Patents Assigned to ACell, Inc.
  • Extracellular matrix sheet devices with improved mechanical properties and method of making
    Patent number: 11826490
    Abstract: Described are devices and associated methods of producing extracellular matrix (ECM) sheet devices with strengthened mechanical properties due to the selective retention of muscle tissue layers during processing.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: November 28, 2023
    Assignee: ACell, Inc.
    Inventors: Nathaniel Remlinger, Luai Huleihel, Jiayu Tang
  • Particulate tissue graft with components of differing density and methods of making and using the same
    Patent number: 11013829
    Abstract: Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: May 25, 2021
    Assignee: ACELL, INC.
    Inventors: Rodney W. Bosley, Jr., Clay Fette, Robert S. Tullius
  • Particulate tissue graft with components of differing density and methods of making and using the same
    Patent number: 11000628
    Abstract: Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: May 11, 2021
    Assignee: ACELL, INC.
    Inventors: Rodney W. Bosley, Jr., Clay Fette, Robert S. Tullius
  • Particulate tissue graft with components of differing density and methods of making and using the same
    Patent number: 10898610
    Abstract: Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: January 26, 2021
    Assignee: ACELL, INC.
    Inventors: Rodney W. Bosley, Jr., Clay Fette, Robert S. Tullius
  • Variable density tissue graft composition and methods of making and using the same
    Patent number: 10517994
    Abstract: Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: December 31, 2019
    Assignee: ACell, Inc.
    Inventors: Rodney W. Bosley, Jr., Clay Fette
  • PARTICULATE TISSUE GRAFT WITH COMPONENTS OF DIFFERING DENSITY AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20190105428
    Abstract: Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.
    Type: Application
    Filed: November 20, 2018
    Publication date: April 11, 2019
    Applicant: ACell, Inc.
    Inventors: Rodney W. Bosley, JR., Clay Fette, Robert S. Tullius
  • PARTICULATE TISSUE GRAFT WITH COMPONENTS OF DIFFERING DENSITY AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20190038804
    Abstract: Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.
    Type: Application
    Filed: October 12, 2018
    Publication date: February 7, 2019
    Applicant: ACell, Inc.
    Inventors: Rodney W. Bosley, JR., Clay Fette, Robert S. Tullius
  • Extracellular matrix for the treatment of intestinal disease and methods thereof
    Patent number: 10092678
    Abstract: A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: October 9, 2018
    Assignee: ACell, Inc.
    Inventor: Alan R. Spievack
  • Extracellular matrix compositions with bactericidal or bacteriostatic characteristics useful for protecting and treating patients with bacterial infections
    Publication number: 20180280574
    Abstract: Described is a formulation and method for reducing and treating bacterial infections in humans and animals with digested or non-digested extracellular matrix materials derived from non-epithelial and epithelial tissues.
    Type: Application
    Filed: March 26, 2018
    Publication date: October 4, 2018
    Applicants: ACell, Inc., University of Pittsburgh
    Inventors: Thomas Wayne Gilbert, Yuanpu Di
  • Methods of manufacturing bioactive gels from extracellular matrix material
    Patent number: 9795713
    Abstract: The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: October 24, 2017
    Assignee: ACell, Inc.
    Inventors: Kimberly Kentner, Katherine A. Stuart, Abram D. Janis
  • Hemostatic device
    Patent number: 9764056
    Abstract: A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce homeostasis at an anatomical site.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: September 19, 2017
    Assignee: ACell, Inc.
    Inventors: Clay Fette, Abram Janis, Benjamin Kibalo
  • PARTICULATE TISSUE GRAFT WITH COMPONENTS OF DIFFERING DENSITY AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20170112965
    Abstract: Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.
    Type: Application
    Filed: November 17, 2016
    Publication date: April 27, 2017
    Applicant: ACell, Inc.
    Inventors: Rodney W. BOSLEY, JR., Clay Fette, Robert S. Tullius
  • Variable density tissue graft composition and methods of making and using the same
    Patent number: 9579183
    Abstract: Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: February 28, 2017
    Assignee: ACell, Inc.
    Inventors: Rodney W. Bosley, Jr., Clay Fette
  • Particulate tissue graft with components of differing density and methods of making and using the same
    Patent number: 9561307
    Abstract: Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: February 7, 2017
    Assignee: ACell, Inc.
    Inventors: Rodney W. Bosley, Jr., Clay Fette, Robert S. Tullius
  • Hemostatic device
    Patent number: 9480771
    Abstract: A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce hemostasis at an anatomical site.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: November 1, 2016
    Assignee: ACell, Inc.
    Inventors: Clay Fette, Abram Janis, Benjamin Kibalo
  • Methods of manufacturing bioactive gels from extracellular matrix material
    Patent number: 9474829
    Abstract: The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: October 25, 2016
    Assignee: ACell, Inc.
    Inventors: Kimberly A. Kentner, Katherine A. Stuart, Abram D. Janis
  • Extracellular matrix for the treatment of intestinal disease and methods thereof
    Patent number: 9433701
    Abstract: A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: September 6, 2016
    Assignee: ACell, Inc.
    Inventor: Alan R. Spievack
  • Hemostatic device
    Patent number: 9404077
    Abstract: A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce hemostasis at an anatomical site.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: August 2, 2016
    Assignee: ACell, Inc.
    Inventors: Clay Fette, Abram Janis, Benjamin Kibalo
  • Tissue regenerative composition, method of making, and method of use thereof
    Patent number: 9265860
    Abstract: A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: February 23, 2016
    Assignee: ACell, Inc.
    Inventor: Alan R. Spievack
  • Methods of manufacturing bioactive gels from extracellular matrix material
    Patent number: 9238091
    Abstract: The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: January 19, 2016
    Assignee: ACell, Inc.
    Inventors: Kimberly A. Kentner, Katherine A. Stuart, Abram D. Janis