Patents Assigned to ADIR
  • Benzimidazole compounds
    Patent number: 5639756
    Abstract: An antidiabetic compound selected from those of formula (I): ##STR1## wherein A, B, C, D, n, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y and Z are as defined in the description.Medicaments containing the same.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: June 17, 1997
    Assignee: Adir et Compagnie
    Inventors: Vera Alekseevna Anisimova, Margarita Valentinovna Levchenko, Tatyana Borisovna Korochina, Alexander Alexeyevich Spasov, Sergei Gennadyevich Kovalev, Galina Petrovna Dudchenko
  • (Thia) cycloalkyl[B]indole compounds as anti-inflammatory agents
    Patent number: 5635516
    Abstract: A compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and A are as defined in the description.
    Type: Grant
    Filed: June 27, 1995
    Date of Patent: June 3, 1997
    Assignee: Adir et Compagnie
    Inventors: Paul Caubere, Brigitte Jamart-Gregoire, Catherine Caubere, Dominique Manechez, Pierre Renard, Gerard Adam, Catherine Nguyen
  • Diosmetin compounds
    Patent number: 5629339
    Abstract: Disclosed herein are new diosmetin compounds of formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are as defined in the description.The said compounds are useful in the treatment of chronic venous insufficiency.
    Type: Grant
    Filed: October 24, 1995
    Date of Patent: May 13, 1997
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Marie-Fran.cedilla.oise Boussard, Tony Verbeuren, Marie-Odile Vallez, Emmanuel Canet, Yves Rolland
  • Substituted phenoxyisobutyric acids and esters
    Patent number: 5627205
    Abstract: New substituted phenoxyisobutyric acids and esters that can be used as medicaments and correspond to the formula: ##STR1## wherein X, A, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and Z are as defined in the description.Those compounds and their physiologically tolerable salts can be used therapeutically.
    Type: Grant
    Filed: August 3, 1995
    Date of Patent: May 6, 1997
    Assignee: Adir Et Compagnie
    Inventors: Gilbert Regnier, Claude Guillonneau, Jean-Paul Vilaine, Albert Lenaers, Christine Breugnot
  • Tricyclic oxime ethers
    Patent number: 5627203
    Abstract: The present invention relates to compounds of formula (I): ##STR1## wherein A, x, y, R.sub.1, R.sub.2 and R.sub.3 are as defined in the description. The compounds are useful for treating diseases requiring a selective serotonin reuptake site and 5-HT.sub.2c or 5-HT.sub.3 ligand.
    Type: Grant
    Filed: December 21, 1995
    Date of Patent: May 6, 1997
    Assignee: Adir et Compagnie
    Inventors: Sylvain Rault, Max Robba, Jean-Charles Lancelot, Herv e Prunier, Pierre Renard, Bruno Pfeiffer, B eatrice Guardiola-Lemaitre, Marie-Claire Rettori
  • Benzopyrrolizinoquinolizinones
    Patent number: 5622957
    Abstract: A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: April 22, 1997
    Assignee: Adir et Compagnie
    Inventors: Jean-Daniel Brion, Claude Thal, Luc Demuynck, Jean-Gilles Parmentier, Jean Lepagnol, Pierre Lestage, Jean-Fran.cedilla.ois Pujol, Pascal Schmitt, Pierre Potier
  • Benzimidazole compounds
    Patent number: 5623073
    Abstract: Compounds of the general formula (I): ##STR1## wherein A, B, C, D, n, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y and Z are as defined in the description, and their use as antidiabetics are disclosed.
    Type: Grant
    Filed: May 18, 1993
    Date of Patent: April 22, 1997
    Assignee: Adir Et Compagnie
    Inventors: Vera A. Anisimova, Margarita V. Levchenko, Tatyana B. Korochina, Alexander A. Spasov, Sergei G. Kovalev, Galina P. Dudchenko
  • 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds
    Patent number: 5618819
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## wherein R.sub.1, W and Y are as defined in the description, its geometric and/or optical useful as anti-algies.
    Type: Grant
    Filed: July 3, 1995
    Date of Patent: April 8, 1997
    Assignee: Adir et Compagnie
    Inventors: G erald Guillaumet, Marie-Claude Viaud, Laurence Savelon, Panayota Pavli, Pierre Renard, Bruno Pfeiffer, Daniel-Henri Caignard, Jean-Guy Bizot-Espiard, G erard Adam
  • Naphthylalkylamines
    Patent number: 5616614
    Abstract: The invention relates to a compound selected from those of general formula (I): ##STR1## in which R, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, an optical isomer, and an addition salt thereof with a pharmaceutically-acceptable base. Medicinal product which is useful in the treatment of disorders linked to abnormal melatonin activity.
    Type: Grant
    Filed: January 25, 1995
    Date of Patent: April 1, 1997
    Assignee: Adir ET Compagnie
    Inventors: Said Yous, Daniel Lesieur, Patrick Depreux, B eatrice Guardiola-Lemaitre, G erard Adam, Pierre Renard, Daniel H. Caignard
  • O-arylmethyl-N-(thio)acylhydroxylamines
    Patent number: 5612368
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which Ar, X, R.sub.1 and R.sub.2 are as defined in the description and a medicinal product containing the same in order to treat a disorder of the melatoninergic system.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: March 18, 1997
    Assignee: Adir et Compagnie
    Inventors: Jean Andrieux, Michel Langlois, Pierre Renard, Philippe Delagrange
  • Preparation of phosphoramidon
    Patent number: 5608045
    Abstract: Compound of formula (I): ##STR1## in which: R.sub.1 represents a hydroxyl, alkoxy or amino (unsubstituted or substituted) group,R.sub.2 represents an unsubstituted or substituted alkyl group,X.sub.1 represents --NH--,X.sub.2 represents --O--,R.sub.3 represents a hydrogen atom or an alkyl or phenyl group,R.sub.4 represents an alkyl group which is always substituted with one or more hydroxyl, benzyloxy, benzyloxycarbonylamino, amino, mono- or dialkylamino, acetoxy or 2,2-dimethyl-1,3-dioxolan-4-yl groups, such groups being identical or different,R.sub.5 represents a 3-indolylmethyl, naphthylmethyl, alkyl, phenyl or benzyl group, its isomers as well as its addition salts with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful as endothelin convertase inhibitor.
    Type: Grant
    Filed: July 3, 1995
    Date of Patent: March 4, 1997
    Assignee: Adir et Compagnie
    Inventors: Guillaume de Nanteuil, Georges Remond, Tony Verbeuren
  • Arylalkyl (thio)amides
    Patent number: 5604261
    Abstract: A compound which is selected from those of formula (I) : ##STR1## in which A, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are as defined in the description, its optical isomers, and its addition salts thereof with a pharmaceutically-acceptable acid or base,and medicinal products containing the same which are useful for treating a disorder of the melatoninergic system.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: February 18, 1997
    Assignee: Adir Et Compagnie
    Inventors: Michel Langlois, Pierre Renard, G erard Adam
  • EburnanE analogues
    Patent number: 5602131
    Abstract: A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical selected from ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: February 11, 1997
    Assignee: Adir et Compagnie
    Inventors: Jean-Daniel Brion, Claude Thal, Luc Demuynck, Jean-Gilles Parmentier, Jean Lepagnol, Pierre Lestage, Jean-Fran.cedilla.ois Pujol, Pascal Schmitt, Pierre Potier
  • Cyclised analogues of fatty acid metabolites
    Patent number: 5599975
    Abstract: A compound selected from those of formula (I): ##STR1## wherein A, X, Y, Z, R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the description.This compound or its physiologically tolerable salts may be used therapeutically as platelet anti-aggregation agent.
    Type: Grant
    Filed: October 27, 1994
    Date of Patent: February 4, 1997
    Assignee: Adir Et Compagnie
    Inventors: Ren e Gree, Ali M. Hachem, Danielle Gree, Yves Le Floc'h, Yves Rolland, Serge Simonet, Tony Verbeuren
  • Tricyclic pyrrolopyrazine 5-HT.sub.3 -active compounds
    Patent number: 5599812
    Abstract: The present invention relates to a compound selected from these of formula (I): ##STR1## in which A and R.sub.1 are as defined in the description, and medicinal product containing the same which is useful for treating a disorder linked to the 5-HT.sub.3 receptors.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: February 4, 1997
    Assignee: Adir Et Compagnie
    Inventors: Sylvain Rault, Jean-Charles Lancelot, Herv e Prunier, Max Robba, Philippe Delagrange, Pierre Renard, G erard Adam
  • Phenothiazine cytokine inhibitors
    Patent number: 5597819
    Abstract: New benzothiazine derivatives corresponding to the general formula I: ##STR1## in which: X represents halogen,n represents 0, 1, or 2,B represents the following formula: ##STR2## in which: R.sub.1 & R.sub.2 together with the carbons to which they are attached form a 6-carbon-atom aromatic ring which is optionally substituted by a group X' representing halogen, andY represents the radical --(SO.sub.2).sub.x --Alk--Z, x, Alk, and Z are as defined in the specification;as well as their possible stereoisomers, epimers, N-oxides and pharmaceutically-acceptable acid or base addition salts; and medicinal products containing the same, useful in the treatment of inflammatory disorders requiring an inhibitor of cytokines.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: January 28, 1997
    Assignee: Adir Et Compagnie
    Inventors: Jean-Daniel Brion, Anne-Marie Chollet, Luc Demuynck, Lucy De Montarby, Yves Rolland, Jacqueline Bonnet, Pietro Ghezzi, Armel Fradin
  • Tetrahydropyran compounds
    Patent number: 5595976
    Abstract: A compound selected from those of formula (I): ##STR1## in which: A either represents --OR.sub.6, and B represents --CH.sub.2 --X,or, together with B and the carbon atom carrying them, forms an oxygen-containing heterocycle selected from oxirane, 2,2-dimethyl[1,3]dioxolane and [1,3]dioxolan-2-one,and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and X are as defined in the description.
    Type: Grant
    Filed: August 30, 1995
    Date of Patent: January 21, 1997
    Assignee: Adir et Compagnie
    Inventors: David Billington, Gilbert Dorey, Pascale Leon, Ghanem Atassi, Alain Pierre, Michael Burbridge, Nicolas Guilbaud
  • Tetracyclic 1,4-oxazine compounds
    Patent number: 5593989
    Abstract: New compounds of formula: ##STR1## wherein A--B, X, Y, R and n are as defined in the description. The geometric isomers, racemate and optical isomers thereof and the addition salts with pharmaceutically acceptable acids, and medicinal products containing the same are useful for treating psychotic disorders, depression, Parkinson's disease, memory disorders and disorders associated with drug abuse.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: January 14, 1997
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Joel Vian, Bertrand Goument, Mark Millan, Val erie Audinot, Jean-Charles Schwartz, Pierre Sokoloff
  • New phosphonic acid compounds
    Patent number: 5591728
    Abstract: Compound of formula (I): ##STR1## in which: R.sub.1 represents a hydroxyl, alkoxy or amino (unsubstituted or substituted) group,R.sub.2 represents an unsubstituted or substituted alkyl group,X.sub.1 represents --NH--,X.sub.2 represents --O--,R.sub.3 represents a hydrogen atom or an alkyl or phenyl group,R.sub.4 represents an alkyl group which is always substituted with one or more hydroxyl, benzyloxy, benzyloxycarbonylamino, amino, mono- or dialkylamino, acetoxy or 2,2-dimethyl-1,3-dioxolan-4-yl groups, such groups being identical or different,R.sub.5 represents a 3-indolylmethyl, naphthylmethyl, alkyl, phenyl or benzyl group, its isomers as well as its addition salts with a pharmaceutically acceptable acid or base,and medicinal products containing the same are useful as endothelin convertase inhibitor.
    Type: Grant
    Filed: July 3, 1995
    Date of Patent: January 7, 1997
    Assignee: Adir Et Compagnie
    Inventors: Guillaume de Nanteuil, Georges Remond, Tony Verbeuren
  • Trisubstituted naphthylalkylamides for disorders of the melatoninergic system
    Patent number: 5591775
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which R, R.sub.1, R.sub.2 and R.sub.3 are as defined herein for use in the treatment of a disorder of the melatoninergic system.
    Type: Grant
    Filed: December 6, 1994
    Date of Patent: January 7, 1997
    Assignee: Adir et Compagnie
    Inventors: Patrick Depreux, Hamid A. Mansour, Daniel Lesieur, Fran.cedilla.ois Lefoulon, Pierre Renard, Gerard Adam, Philippe Delagrange