Patents Assigned to Advanced Cell Technology, Inc.
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Patent number: 10047340Abstract: Methods for producing stem cell banks, preferably human, which optionally may be transgenic, e.g., comprised of homozygous MHC allele cell lines are provided. These cells are produced preferably from parthenogenic, IVF, or same-species or cross-species nuclear transfer embryos or by dedifferentiation of somatic cells by cytoplasm transfer. Methods for using these stem cell banks for producing stem and differentiated cells for therapy, especially acute therapies, and for screening for drugs for disease treatment are also provided.Type: GrantFiled: December 20, 2012Date of Patent: August 14, 2018Assignee: Advanced Cell Technology, Inc.Inventor: Michael West
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Publication number: 20170152475Abstract: This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.Type: ApplicationFiled: October 28, 2014Publication date: June 1, 2017Applicant: Advanced Cell Technology, Inc.Inventors: Michael D. West, Karen B. Chapman, Roy Geoffrey Sargent
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Patent number: 9580683Abstract: Methods for de-differentiating or altering the life-span of desired “recipient” cells, e.g., human somatic cells, by the introduction of cytoplasm from a more primitive, less differentiated cell type, e.g., oocyte or blastomere are provided. These methods can be used to produce embryonic stem cells and to increase the efficiency of gene therapy by allowing for desired cells to be subjected to multiple genetic modifications without becoming senescent. Such cytoplasm may be fractionated and/or subjected to subtractive hybridization and the active materials (sufficient for de-differentiation) identified and produced by recombinant methods.Type: GrantFiled: June 11, 2014Date of Patent: February 28, 2017Assignee: Advanced Cell Technology, Inc.Inventor: Karen B. Chapman
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Publication number: 20160175361Abstract: Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.Type: ApplicationFiled: September 17, 2014Publication date: June 23, 2016Applicant: Advanced Cell Technology, Inc.Inventors: Robert P. Lanza, Shi-Jiang Lu, Wei Wang
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Patent number: 9334478Abstract: The invention relates to assays for screening growth factors, adhesion molecules, immunostimulatory molecules, extracellular matrix components and other materials, alone or in combination, simultaneously or temporally, for the ability to induce directed differentiation of pluripotent and multipotent stem cells.Type: GrantFiled: February 3, 2009Date of Patent: May 10, 2016Assignee: Advanced Cell Technology, Inc.Inventors: Michael D. West, Raymond L. Page, Hans Schoeler, Karen B. Chapman
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Publication number: 20160038543Abstract: The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and methods of treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.Type: ApplicationFiled: October 1, 2014Publication date: February 11, 2016Applicant: Advanced Cell Technology, Inc.Inventors: Erin Anne Kimbrel, Robert P. Lanza, Jianlin Chu, Nicholas Arthur Kouris
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Publication number: 20160022736Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.Type: ApplicationFiled: October 16, 2014Publication date: January 28, 2016Applicant: ADVANCED CELL TECHNOLOGY, INC.Inventors: QIANG FENG, SHI-JIANG LU, ROBERT P. LANZA
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Publication number: 20150232808Abstract: This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.Type: ApplicationFiled: October 28, 2014Publication date: August 20, 2015Applicant: Advanced Cell Technology, Inc.Inventors: Michael D. West, Karen B. Chapman, Roy Geoffrey Sargent
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Publication number: 20150175960Abstract: The present invention relates generally to the field of somatic cell nuclear transfer (SCNT) and to the creation of cloned animals and cells. The disclosure relates to a method of cloning a mammal, obtaining pluripotent cells such as embryonic stem cells, or for reprogramming a mammalian cell using an oocyte and a fertilized embryo.Type: ApplicationFiled: July 23, 2014Publication date: June 25, 2015Applicant: Advanced Cell Technology, Inc.Inventors: Robert P. Lanza, Young Gie Chung
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Publication number: 20150132853Abstract: Methods for de-differentiating or altering the life-span of desired “recipient” cells, e.g., human somatic cells, by the introduction of cytoplasm from a more primitive, less differentiated cell type, e.g., oocyte or blastomere are provided. These methods can be used to produce embryonic stem cells and to increase the efficiency of gene therapy by allowing for desired cells to be subjected to multiple genetic modifications without becoming senescent. Such cytoplasm may be fractionated and/or subjected to subtractive hybridization and the active materials (sufficient for de-differentiation) identified and produced by recombinant methods.Type: ApplicationFiled: June 11, 2014Publication date: May 14, 2015Applicant: Advanced Cell Technology, Inc.Inventor: Karen B. Chapman
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Publication number: 20150086512Abstract: The present invention provides improved methods for producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The invention also relates to human retinal pigmented epithelial cells derived from human embryonic stem cells or other human multipotent or pluripotent stem cells. hRPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The hRPE cells described herein are useful for treating retinal degenerative diseases.Type: ApplicationFiled: April 16, 2014Publication date: March 26, 2015Applicant: Advanced Cell Technology, Inc.Inventors: Christopher Malcuit, Linda Lemieux, William Holmes, Pedro Huertas, Lucy Vilner
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Publication number: 20140377865Abstract: This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.Type: ApplicationFiled: January 13, 2014Publication date: December 25, 2014Applicant: ADVANCED CELL TECHNOLOGY, INC.Inventors: ROBERT P. LANZA, YOUNG GIE CHUNG
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Publication number: 20140370007Abstract: This disclosure generally relates to cell-based therapies for treatment of visual disorders, including disorders of the cornea. Methods are exemplified for directed differentiation of corneal cells from stem cells. Compositions of corneal endothelial cells and uses thereof are also provided. Exemplary compositions exhibit improved cell density and/or more “youthful” gene expression relative to cells obtained from donated tissue.Type: ApplicationFiled: December 6, 2012Publication date: December 18, 2014Applicant: Advanced Cell Technology, Inc.Inventors: Kathryn L. McCabe, Shi-Jiang Lu, Robert P. Lanza
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Publication number: 20140356952Abstract: This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.Type: ApplicationFiled: April 30, 2014Publication date: December 4, 2014Applicant: Advanced Cell Technology, Inc.Inventors: Young Gie Chung, Robert P. Lanza, Irina V. Klimanskaya
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Publication number: 20140356432Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.Type: ApplicationFiled: March 27, 2014Publication date: December 4, 2014Applicant: Advanced Cell Technology, Inc.Inventors: Irina V. Klimanskaya, Robert P. Lanza
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Publication number: 20140294778Abstract: Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.Type: ApplicationFiled: March 14, 2014Publication date: October 2, 2014Applicant: Advanced Cell Technology, Inc.Inventors: Robert P. Lanza, Shi-Jiang Lu, Wei Wang
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Publication number: 20140294779Abstract: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.Type: ApplicationFiled: March 27, 2014Publication date: October 2, 2014Applicant: Advanced Cell Technology, Inc.Inventors: Irina V. Klimanskaya, Robert P. Lanza
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Publication number: 20140271590Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.Type: ApplicationFiled: December 21, 2013Publication date: September 18, 2014Applicant: Advanced Cell Technology, Inc.Inventors: Qiang Feng, Shi-Jiang Lu, Robert P. Lanza
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Patent number: 8796021Abstract: The present invention relates generally to the field of somatic cell nuclear transfer (SCNT) and to the creation of cloned animals and cells. The disclosure relates to a method of cloning a mammal, obtaining pluripotent cells such as embryonic stem cells, or for reprogramming a mammalian cell using an oocyte and a fertilized embryo.Type: GrantFiled: February 22, 2008Date of Patent: August 5, 2014Assignee: Advanced Cell Technology, Inc.Inventors: Robert Lanza, Young Chung
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Patent number: 8742200Abstract: This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as IVF.Type: GrantFiled: January 11, 2011Date of Patent: June 3, 2014Assignee: Advanced Cell Technology, Inc.Inventors: Young Gie Chung, Robert Lanza, Irina V. Klimanskaya