Patents Assigned to Acucela Inc.
  • Patent number: 11409136
    Abstract: A contact lens may include a body of contact lens material extending between a first surface and a second surface. An electromechanical component may be supported in the contact lens material between the first surface and the second surface. A support comprising a plurality of pillars may be formed of the contact lens material and may extend from at least one of the first surface and the second surface to the electromechanical component.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: August 9, 2022
    Assignee: ACUCELA INC.
    Inventors: Ryo Kubota, Gordon Frederick Maccabee, Ferry Widjaja, Amitava Gupta
  • Patent number: 11402662
    Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: August 2, 2022
    Assignee: ACUCELA INC.
    Inventors: Beat Wyss, Jean-Noël Fehr, Glenn Noronha, Karim Haroud, Julien Sauvet, Hans Bernhard, Christian Oggenfuss, Amitava Gupta, Ryo Kubota
  • Patent number: 11393094
    Abstract: A neural network is trained to segment interferogram images. A first plurality of interferograms are obtained, where each interferograms corresponds to data acquired by an OCT system using a first scan pattern, annotating each of the plurality of interferograms to indicate a tissue structure of a retina, training a neural network using the plurality of interferograms and the annotations, inputting a second plurality of interferograms corresponding to data acquired by an OCT system using a second scan pattern and obtaining an output of the trained neural network indicating the tissue structure of the retina that was scanned using the second scan pattern. The system and methods may instead receive a plurality of A-scans and output a segmented image corresponding to a plurality of locations along an OCT scan pattern.
    Type: Grant
    Filed: August 10, 2021
    Date of Patent: July 19, 2022
    Assignee: ACUCELA INC.
    Inventors: Stephan Wyder, Matthias Pfister, Cyril Stoller, Philip M. Buscemi
  • Publication number: 20220221738
    Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.
    Type: Application
    Filed: March 29, 2022
    Publication date: July 14, 2022
    Applicant: ACUCELA INC.
    Inventors: Ryo KUBOTA, Amitava GUPTA
  • Publication number: 20220214564
    Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.
    Type: Application
    Filed: March 18, 2022
    Publication date: July 7, 2022
    Applicant: ACUCELA INC.
    Inventors: Ryo KUBOTA, Philip M. BUSCEMI, Amitava GUPTA, Stefan BAUER, Benjamin CROOK, Julien SAUVET
  • Patent number: 11369266
    Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: June 28, 2022
    Assignee: ACUCELA INC.
    Inventors: Ryo Kubota, Stephan Wyder, Philip M. Buscemi, Matthias Pfister, Alexander Holzer
  • Patent number: 11366341
    Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: June 21, 2022
    Assignee: ACUCELA INC.
    Inventors: Ryo Kubota, Philip M. Buscemi, Pascal Loser, Ben Crook, Massimo Pinazza, Jim Niebanck, James Phillips, Stefan Bauer
  • Patent number: 11366339
    Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: June 21, 2022
    Assignee: ACUCELA INC.
    Inventors: Ryo Kubota, Philip M. Buscemi, Amitava Gupta, Stefan Bauer, Benjamin Crook, Julien Sauvet
  • Patent number: 11357401
    Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: June 14, 2022
    Assignee: ACUCELA INC.
    Inventors: Christian Oggenfuss, Karim Haroud, Lukas Scheibler, Matthias Pfister, Urban Schnell, Stefan Troller, Ryo Kubota, Philip M. Buscemi
  • Patent number: 11358001
    Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: June 14, 2022
    Assignee: ACUCELA INC.
    Inventors: Ryo Kubota, Karim Haroud, Beat Wyss, Hans Bernhard, Jean-Noël Fehr, Patrizia Weber, Moritz Haeberli, Amitava Gupta
  • Publication number: 20220163820
    Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.
    Type: Application
    Filed: February 8, 2022
    Publication date: May 26, 2022
    Applicant: ACUCELA INC.
    Inventors: Philip M. BUSCEMI, Ryo KUBOTA
  • Publication number: 20220155616
    Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10?1 to 2.5×101 cycles per degree.
    Type: Application
    Filed: February 7, 2022
    Publication date: May 19, 2022
    Applicant: ACUCELA INC.
    Inventors: Ryo KUBOTA, Nabin JOSHI, Arkady SELENOW, Steven ALI, Stefan BAUER, Jean-Noël FEHR, Moritz HAEBERLI, Patrizia WEBER, Julien SAUVET, Amitava GUPTA
  • Patent number: 11320674
    Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: May 3, 2022
    Assignee: ACUCELA INC.
    Inventors: Ryo Kubota, Amitava Gupta
  • Patent number: 11281022
    Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: March 22, 2022
    Assignee: ACUCELA INC.
    Inventors: Philip M. Buscemi, Ryo Kubota
  • Publication number: 20220084197
    Abstract: A neural network is trained to segment interferogram images. A first plurality of interferograms are obtained, where each interferograms corresponds to data acquired by an OCT system using a first scan pattern, annotating each of the plurality of interferograms to indicate a tissue structure of a retina, training a neural network using the plurality of interferograms and the annotations, inputting a second plurality of interferograms corresponding to data acquired by an OCT system using a second scan pattern and obtaining an output of the trained neural network indicating the tissue structure of the retina that was scanned using the second scan pattern. The system and methods may instead receive a plurality of A-scans and output a segmented image corresponding to a plurality of locations along an OCT scan pattern.
    Type: Application
    Filed: August 10, 2021
    Publication date: March 17, 2022
    Applicant: ACUCELA INC.
    Inventors: Stephan WYDER, Matthias PFISTER, Cyril STOLLER, Philip M. BUSCEMI
  • Patent number: 11275259
    Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10?1 to 2.5×101 cycles per degree.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: March 15, 2022
    Assignee: ACUCELA INC.
    Inventors: Ryo Kubota, Nabin Joshi, Arkady Selenow, Steven Ali, Stefan Bauer, Jean-Noël Fehr, Moritz Haeberli, Patrizia Weber, Julien Sauvet, Amitava Gupta
  • Publication number: 20220039647
    Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.
    Type: Application
    Filed: February 11, 2021
    Publication date: February 10, 2022
    Applicant: ACUCELA INC. (dba Kubota Vision, Inc.)
    Inventors: Ryo KUBOTA, Stephan WYDER, Philip M. BUSCEMI, Matthias PFISTER, Alexander HOLZER
  • Patent number: 11209672
    Abstract: A contact lens may include a body of contact lens material extending between a first surface and a second surface. An electromechanical component may be supported in the contact lens material between the first surface and the second surface. A support comprising a plurality of pillars may be formed of the contact lens material and may extend from at least one of the first surface and the second surface to the electromechanical component.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: December 28, 2021
    Assignee: ACUCELA INC.
    Inventors: Ryo Kubota, Gordon Frederick MacCabee, Ferry Widjaja, Amitava Gupta
  • Publication number: 20210389607
    Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.
    Type: Application
    Filed: June 9, 2021
    Publication date: December 16, 2021
    Applicant: ACUCELA INC.
    Inventors: Philip M. BUSCEMI, Ryo KUBOTA
  • Patent number: D950618
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: May 3, 2022
    Assignee: ACUCELA INC.
    Inventors: Karim Haroud, Matthias Pfister, Jean-Christophe Roulet, Stefan Troller, Jacob Schubert