Abstract: The present invention relates to a method of modulating repair of a wound. The method includes modulating expression and/or activity of Flightless I in cells involved in repair of the wound.

Abstract: A system for producing a laser light pulse is disclosed. The system includes a travelling wave or ring laser incorporating a gain medium with polarizing means for introducing substantially polarized radiation having a first polarization state into the travelling wave laser and output coupling means to substantially output couple radiation having an output polarization state from the travelling wave laser. The system further includes polarization changing means incorporated into the optical path of the travelling wave laser for changing the polarization of radiation having the first polarization state to a seeding polarization state, wherein radiation with the seeding polarization state seeds the gain medium, and radiation intensity modulation means for modulating the intensity of radiation in the travelling wave laser to vary the feedback of radiation into the gain medium, wherein the radiation intensity modulation means also modulates the radiation with respect to the output coupling means.

Abstract: A method for estimating the activity topology of a set of sensed data windows is described. Each of the sensed data windows related to a corresponding sensed region. The method includes the steps of determining a subset of sensed data windows that are not connected; and excluding the subset of sensed data windows from the set of sensed data windows. In one embodiment, the sensed data windows corresponding to image windows such as would be provided by a visual surveillance system.

Abstract: The present invention provides a method of isolating a pluripotent cell from a pre-implantation embryo without isolation of the pluripotent cells from other cells, the method including propagating a whole pre-implantation embryo including one or more pluripotent cells, embedded in a feeder cell layer and cultivated in a medium substantially free of serum, and isolating a pluripotent cell from the one or more pluripotent cells. The present invention also provides pluripotent cells generated by the method and uses thereof.

Abstract: The present invention is predicated on the discovery that a polysaccharide transferase purified from barley seedlings can catalyze the formation of covalent bonds between different polysaccharides, including between xyloglucans and cellulose, and between xyloglucans and (1,3;1,4)-?-D-glucans. The present invention thus provides, among other things, an isolated or substantially purified polysaccharide transferase, wherein said polysaccharide transferase is capable of catalyzing the formation of a covalent bond between a donor polysaccharide and an acceptor polysaccharide; or a functionally active fragment or variant of said polysaccharide transferase.

Abstract: A vineyard trellis system that includes a ground anchored upright post, at least one foliage wire passing by the post and having a supporting interengagement with the post, and lifting means arranged to effect a lifting or lowering of the wire in relation to the post where said lifting means include a support member slidably engaging with the post and engaging with the foliage wire, and a winch arrangement adapted to assist in a lifting or lowering of the support member to effect a change in height of the foliage wire with respect to the post.

Abstract: A die and method for extruding an extrudable material to form an extruded member is described. In one embodiment, the die comprises a barrier member comprising a plurality of feed channels that extend through the barrier member. Furthermore, the die incorporates a passage forming member extending from the barrier member substantially in the direction of extrusion. The feed channels are arranged with respect to the passage forming member to allow the extrudable material to substantially flow about the passage forming member to form a corresponding passage in the extruded member.

Abstract: The present invention relates generally to transcriptional control sequences for effecting expression of a nucleotide sequence of interest in a plant. The present invention is predicated, in part, on the identification and functional characterisation of transcriptional control sequences derived from genes which encode polypeptides comprising the amino acid sequence set forth in SEQ ID NO: 1 and homologs thereof. Among other things, the present invention has identified that transcriptional control sequences derived from the subject genes can effect specific or preferential expression of an operably connected nucleotide sequence in a reproduction-associated plant part such as a seed or anther.

Abstract: The present invention relates generally to transcriptional control sequences. Generally, the present invention relates to transcriptional control sequences that specifically or preferentially direct expression of a nucleotide sequence of interest in a plant egg cell. The present invention is predicated, in part, on the identification of transcriptional control sequences derived from EC1 genes which, in preferred embodiments, direct preferential expression in an egg cell of at least one plant taxon.

Abstract: The present invention relates generally to methods and transcriptional control sequences suitable for effecting expression of a nucleotide sequence of interest in a plant. More particularly, the present invention relates to methods and transcriptional control sequences suitable for directing specific or preferential expression of a nucleotide sequence of interest in a plant seed. Of particular interest as a transcriptional control sequence in this invention is the promoter PR602 (SEQ ID NO: 1) found in the 5?-untranslated region of the rice END1-like gene and isolated from a rice panicle library.

Abstract: The present invention relates to a method for identifying an inhibitor of a biotin protein ligase. The method include the steps of (a) providing a substrate, wherein the substrate may be biotinylated; (b) contacting the substrate with biotin and a biotin protein ligase in the presence of a test compound; (c) determining the extent of biotinylation of the substrate by the biotin protein ligase in the presence of the test compound; and (d) identifying the test compound as an inhibitor of the biotin protein ligase by a reduction in the biotinylation of the substrate in the presence of the test compound as compared to the extent of biotinylation of the substrate in the absence of the test compound.

Abstract: A method for generating a three dimensional (3D) model of an object is depicted in a two dimensional (2D) image is disclosed, The 2D image includes associated 3D information. The method includes an operator determining a geometric primitive corresponding to shape characteristics of the object and then the generation of the 3D model based on the determined geometric primitive, the 2D image, and the associated 3D information.

Abstract: The present invention relates generally to polysaccharide synthases. More particularly, the present invention relates to (1,3;1,4)-beta-D-glucan synthases. The present invention provides, among other things, methods for influencing the level of (1,3;1,4)-beta-D-glucan produced by a cell and nucleic acid and amino acid sequences which encode (1,3;1,4)-beta-D-glucan synthases.

Abstract: A system for producing a laser light pulse is disclosed. The system includes a travelling wave or ring laser incorporating a gain medium with polarizing means for introducing substantially polarized radiation having a first polarization state into the travelling wave laser and output coupling means to substantially output couple radiation having an output polarization state from the travelling wave laser. The system further includes polarization changing means incorporated into the optical path of the travelling wave laser for changing the polarization of radiation having the first polarization state to a seeding polarization state, wherein radiation with the seeding polarization state seeds the gain medium, and radiation intensity modulation means for modulating the intensity of radiation in the travelling wave laser to vary the feedback of radiation into the gain medium, wherein the radiation intensity modulation means also modulates the radiation with respect to the output coupling means.

Abstract: The present invention relates to a method of identifying a subject predisposed to ischemic stroke. The method includes the step of identifying a mutation in the subject that reduces the release rate of tissue plasminogen activator.

Abstract: The present invention relates to a method of modulating apoptosis of a granulosa cell. The method includes one or more of the following steps: (i) modulating the concentration and/or activity of BMP-15 and/or BMP-6 that the granulosa cell is exposed to; (ii) modulating activity of a BMP-15 dependent signalling pathway in the granulosa cell; and (iii) modulating activity of a BMP-6 dependent signalling pathway in a granulosa cell.

Abstract: A target asparagine residue of HIF 1 alpha and 2 alpha is hydroxylated at high oxygen tension to render HIF as a weak transcription factor. An asparagine hydroxylase hydroxylation motif and binding motif is proposed. A method of screening for agonists or antagonists of an asparagine hydroxylase is also proposed and involves mixing peptides or proteins having the hydroxylation and or the binding motif with asparagine hydroxylase and a candidate agonist or antagonist. The extent of inhibition or enhancement of binding; level of asparagine hydroxylation or transactivation may be measured depending on the nature of the protein or peptide. Additionally altered proteins resistant to hydroxylation are described as are nucleic acids encoding such proteins.

Abstract: The present invention relates to a method of identifying a subject predisposed to lacunar stroke. The method includes the step of identifying in the subject the presence of a thymine to cytosine mutation at position -107 in both alleles of the paraoxonase 1 locus.

Abstract: The present invention is predicated on the discovery of certain interactions between cellular growth factors and opposing actions that control differentiation and migration or invasion of cytotrophoblasts into the uterine endometrium during pregnancy. IGF-II and latent transforming growth factor beta (TGF?), the inactive precursor of TGF?, compete for binding to the CIM6P receptor. IGF-II prevents latent TGF? binding to the CIM6P receptor. The invention therefore offers a method of regulating and directing cytotrophoblast differentiation and function based on the interaction between IGF-II, latent TGF? and the CIM6P receptor. There is disclosed a method of regulating cytotrophoblast and stem cell differentiation and migration characterized by adjusting levels of insulin-like growth factor II (IGF-II) available for binding to the cation-independent mannose-6-phosphate (CIM6P) receptor. The discovery may be applied to embryonic or adult stem cells to control their differentiation and migratory behaviour.

Abstract: The present invention relates to a method of comparing at least one chromosome or part thereof from a cell with a first karyotype with the corresponding chromosome or part thereof from a cell with a second karyotype.