Patents Assigned to Advanced Cardiovascular Systems
  • Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
    Patent number: 8521259
    Abstract: A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the treatment site; and introducing a treatment agent through the needle to the treatment site. A composition including an inflammation-inducing agent and a carrier in the form of microspheres having a particle size suitable for transvascular delivery. A composition including a therapeutic angiogenesis promoter in a carrier and an opsonin-inhibitor coupled to the carrier. An apparatus for delivery of a therapeutic angiogenesis promoter.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: August 27, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Evgenia Mandrusov, Murthy V. Simhambhatla, Syed Hossainy, Eugene T. Michal, Charles Claude, Jessica G. Chiu
  • Drug eluting stent for the treatment of dialysis graft stenoses
    Patent number: 8518100
    Abstract: A drug-eluting stent having a first cell pattern at one end and a second cell pattern on an opposite end. The cells in the first cell pattern have a smaller MCUSA than those in the second cell pattern. An anti-restonic drug can be coated on the first cell pattern and an anti-thrombotic drug on the second, with the anti-thrombotic drug overlaying and covering both the first and second cell patterns. The stent is operatively positionable at a distal graft-vein anastomosis with the first cell pattern adjacent the stenosis, and with the second cell pattern positioned adjacent the vein or the graft.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: August 27, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Paul Consigny, Tracey Krausa, Matthew C. Merkert
  • Stent delivery catheter with improved stent retention and method of making same
    Patent number: 8512388
    Abstract: A stent delivery catheter system having a catheter with stent releasably mounted on a stent retention portion of the catheter for delivery and deployment within a patient's body lumen, and a method of mounting the stent on the stent retention portion of the catheter. The method generally includes exposing the stent retention portion and/or the stent to a solvent, the solvent being in the vapor phase. The vapor phase solvent typically softens the stent retention portion of the catheter, and/or, in one embodiment in which the stent has a coating on the stent body, the vapor phase solvent softens the stent coating. In a presently preferred embodiment, the stent polymeric coating has a therapeutic agent, and the method of the invention prevents or inhibits disadvantageously affecting the therapeutic agent coating during mounting of the stent on the catheter.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: August 20, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Wouter Roorda, Tim A. Limon, Stephen D. Pacetti
  • Micronized peptide coated stent
    Patent number: 8506617
    Abstract: A coating for an implantable device such as a stent is provided including micronized peptides. A method of making the same is also provided.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: August 13, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Eugene T Michal, Ashok A Shah, Ni Ding
  • Biobeneficial coating compositions and methods of making and using thereof
    Patent number: 8501211
    Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the composition, and a method of treating a disorder are provided.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: August 6, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen D. Pacetti
  • Apparatus to prevent reperfusion injury
    Patent number: 8486012
    Abstract: Embodiments of a method and apparatus to prevent reperfusion injury. In one embodiment, blood flow proximal to a lesion is occluded. An infusion catheter is advanced to a region distal to the lesion and an anti-reperfusion injury drug is delivered. The lesion may then be treated with a dilating device to reintroduce blood flow to the region distal to the lesion.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: July 16, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Daniel L. Cox, Hongzhi Bai, Paul Consigny, Jessica G. Chiu
  • Reduced temperature sterilization of stents
    Patent number: 8475713
    Abstract: Methods and systems for reduced temperature radiation sterilization of stents are disclosed.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: July 2, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Bin Huang, Abigail Freeman, Daniel Castro, David C. Gale
  • Stent with anchors to prevent vulnerable plaque rupture during deployment
    Patent number: 8475518
    Abstract: A stent for implantation in a body lumen for protecting from rupture a fibrous cap in order to treat vulnerable plaque. One embodiment of the stent achieves staged expansion through stronger and weaker circumferential regions, and includes optional anchors positioned at the circumferential transition between the stronger and weaker regions. During the first stage expansion, the weaker region expands moving the anchors laterally apart. The anchors straddle the fibrous cap and embed into the vessel wall. The second stage expansion of the stent exerts gentler stresses by the weaker region against the fibrous cap while the stronger region exerts greater stresses on the remainder of the vessel wall to open the vessel.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: July 2, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Daniel L. Cox, Christopher Feezor
  • TiNxOy modified surface for an implantable device and a method of producing the same
    Patent number: 8470019
    Abstract: Implantable devices, such as stents, having a surface modified with TiNxOy or TiNxCy are disclosed.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: June 25, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Shamim M. Malik, Avijit Mukherjee
  • Stent-catheter assembly with a releasable connection for stent retention
    Patent number: 8470014
    Abstract: Medical assemblies with a releasable connection and methods of constructing such medical assemblies are disclosed. The medical assemblies generally comprise a stent, a catheter assembly having catheter body a balloon, and a releasable connection between the stent and the catheter assembly that releases the stent from the catheter assembly in response to enlargement of the balloon or when the balloon has been enlarged to an expanded configuration.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: June 25, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: David C. Gale, Klaus Kleine, Anthony Abbate, Svava M. Atladottir, Bin Huang
  • Nitric oxide generating medical devices
    Patent number: 8470358
    Abstract: Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: June 25, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Thierry Glauser, Stephen D. Pacetti, Paul Consigny
  • Rotatable support elements for stents
    Patent number: 8465789
    Abstract: Various embodiments of methods and devices for coating stents are described herein.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: June 18, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Jason Van Sciver
  • COATINGS FOR DRUG DELIVERY DEVICES
    Publication number: 20130150460
    Abstract: A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.
    Type: Application
    Filed: January 4, 2013
    Publication date: June 13, 2013
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventor: Advanced Cardiovascular Systems, Inc.
  • COATINGS FOR DRUG DELIVERY DEVICES
    Publication number: 20130150459
    Abstract: A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.
    Type: Application
    Filed: January 4, 2013
    Publication date: June 13, 2013
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventor: Advanced Cardiovascular Systems, Inc.
  • Methods of Forming Coatings with a Crystalline or Partially Crystalline Drug for Implantable Medical Devices using Sonocrystallization
    Publication number: 20130142939
    Abstract: Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.
    Type: Application
    Filed: December 18, 2012
    Publication date: June 6, 2013
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventor: Advanced Cardiovascular Systems, Inc.
  • Transition matching stent
    Patent number: 8454676
    Abstract: The bending flexibility profile of a stent closely matches the flexibilities of the stent delivery system on either side of the stent. In one embodiment, a stent has a longitudinal axis and at least one link attaching each ring to an adjacent ring. The links closest to the stent end rings have the greatest bending flexibility and the links closest to the center of the stent have the least bending flexibility.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: June 4, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Karim Said Osman
  • Intravascular stent and method of use
    Patent number: 8439966
    Abstract: An expandable stent is implanted in a body lumen, such as a coronary artery, peripheral artery, or other body lumen for treating an area of vulnerable plaque. The invention provides for a an intravascular stent having a plurality of cylindrical rings connected by undulating links. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. A central section is positioned between distal and proximal sections and is aligned with the area of vulnerable plaque to enhance growth of endothelial cells over the fibrous cap of the vulnerable plaque to reinforce the area and reduce the likelihood of rupture.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: May 14, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Timothy Limon
  • Delivery system for a device such as a stent
    Patent number: 8435279
    Abstract: A delivery system for a medical device. The delivery system comprises an inner member, a retractable sheath disposed over the inner member and being slideable over the inner member, and a retraction member coupled to the retractable sheath and disposed at least in portion within the retractable sheath, the retraction member being slideable over the inner member. An axial movement of the retraction member retracts or actuates the retractable member.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: May 7, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Dagmar Beyerlein, Christopher Feezor, Karim Osman, Denise Horrilleno Burns, Carla Rosa Pienknagura, Barbara Stamberg
  • Stent support devices
    Patent number: 8430057
    Abstract: A collet shaped to minimize the contact area of a stent end with a surface of the collet. The collet has an end surface for contacting a stent end that includes a raised or projecting portion and a flat or relatively flat portion. The projecting, portion has at least three segments radiating from a center to the edge of the surface.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: April 30, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Ryan E. Guerriero, Yung-Ming Chen, Celenia Gutierrez, Ian J. Coulson, Nathan Harold, Andrew Tochterman
  • Biobeneficial coating compositions and methods of making and using thereof
    Patent number: 8426476
    Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, and an implantable device coated with the composition are provided.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: April 23, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen D. Pacetti