Patents Assigned to Achaogen, Inc.
  • Antibacterial aminoglycoside analogs
    Patent number: 8481502
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q5, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: July 9, 2013
    Assignee: Achaogen, Inc.
    Inventors: James Bradley Aggen, Paola Dozzo, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Micah James Gliedt, Martin Sheringham Linsell
  • Carbacephem ?-lactam antibiotics
    Patent number: 8445476
    Abstract: Carbacephem ?-lactam antibiotics having the following chemical structures (I) and (II) are disclosed: including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, R1, R2 and R3 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: May 21, 2013
    Assignee: Achaogen, Inc.
    Inventors: Allan S. Wagman, Heinz E. Moser
  • Antibacterial aminoglycoside analogs
    Patent number: 8399419
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Z1, Z2, Z3, Z4, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: March 19, 2013
    Assignee: Achaogen, Inc.
    Inventors: James Bradley Aggen, Martin Sheringham Linsell, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Paola Dozzo, Micah James Gliedt, Stephen Hanessian, Alexandre Giguère, Justyna Grzyb, Juan Pablo Maianti
  • Antibacterial aminoglycoside analogs
    Patent number: 8383596
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: February 26, 2013
    Assignee: Achaogen, Inc.
    Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
  • Antibacterial aminoglycoside analogs
    Patent number: 8372813
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: February 12, 2013
    Assignee: Achaogen, Inc.
    Inventors: James Bradley Aggen, Martin Sheringham Linsell, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Paola Dozzo, Micah James Gliedt, Heinz Ernst Moser
  • Antibacterial aminoglycoside analogs
    Patent number: 8367625
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: February 5, 2013
    Assignee: Achaogen, Inc.
    Inventors: James Bradley Aggen, Martin Sheringham Linsell, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Paola Dozzo, Micah James Gliedt, Heinz Ernst Moser
  • Antibacterial aminoglycoside analogs
    Patent number: 8318685
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Q1 and Q2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: November 27, 2012
    Assignee: Achaogen, Inc.
    Inventors: Adam Aaron Goldblum, Paola Dozzo, Timothy Robert Kane, James Bradley Aggen, Martin Sheringham Linsell, Darin James Hildebrandt, Micah James Gliedt
  • ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
    Publication number: 20120283208
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: April 6, 2012
    Publication date: November 8, 2012
    Applicant: Achaogen, Inc.
    Inventors: James Bradley Aggen, Adam Aaron Goldblum, Paola Dozzo, Darin James Hildebrandt, Timothy Robert Kane, Micah James Gliedt, Martin Sheringham Linsell
  • ANTIBACTERIAL COMPOSITIONS
    Publication number: 20120283175
    Abstract: The present invention provides a methods and pharmaceutical compositions useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, a synergistic combination of an inhibitor of LpxC and second antibacterial agent.
    Type: Application
    Filed: November 4, 2011
    Publication date: November 8, 2012
    Applicant: Achaogen, Inc.
    Inventors: Phillip A. Patten, Eliana Saxon Armstrong
  • ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
    Publication number: 20120283209
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: April 6, 2012
    Publication date: November 8, 2012
    Applicant: Achaogen, Inc.
    Inventors: Paola Dozzo, Adam Aaron Goldblum, James Bradley Aggen, Martin Sheringham Linsell
  • ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
    Publication number: 20120283207
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: April 6, 2012
    Publication date: November 8, 2012
    Applicant: Achaogen, Inc.
    Inventors: Juan Pablo Maianti, James Bradley Aggen, Paola Dozzo, Adam Aaron Goldblum, Martin Sheringham Linsell, Stephen Hanessian, Alexandre Giguère, Justyna Grzyb
  • ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
    Publication number: 20120258925
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q5, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: April 6, 2012
    Publication date: October 11, 2012
    Applicant: Achaogen, Inc.
    Inventors: James Bradley Aggen, Paola Dozzo, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Micah James Gliedt, Martin Sheringham Linsell
  • TREATMENT OF URINARY TRACT INFECTIONS WITH ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS
    Publication number: 20120214760
    Abstract: A method for treating a urinary tract infection in a mammal in need thereof is disclosed, the method comprising administering to the mammal an effective amount of an antibacterial aminoglycoside compound.
    Type: Application
    Filed: November 11, 2011
    Publication date: August 23, 2012
    Applicant: Achaogen, Inc.
    Inventors: Jon B. Bruss, George H. Miller, James Bradley Aggen, Eliana Saxon Armstrong
  • TREATMENT OF KLEBSIELLA PNEUMONIAE INFECTIONS WITH ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS
    Publication number: 20120214759
    Abstract: A method for treating a Klebsiella pneumonia infection in a mammal in need thereof is disclosed, the method comprising administering to the mammal an effective amount of an antibacterial aminoglycoside compound.
    Type: Application
    Filed: November 11, 2011
    Publication date: August 23, 2012
    Applicant: Achaogen, Inc.
    Inventors: Jon B. Bruss, George H. Miller, James Bradley Aggen, Eliana Saxon Armstrong
  • AMINOGLYCOSIDE DOSING REGIMENS
    Publication number: 20120208781
    Abstract: The present invention provides new aminoglycoside dosing regimens associated with enhanced microbicidal activity and reduced nephrotoxicity, as well as methods of using these dosing regimens to treat various bacterial infections.
    Type: Application
    Filed: November 11, 2011
    Publication date: August 16, 2012
    Applicant: Achaogen, Inc.
    Inventors: Jon B. Bruss, Corwin F. Kostrub, Eliana Saxon Armstrong, Robert T. Cass, George H. Miller, James Bradley Aggen, Adam Aaron Goldblum, Paola Dozzo, Martin Sheringham Linsell
  • COMBINATION THERAPIES USING ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS
    Publication number: 20120196791
    Abstract: Methods for treating a bacterial infection in a mammal in need thereof, and compositions related thereto, are disclosed, the methods comprising administering to the mammal an effective amount of an antibacterial aminoglycoside compound and a second antibacterial agent.
    Type: Application
    Filed: December 15, 2011
    Publication date: August 2, 2012
    Applicant: Achaogen, Inc.
    Inventors: Eliana Saxon Armstrong, Jon B. Bruss
  • ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
    Publication number: 20120184501
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R11 and R12 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: November 14, 2011
    Publication date: July 19, 2012
    Applicant: Achaogen, Inc.
    Inventors: Paola Dozzo, Adam Aaron Goldblum, James Bradley Aggen, Martin Sheringham Linsell
  • ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
    Publication number: 20120172332
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: April 7, 2011
    Publication date: July 5, 2012
    Applicant: Achaogen, Inc.
    Inventors: James Bradley Aggen, Martin Sheringham Linsell, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Paola Dozzo, Micah James Gliedt, Heinz Ernst Moser
  • ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
    Publication number: 20120165282
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2, R3, R11 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: November 14, 2011
    Publication date: June 28, 2012
    Applicant: Achaogen, Inc.
    Inventors: Paola Dozzo, Adam Aaron Goldblum, James Bradley Aggen, Martin Sheringham Linsell
  • ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
    Publication number: 20120135945
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: November 14, 2011
    Publication date: May 31, 2012
    Applicant: Achaogen, Inc.
    Inventors: Paola Dozzo, Adam Aaron Goldblum, James Bradley Aggen, Martin Sheringham Linsell