Patents Assigned to ABS Global, Inc.
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Patent number: 11415936Abstract: The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.Type: GrantFiled: August 26, 2021Date of Patent: August 16, 2022Assignee: ABS GLOBAL, INC.Inventors: Daniel Mueth, Joseph Plewa, Jessica Shireman, Amy Anderson, Lewis Gruber, Neil Rosenbaum
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Patent number: 11399521Abstract: Systems for selecting, generating, and breeding hybrid dairy cattle are described, as are methods for maintaining herds of hybrid cattle.Type: GrantFiled: November 13, 2018Date of Patent: August 2, 2022Assignee: ABS Global, Inc.Inventors: Jon Lightner, Richard Williams
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Patent number: 11342473Abstract: A cytometer includes an avalanche photodiode, a switching power supply, a filter, and voltage adjustment circuitry. The switching power supply includes a feedback loop. The filter is electrically connected between the switching power supply and the avalanche photodiode. The voltage adjustment circuitry adjusts a voltage on the feedback loop based at least in part on a voltage measured between the filter and the avalanche photodiode.Type: GrantFiled: November 20, 2020Date of Patent: May 24, 2022Assignee: ABS Global, Inc.Inventors: Frederick Savage, Glenn J. Szejna, Zheng Xia
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Patent number: 11331670Abstract: A microfluidic system configured to focus particles suspended in a fluid. One general aspect includes a microfluidic system comprising one or more substrates and a focusing channel formed in the one or more substrates and spanning a length from an inlet to an outlet for receiving a flow of particles suspended in fluid, wherein the particles have a diameter (a) and the focusing channel has a hydraulic diameter (dh).Type: GrantFiled: May 22, 2019Date of Patent: May 17, 2022Assignee: ABS GLOBAL, INC.Inventors: Gerson Aguirre, Zheng Xia, Gopakumar Kamalakshakurup
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Patent number: 11297831Abstract: Technologies for cryopreserving ungulate embryos for implantation into recipient females are described.Type: GrantFiled: July 13, 2016Date of Patent: April 12, 2022Assignee: ABS Global, Inc.Inventor: Bruno Valente Sanches
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Patent number: 11243494Abstract: The invention, provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.Type: GrantFiled: January 3, 2019Date of Patent: February 8, 2022Assignee: ABS GLOBAL, INC.Inventors: Daniel Mueth, Joseph Plewa, Jessica Shireman, Amy Anderson, Lewis Gruber, Neil Rosenbaum
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Publication number: 20210368750Abstract: The disclosure relates to Bovine germplasm of Bos taurus HO840003210132823. Included in the present disclosure are cells comprising the genome of Bovine HO840003210132823 characterized by the presence of homozygous loci and spermatozoa obtained from said cells. Also provided by the present disclosure are tissue cultures of cells, animals obtained from said cells, and parts thereof, including F1 spermatozoa. The disclosure further provides for methods of breeding, selecting, and using the germplasm to improve existing commercial cattle herds generated from in vitro fertilization methods and progeny cattle obtained from in vitro fertilization and implantation and artificial insemination methods.Type: ApplicationFiled: May 18, 2021Publication date: December 2, 2021Applicant: ABS Global, Inc.Inventors: Katrina Dattilo, Devan Funk
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Patent number: 11187224Abstract: A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.Type: GrantFiled: October 9, 2019Date of Patent: November 30, 2021Assignee: ABS GLOBAL, INC.Inventors: Zheng Xia, Yu Zhou, John Larsen, Guocheng Shao, Shane Peterson, Marjorie Faust
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Patent number: 10981163Abstract: This disclosure concerns a method of providing a hydrophobic coating on a microfluidic chip that promotes the discrete flow of at least one liquid. It includes applying the hydrophobic coating onto an area of the microfluidic chip. The disclosure further includes a microfluidic chip that provides discrete flow of at least one liquid.Type: GrantFiled: September 12, 2017Date of Patent: April 20, 2021Assignee: ABS GLOBAL, INC.Inventors: John Larsen, Yu Zhou, Zheng Xia
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Patent number: 10975351Abstract: The disclosure relates to Bovine germplasm of Bos taurus variety JE840003146074527. Included in the present disclosure are cells comprising the Bovine variety JE840003146074527. Also provided by the present disclosure are tissue cultures of cells, animals obtained from said cells, and parts thereof, including F1 spermatozoa. The disclosure further provides for methods of breeding, selecting, and using the germplasm to improve existing commercial cattle herds generated from in vitro fertilization methods and progeny cattle obtained from in vitro fertilization and implantation and artificial insemination methods.Type: GrantFiled: June 17, 2019Date of Patent: April 13, 2021Assignee: ABS Global, Inc.Inventors: Aaron Horst, Katrina Dattilo, Devan Funk
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Patent number: 10928298Abstract: An apparatus and method of identifying objects includes: a microfluidic chip in which are disposed a plurality of channels, the microfluidic chip including: a main fluid channel into which a sample fluid mixture of objects to be identified is introduced; a plurality of sheath fluid channels into which sheath fluids are introduced, the sheath fluids which orient the objects in the main fluid channel in a predetermined direction while still maintaining laminar flow in the main fluid channel; an interrogation apparatus which detects and interrogates the oriented objects in the main fluid channel; and a focused energy apparatus which performs an action on the objects.Type: GrantFiled: June 18, 2014Date of Patent: February 23, 2021Assignee: ABS GLOBAL, INC.Inventors: David Appleyard, Jeff Betthauser, Marjorie Faust, John Larsen, Guocheng Shao, Zheng Xia, Yu Zhou
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Patent number: 10879416Abstract: A cytometer includes an avalanche photodiode, a switching power supply, a filter, and voltage adjustment circuitry. The switching power supply includes a feedback loop. The filter is electrically connected between the switching power supply and the avalanche photodiode. The voltage adjustment circuitry adjusts a voltage on the feedback loop based at least in part on a voltage measured between the filter and the avalanche photodiode.Type: GrantFiled: March 18, 2020Date of Patent: December 29, 2020Assignee: ABS Global, Inc.Inventors: Frederick Savage, Glenn J. Szejna, Zheng Xia
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Publication number: 20200390089Abstract: The disclosure relates to Bovine germplasm of Bos taurus variety JE840003146074527. Included in the present disclosure are cells comprising the Bovine variety JE840003146074527. Also provided by the present disclosure are tissue cultures of cells, animals obtained from said cells, and parts thereof, including F1 spermatozoa. The disclosure further provides for methods of breeding, selecting, and using the germplasm to improve existing commercial cattle herds generated from in vitro fertilization methods and progeny cattle obtained from in vitro fertilization and implantation and artificial insemination methods.Type: ApplicationFiled: June 17, 2019Publication date: December 17, 2020Applicant: ABS Global, Inc.Inventors: Aaron Horst, Katrina Dattilo, Devan Funk
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Publication number: 20200305399Abstract: The disclosure relates to Bovine germplasm of Bos taurus variety HO840M003150607238. Included in the present disclosure are cells comprising the genome of Bovine variety HO840M003150607238 characterized by the presence of homozygous loci and spermatozoa obtained from said cells. Also provided by the present disclosure are tissue cultures of cells, animals obtained from said cells, and parts thereof, including F1 spermatozoa. The disclosure further provides for methods of breeding, selecting, and using the germplasm to improve existing commercial cattle herds generated from in vitro fertilization methods and progeny cattle obtained from in vitro fertilization and implantation and artificial insemination methods.Type: ApplicationFiled: March 26, 2019Publication date: October 1, 2020Applicant: ABS Global, inc.Inventors: Devan Charles FUNK, Katrina Dattilo
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Patent number: 10763387Abstract: A cytometer includes an avalanche photodiode, a switching power supply, a filter, and voltage adjustment circuitry. The switching power supply includes a feedback loop. The filter is electrically connected between the switching power supply and the avalanche photodiode. The voltage adjustment circuitry adjusts a voltage on the feedback loop based at least in part on a voltage measured between the filter and the avalanche photodiode.Type: GrantFiled: May 3, 2019Date of Patent: September 1, 2020Assignee: ABS Global, Inc.Inventors: Frederick Hershel Savage, Glenn J. Szejna, Zheng Xia
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Patent number: 10488320Abstract: A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.Type: GrantFiled: December 22, 2014Date of Patent: November 26, 2019Assignee: ABS GLOBAL, INC.Inventors: Zheng Xia, Yu Zhou, John Larsen, Guocheng Shao, Shane Peterson, Marjorie Faust
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Publication number: 20050130115Abstract: The present invention describes a methodology for exploiting differences in the aging rates of X- and Y-bearing spermatozoa to enable pre-selection of gender of offspring in mammals.Type: ApplicationFiled: November 1, 2004Publication date: June 16, 2005Applicant: ABS Global,Inc.Inventors: Dennis Funk, Stuart Revell, Marvin Pace, Jeffery Betthauser, Marjorie Faust
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Patent number: 5843754Abstract: A process of parthenogenic activation of mammalian oocytes which includes increasing intercellular levels of divalent cations in the oocyte; and reducing phosphorylation of cellular proteins in the oocyte. One method of accomplishing this is by introducing Ca.sup.2+ free cation, such as ionomycin, to the oocyte and then preventing phosphorylation of the cellular proteins within the oocyte by adding a serine-threonine kinase inhibitor, such as 6-dimethylaminopurine (DMAP).Type: GrantFiled: June 6, 1995Date of Patent: December 1, 1998Assignee: ABS Global, Inc.Inventors: Joan L. Susko-Parrish, David L. Northey, M. Lorraine Leibfried-Rutledge, Steven L. Stice