Patents Assigned to Academia Sinica
  • Engineered yeast for production of enzymes
    Patent number: 10087450
    Abstract: Described herein is an engineered Kluyveromyces marxianus cell, the cell comprising in its genome: (i) two different nucleic acid molecules that each contain a promoter operably linked to a gene encoding a functional enzyme, and (ii) a selection nucleic acid molecule that contains a promoter operably linked to a gene encoding a selectable marker, wherein all of the nucleic acids molecules of (i) and (ii) are in tandem and the engineered cell expresses all of the proteins encoded by the genes of (i) and (ii).
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: October 2, 2018
    Assignee: Academia Sinica
    Inventors: Jui-Jen Chang, Wen-Hsiung Li, Chieh-Chen Huang, Hao-Yeh Lin, Ming-Che Shih
  • RM2 antigens and use thereof
    Patent number: 10086054
    Abstract: Described herein are synthetic glycan conjugates, immunogenic compositions thereof, vaccines thereof, and kits thereof. The present invention further provides methods of using the synthetic glycan conjugates, immunogenic compositions, or vaccines thereof to treat and/or prevent and/or diagnose proliferative diseases such as cancer. The provided glycan conjugate comprises a carrier and a glycan moiety of Formula (I-i) or Formula (I-ii): (structurally represented).
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: October 2, 2018
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Chung-Yi Wu, Hong-Yang Chuang, Chien-Tai Ren
  • Methods for modifying human antibodies by glycan engineering
    Patent number: 10087236
    Abstract: Modified Fc regions of antibodies and antibody fragments, both human and humanized, and having enhanced stability and efficacy, are provided. Fc regions with core fucose residues removed, and attached to oligosaccharides comprising terminal sialyl residues, are provided. Antibodies comprising homogeneous glycosylation of Fc regions with specific oligosaccharides are provided. Fc regions conjugated with homogeneous glycoforms of monosaccharides and trisaccharides, are provided. Methods of preparing human antibodies with modified Fc using glycan engineering, are provided.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: October 2, 2018
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Chung-Yi Wu
  • PLASMID, TRANSFORMED PLANT CELL AND TRANSGENIC PLANT COMPRISING THE SAME, AND METHODS FOR PREPARING A TRANSGENIC PLANT AND FOR INCREASING YIELD OF A PLANT UNDER ABIOTIC STRESSES
    Publication number: 20180273970
    Abstract: A method for increasing yield of a plant, and particularly a method for increasing yield of a plant under abiotic stresses. The method includes preventing or reducing antagonism of Snf1 protein kinase (SnRK1A) by a protein encoded by SEQ ID No: 2 or SEQ ID No: 4.
    Type: Application
    Filed: June 1, 2018
    Publication date: September 27, 2018
    Applicant: Academia Sinica
    Inventors: Su-May Yu, Chien-Ru Lin
  • CORE CONSTRUCTS AND THEIR USES IN CONFIGURING PHARMACEUTICAL MOLECULES
    Publication number: 20180264129
    Abstract: The present disclosure provides various core constructs. According to embodiments of the present disclosure, the core construct can be used to configure pharmaceutical molecules. In particular, the core construct may be conjugated with a functional element via the click chemistry.
    Type: Application
    Filed: May 23, 2018
    Publication date: September 20, 2018
    Applicant: Academia Sinica
    Inventors: Tse-Wen CHANG, Hsing-Mao CHU, Chun-Yu LIN
  • ANTAGONISTIC PDL1 APTAMERS AND THEIR APPLICATIONS IN CANCER THERAPY
    Publication number: 20180258431
    Abstract: Aptamers that bind to and antagonize PDL1 and uses thereof in enhancing immune activity (e.g., promoting T cell proliferation), treating cancer, and/or infectious diseases such as infections caused by enterovirus, HBV, or HCV infection.
    Type: Application
    Filed: August 31, 2016
    Publication date: September 13, 2018
    Applicants: Academia Sinica, National Taiwan University
    Inventors: Pan-Chyr Yang, Wei-Yun Lai, Bo-Tsang Huang
  • Compositions and methods for detection of protein S-nitrosylation and oxidation
    Patent number: 10072097
    Abstract: The present invention discloses a novel isolated antibody that specifically binds to an N-phenyl-acetamide group. Also disclosed are related compositions, kits, methods for detecting protein S-nitrosylation or oxidation vivo or in vitro, and drug screening methods.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: September 11, 2018
    Assignee: Academia Sinica
    Inventors: Tzu-Ching Meng, Geen-Dong Chang, Ming-Fo Hsu
  • Lung cancer biomarker
    Patent number: 10048264
    Abstract: The present invention relates to a lung cancer biomarker for diagnosing early stage lung cancers or predicting prognosis of lung cancers, which comprises a GM2AP protein. The present invention also relates to a method for diagnosing early stage lung cancers or predicting prognosis of lung cancers in vitro by detection of the biomarker.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: August 14, 2018
    Assignees: ACADEMIA SINICA, NATIONAL TAIWAN UNIVERSITY
    Inventors: Shui-Tein Chen, Chong-Jen Yu, Potprommanee Laddawan, Haou-Tzong Ma
  • Increase of protein synthesis ameliorates synaptopathy-related neurological disorders
    Patent number: 10034848
    Abstract: Disclosed herein is a method for increasing the dendritic spine formation or dendritic spine density in a subject, who is affected by a dendritic spine defect caused by the impairment in neurofibromin (NF1 protein), valosin-containing protein (VCP), atlastin-1 (ATL1), or superoxide dismutase 1 (SOD1). Accordingly, also disclosed herein is a method for treating a subject having or suspected of having a synaptopathy caused by the impairment in NF1, VCP, ATL1, or SOD1.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: July 31, 2018
    Assignee: Academia Sinica
    Inventor: Yi-Ping Hsueh
  • Method of inhibiting sprouting in plant tissues
    Patent number: 10036033
    Abstract: The present invention relates to a method for inhibiting sprouting, particularly pre-harvest sprouting, in plant seeds, by introducing a polynucleotide encoding a FCA protein into the plant.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: July 31, 2018
    Assignee: Academia Sinica
    Inventors: Tuan-Hua David Ho, Wan-chi Lin, Kuan-Ying Huang
  • APPARATUS AND METHOD FOR ENHANCING FIGURE OF MERIT IN COMPOSITE THERMOELECTRIC MATERIALS WITH AEROGEL
    Publication number: 20180204992
    Abstract: At least one of the present embodiments generally relates to an apparatus and a method for enhancing the figure of merit (zT) in composite thermoelectric materials using aerogel such as e.g., silicate/silica aerogel, carbon aerogel, chalcogenide aerogel and metal oxide aerogel. For example, the present embodiments provide apparatuses and methods for the addition of aerogels to two commonly used p and n type thermoelectric materials and thereby enhancing their thermoelectric figure of merits to record levels.
    Type: Application
    Filed: January 9, 2018
    Publication date: July 19, 2018
    Applicant: Academia Sinica
    Inventors: Maw-Kuen Wu, Phillip M. Wu, Yang-Yuan Chen, Chung-Chieh Chang, Pai-Chun Wei, Tian-Wey Lan, Yu-Ruei Wu
  • ANTAGONISTS FOR INTERLEUKIN-17 RECEPTOR B (IL-17RB) AND ITS LIGAND IL-17B FOR CANCER THERAPY
    Publication number: 20180201672
    Abstract: Methods and compositions for treatment and therapy of cancer are provided. Specifically, antagonists specific for interleukin-17 receptor B (IL-17RB) and its ligand IL-17B are provided. Potent neutralizing antibodies specific for IL-17RB and methods for their manufacture and use are disclosed. The invention also relates to antisense, RNAi and shRNA compositions for the prevention and treatment of cancer, in particular breast cancer and pancreatic cancer.
    Type: Application
    Filed: June 30, 2015
    Publication date: July 19, 2018
    Applicant: Academia Sinica
    Inventors: Wen-Hwa Lee, Jin-Yuh Shew, Che Ma, Chia-Lin Chen, Wen-Hsin Lee, Chun-Kai Huang, Heng-Hsiung Wu
  • Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
    Patent number: 10023892
    Abstract: The present disclosure relates to glycoproteins, particularly monoclonal antibodies, comprising a glycoengineered Fc region, wherein said Fc region comprises an optimized N-glycan having the structure of Sia2(?2-6)Gal2GlcNAc2Man3GlcNAc2. The glycoengineered Fc region binds Fc?RIIA or Fc?RIIIA with a greater affinity, relative to comparable monoclonal antibodies comprising the wild-type Fc region. The monoclonal antibodies of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by Fc?R is desired, e.g., cancer, autoimmune, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: July 17, 2018
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Chung-Yi Wu, Che Ma
  • Iron-sulfur complex and method for producing hydrogen using the same as catalyst
    Patent number: 10016748
    Abstract: This invention relates to an iron-sulfur complex that is capable of efficiently catalyzing formation of hydrogen, and a method for producing hydrogen using the complex as a catalyst. The iron-sulfur complex provided herein comprises: a structure of formula (I) wherein the ligands L1 to L3, L5 and L6 and the groups X1 to X3 are each selected from the group consisting of alkyl, alkenyl, alkynyl and aryl that are substituted or unsubstituted, hydroxyl, carbonyl, aldehyde, and so on; L4 is a bridging ligand selected from the group consisting of hydroxyl, carbonyl, and so on; and the symbol “z” means the charge, which is an integer with the range of ?3 to +2. X1 and X2 may join together to form a bridging group between the two sulfur atoms. X3 may alternatively be a vacant site.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: July 10, 2018
    Assignee: ACADEMIA SINICA
    Inventors: Ming-Hsi Chiang, Yu-Chiao Liu, Kai-Ti Chu
  • NOVEL GLUCAGON-LIKE PEPTIDE 1 MODULATOR AND USES THEREOF
    Publication number: 20180179172
    Abstract: Disclosed herein are novel glucagon-like peptide-1 (GLP-1) modulators and their uses in manufacturing medicaments for the treatment and/or prophylaxis of diseases and/or disorders associated with hyperglycemia.
    Type: Application
    Filed: June 30, 2016
    Publication date: June 28, 2018
    Applicant: Academia Sinica
    Inventors: Rong-Jie CHIEN, Klim KING, Nai-Pin LIN, Yu-Hong CHENG
  • Anti-HER2 glycoantibodies and uses thereof
    Patent number: 10005847
    Abstract: The present disclosure relates to a novel class of anti-HER2 monoclonal antibodies comprising a homogeneous population of anti-HER2 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-HER2 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: June 26, 2018
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Chung-Yi Wu
  • Molecular catalysts capable of catalyzing oxidation of hydrocarbons and method for oxidizing hydrocarbons
    Patent number: 10005746
    Abstract: This invention relates to molecular catalysts and chemical reactions utilizing the same, and particularly to molecular catalysts for efficient catalytic oxidation of hydrocarbons, such as hydrocarbons from natural gas. The molecular catalytic platform provided herein is capable of the facile oxidation of hydrocarbons, for example, under ambient conditions such as near room temperature and atmospheric pressure.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: June 26, 2018
    Assignees: ACADEMIA SINICA, NATIONAL TAIWAN UNIVERSITY
    Inventors: Sunney Ignatius Chan, Sheng-Fa Yu, Penumaka Nagababu, Suman Maji, Ping-Yu Chen, Ravirala Ramu, Chung-Yuan Mou, Chih-Cheng Liu
  • Endoglycosidase mutants for glycoprotein remodeling and methods of using it
    Patent number: 10000747
    Abstract: A mutant of EndoS2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO: 1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of EndoS2 has a low hydrolyzing activity and a high tranglycosylation activity, as compared to those of the wild-type EndoS2. A method for preparing an engineered glycoprotein using the mutant of EndoS2 includes coupling an activated oligosaccharide to a glycoprotein acceptor. The activated oligosaccharide is a glycan oxazoline.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: June 19, 2018
    Assignees: Academia Sinica, CHO Pharma Inc.
    Inventors: Nan-Horng Lin, Lin-Ya Huang, Sachin S Shivatare, Li-Tzu Chen, Chi-Huey Wong, Chung-Yi Wu, Ting Cheng
  • TRANSGENIC PLANTS EXPRESSING TYPE 2C PROTEIN PHOSPHATASE ABSCISIC ACID (PP2CABA) PROTEINS AND USES THEREOF
    Publication number: 20180163221
    Abstract: The present disclosure relates to transgenic plants that over-express PP2CABA and methods of using such for enhancing osmotic stress tolerance.
    Type: Application
    Filed: December 12, 2017
    Publication date: June 14, 2018
    Applicant: Academia Sinica
    Inventors: Su-May Yu, Chun-Hsien Lu, Tuan-Hua David Ho, Shuen-Fang Lo
  • BROADBAND META-OPTICAL DEVICE
    Publication number: 20180156949
    Abstract: The present invention provides an optical component comprising a dielectric layer and a nanorod array; the nanorod array is formed on a surface of the dielectric layer and extends along a lateral direction and a vertical direction. The nanorod array comprises a plurality of nanorods extending along the dielectric layer. The nanorods have a gap between one another, and an angle is defined by two adjacent nanorods. A bump is formed at each of two ends of the nanorod.
    Type: Application
    Filed: May 19, 2017
    Publication date: June 7, 2018
    Applicant: Academia Sinica
    Inventors: Din-Ping TSAI, Pin-Chieh WU