Patents Assigned to Acucela Inc.
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Patent number: 11974807Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. Measurement data may be processed using a decurving process to enhance the resolution of the ILM layer and provide improved determinations of retinal thickness.Type: GrantFiled: August 10, 2021Date of Patent: May 7, 2024Assignee: ACUCELA INC.Inventors: Ryo Kubota, Stephan Wyder, Philip M. Buscemi, Matthias Pfister, Cyril Stoller
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Patent number: 11971615Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.Type: GrantFiled: August 19, 2022Date of Patent: April 30, 2024Assignee: ACUCELA INC.Inventors: Ryo Kubota, Amitava Gupta
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Publication number: 20240108216Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.Type: ApplicationFiled: November 30, 2023Publication date: April 4, 2024Applicant: ACUCELA INC.Inventors: Lukas SCHEIBLER, Matthias PFISTER, Urban SCHNELL, Stefan TROLLER, Ryo KUBOTA
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Publication number: 20240103300Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.Type: ApplicationFiled: November 14, 2023Publication date: March 28, 2024Applicant: ACUCELA INC.Inventors: Ryo KUBOTA, Philip M. BUSCEMI, Pascal LOSER, Ben CROOK, Massimo PINAZZA, Jim NIEBANCK, James PHILLIPS, Stefan BAUER
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Patent number: 11911105Abstract: Embodiments of the present disclosure are directed to systems, apparatuses and methods for prediction, diagnosis, planning and monitoring for myopia and myopic progression. In some embodiments, one or more refractive properties of the eye is determined for each of a plurality of retinal locations of the eye. The plurality of locations may comprise a central region, such as a fovea of the eye, or non-foveal region such as a peripheral region or a region of the macula outside the fovea. Measuring the refractive properties of the eye for the plurality of locations may be helpful in diagnosing myopia and other ocular conditions by providing the refractive properties of the eye for locations away from the fovea, such as the peripheral retina.Type: GrantFiled: September 30, 2021Date of Patent: February 27, 2024Assignee: ACUCELA INC.Inventors: Ryo Kubota, Philip M. Buscemi
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Patent number: 11896308Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.Type: GrantFiled: December 12, 2022Date of Patent: February 13, 2024Assignee: ACUCELA INC.Inventors: Christian Oggenfuss, Karim Haroud, Lukas Scheibler, Matthias Pfister, Urban Schnell, Stefan Troller, Ryo Kubota, Philip Buscemi
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Patent number: 11890053Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.Type: GrantFiled: March 3, 2023Date of Patent: February 6, 2024Assignee: ACUCELA INC.Inventors: Lukas Scheibler, Matthias Pfister, Urban Schnell, Stefan Troller, Ryo Kubota
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Publication number: 20240023805Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.Type: ApplicationFiled: September 27, 2023Publication date: January 25, 2024Applicant: ACUCELA INC.Inventors: Christian OGGENFUSS, Karim HAROUD, Lukas SCHEIBLER, Matthias PFISTER, Urban SCHNELL, Stefan TROLLER, Ryo KUBOTA, Philip M. BUSCEMI
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Patent number: 11860454Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.Type: GrantFiled: February 28, 2023Date of Patent: January 2, 2024Assignee: ACUCELA INC.Inventors: Ryo Kubota, Philip M. Buscemi, Pascal Loser, Ben Crook, Massimo Pinazza, Jim Niebanck, James Phillips, Stefan Bauer
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Publication number: 20230414097Abstract: An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser (“VCSEL”).Type: ApplicationFiled: August 18, 2023Publication date: December 28, 2023Applicant: ACUCELA INC.Inventors: Ryo KUBOTA, Philip M. BUSCEMI, Matthias PFISTER, Stephan WYDER, Amitava GUPTA
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Publication number: 20230363640Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.Type: ApplicationFiled: May 15, 2023Publication date: November 16, 2023Applicant: ACUCELA INC.Inventors: Ryo KUBOTA, Stephan WYDER, Philip M. BUSCEMI, Matthias PFISTER, Alexander HOLZER
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Publication number: 20230363638Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. Measurement data may be processed using a decurving process to enhance the resolution of the ILM layer and provide improved determinations of retinal thickness.Type: ApplicationFiled: August 10, 2021Publication date: November 16, 2023Applicant: ACUCELA INC.Inventors: Ryo KUBOTA, Stephan WYDER, Philip M. BUSCEMI, Matthias PFISTER, Cyril STOLLER
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Patent number: 11795136Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.Type: GrantFiled: July 21, 2020Date of Patent: October 24, 2023Assignee: ACUCELA INC.Inventors: Claes Olof Bavik, Susan Hayes Henry, Ryo Kubota, Vladimir A. Kuksa
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Patent number: 11798164Abstract: A neural network is trained to segment interferogram images. A first plurality of interferograms are obtained, where each interferograms corresponds to data acquired by an OCT system using a first scan pattern, annotating each of the plurality of interferograms to indicate a tissue structure of a retina, training a neural network using the plurality of interferograms and the annotations, inputting a second plurality of interferograms corresponding to data acquired by an OCT system using a second scan pattern and obtaining an output of the trained neural network indicating the tissue structure of the retina that was scanned using the second scan pattern. The system and methods may instead receive a plurality of A-scans and output a segmented image corresponding to a plurality of locations along an OCT scan pattern.Type: GrantFiled: March 2, 2023Date of Patent: October 24, 2023Assignee: ACUCELA INC.Inventors: Stephan Wyder, Matthias Pfister, Cyril Stoller, Philip M. Buscemi
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Patent number: 11787791Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.Type: GrantFiled: September 27, 2019Date of Patent: October 17, 2023Assignee: ACUCELA INC.Inventors: Mark W. Orme, Edison S. Zuniga, Vladimir A. Kuksa, Russell Stuart Craft, Eduardo Moreno Saveedra, Johannes Wilhelm Georg Meissner, Jacobus Antonius Joseph den Hartog, Albert Cornelis Dros
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Publication number: 20230324717Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.Type: ApplicationFiled: June 6, 2023Publication date: October 12, 2023Applicant: ACUCELA INC.Inventors: Ryo KUBOTA, Philip M. BUSCEMI, Amitava GUPTA, Stefan BAUER, Benjamin CROOK, Julien SAUVET
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Patent number: 11779206Abstract: An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser (“VCSEL”).Type: GrantFiled: September 28, 2022Date of Patent: October 10, 2023Assignee: ACUCELA INC.Inventors: Ryo Kubota, Philip M. Buscemi, Matthias Pfister, Stephan Wyder, Amitava Gupta
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Patent number: 11777340Abstract: A contact lens charging case comprises a container sized and shaped to receive an electronic contact lens (“eCL”) and charging coil to couple to a coil of the eCL. In some embodiments, the charging coil comprises a diameter larger than a diameter of the coil of the eCL, so as to decrease sensitivity of the location and orientation of the eCL in the container and improve coupling between the coils. In some embodiments, the charging coil is dimensioned so as to extend at least partially around the container that receives the eCL.Type: GrantFiled: February 19, 2021Date of Patent: October 3, 2023Assignee: ACUCELA INC.Inventors: Ryo Kubota, Patrizia Weber, Marco Burgener, Jonas Butscher, Praveenth Sanmugarajah, Hans Bernhard, Amitava Gupta
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Publication number: 20230284897Abstract: Embodiments of the present disclosure are directed to systems, apparatuses and methods for prediction, diagnosis, planning and monitoring for myopia and myopic progression. In some embodiments, one or more refractive properties of the eye is determined for each of a plurality of retinal locations of the eye. The plurality of locations may comprise a central region, such as a fovea of the eye, or non-foveal region such as a peripheral region or a region of the macula outside the fovea. Measuring the refractive properties of the eye for the plurality of locations may be helpful in diagnosing myopia and other ocular conditions by providing the refractive properties of the eye for locations away from the fovea, such as the peripheral retina.Type: ApplicationFiled: September 30, 2021Publication date: September 14, 2023Applicant: ACUCELA INC.Inventors: Ryo KUBOTA, Philip M. BUSCEMI
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Publication number: 20230273460Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person’s eye. The stimulus or stimuli creates an image that is defocused in front of the person’s retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.Type: ApplicationFiled: May 10, 2023Publication date: August 31, 2023Applicant: ACUCELA INC.Inventors: Philip M. BUSCEMI, Ryo KUBOTA