Abstract: A method of assigning parent-of-origin to a haplotype, a sub-haplotype or an allele associated with a haplotype. Chromosome-length haplotypes of a genome are generated and a differential methylation status of at least one imprinted differentially methylated region (iDMR) associated with each one of the autosomal chromosomes is determined. The differential methylation status of the at least one iDMR is used to assign parent-of-origin for each one of the chromosome-length haplotypes.
Type:
Application
Filed:
January 7, 2025
Publication date:
May 8, 2025
Inventors:
Peter LANSDORP, Kasmintan SCHRADER, Steven JONES, Vincent HANLON, Vahid AKBARI, Kieran O'NEILL
Abstract: The present disclosure is generally directed to anchoring primary nucleic acid probes in a polymer matrix, which are configured to hybridize to cellular nucleic acid, embedding in a polymer matrix, clearing cellular components including the cellular nucleic acid and imaging. The disclosure describes methods for imaging cellular RNA in an RNase insensitive method.
Abstract: The present disclosure relates to materials and methods for spatially analyzing nucleic acids that have been fragmented with a transposase enzyme, alone or in combination with other types of analytes.
Type:
Application
Filed:
January 14, 2025
Publication date:
May 8, 2025
Inventors:
Michael Schnall-Levin, Michael Ybarra Lucero, Tarjei Sigurd Mikkelsen, Patrik Stahl, Jonas Frisen, Maja Marklund, Enric Llorens Bobadilla
Abstract: Disclosed are compositions, methods, and kits that can be used to Epstein-Barr virus (EBV) in a sample undergoing testing. Nucleic acids of EBV can be isolated, amplified and detected with specificity, and without interference from non-EBV organisms. In some embodiments, nucleic acids used for amplification are isolated from human blood, or blood products. Nucleic acid isolation, amplification and detection steps can all be carried out using an automated instrument.
Abstract: A mixture includes a nickel-containing ore and/or concentrate thereof and an extraction composition including a fermentation broth obtained from an Aspergillus species (spp.), Acetobacter spp., Bacillus spp., Propionibacterium spp., Corynebacterium spp., Rhizopus spp., Clostridium spp., Fusobacterium spp., Pseudomonas spp., Bifidobacterium spp., Saccharomyces spp., Enterobacter spp., Escherichia spp., among others. The extraction composition is configured to selectively solubilize one or more components, such as a magnesium component from the nickel-containing ore and/or concentrate thereof. A method for extracting a metal from a nickel-containing ore and/or concentrate includes selectively solubilizing a magnesium component from the nickel-containing ore and/or concentrate thereof into an extraction composition including the fermentation broth.
Type:
Application
Filed:
November 4, 2024
Publication date:
May 8, 2025
Applicant:
Allonnia, LLC
Inventors:
Dayal Saran, Coy Zimmermann, Tom Lankiewicz, Michaeline Albright, Kathleen Radloff, Kent Sorenson, Dan Stigers
Abstract: A showerhead for a substrate processing system includes a backplate made of a metallic material and a faceplate made of a ceramic material. The showerhead further comprises a first cooling plate arranged between the backplate and a center region of the faceplate and a plurality of heaters arranged between the backplate and a peripheral region of the faceplate.
Abstract: A substrate support unit includes a chuck having an upper surface on which to mount a substrate, and including a heater for heating the substrate; a shaft assembly supporting a lower portion of the chuck, and including an electric line connected to the heater; a support assembly having an accommodation space surrounding and accommodating a portion of the shaft assembly, and supporting the shaft assembly; a seal sealing a lower portion of the accommodation space; an inlet communicating with the accommodation space and configured to transfer cooling gas for cooling the electric line into the accommodation space, the inlet being disposed in one of the support assembly and the seal; and an outlet disposed in the support assembly, communicating with the accommodation space, and configured to transfer the cooling gas out of the support assembly.
Type:
Application
Filed:
May 23, 2024
Publication date:
May 8, 2025
Inventors:
Yeontae Kim, Yihwan Kim, Minsu Lee, Hyeonjin Jeon, Hyeongun Jeon
Abstract: The present disclosure relates to a glass cloth, prepreg, and printed circuit board. There is provided a glass cloth including woven glass yarns, wherein a bulk dissipation factor of a glass in the glass yarns is 0.0010 or less, a bending rigidity (gf-cm/cm) per warp direction basis weight (g/m2) of the glass cloth is in the range of 0.0002 to 0.0014, and a dissipation factor of the glass cloth at 10 GHz is in the range of greater than 0 and 0.0010 or less.
Abstract: An overall process of providing information needed for a circular loom to produce articles of clothing on demand is disclosed. Initially body data or measurements are generated for a person by scanning with a camera or other image capture device or estimated based on user-input body parameters. Measurements are extracted from the body data which are then processed with linear regression and other parameter extraction techniques. The extracted measurements are then processed. The resulting panel shapes are used to automatically produce the article of clothing as woven output with the loom.
Type:
Application
Filed:
January 31, 2023
Publication date:
May 8, 2025
Applicant:
UNSPUN, INC
Inventors:
Stephen E. THOMA, Oras PHONGPANANGAM, Kevin P. MARTIN, Brian J. GORMLEY
Abstract: The present application relates to a clothing processing apparatus comprising: a tub including a tub body which provides a space in which water is stored, and a tub inlet which is provided to pass through one surface of the tub body; a drum including a drum body which is rotatably provided within the tub and in which clothes are stored, and a drum inlet which is provided to pass through one surface of the drum body and communicates with the tub inlet; a water supply unit which supplies water into the tub; a detergent supply unit which supplies a detergent into the tub; and a sensor which is provided to sense a capacitance change in the tub body and can sense at least one of the height of foam generated in the tub body and the height of water stored in the tub body.
Abstract: Embodiments herein generally relate to a fabric cutting device with a modular cutting assembly, and methods of assembling and operating thereof. In some examples, the fabric cutting device, comprises a pair of modular cutting assemblies for cutting fabric into one or more fabric strips, each assembly comprising a removable and reconfigurable stacked arrangement of cutting and spacer component sets; and a driving assembly coupled to the pair of modular cutting assemblies, and configured to cause rotation of the cutting assemblies to cut the fabric.
Type:
Application
Filed:
October 16, 2024
Publication date:
May 8, 2025
Inventors:
Jonathan Ryan Prill, Mark Lawrence Sheehan, Nasim Morawej
Abstract: A road surface evaluation apparatus includes a microprocessor configured to perform: acquiring driving information of a vehicle which is traveling including acceleration information, speed information, and position information of the vehicle, acquiring map information including information on a road on which the vehicle travels, acquiring weather information including information relating to weather; deriving a road surface roughness value representing roughness of a road surface on which the vehicle travels based on the driving information of the vehicle estimating the weather in a section where the vehicle has traveled based on the weather information to correct the road surface roughness value based on the estimation result; and outputting the road surface roughness value in association with the information on the road.
Abstract: A powered conveying surface bucket assembly for attachment to a vehicle, includes a bucket assembly; a conveyor system that extends at least a portion of a width of a bucket bottom wall of the bucket assembly; and a power system connected to the conveyor system to rotate the conveyor system with respect to the bucket bottom wall.
Abstract: A ligature mitigation drain apparatus and method is disclosed which comprises an outer ring, an inner ring, and a termination ring. The outer ring surrounds the inner ring, and the inner ring surrounds the termination ring. The outer ring further comprises at least two extensions extending toward and touching the inside ring and the inner ring further comprises at least two extensions extending toward and touching the termination ring.
Type:
Application
Filed:
January 11, 2025
Publication date:
May 8, 2025
Inventors:
Mark Ciepluch, Michelle Kartman, Lucas Boesel
Abstract: Systems and methods are described herein for manufacturing and using roofing membranes that are faster and easier to install than conventional adhesive-only membrane materials. In some embodiments, membrane materials are surface treated using a plasma flow, e.g., a blown-arc plasma flow, atmospheric plasma, corona plasma, or from portable plasma units, generated by passing a compressed plasma-generating gas through an electrical current to form the plasma-treated roofing membrane. The plasma treatments described herein may be applied as part of the manufacturing process, or in-situ at the site of roof installation. In some embodiments, membrane materials have surface chemistries, roughnesses and other surface characteristics that yield desired adhesion properties.
Type:
Application
Filed:
January 6, 2025
Publication date:
May 8, 2025
Inventors:
Lingtao Yu, Linlin Xing, Daniel E. Boss
Abstract: Disclosed herein are gutter guard systems arranged to efficiently manage the flow of rainwater across the system and prevent the matting of debris onto the system. In one exemplary embodiment, a gutter guard system includes a main body and a screen covering the main body. The gutter guard assembly further includes a front receiver and a rear receiver that secure the screen to the main body. The screen includes at least one feature arranged to manage the flowrate of rainwater across the gutter guard system. In one example, the feature is a raised rounded area that slows the flowrate of rainwater across the gutter guard system. In another embodiment, the screen includes an upwardly angled section and a transition section. Once assembled and installed, the transition section and optionally the angled section forms hurdles that slows the flowrate of rainwater across the gutter guard system.
Abstract: The present invention relates to a novel one-piece bathroom rug or floor covering designed to accommodate the floor area near fixtures in a bathroom. The bathroom rug features a toilet rug portion for covering surface area in front of a toilet bowl, a shower rug portion for covering surface area in front of the shower or tub and a sink basin rug portion for covering surface area below and in front of a sink. The toilet rug portion includes a cut-out contoured to a toilet base and adapted to receive therein the toilet base. The bathroom rug is a multi-layered structure and absorbs water, increases comfort and safety, and improves the overall aesthetic of a bathroom.
Abstract: An apparatus includes a platform having a first end and a second end and a handle. The apparatus includes a first leg assembly rotatably attached to the platform in proximity to the first end. The apparatus includes a second leg assembly attentively attached to the platform in proximity to the second end. When the first and second leg assemblies are essentially perpendicular to the platform, the apparatus is in a use state and the user is able to stand on the platform and be supported by the first and second leg assemblies. When the apparatus is in the use state, the user is able to pick up the apparatus by the handle with only one of the hands without tipping the apparatus. A method for a user with hands to stand on an apparatus.
Type:
Application
Filed:
January 13, 2025
Publication date:
May 8, 2025
Inventors:
Steve Woodward, Joe Dangrow, Shannon Lessner
Abstract: A locking actuator for automotive applications which is equipped with a housing, further equipped with an electromotive drive arranged in the housing, and equipped with a locking element guided outward through an opening in the housing. The electromotive drive has at least one electric motor, an output element, an output gear meshing with the output element, and a gearwheel meshing with the output gear in order to act upon the locking element. According to the invention, a manually actuable emergency actuation element engaging the gearwheel is provided.
Abstract: A compact downhole tool, such as a frac plug, may include a single frustoconical member and a single set of slips. The slips may further include an internal button that engages with the frustoconical member. Various elements in the downhole tool may be dissolvable or degradable.
Type:
Application
Filed:
January 9, 2025
Publication date:
May 8, 2025
Applicant:
NINE DOWNHOLE TECHNOLOGIES, LLC
Inventors:
Donald Roy Greenlee, Donald Jonathan Greenlee