claeson, Birgitta Gunilla Karlsson
Abstract: Novel synthetic peptides of the general formula ##STR1## and the corresponding reduced, linear form. The cyclic form of the peptide is produced by oxidation of the corresponding linear compound thereby providing the divalent dithio group --S--S-- joining the beta carbon of each of the cysteine moieties. In the above formula X is serine (SER) or lysine (Lys), and Y is OH or Thr-Glu-Gly-Phe. The obtained synthetic peptides, in either form, are useful in promoting growth of cells of mammalian tissues.
Type:
Grant
Filed:
April 28, 1975
Date of Patent:
November 15, 1977
Assignee:
AB Kabi
Inventors:
Hans Sievertsson, Ronny Hugo Loritz Lundin, Gertrud Elisabeth Westin Sjodahl
Abstract: The application discloses (A) a growth-promoting polypeptide having molecular weight from about 5,000 to about 7,000 chromatographic mobility under electrophoresis from about 0.25 to about 0.37 relative to lysine at pH 5 and from about 0.17 to about 0.43 relative to aspartic acid at pH 7.5, terminal amino acid at its amino end being asparagine or aspartic acid, and respective amounts of aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, leucine, tyrosine, phenylalanine, lysine, arginine, trypophan, and cysteine or carboxymethyl cysteine, and also a couple of instances also methionine, isoleucine and histidine; and (B) the derivation of the polypeptides from blood serum or plasma or a plasma fraction by combined steps of (a) homogenizing the starting material in water, (b) admixing a solution of hydrochloric acid in ethanol thereby splitting the polypeptide from its carrier proteins and precipitating them, (c) adjusting the pH to 8.
Type:
Grant
Filed:
May 15, 1974
Date of Patent:
October 18, 1977
Assignee:
AB Kabi
Inventors:
Hans Uno Sievertsson, Linda Fryklund, Knut Oivind Uthne
Abstract: The blood coagulation factors I (fibrinogen) and VIII (antihemophilia factor, abbreviated AHF) are isolated in high yields from animal tissue materials such as blood or blood products (e.g. plasma) or plasma fractions by a procedure involving the essential step of adsorption (as in affinity chromatography) of at least one of these factors, in a liquid system, onto a water-insoluble gel matrix primarily composed of a cross-linked sulfated or sulfonated, gel-forming carbohydrate such as cross-linked dextran sulfate-agarose, cross-linked dextran sulfate-dextran, cross-linked heparin-agarose and other such gel matrix-providing substances.
Type:
Grant
Filed:
July 30, 1975
Date of Patent:
May 10, 1977
Assignee:
AB Kabi
Inventors:
Lars-Olov Andersson, Hakan Gunnar Borg, Nanna Forsman, Gunnar Hanshoff, Goran Lindroos, Maggie Miller-Andersson, Elisabeth Charlotte Carling nee Ehrenberg
Abstract: Disclosed are benzidine derivatives substituted in each of the 3,3'-positions by the substituent ##STR1## wherein W is hydrogen or an alkali metal, the subscript n is zero when A is the divalent branched chain alkylene having from 2 to about 7 carbon atoms, and n is one when A is straight chain divalent alkylene with 3 or 4 carbons. Also disclosed are the corresponding derivatives wherein the sulfonyl group is replaced by the carbonyl group. Further disclosed are chromogen-reactive indicator compositions having as their chromogen constituent one of the foregoing benzidine derivatives. These compositions (1) are useful to test for a substance for which there exists a specific oxygen-oxidoreductase, such as a sugar, an amino acid, uric acid, and the like, and thus (2) contain also a peroxidase, a hydrogen-peroxide-oxidoreductase, and a specific oxygen-oxidoreductase for the specific material in the testing of which the composition is to be used.
Type:
Grant
Filed:
October 16, 1974
Date of Patent:
February 15, 1977
Assignee:
AB Kabi
Inventors:
Nils Ake Jonsson, Ferenc Merenyl, Lars-Erik Westlund
Abstract: Disclosed are in vitro active cell growth factors that stimulate deoxyribonucleic acid synthesis in the cells, are polypeptide in chemical structure, having a molecular weight range of from 4,000 to 6,000 and an isoelectric range of from pH 4.3 to 5.3, are inert to about 72% aqueous ethanol containing by volume about 0.047% of concentrated hydrochloric acid, soluble in and precipitated from such acid aqueous ethanol solution by admixing in it 3.5 times its volume of a mixture of five parts of acetone with three parts of ethanol, and are soluble in about twice their weight of 20% formic acid.
Abstract: New pharmacodynamically active nitrogen containing heterocyclic compounds of the general formula ##SPC1##As well as methods of preparing the same; andPharmacodynamical compositions containing the same, preferrably for treating psychiatric and psychosomatic diseases.
Type:
Grant
Filed:
September 11, 1972
Date of Patent:
March 30, 1976
Assignee:
AB Kabi
Inventors:
Nils Ake Jonsson, Lembit Mikiver, Pinchas Moses