Abstract: Medical devices and coatings for medical devices are disclosed, including methods for forming the devices and coatings. The devices and coatings comprise a phase-separated block copolymer matrix and one or more active agents. The phase-separated block copolymer matrix can be used to modulate the release-rate of one or more active agents from the medical device.
Abstract: Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.
Type:
Grant
Filed:
October 24, 2007
Date of Patent:
May 5, 2015
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Jessica G. Chiu, Gregory Waimong Chan, Gabriel Asongwe, Robert C. Esselstein, Douglas Gesswein, Srinivasan Sridharan, Nianjiong Joan Bei, William E. Webler, Stephen G. Schaible, Mina Chow, Yan Shen, Hongzhi Bai, Mark J. Bly, Thomas R. Hatten
Abstract: A polymer of hydrophobic monomers and hydrophilic monomers is provided. It is also provided a polymer blend that contains the polymer and another biocompatible polymer. The polymer or polymer blend and optionally a biobeneficial material and/or a bioactive agent can form a coating on an implantable device such as a drug delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
Abstract: Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
Type:
Grant
Filed:
June 21, 2013
Date of Patent:
March 24, 2015
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Thierry Glauser, Stephen D. Pacetti, Paul M. Consigny
Abstract: A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
Type:
Grant
Filed:
May 29, 2009
Date of Patent:
March 17, 2015
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Stephen Dirk Pacetti, Yiwen Tang, Syed Faiyaz Ahmed Hossainy
Abstract: Methods and apparatuses for positioning medical devices onto (or close to) a desired portion of the interior wall of an internal channel, such as for scan imaging, for photodynamic therapy and/or for optical temperature measurement. In one embodiment, a catheter assembly has a distal portion that can be changed from a configuration suitable for traversing the internal channel to another configuration suitable for scan at least a spiral section of the interior wall of an internal channel, such as an artery. In one example, the distal portion spirals into gentle contact with (or close to) a spiral section of the artery wall for Optical Coherence Tomography (OCT) scanning. The spiral radius may be changed through the use of a guidewire, a tendon, a spiral balloon, a tube, or other ways.
Abstract: A method of coating a stent is presented such that less than 50% of the total amount of 40-O-(2-hydroxyl)ethyl-rapamycin, or an analog or derivative thereof, is released in vivo in a 24 hour period, wherein the method comprises exposing the coating to sufficient temperature to modify the structure of the polymer.
Type:
Grant
Filed:
September 26, 2006
Date of Patent:
February 24, 2015
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Syed F. A. Hossainy, Gordon Stewart, Mark A. Williams, Jeff Royal, Paul M. Consigny, Dorie M. Happ, Kurt Scheinpflug, Ty Hu
Abstract: A block copolymer comprising a methoxyethyl methacrylate (MOEMA) midblock is provided for forming a coating a medical device for controlled release of a bioactive agent.
Abstract: Embodiments of a method and apparatus to prevent reperfusion injury. In one embodiment, blood flow proximal to a lesion is occluded. An infusion catheter is advanced to a region distal to the lesion and an anti-reperfusion injury drug is delivered. The lesion may then be treated with a dilating device to reintroduce blood flow to the region distal to the lesion.
Type:
Grant
Filed:
December 10, 2012
Date of Patent:
February 17, 2015
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Daniel L. Cox, Hongzhi Bai, Paul Consigny, Jessica G. Chiu
Abstract: A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.
Type:
Grant
Filed:
August 30, 2006
Date of Patent:
January 20, 2015
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Gina Zhang, Jessica Renee DesNoyer, Gordon Stewart, Maricela Kezis, Syed Faiyaz Ahmed Hossainy
Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
Type:
Grant
Filed:
September 28, 2012
Date of Patent:
December 9, 2014
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Syed Faiyaz Ahmed Hossainy, Eugene Michal, Thierry Glauser, Connie Kwok, Stephen Dirk Pacetti
Abstract: A stent for treating a bodily lumen with a flexible section in a high strain region is disclosed. A flexible section may be selectively positioned to reduce an amount of strain in the high strain region when subjected to the applied stress during use to inhibit or prevent fracturing in the high strain region.
Type:
Grant
Filed:
October 7, 2008
Date of Patent:
November 25, 2014
Assignee:
Advanced Cardiovascular Systems Inc.
Inventors:
David C. Gale, Klaus Kleine, Anthony J. Abbate, Svava Maria Atladottir, Stephen Pacetti
Abstract: A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.
Abstract: A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The coating compensates for regions of higher stress and resulting strain due to the geometry of the device. Certain embodiments may include a nonuniform coating on the device in which a strain on the nonuniform coating is less than a strain on a uniform coating when the device is placed under an applied stress during use. Other embodiments may include a coating with a greater resistance to strain on higher strain regions of the device.
Type:
Grant
Filed:
August 16, 2013
Date of Patent:
October 21, 2014
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Philip Foreman, Charles W. Snyder, Gregg Teaby, Eric Penn
Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
Type:
Grant
Filed:
March 12, 2010
Date of Patent:
October 14, 2014
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Syed F. A. Hossainy, Stephen D. Pacetti, Keith E. Fong, Vinayak Bhat, Deborra Sanders Millare, Judy A. Guruwaiya, Daryush Mirzaee, Evgenia Mandrusov
Abstract: A stent with at least one severable supporting device and methods of coating using the same are disclosed. The severable supporting device can be an end tube or a tab attached to some portion of the stent by at least one “gate” or attachment. The end tube or tab may be part of the design of the stent when it is originally manufactured, or it may be attached to the stent in a secondary process by a biocompatible glue or solder. The end tube or tab can be used to support a stent during a coating process eliminating the need for a mandrel which would otherwise contact the stent during the coating process.
Abstract: A medical article is disclosed, comprising a biologically degradable AB block copolymer and a biologically degradable polymer that is capable, at equilibrium and at room temperature, of absorbing less than about 5 mass % water.
Type:
Grant
Filed:
July 29, 2008
Date of Patent:
September 30, 2014
Assignee:
Advanced Cardiovascular Systems, Inc.
Inventors:
Yiwen Tang, Syed F. A. Hossainy, Andrew C. Tung, Stephen D. Pacetti