Patents Assigned to ADIR
  • 1-phenylbicyclo[2.2.2]octane compounds
    Patent number: 5403953
    Abstract: Compound of formula (I): ##STR1## in which: R.sub.1 represents halogen, or hydroxy, alkyl, alkoxy, cyano, amino, mercapto, alkylthio or phenoxy,R.sub.2 and R'.sub.2 represent two hydrogen when the ring is unsaturated, or alternatively identical or different, represent hydrogen or halogen, or hydroxy, alkyl, alkoxy, cyano, amino or oxo when the ring is saturated,R.sub.3 represents any one of the following groups: ##STR2## in which: m represents 1, 2 or 3,X represents oxygen or sulfur or N-R, R.sub.5 or R.sub.6, which are identical or different, represent hydrogen or alkyl or trifluoromethyl or form (C.sub.3 -C.sub.6) cycloalkyl,n represents 0, 1 or 2,R.sub.7 represents hydroxy, alkoxy, amino, or --O--CH.sub.2 --CO--NRR',R.sub.4 represents hydrogen or halogen or alkyl, alkoxy or trihaloalkyl.
    Type: Grant
    Filed: November 23, 1993
    Date of Patent: April 4, 1995
    Assignee: Adir et Compagnie
    Inventors: Guillaume de Nanteuil, Michel Vincent, Christine Lila, Jacqueline Bonnet, Armel Fradin
  • 3-aminochroman spiro compounds
    Patent number: 5397783
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, A and m are as defined in the description.Medicinal product which is useful for treating depression and anxiety.
    Type: Grant
    Filed: December 27, 1993
    Date of Patent: March 14, 1995
    Assignee: Adir et Compagnie
    Inventors: Gerald Guillaumet, Tchao Podona, Gerard Adam, Beatrice Guardiola, Pierre Renard
  • New benzopyran compounds
    Patent number: 5395834
    Abstract: A compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and n are as defined in the description, its optical isomers, and its addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal product containing the same for treating a mammal afflicted with a disorder connected with peroxydation processes and biosynthesis of eicosanoids.
    Type: Grant
    Filed: April 11, 1994
    Date of Patent: March 7, 1995
    Assignee: Adir et Compagnie
    Inventors: Guillaume Le Baut, Jean-Paul Babingui, Sylvie Robert-Piessard, Pierre Renard, Daniel-Henri Caignard, Jean-Francois Renaud de la Faverie, Gerard Adam
  • Benzopyran compounds
    Patent number: 5393775
    Abstract: A compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and n are as defined in the description, its optical isomers, and its addition salts thereof with a pharmaceutically-acceptable acid or base,and medicinal product containing the same for treating a mammal afflicted with a disorder connected with peroxydation processes and biosynthesis of eicosanoids.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: February 28, 1995
    Assignee: Adir et Compagnie
    Inventors: Guillaume Le Baut, Jean-Paul Babingui, Sylvie Robert-Piessard, Pierre Renard, Daniel-henri Caignard, jean-Francois Renaud de la Faverle, Gerard Adam
  • New chromene compounds having a triene side chain
    Patent number: 5391569
    Abstract: A compound selected from those of formula (I): ##STR1## in which the groups R.sub.1 to R.sub.8 are as defined the description. Medicaments.
    Type: Grant
    Filed: September 28, 1993
    Date of Patent: February 21, 1995
    Assignee: Adir et Compagnie
    Inventors: Jean-Daniel Brion, Guillaume Le Baut, Guillaume Poissonnet, Lucy De Montarby, Larbi Belachmi, Jacqueline Bonnet, Massimo Sabatini, Charles Tordjman
  • New pyridylsulphonylurea compound
    Patent number: 5391559
    Abstract: The invention relates to the compound of formula (I) ##STR1## and the addition salts thereof with a pharmaceutically acceptable acid or base.A pharmaceutical product which is useful for treating an ischemic or hypoxic disorder or a peripheral or central oedema.
    Type: Grant
    Filed: January 5, 1993
    Date of Patent: February 21, 1995
    Assignee: Adir et Compagnie
    Inventors: Bernard Masereel, Bernard Pirotte, Marc Schynts, Jacques Delarge
  • Naphthylethylureas
    Patent number: 5389683
    Abstract: A compound selected from those of formula (I): ##STR1## in which the meanings of R, R.sub.1, R.sub.2 and X are as defined in the specification, andmedicinal products containing the same which are in treating or in preventing a disorder of the melatoninergic system.
    Type: Grant
    Filed: August 14, 1992
    Date of Patent: February 14, 1995
    Assignee: Adir et Compagnie
    Inventors: Daniel Lesieur, Said Yous, Patrick Depreux, Gerard Adam, Pierre Renard, Bruno Pfeiffer, Beatrice Guardiola-Lemaitre
  • Thiochroman compounds
    Patent number: 5389668
    Abstract: The invention relates to compounds of the formula I: ##STR1## in which R.sub.1 is as defined in the description, their optical isomers and their addition salts with a pharmaceutically-acceptable acid or base, and medicinal products which are useful for treating Central Nervous System disorders.
    Type: Grant
    Filed: January 12, 1994
    Date of Patent: February 14, 1995
    Assignee: Adir Et Compagnie
    Inventors: Gerald Guillaumet, Gerard Coudert, Tchao Podona, Beatrice Guardiola-Lemaitre, Pierre Renard, Gerard Adam, Daniel Henri-Caignard
  • 1,4-dihydropyridine compounds
    Patent number: 5389644
    Abstract: The compounds are 2,4-disubstituted 3-ethoxycarbonyl 5-methoxycarbonyl 6-methyl 1,4-dihydropyridines in their dextrorotatory form, useful to potentiate the activity of cytotoxic agents and to increase the sensitivity of tumor cells to antitumor agents.A compound disclosed is d-2-{[2-(2-(N-p-nitrobenzylamino)ethoxy)ethoxy]methyl}-4-(2,3-dichlorophen yl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine.
    Type: Grant
    Filed: February 4, 1993
    Date of Patent: February 14, 1995
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Ghanem Aasssi, Alain Pierre, Laurence Kraus-Berthier, Nicolas Guilbaud, Jean-Paul Vilaine
  • Pyrrolidine compounds
    Patent number: 5387591
    Abstract: Compounds of formula (I): ##STR1## in which: R.sub.1 represents:optionally substituted alkyl,optionally substituted phenyl,pyridyl,optionally substituted phenylsulfonyl,acyl,optionally substituted benzoyl or pyridylcarbonyl,alkylaminocarbonyl or phenylaminocarbonyl,acylamino or benzoylamino,R2 represents:hydrogen,optionally substituted phenyl,optionally substituted 3-pyridyl or 2-pyridyl,R.sub.3 represents any one of the following groups: ##STR2## in which m is equal to 2, 3 or 4,n is equal to 4, 5, 6 or 7, and R represents hydrogen or alkyl.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: February 7, 1995
    Assignee: Adir et Compagnie
    Inventors: Gilbert Lavielle, Thierry Dubuffet, Olivier Muller, Michel Laubie, Tony Verbeuren
  • (Aryl(alkyl)carbonyl)-heterocyclic compounds, compositions and use
    Patent number: 5387586
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## wherein Ar, n, B and A are as defined in the description, to their optical isomers, and to their addition salts there of with a pharmaceutically-acceptable acid or base.Medicinal product which is useful for treating pain and treating or preventing pathologies which require psychotropic agents.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: February 7, 1995
    Assignee: Adir et Compagnie
    Inventors: Ousmane Diouf, Daniel Lesieur, Patrick Depreux, Beatrice Guardiola-Lemaitre, Daniel-Henri Caignard, Pierre Renard, Gerard Adam
  • Diacylglycerol nicotinates
    Patent number: 5385920
    Abstract: Compounds of formula (I): ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, represent a higher alkyl or higher alkenyl radical,R.sub.3 represents a pyridyl or pyrazinyl radical,their isomers and their addition salts with a pharmaceutically acceptable acid and medicaments for the reduction of plasma lipids containing the same.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: January 31, 1995
    Assignee: Adir et Compagnie
    Inventors: Alex Cordi, Jean-Michel Lacoste, Jacques Duhault, Joseph Espinal, Michelle Boulanger
  • Thiochroman compounds
    Patent number: 5385930
    Abstract: The invention relates to compounds of the formula I: ##STR1## in which R.sub.1 is as defined in the description, their optical isomers and their addition salts with a pharmaceutically-acceptable acid or base, and medicinal products which are useful for treating Central Nervous System disorders.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: January 31, 1995
    Assignee: Adir et Compagnie
    Inventors: Gerald Guillaumet, Gerard Coudert, Tchao Podona, Beatrice Guardiola-Lemaitre, Pierre Renard, Gerard Adam, Daniel Henri-Caignard
  • Naphthylethylureas and naphthylethylthioureas
    Patent number: 5385944
    Abstract: A compound selected from those of formula (I): ##STR1## in which the meanings of R, R.sub.1, R.sub.2 and X are defined in the specification, andmedicinal products containing the same which are useful in treating or in preventing a disorder of the melatoninergic system.
    Type: Grant
    Filed: April 27, 1993
    Date of Patent: January 31, 1995
    Assignee: Adir et Compagnie
    Inventors: Daniel Lesieur, Said Yous, Patrick Depreux, Gerard Adam, Pierre Renard, Bruno Pfeiffer, Beatrice Guardiola-Lemaitre
  • 2-(alkoxy benzothiazolinon-3yl) ethylamines
    Patent number: 5386034
    Abstract: Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products. Useful for treating sleep disorders comprising the same.
    Type: Grant
    Filed: June 15, 1993
    Date of Patent: January 31, 1995
    Assignee: Adir et Compagnie
    Inventors: Said Yous, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
  • Nitrogen-containing bicyclic compounds and pharmaceutical compositions thereof
    Patent number: 5384322
    Abstract: The invention relates to the compounds of formula (I): ##STR1## in which: A represents, with the nitrogen and carbon atoms to which it is bound, a heterocycle,B represents, with the nitrogen atom to which it is bound, a heterocycle,R.sub.1 represents alkoxy, benzyloxy, phenoxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or substituted or unsubstituted cycloalkyl,their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid, medicinal products containing the same.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: January 24, 1995
    Assignee: Adir et Compagnie
    Inventors: Michel Vincent, Georges Remond, Bernard Portevin, Yolande Herve, Jean Lepagnol, Guillaume de Nanteuil
  • New 3-(hydroxybenzylidenyl)-indolin-2-ones
    Patent number: 5382593
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and X are as defined in the description, its Z and E isomers, its optical isomers, in pure form or in the form of a mixture, and its addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in treating a disorder resulting from or associated with peroxidation phenomena, disturbances in eicosanoid synthesis, or with platelet aggregation disorders.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: January 17, 1995
    Assignee: Adir et Compagnie
    Inventors: Guillaume Le Baut, Marie-Renee Nourrisson, Jean-Francois Renaud de la Faverie, Jean-Guy Bizot Espiard, Daniel-Henri Caignard, Pierre Renard, Gerard Adam
  • Arylethylamine compounds
    Patent number: 5380750
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which Ar', R.sub.1 and R.sub.2 are as defined in the specification, an optical isomer,and an addition salt thereof with a pharmaceutically-acceptable acid or base.Medicinal product which is useful in treating or in preventing a disorder of the melatoninergic system.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: January 10, 1995
    Assignee: Adir et Compagnie
    Inventors: Daniel Lesieur, Said Yous, Patrick Depreux, Jean Andrieux, Gerard Adam, Daniel H. Caignard, Beatrice Guardiola
  • 3-aminochroman spiro compounds
    Patent number: 5376661
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, A and m are as defined in the description.Medicinal product which is useful for treating depression and anxiety.
    Type: Grant
    Filed: March 24, 1993
    Date of Patent: December 27, 1994
    Assignee: Adir et Compagnie
    Inventors: Gerald Guillaumet, Tchao Podona, Gerard Adam, Beatrice Guardiola, Pierre Renard
  • Peptide and pseudopeptide compounds which are therapeutically active in the blood coagulation cascade
    Patent number: 5371071
    Abstract: The invention relates to the compounds of formula (I):X - A.sub.1 - A.sub.2 - A.sub.3 - A.sub.4 - A.sub.5 - A.sub.6 - A.sub.7 - A.sub.8 - A.sub.9 - A.sub.10 - Y (I)in which X, A.sub.1, A.sub.2, A.sub.3, A.sub.4, A.sub.5, A.sub.6, A.sub.7, A.sub.8, A.sub.9, A.sub.10 and Y are as defined in the description.Medicinal products.
    Type: Grant
    Filed: January 13, 1993
    Date of Patent: December 6, 1994
    Assignee: Adir et Compagnie
    Inventors: Jean-Luc Fauchere, Christophe Thurieau, Tony Verbeuren, Joseph Paladino