Patents Assigned to ADA Foundation
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Patent number: 7846411Abstract: Calcium peroxyphosphate compounds and dental compositions comprising these compounds that combine both whitening/stain removal of teeth with remineralization are disclosed. The calcium peroxyphosphate compounds are capable of releasing, in an aqueous environment, whitening and remineralization effective amounts of calcium ion, phosphate ion, and active oxygen. Preferred compounds are calcium peroxymonophosphate or calcium diperoxymonophosphate compounds. These compounds may be used in humans and other animals, including other mammals.Type: GrantFiled: June 17, 2004Date of Patent: December 7, 2010Assignee: ADA FoundationInventor: Ming Tung
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Publication number: 20100212545Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders, liquid glycerol, organic acid and gelling agent. The paste is stable, resistant to washout and will harden upon exposure to water. Physical characteristics of the paste, including consistency, porosity, and hardening time, are controlled by the choice and ratio of constituents.Type: ApplicationFiled: May 3, 2010Publication date: August 26, 2010Applicant: ADA FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 7713542Abstract: Living cellular material is encapsulated or placed in a protective material (cell protector) which is biocompatible, biodegradable and has a three-dimensional form. The three dimensional form is incorporated into a matrix that maybe implanted in vivo, ultimately degrade and thereby by replaced by living cell generated material.Type: GrantFiled: May 18, 2005Date of Patent: May 11, 2010Assignee: ADA FoundationInventors: Huakun Xu, Michael D. Weir
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Patent number: 7709029Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders, liquid glycerol, organic acid and gelling agent. The paste is stable, resistant to washout and will harden upon exposure to water. Physical characteristics of the paste, including consistency, porosity, and hardening time, are controlled by the choice and ratio of constituents.Type: GrantFiled: March 11, 2004Date of Patent: May 4, 2010Assignee: ADA FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 7619016Abstract: Remineralizing dental cements contain source(s) of calcium and phosphate ions, adhesive resin monomers, reinforcing base resin monomers, and catalysts able to initiate the polymerization of the adhesive and reinforcing base resin monomers. Such dental cements can be used as orthodontic cements, crown and bridge cements, adhesives, sealants, cavity liners, and protective coatings. The release of calcium and phosphate ions and, optionally, fluoride ions, protects tooth structure from demineralization, a precursor of tooth decay.Type: GrantFiled: July 2, 2004Date of Patent: November 17, 2009Assignee: ADA FoundationInventors: Sabine H. Dickens, Frederick C. Eichmiller
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Publication number: 20090188622Abstract: Disclosed are compositions that comprise vinylarylalkylene ethers of cyclodextrins optionally containing ether-linked adhesion-promoting groups, in combination with copolymerizable monomer or monomers. The copolymerizable monomer or monomers may include vinylarylalkylene ethers of oligohydroxy compounds (for example, sorbitol divinylbenzyl ether and others). The composition further may include stabilizers (for example, 1,3,5-trimethyl-2,4,6-tris(3,5-di-(tert)-butyl-4-hydroxybenzyl)benzene and others), and polymerization initiators (for example, phenylbis[2,4,6-trimethylbenzoyl]phosphine oxide and others) and reinforcing materials (for example, imogolite). Methods of preparing the compositions as well as the components of compositions and methods for their use in dental and other applications are also disclosed.Type: ApplicationFiled: January 27, 2009Publication date: July 30, 2009Applicant: ADA FoundationInventor: Rafael L. Bowen
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Publication number: 20090093566Abstract: Combining nanosized particles of a source of desired dental restorative, repair or therapeutic materials with strengthening agents in various generally nanosized form such as whiskers, fibers, particles and the like in a resin matrix provides a highly strain resistant composite which more effectively releases the therapeutic agents. The utilization of nano sized particles of the therapeutic agent in the combination enables observation of significantly improved therapeutic results.Type: ApplicationFiled: October 17, 2008Publication date: April 9, 2009Applicant: ADA FoundationInventors: Huakun Xu, Limin Sun, Shozo Takagi, Laurence C. Chow
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Publication number: 20080292565Abstract: Compositions and methods for forming, in an aqueous environment, a nanoaggregate of calcium fluoride and amorphous calcium phosphate-containing compound, such as amorphous calcium phosphate fluoride or amorphous calcium carbonate phosphate fluoride are described. The nanoaggregate (or nanocomposite) can release calcium, phosphate, and fluoride, and ultimately convert to the tooth mineral, fluorapatite. One method for forming such a nanoaggregate involves applying a non-aqueous (e.g., varnish-based) composition (e.g., a suspension), containing solid particles of water soluble salts of calcium, phosphate, and fluoride, to the aqueous environment of the mouth. This results in rapid solubilization of the salts, precipitation of the nanoaggregate, and tooth remineralization. Tooth fluoridation and remineralization may also be carried out by applying to the tooth a non-aqueous carrier containing the nanoaggregate. Whitening agents can also be added to these compositions and methods.Type: ApplicationFiled: May 23, 2008Publication date: November 27, 2008Applicant: ADA FoundationInventor: Ming S. Tung
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Patent number: 7294187Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders and a solution that is (1) an acidic calcium phosphate solution saturated with respect to one or more calcium phosphate compounds, (2) a concentrated acid solution, or (3) salt solutions with a cationic component other than calcium. The paste is stable, resistant to washout and will form hydroxyapatite and harden relatively rapidly to a cement.Type: GrantFiled: September 15, 2004Date of Patent: November 13, 2007Assignee: ADA FoundationInventors: Laurence C. Chow, Shozo Takagi
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Publication number: 20070123604Abstract: The present invention relates to methods and compositions of dental materials containing nano-sized calcium phosphate and other fillers that release calcium, phosphate and fluoride. This invention further relates to dental compositions for restorations, stress-bearing applications, artificial crowns, anterior and posterior tooth fillings, adhesives, cavity liners, cements, bases, orthodontic devices, prostheses, and sealants utilizing high stress-bearing materials that release materials for the remineralization of decayed tooth structures.Type: ApplicationFiled: May 26, 2005Publication date: May 31, 2007Applicant: ADA FoundationInventors: Huakun Xu, Limin Sun, Shozo Takagi, Laurence Chow
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Publication number: 20070098652Abstract: Disclosed are dental compositions and methods. In accordance with one embodiment, a dental composition includes calcium, fluorine, which is generally present in the form of fluoride, and phosphate or another stabilizing anion. The composition is stable as against precipitation of calcium fluoride during transport and storage, but is unstable against the precipitation of calcium fluoride in the oral cavity of a human. In many embodiments, the amount of fluoride may be less than the amount of fluoride used in a comparable composition intended for a similar purpose. A dental method comprises applying the composition to the oral cavity of a patient, whereupon calcium fluoride precipitates from the composition.Type: ApplicationFiled: October 24, 2006Publication date: May 3, 2007Applicant: ADA FoundationInventors: Laurence Chow, Shozo Takagi
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Publication number: 20070092580Abstract: Disclosed are dual-phase cement precursor systems and related methods and kits. The cement precursor systems are composed of a first and second discrete phases, at least one of which is aqueous. When combined, the cement precursor phases form a cement that is suitable as a bone graft material for bone repair procedures. In preferred embodiments, the materials are highly biocompatible, osteoinductive, and bioresorbable. A number of different but not mutually exclusive cement chemistries may be employed in the cement precursor systems. For instance, hydrogel-forming polymer cements, carboxyl/calcium cements, or calcium phosphate cements may be employed.Type: ApplicationFiled: October 18, 2006Publication date: April 26, 2007Applicant: ADA FoundationInventors: Laurence Chow, Shozo Takagi
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Publication number: 20070092856Abstract: Disclosed are endodontic filling materials and methods. A method for filling a dental root canal may include providing a hydrosetting filling material and inserting the hydrosetting filling material into the dental root canal, the material setting in the root canal to form a biocompatible filling. The hydrosetting filling material comprises a hydrogel former and a filler. The hydrogel former is at least one of a reactive organic hydrogel formers, an inorganic hydrogel formers, and a non-reactive organic hydrogel formers, and the filler is at least one of a self-hardening and a non-hardening filler. Plural filling material precursor compositions that collectively contain hydrogel formers and fillers may be provided.Type: ApplicationFiled: October 18, 2006Publication date: April 26, 2007Applicant: ADA FoundationInventors: Laurence Chow, Shozo Takagi
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Publication number: 20060270752Abstract: Combining nanosized particles of a source of desired dental restorative, repair or therapeutic materials with strengthening agents in various generally nanosized form such as whiskers, fibers, particles and the like in a resin matrix provides a highly strain resistant composite which more effectively releases the therapeutic agents. The utilization of nano sized particles of the therapeutic agent in the combination enables observation of significantly improved therapeutic results.Type: ApplicationFiled: May 24, 2006Publication date: November 30, 2006Applicant: ADA FoundationInventors: Huakun Xu, Limin Sun, Shozo Takagi, Laurence Chow
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Publication number: 20060263443Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders, liquid glycerol, organic acid and gelling agent. The paste is stable, resistant to washout and will harden upon exposure to water. Physical characteristics of the paste, including consistency, porosity, and hardening time, are controlled by the choice and ratio of constituents.Type: ApplicationFiled: March 11, 2004Publication date: November 23, 2006Applicant: ADA FoundationInventors: Laurence Chow, Shozo Takagi
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Publication number: 20060159717Abstract: Living cellular material is encapsulated or placed in a protective material (cell protector) which is biocompatible, biodegradable and has a three-dimensional form. The three dimensional form is incorporated into a matrix that maybe implanted in vivo, ultimately degrade and thereby by replaced by living cell generated material.Type: ApplicationFiled: May 18, 2005Publication date: July 20, 2006Applicant: ADA FoundationInventors: Huakun Xu, Michael Weir
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Publication number: 20050074415Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders and a solution that is (1) an acidic calcium phosphate solution saturated with respect to one or more calcium phosphate compounds, (2) a concentrated acid solution, or (3) salt solutions with a cationic component other than calcium. The paste is stable, resistant to washout and will form hydroxyapatite and harden relatively rapidly to a cement.Type: ApplicationFiled: September 15, 2004Publication date: April 7, 2005Applicant: ADA FoundationInventors: Laurence Chow, Shozo Takagi
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Publication number: 20050020720Abstract: Remineralizing dental cements contain source(s) of calcium and phosphate ions, adhesive resin monomers, reinforcing base resin monomers, and catalysts able to initiate the polymerization of the adhesive and reinforcing base resin monomers. Such dental cements can be used as orthodontic cements, crown and bridge cements, adhesives, sealants, cavity liners, and protective coatings. The release of calcium and phosphate ions and, optionally, fluoride ions, protects tooth structure from demineralization, a precursor of tooth decay.Type: ApplicationFiled: July 2, 2004Publication date: January 27, 2005Applicant: ADA FoundationInventors: Sabine Dickens, Frederick Eichmiller
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Patent number: 6793725Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate powders, that are capable of forming hydroxyapatite, with liquid glycerol and hydroxypropyl methylcellulose and Na2HPO4. The paste will harden upon exposure to water with the time to harden controlled by the choice and ratio of constituents.Type: GrantFiled: January 23, 2002Date of Patent: September 21, 2004Assignee: ADA FoundationInventors: Laurence C. Chow, Shozo Takagi