Patents Assigned to Advanced Industrial Science and Technology
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Patent number: 10256288Abstract: A nonvolatile memory device can be manufactured without adding any major modification to a structure and component elements of a conventional MOS type silicon device, and is realized without deteriorating an electrical characteristic of an insulating-film/semiconductor interface and on the basis of a new operational principle. The nonvolatile memory device 10 is a capacitor configured by a metal electrode 16, two kinds of insulating films 13 and 15, and an interface structure of an insulating film 12/semiconductor 11, and has a MIS structure of providing a monolayer-level O-M1-O layer 14 to an insulating-film 13/semiconductor 15 interface. The nonvolatile memory device 10 realizes a nonvolatile information storage operation by changing strength or polarities of interface dipoles induced near the O-M1-O layer 14 through electrical stimulation applied from a gate electrode.Type: GrantFiled: August 25, 2016Date of Patent: April 9, 2019Assignee: National Institute of Advanced Industrial Science and TechnologyInventor: Noriyuki Miyata
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Patent number: 10247733Abstract: It is intended to find a highly specific epithelial ovarian cancer marker and to provide an antibody capable of specifically recognizing and detecting the marker or a fragment of the antibody. The present invention provides an anti-?1,6-N-acetylglucosaminyltransferase 5B antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase ?1,6-N-acetylglucosaminyltransferase 5B as an epithelial ovarian cancer marker. The antibody recognizes, as an epitope, a part of a polypeptide of the enzyme consisting of the amino acid sequence represented by SEQ ID NO: 1.Type: GrantFiled: July 26, 2012Date of Patent: April 2, 2019Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Maki Sogabe, Tomomi Kubota, Akira Togayachi, Yuzuru Ikehara, Hisashi Narimatsu, Hiromichi Sawaki, Hayao Nakanishi, Toru Nakanishi
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Publication number: 20190093253Abstract: A method for manufacturing a diamond substrate, including: a first step of preparing patterned diamond on a foundation surface, a second step of growing diamond from the patterned diamond prepared in the first step to form the diamond in a pattern gap of the patterned diamond prepared in the first step, a third step of removing the patterned diamond prepared in the first step to form a patterned diamond composed of the diamond formed in the second step, and a fourth step of growing diamond from the patterned diamond formed in the third step to form the diamond in a pattern gap of the patterned diamond formed in the third step. There can be provided a method for manufacturing a diamond substrate which can sufficiently suppress dislocation defects, a high-quality diamond substrate, and a freestanding diamond substrate.Type: ApplicationFiled: November 2, 2018Publication date: March 28, 2019Applicants: SHIN-ETSU CHEMICAL CO., LTD., National Institute of Advanced Industrial Science and Technology, NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITInventors: Hitoshi NOGUCHI, Shozo SHIRAI, Toshiharu MAKINO, Masahiko OGURA, Hiromitsu KATO, Hiroyuki KAWASHIMA, Daisuke KUWABARA, Satoshi YAMASAKI, Daisuke TAKEUCHI, Norio TOKUDA, Takao INOKUMA, Tsubasa MATSUMOTO
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Patent number: 10234370Abstract: To provide a particle size measuring device that enables simple in-line measurement of the particle size even in a case of nano-sized particles during dispersion. Provided is a particle size measuring device which measures the particle size of particles that perform Brownian motion in a dispersion medium.Type: GrantFiled: March 30, 2016Date of Patent: March 19, 2019Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Haruhisa Kato, Naoko Oouchi, Ayako Nakamura
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Publication number: 20190078053Abstract: Provided is a method of inducing cardiac progenitor cells or cardiomyocytes from pluripotent stem cells. The present invention provides a method for producing cardiac progenitor cells from pluripotent stem cells, comprising expressing Tbx6 in the pluripotent stem cells. Moreover, the present invention provides a method for producing cardiomyocytes from pluripotent stem cells, comprising: a step of inducing cardiac progenitor cells from pluripotent stem cells, comprising expressing a Tbx6 gene in the pluripotent stem cells; and a step of inducing cardiomyocytes from the cardiac progenitor cells induced in the above step, comprising suppressing the expression of the Tbx6 gene.Type: ApplicationFiled: March 7, 2017Publication date: March 14, 2019Applicants: Keio University, National Institute of Advanced Industrial Science and TechnologyInventors: Masaki IEDA, Taketaro SADAHIRO, Mari ISOMI, Naoki GOSHIMA
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Publication number: 20190071641Abstract: Provided is a method of inducing cardiac progenitor cells or cardiomyocytes from fibroblasts. The present invention provides a method for producing cardiac progenitor cells, comprising introducing one cardiac reprogramming factor into fibroblasts, or a method for producing cardiomyocytes, comprising introducing three cardiac reprogramming factors into fibroblasts.Type: ApplicationFiled: March 7, 2017Publication date: March 7, 2019Applicants: Keio University, National Institute of Advanced Industrial Science and TechnologyInventors: Masaki IEDA, Taketaro SADAHIRO, Mari ISOMI, Naoki GOSHIMA
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Publication number: 20190071684Abstract: The present invention provides information on a mutant xylose isomerase gene and a mutant protein with which it is possible to impart high xylose metabolic capacity to budding yeast. Also provided is a yeast strain having the mutant xylose isomerase gene. Additionally provided is an efficient method for producing a useful substance using the yeast strain. The present invention provides mutant Clostridium-phytofermentans-derived xylose isomerase (CpXI) having high xylose metabolic activity, the CpXI comprising an amino acid sequence corresponding to an amino acid sequence in which the number 63 threonine of SEQ ID NO: 11 of CpXI is substituted by isoleucine, lysine, glycine, or histidine and/or the number 162 valine is substituted by alanine.Type: ApplicationFiled: March 24, 2017Publication date: March 7, 2019Applicant: National Institute of Advanced Industrial Science and TechnologyInventors: Taisuke Seike, Kazuhiro Fujimori, Yosuke Kobayashi, Takehiko Sahara, Satoru Ohgiya, Yoichi Kamagata
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Patent number: 10216278Abstract: A system and method are disclosed in which in a conventional non-grounding man-machine interface having no reaction base on the human body and for giving the existence of a virtual object and the impact force of a collision to a person, a haptic sensation of a torque, a force and the like can be continuously presented in the same direction, which cannot be presented by only the physical characteristic of a haptic sensation presentation device. In a haptic presentation device, the rotation velocity of at least one rotator in the haptic presentation device is controlled by a control device, and a vibration, a force or a torque as the physical characteristic is controlled, so that the user is made to conceive various haptic information of the vibration, force, torque or the like.Type: GrantFiled: October 14, 2016Date of Patent: February 26, 2019Assignees: National Institute of Advanced Industrial Science and Technology, Miraisens, Inc.Inventors: Norio Nakamura, Yukio Fukui, Masataka Sakai
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Publication number: 20190049743Abstract: An optical amplifier includes a polarization splitter, a polarization rotator, first and second optical couplers, and first and second semiconductor optical amplifying devices. The TE polarized wave of light split by the polarization splitter is input to a first input port of the first optical coupler. The TM polarized wave of the split light is converted into a TE polarized wave by the polarization rotator to be input to a second input port of the first optical coupler. First light and second light output from a first output port and a second output port of the first optical coupler are amplified by the first semiconductor optical amplifying device and the second semiconductor optical amplifying device to be input to a first input port and a second input port of the second optical coupler, respectively. Third light is output from an output port of the second optical coupler.Type: ApplicationFiled: August 6, 2018Publication date: February 14, 2019Applicants: FUJITSU LIMITED, National Institute of Advanced Industrial Science and TechnologyInventors: Suguru AKIYAMA, Kazuhiro IKEDA, Takeshi MATSUMOTO, Hitoshi KAWASHIMA, Keijiro SUZUKI, Ken TANIZAWA
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Publication number: 20190051436Abstract: Provided is a new magnetic material with high magnetic stability, as well as a manufacturing method therefor, said magnetic material having a higher saturation magnetization than ferrite-based magnetic materials, and having a higher electrical resistivity than existing metal-based magnetic materials, thus solving problems such as that of eddy current loss. Ti-ferrite nanoparticles obtained through wet synthesis are reduced within hydrogen, and grains are allowed to grow while simultaneously using a phase separation phenomenon due to a disproportionation reaction to produce a magnetic material powder in which an ?-(Fe, Ti) phase and a Ti-enriched phase are nano-dispersed. This powder is then sintered to produce a solid magnetic material.Type: ApplicationFiled: March 24, 2017Publication date: February 14, 2019Applicant: National Institute of Advanced Industrial Science and TechnologyInventors: Nobuyoshi Imaoka, Kimihiro Ozaki
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Publication number: 20190049399Abstract: A dielectric constant microscope to observe a shape of a micro organic specimen includes first and second insulating films that are disposed to oppose each other such that the organic specimen along with the solution is interposed therebetween, and application-side conductive films P1 to Pn (where n is an integer greater than 1). The application-side conductive films are separated from each other on an outward surface of the first insulating film. Additionally, the dielectric constant microscope includes measurement-side conductive films p1 to pm (where m is an integer greater than 1) that are separated from each other on an outward surface of the second insulating film.Type: ApplicationFiled: March 7, 2017Publication date: February 14, 2019Applicant: National Institute of Advanced Industrial Science and TechnologyInventor: Toshihiko OGURA
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Publication number: 20190029953Abstract: The object of the present invention is to provide a therapeutic agent illustrating an immediate and sustained effect on chronic intractable external otitis. The present invention provide a composition, pharmaceutical composition, food and feed for preventing and/or treating chronic intractable external otitis, each comprising interferon-? (IFN?) as an active ingredient. Orally administering the composition of the present invention can provide inhibition, alleviation, treatment and prevention for chronic intractable external otitis. According to the present invention, IFN? can give a sufficient effect even when administered in a very small amount.Type: ApplicationFiled: January 12, 2016Publication date: January 31, 2019Applicants: National Institute of Advanced Industrial Science and Technology, Hokusan Co. LtdInventors: Akira Ito, Takeshi Matsumura, Toru Gotanda, Noriko Tabayashi, Noriko Itchoda, Takashi Aoki, Uiko Kagaya
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Patent number: 10189203Abstract: Provided is a method for forming a pattern of polyimide that is simpler and is more excellent in the pattern shape and in the dimensional accuracy in comparison with the conventional techniques of patterning polyimide, such as photolithography and laser processing. In a method for forming a micropattern of polyimide, which includes using as polyimide a solvent-soluble polyimide resin composition that is photosensitive and is moldable at a temperature of less than or equal to a glass-transition temperature; patterning the composition using thermal imprinting; and thermally curing the composition, ultraviolet irradiation is performed after the composition is released from a mold after a molding step.Type: GrantFiled: August 29, 2014Date of Patent: January 29, 2019Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Sung Won Youn, Sang Cheon Park, Hiroshi Hiroshima, Hideki Takagi, Kenta Suzuki
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Publication number: 20190029090Abstract: In an imaging using fluorescence, for example, it is difficult to perform a surgery while a tumor part is directly confirmed in a bright operating room. A light irradiation system according to an embodiment performs an open/close control of a first eyesight of a first eyesight restrictor and a second eyesight of a second eyesight restrictor at every predetermined time interval. The light irradiation system controls a light-on of a light such that opening and closing timings of the first eyesight match a timing of a light amount control of a surgery lamp and opening and closing timings of the second eyesight match a timing of a light amount control of a fluorescence excitation light source (see FIG. 1).Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Applicants: National Institute of Advanced Industrial Science and Technology, Nikon CorporationInventors: Yuzuru Ikehara, Susumu Makinouchi, Shunji Watanabe, Tetsuro Ishikawa
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Publication number: 20190023051Abstract: Provided are a printing plate, a method for manufacturing a printing plate, and a printing method that allow for high-resolution printing and efficient use of printing ink. The printing plate has an image area and a non-image area. The image area is formed by a layer containing silicone rubber. The non-image area is formed by a layer containing a fluorine compound on a surface of the layer containing silicone rubber. The height difference between a surface of the image area and a surface of the non-image area is 100 nm or less. The method for manufacturing a printing plate has the steps of subjecting a region of a surface of a layer containing silicone rubber to chemical treatment or physical treatment to form hydroxyl groups, the region being a region that becomes a non-image area; and binding a fluorine compound to the region, having the hydroxyl groups formed thereon, of the surface of the layer containing silicone rubber to form a non-image area.Type: ApplicationFiled: September 10, 2018Publication date: January 24, 2019Applicants: FUJIFILM Corporation, National Institute of Advanced Industrial Science and TechnologyInventors: Yasuyuki KUSAKA, Kenichi KODAMA
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Publication number: 20190023050Abstract: Provided are a printing plate and a printing method that allow for high-resolution printing and efficient use of printing ink. The printing plate has an image area and a non-image area. The image area of the printing plate is a recessed area formed by a layer containing silicone rubber. The non-image area is a raised area formed by a layer containing a fluorine compound on a surface of the layer containing silicone rubber. The height difference between a surface of the image area and a surface of the non-image area of the printing plate is from more than 0.1 ?m to 10 ?m. The printing method includes an ink-applying step of applying a printing ink to an image area of a printing plate and a transfer step of transferring the printing ink from the image area to a substrate.Type: ApplicationFiled: September 10, 2018Publication date: January 24, 2019Applicants: FUJIFILM Corporation, National Institute of Advanced Industrial Science and TechnologyInventors: Yasuyuki KUSAKA, Kouki TAKAHASHI
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Publication number: 20190016933Abstract: When conventional photo-reactive compounds are to be liquefied with the application of light, liquefaction thereof is time-consuming due to poor sensitivity to ultraviolet light. In the case of conventional photo-reactive compounds, disadvantageously, light does not penetrate through layers to be adhered to each other when such layers are thick. Thus, peeling is not sufficiently performed. Accordingly, it is an object of the present invention to overcome such drawbacks of conventional photo-reactive compounds and provide a photo-reactive adhesive agent exhibiting high sensitivity to light for fluidization and capable of easy peeling.Type: ApplicationFiled: January 4, 2017Publication date: January 17, 2019Applicant: National Institute of Advanced Industrial Science and TechnologyInventors: Haruhisa AKIYAMA, Hideyuki KIHARA, Aishi YAMASHITA
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Patent number: 10180382Abstract: A linear elastic modulus measurement method and a linear elastic modulus measurement device can reduce external disturbances such as oscillation and electrical noise, and accurately and stably measure the linear elastic modulus of a linear elastic body even in the case where damping due to viscous stress is large. The measurement device computes the oscillation velocity (dx/dt) of an oscillator from the displacement of the oscillator brought into contact with the linear elastic body, and multiplies dx/dt by a linear velocity feedback gain to generate a feedback control signal. The measurement device applies, to the oscillator, a force proportional to the oscillation velocity of the oscillator by the feedback control signal, to cause the oscillator to self-oscillate. The measurement device computes the linear elastic modulus of the linear elastic body from the frequency when the self-oscillation of the oscillator is detected and the mass of the oscillator.Type: GrantFiled: January 25, 2013Date of Patent: January 15, 2019Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Masaharu Kuroda, Yasuyuki Yamamoto, Hiroshi Yabuno
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Patent number: 10164259Abstract: This binder for use in a positive electrode for a lithium ion secondary battery contains a copolymer of both vinyl alcohol and an alkali-metal-neutralized ethylenically unsaturated carboxylic acid.Type: GrantFiled: October 1, 2013Date of Patent: December 25, 2018Assignees: National Institute of Advanced Industrial Science and Technology, Sumitomo Seika Chemicals Co., Ltd.Inventors: Takashi Mukai, Masanori Morishita, Tetsuo Sakai, Yuji Kinpara, Junichi Fujishige, Nobutaka Fujimoto, Shuichi Karashima
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Patent number: D837888Type: GrantFiled: January 5, 2017Date of Patent: January 8, 2019Assignee: National Institute of Advanced Industrial Science and TechnologyInventor: Junji Ohyama