Patents Assigned to Academia Sinica
  • INTERNALLY FIXED LIPID VESICLE
    Publication number: 20190170745
    Abstract: A method of generating an internally fixed lipid vesicle, comprising: providing a precursor lipid vesicle that contains an aqueous interior enclosed by a lipid membrane, wherein the lipid membrane of the precursor lipid vesicle is non-permeable to a crosslinker; permeabilizing the lipid membrane transiently to generate a permeable vesicle; contacting the permeable vesicle with an inactive activatable crosslinker, whereby the inactive activatable crosslinker enters the permeable vesicle; allowing the permeable vesicle to return to a non-permeable vesicle; removing any extravesicular crosslinker; and activating the inactive activatable crosslinker to allow crosslinking to occur inside the non-permeable vesicle, whereby an internally fixed lipid vesicle is generated.
    Type: Application
    Filed: July 28, 2017
    Publication date: June 6, 2019
    Applicant: Academia Sinica
    Inventors: Che-Ming Jack HU, Hui-Wen CHEN, Yuan-I CHEN, Chen-Ying CHEIN, Jung-Chen LIN
  • Methods and compositions for immunization against virus
    Patent number: 10307475
    Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: June 4, 2019
    Assignee: Academia Sinica
    Inventors: Chi-Huey Wong, Che Ma, Cheng-Chi Wang, Juine-Ruey Chen
  • HDAC8 inhibitors for treating cancer
    Patent number: 10308596
    Abstract: Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: June 4, 2019
    Assignees: CITY OF HOPE, TAIPEI MEDICAL UNIVERSITY, ACADEMIA SINICA
    Inventors: Ya-Huei Kuo, Wei-Jan Huang, Chung-I Chang
  • Antibody-mediated anti-tumor activity induced by Reishi mushroom polysaccharides
    Patent number: 10307470
    Abstract: Immunogenic compositions, cancer vaccines and methods for treating cancer comprising FMS, the fucose-enriched polysaccharide fraction from Reishi F3, are provided. Compositions comprise fucose-enriched Reishi polysaccharide fraction (FMS) MW=˜35 kDa, wherein the FMS is isolated by size-exclusion chromatography from Reishi F3, and the FMS comprises polysaccharides having primarily a backbone selected from 1,4-mannan and 1,6-?-galactan, wherein the backbone is linked to a terminal fucose-containing side-chain Immunogenic compositions comprising glycolipid adjuvants are provided. Antibodies generated by immunogenic compositions disclosed herein bind cancer cells comprising antigens Globo H, Globo H, Gb3, Gb4, Gb5 (SSEA-3) and SSEA-4 on the cell surface.
    Type: Grant
    Filed: July 26, 2014
    Date of Patent: June 4, 2019
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Chung-Yi Wu, Hsien-Yeh Hsu, Shih-Fen Liao, Chi-Hui Liang
  • Plant defense signaling peptides and applications thereof
    Patent number: 10306895
    Abstract: A plant defense signaling peptide and applications thereof for inducing systemic immune responses in a plant. In some embodiments, methods for inducing systemic immune responses in a plant comprises applying to the plant a plant defense signaling polypeptide comprising a motif of SEQ ID NO: 1 or SEQ ID NO: 28, or a composition comprising the polypeptide, wherein the polypeptide has up to 100 amino acids in length.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: June 4, 2019
    Assignee: Academia Sinica
    Inventors: Yet-Ran Chen, Ying-Lan Chen, Mei-Chun Tseng
  • Compounds for use in prevention and treatment of neurodegenerative diseases and pain
    Patent number: 10301348
    Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of N6-[(3-halothien-2-yl)methyl]adenosine, N6-[(4-halothien-2-yl)methyl]adenosine, and N6-[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting of N6-[(2-bromothien-3-yl)methyl]adenosine, N6-[(4-bromothien-3-yl)methyl]adenosine, N6-[(5-bromothien-3-yl)methyl]adenosine N6-[(2-chlorothien-3-yl)methyl]adenosine, N6-[(4-chlorothien-3-yl)methyl]adenosine, and N6-[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: May 28, 2019
    Assignee: ACADEMIA SINICA
    Inventors: Jim-Min Fang, Yun-Lian Lin, Jung-Hsin Lin, Chun-Jung Lin, Yijuang Chern, Nai-Kuei Huang, Hung-Li Wang, Benjamin Pang-hsien Tu, Chih-Cheng Chen
  • Organic electroluminescent material containing alkaline earth metal based metal-organic frameworks and organic electroluminescent device using the same
    Patent number: 10283714
    Abstract: An organic electroluminescent material is shown in the following general formula (1), {[M(L)(H2O)x].(H2O)y}n??General Formula (1) wherein x is between 1 and 4, y is between 1 and 8, and n is a positive integer. M is any one selected from the group consisting of beryllium (Be), strontium (Sr), and radium (Ra). L is an organic ligand containing a naphthalene group and an anhydride group. M and L form metal-organic frameworks. An organic electroluminescent device containing the organic electroluminescent material is also disclosed.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: May 7, 2019
    Assignees: ACADEMIA SINICA, NATIONAL TAIWAN UNIVERSITY
    Inventors: Kuang-Lieh Lu, Muhammad Usman, Yang-Fang Chen, Golam Haider, Shruti Mendiratta, Tzuoo-Tsair Luo
  • Batch-process supertorrefaction system and method
    Patent number: 10273411
    Abstract: A compact, transportable batch-process supertorrefaction system includes at least one supertorrefying unit, a liquid tank containing molten salt, and a wash tank including a plurality of basins containing water having different temperatures and different salinity. The liquid tank and the wash tank sequentially supply the molten salt and the water to a receiving space of the at least one supertorrefying unit to supertorrefy the biomass into charcoal and to rinse and cool the charcoal, respectively. The plurality of basins of the wash tank sequentially supply water having different temperatures and salinity to the same receiving space to gradually rinse and cool the charcoal. The biomass is not moved in the at least one supertorrfeying unit during biomass supertorrefaction. The charcoal is not moved during charcoal cooling.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: April 30, 2019
    Assignees: ACADEMIA SINICA
    Inventors: Frank H. Shu, Fen-Tair Luo, Michael J. Cai
  • Glycan arrays on PTFE-like aluminum coated glass slides and related methods
    Patent number: 10274488
    Abstract: Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: 1) the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; 2) the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and 3) the slides are more sensitive than transparent glass slides in binding analysis.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: April 30, 2019
    Assignee: ACADEMIA SINICA
    Inventors: Chi-Huey Wong, Chung-Yi Wu, Susan Y. Tseng
  • COMPOSITIONS AND METHODS RELATING TO UNIVERSAL GLYCOFORMS FOR ENHANCED ANTIBODY EFFICACY
    Publication number: 20190119713
    Abstract: The present disclosure relates to glycoproteins, particularly monoclonal antibodies, comprising a glycoengineered Fc region, wherein said Fc region comprises an optimized N-glycan having the structure of Sia2(?2-6)Gal2GlcNAc2Man3GlcNAc2. The glycoengineered Fc region binds Fc?RIIA or Fc?RIIIA with a greater affinity, relative to comparable monoclonal antibodies comprising the wild-type Fc region. The monoclonal antibodies of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by Fc?R is desired, e.g., cancer, autoimmune, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.
    Type: Application
    Filed: June 26, 2018
    Publication date: April 25, 2019
    Applicant: Academia Sinica
    Inventors: Chi-Huey WONG, Chung-Yi WU, Che MA
  • Methods for enhancing root growth of plants
    Patent number: 10266838
    Abstract: The present invention relates to a method for enhancing root growth of a plant by introducing a polynucleotide encoding late embryogenesis abundant protein, group 3 (LEA3) into the plant. Plant root architecture is essential for its functions in water and nutrient uptake, anchorage and interactions with microbes in the soil.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: April 23, 2019
    Assignee: Academia Sinica
    Inventors: Su-May Yu, Yi-Shih Chen, Shuen-Fang Lo, Tuan-Hua David Ho
  • Oblivious parallel random access machine system and methods
    Patent number: 10248324
    Abstract: A secure parallel processing technique for converting any parallel random access machine (PRAM) into an oblivious parallel random access machine (OPRAM), whose distribution of memory accesses is statistically independent of the data (with negligible error), while only inducing a polylogarithmic slowdown to both the total and parallel complexities of the program.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: April 2, 2019
    Assignees: Cornell University, Technion Research & Development Limited, Academia Sinica
    Inventors: Rafael Pass, Elette Boyle, Kai-Min Chung
  • Sesquiterpene derivatives and their use in inflammation or cancer treatment
    Patent number: 10238631
    Abstract: A new class of sesquiterpene derivative useful for treating cancerous and inflammatory diseases are disclosed. These deoxyelephantopin derivatives are effective in suppressing proliferation, migration, mobility, invasion, growth, and/or metastasis of cancer cells in a patient, or useful for enhancing an anti-proliferative effect of another anti-cancer drug on cancer cells when treating a patient, or for sensitizing and/or enhancing an anti-cancer effect of a gluthathione synthesis blocker on inhibition of triple negative breast cancer cell activity, or for treatment and/or prophylaxis of lipopolysaccharide-stimulated inflammatory response in a patient, or for all of the above. Also disclosed are methods of preparing the deoxyelephantopin derivatives.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: March 26, 2019
    Assignee: Academia Sinica
    Inventors: Lie-Fen Shyur, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto, Jia-Hua Feng, Jo-Yu Chen, Wai-Leng Lee, Yu-Ting Cheng, Jing-Ying Huang
  • PHAGE-DISPLAYED SINGLE-CHAIN VARIABLE FRAGMENT LIBRARIES AND USES THEREOF
    Publication number: 20190085323
    Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized in having a specific CS combination and a specific sequence in each CDR. The present scFv library is useful in efficiently producing different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.
    Type: Application
    Filed: November 28, 2018
    Publication date: March 21, 2019
    Applicant: Academia Sinica
    Inventors: An-Suei Yang, Jhih-Wei Jian, Hong-Sen Chen, Yi-Kai Chiu, Hung-Pin Peng, Chao-Ping Tung, Chung-Ming Yu, Wei-Ying Kuo, Hung-Ju Hsu
  • Use of an antimicrobial peptide TP4 in treating a cancer
    Patent number: 10232013
    Abstract: The preset invention relates to a new approach for treating a cancer, particularly a malignant tumor, a multidrug-resistant (MDR) cancer, a recurrent cancer or a metastatic cancer, using a specific cationic antimicrobial peptide (CAP), tilapia piscidin 4 (TP4), which is derived from Nile Tilapia (Oreochromis niloticus). Also provided is a method for treating a breast cancer, particularly triple negative breast cancer (TNBC) with TP4.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: March 19, 2019
    Assignee: Academia Sinica
    Inventors: Jyh-Yih Chen, Chen-Hung Ting
  • Cell-permeable probes for identification and imaging of sialidases
    Patent number: 10214765
    Abstract: Provided herein are compounds for use as sialidase inhibitors, including alkynyl-3-fluorosialyl fluoride. The compounds, which include the compound DFSA, function by trapping a 3-fluorosialylenzyme intermediate (reporter-inhibitor-enzyme conjugate). These compounds can be conjugated with a detectable tagging moiety for isolation and identification of sialidases.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: February 26, 2019
    Assignee: Academia Sinica
    Inventors: Chi-Huey Wong, Jim-Min Fang, Yih-Shyun E. Cheng, Chamg-Sheng Tsai
  • Fabricating device of three-dimensional scaffold and fabricating method thereof
    Patent number: 10213967
    Abstract: A fabricating device of a three-dimensional (3-D) scaffold comprises a bubble generator, a bubble mixing channel, a coagulating solution channel and a bubble collector. The bubble generator includes a gas channel and a gel solution channel crossing the gas channel. The bubble mixing channel is connected with a first outlet of the bubble generator. The coagulating solution channel is connected with the bubble mixing channel. The bubble collector is connected with a second outlet of the bubble mixing channel.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: February 26, 2019
    Assignee: Academia Sinica
    Inventors: Keng-Hui Lin, Yi-Hsuan Lee
  • Antimicrobial peptides derived from hepatitis B virus core protein arginine-rich domain
    Patent number: 10214564
    Abstract: A pharmaceutical composition for use in killing and/or inhibiting the growth and/or proliferation of a microorganism in a subject in need thereof, or for treating a subject afflicted with a microbial infection is disclosed. The composition comprises: (a) an effective amount of an isolated peptide, wherein the peptide comprises the arginine-rich carboxy-terminal region of hepatitis B virus core protein (HBc) and exhibits an antimicrobial activity; and (b) a pharmaceutically acceptable carrier. The peptide exhibits an activity against Gram-negative bacteria, Gram-positive bacteria, and/or fungi.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: February 26, 2019
    Assignee: Academia Sinica
    Inventors: Chiaho Shih, Heng-Li Chen, Pei-Yi Su
  • IMMUNOCONJUGATE AND USES THEREOF
    Publication number: 20190040151
    Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.
    Type: Application
    Filed: October 22, 2018
    Publication date: February 7, 2019
    Applicant: Academia Sinica
    Inventors: An-Suei YANG, Wei-Ying KUO, Hung-Ju HSU, Hong-Sen CHEN, Yu-Chi CHOU, Yueh-Liang TSOU, Hung-Pin PENG, Jhih-Wei JIAN, Chung-Ming YU, Yi-Kai CHIU, Ing-Chein CHEN, Chao-Ping TUNG, Michael HSIAO, Hwei-Jiung WANG
  • Anti-vascular endothelial growth factor receptor 2 (VEGFR2) antibody and methods of use thereof for detecting VEGFR2 and for inhibiting tumor growth, tumor angiogenesis and/or inducing cancer cell cytotoxicity
    Patent number: 10196447
    Abstract: An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74) is disclosed. The epitope within the domain 3 of the VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. Use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting tumor growth, tumor angiogenesis, and/or inducing cancer cell cytotoxicity in a subject in need thereof is also disclosed. Also disclosed is a method of detecting the presence of VEGFR2 in a tumor vascular endothelial cell or a cancer cell in a biological sample.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: February 5, 2019
    Assignee: Academia Sinica
    Inventors: Han-Chung Wu, Ruei-Min Lu, Chiung-Yi Chiu, I-Ju Liu, Yu-Ling Chang