Patents Assigned to Achaogen, Inc.
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Publication number: 20120135946Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 or R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: ApplicationFiled: November 14, 2011Publication date: May 31, 2012Applicant: Achaogen, Inc.Inventors: Adam Aaron Goldblum, Paola Dozzo, James Bradley Aggen, Martin Sheringham Linsell
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Publication number: 20120135948Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: ApplicationFiled: November 14, 2011Publication date: May 31, 2012Applicant: Achaogen, Inc.Inventors: Adam Aaron Goldblum, Paola Dozzo, James Bradley Aggen, Martin Sheringham Linsell
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Publication number: 20120122809Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Q1 and Q2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: ApplicationFiled: November 14, 2011Publication date: May 17, 2012Applicant: Achaogen, Inc.Inventors: Adam Aaron Goldblum, Paola Dozzo, Timothy Robert Kane, James Bradley Aggen, Martin Sheringham Linsell, Darin James Hildebrandt, Micah James Gliedt
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Publication number: 20120058989Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: ApplicationFiled: April 7, 2011Publication date: March 8, 2012Applicant: Achaogen, Inc.Inventors: Allan S. Wagman, Heinz E. Moser, Glenn A. McEnroe, James B. Aggen, Martin S. Linsell, Adam A. Goldblum, John H. Griffin, Lloyd J. Simons, Thomas R. Belliotti, Christina R. Harris, Toni-Jo Poel, Michael J. Melnick, Ricky D. Gaston
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Publication number: 20110288041Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: ApplicationFiled: April 7, 2011Publication date: November 24, 2011Applicant: Achaogen, Inc.Inventors: James Bradley Aggen, Martin Sheringham Linsell, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Paola Dozzo, Micah James Gliedt, Heinz Ernst Moser
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Publication number: 20110275586Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Z1, Z2, Z3, Z4, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: ApplicationFiled: March 9, 2011Publication date: November 10, 2011Applicant: Achaogen, Inc.Inventors: James Bradley Aggen, Martin Sheringham Linsell, Adam Aaron Goldblum, Darin James Hildebrandt, Timothy Robert Kane, Paola Dozzo, Micah James Gliedt, Stephen Hanessian, Alexandre Giguère, Justyna Grzyb, Juan Pablo Maianti
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Publication number: 20110224186Abstract: Carbacephem ?-lactam antibiotics having the following chemical structure (I) are disclosed: including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, X, R1 and R2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.Type: ApplicationFiled: March 10, 2011Publication date: September 15, 2011Applicant: Achaogen, Inc.Inventors: Allan Scott Wagman, Heinz Ernst Moser
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Publication number: 20100267686Abstract: Carbacephem ?-lactam antibiotics having the following chemical structures (I) and (II) are disclosed: including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, R1, R2 and R3 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.Type: ApplicationFiled: April 21, 2010Publication date: October 21, 2010Applicant: Achaogen, Inc.Inventors: Allan S. Wagman, Heinz E. Moser
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Publication number: 20100190766Abstract: Antibacterial compounds of formula (I) are provided: as well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.Type: ApplicationFiled: December 10, 2009Publication date: July 29, 2010Applicant: Achaogen, Inc.Inventors: Heinz E. Moser, Qing Lu, Phillip A. Patten, Dan Wang, Ramesh Kasar, Stephen Kaldor, Brian D. Patterson
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Publication number: 20100099661Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: ApplicationFiled: June 18, 2009Publication date: April 22, 2010Applicant: Achaogen, Inc.Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
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Publication number: 20090220982Abstract: The present invention provides novel in vitro assays for determining the nephrotoxicity of a compound. These assays correlate well with in vivo nephrotoxicity and also provide high-throughput methods to screen multiple compounds for in vivo nephrotoxicity. In addition, the methods of the present invention may be adapted to screen for nephroprotectant compounds, including those that protect cells and animals from the nephrotoxic effects of aminoglycoside antibiotics.Type: ApplicationFiled: February 24, 2009Publication date: September 3, 2009Applicant: Achaogen Inc..Inventors: Eliana Saxon Armstrong, Lee Ann Feeney, Corwin F. Kostrub
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Publication number: 20090136518Abstract: The present invention provides methods and compositions for said inhibition of drug resistance. In one embodiment, said invention provides methods and compositions for said inhibition of antibiotic resistance. The invention generally involves said administration of achaogens, agents that inhibit said mutational process, to inhibit said evolution of drug resistance. Also, described herein are compositions that are suitable for use as achaogens.Type: ApplicationFiled: October 9, 2008Publication date: May 28, 2009Applicants: The Scripps Research Institute, Achaogen, Inc.Inventors: Floyd Romesberg, Nathaniel E. David, Ryan Cirz
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Publication number: 20080300199Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.Type: ApplicationFiled: April 10, 2008Publication date: December 4, 2008Applicant: Achaogen Inc.Inventors: Martin Linsell, Adam Aaron Goldblum, James Aggen, Heinz Ernst Moser, Stephen Hanessian, Kandasamy Pachamuthu, Ellen Klegraf
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Patent number: 7455840Abstract: The present invention provides methods and compositions for said inhibition of drug resistance. In one embodiment, said invention provides methods and compositions for said inhibition of antibiotic resistance. The invention generally involves said administration of achaogens, agents that inhibit said mutational process, to inhibit said evolution of drug resistance. Also, described herein are compositions that are suitable for use as achaogens.Type: GrantFiled: November 19, 2004Date of Patent: November 25, 2008Assignees: The Scripps Research Institute, Achaogen, Inc.Inventors: Floyd Romesberg, Nathaniel E. David, Ryan Cirz
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Publication number: 20070033061Abstract: Business methods for the commercialization of antimicrobial and cytotoxic compounds, including antibiotics and chemotherapeutic agents, are disclosed. According to one embodiment of the invention, drugs that are found to be effective but unsafe at therapeutic dosages are rescued by way of the use of an inhibitor of DNA repair, recombination, or replication, which sensitized microorganisms and cells, thereby permitting their use at a lower and safe dosage. In another embodiment, drugs that are found to be effective but cost prohibitive are rescued by way of the use of an inhibitor of DNA repair, recombination, or replication, thereby permitting their use at lower dosages and costs. A biopharmaceutical company may then, commercialize or charge royalties on such drugs.Type: ApplicationFiled: April 5, 2006Publication date: February 8, 2007Applicant: Achaogen, Inc.Inventors: Phillip Patten, J. Judice
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Publication number: 20060286574Abstract: The present invention provides compositions useful in treating drug-resistant microorganisms and cells, as well as related methods of identifying and using such compositions. In addition, the present invention includes compositions useful in enhancing the sensitivity of both drug-resistant and drug-sensitive microorganisms and cells to microbicidal and cytotoxic agents, including antibiotics and chemotherapeutic drugs. Methods of identifying these compositions, as well as methods of using these agents in treating both drug-resistant and drug-sensitive diseases and conditions are further provided.Type: ApplicationFiled: April 5, 2006Publication date: December 21, 2006Applicants: The Scripps Research Institute & Achaogen, Inc., Achaogen Inc.Inventors: Floyd Romesberg, Ryan Cirz, Philip Patten