Patents Assigned to Advanced Research and Technology
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Patent number: 6281200Abstract: The inventors have cloned and expressed the chemokine-like genes from MCV type 1 and the closely related MCV type 2 in order to determine a potential role for these proteins in the viral life cycle. These are the first viral chemokines that have been shown to antagonize the chemotactic activity of human chemokines and the first viral chemokines that have been shown to have inhibitory activity on human hematopoietic progenitor cells. Methods and compositions for exploiting these proteins are disclosed herein.Type: GrantFiled: August 13, 1998Date of Patent: August 28, 2001Assignee: Advanced Research & Technology InstituteInventors: Kenneth H. Fife, Michell D. Krathwohl, Robert Hromas, Darron R. Brown, Hal E. Broxmeyer
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Patent number: 6267717Abstract: An apparatus for treating a body structure with radiation and a method for using the same. The apparatus comprising a concentrator for receiving a solution comprising a radioactive material and for increasing the concentration of the radioactive material in solution; a calibrator operatively associated with the concentrator for measuring a level of radiation associated with the radioactive material; and a delivery unit for transferring the solution directly from the apparatus to a balloon catheter.Type: GrantFiled: March 31, 1998Date of Patent: July 31, 2001Assignee: Advanced Research & Technology InstituteInventors: Hans-Peter Stoll, Keith L. March, Gary Hutchins
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Patent number: 6255347Abstract: The present invention relates generally to the fields of chemotherapeutic treatments. More particularly, it concerns the use of ibuprofen, a non-steroid anti-inflammatory drug, in the treatments of disease. More particularly, it has been discovered that the R-enantiomer of ibuprofen, previously thought to be inactive, may be used as an antineoplastic agent and also in the prophylactic and therapeutic treatment of Alzheimer's and Alzheimer's related diseases.Type: GrantFiled: June 20, 1997Date of Patent: July 3, 2001Assignee: Advanced Research and Technology InstituteInventors: Qian Xiaotao, Stephen D. Hall
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Patent number: 6252048Abstract: Described are DNA-repair fusion proteins of multiple, complementary DNA repair proteins and having the activity of each protein, and related polynucleotides and vectors. The proteins, when expressed in cells, e.g., hematopoietic cells, increase the survival rate of the cells when contacted with chemotherapeutic agents. Also described are transgenic animal models wherein these proteins are expressed in essentially all cells of the animal. Such animal models are useful for instance in testing chemotherapeutic agents.Type: GrantFiled: April 3, 2000Date of Patent: June 26, 2001Assignee: Advanced Research and Technology InstituteInventors: Mark Kelley, David Williams
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Patent number: 6251067Abstract: A method and apparatus for allowing a male with erectile dysfunction to participate in normal coitus is disclosed. A two piece device forms a male erectile prosthesis which can be utilized to allow a man with erectile dysfunction to participate in sexual activity. The prosthesis includes a penile wrap for providing rigidity to the penis and a thrust plate which is operable to provide resistance against any backward movement of the penis.Type: GrantFiled: June 23, 1999Date of Patent: June 26, 2001Assignee: Advanced Research & Technology InstituteInventor: Alfred Strickholm
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Patent number: 6235496Abstract: The invention relates generally to compositions of and methods for obtaining mu opioid receptor polypeptides. The invention relates as well to polynucleotides encoding mu opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant opioid receptor polypeptides. The invention includes as well, methods for using the isolated, recombinant receptor polypeptide in assays designed to select and improve substances capable of interacting with mu opioid receptor polypeptides for use in diagnostic, drug design and therapeutic applications.Type: GrantFiled: September 13, 1993Date of Patent: May 22, 2001Assignee: Advanced Research & Technology InstituteInventor: Lei Yu
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Patent number: 6233478Abstract: Apparatus and method are provided for constructing image slices through a selected object undergoing a cyclic motion wherein a scanner is used for collecting image data associated with the selected object. A probe is provided for detecting a signal from the selected object, the signal being indicative of the cyclic motion of the object. The scanner and the probe are operatively connected with a controller. The controller receives the signal from the probe and generates therefrom a command for enabling the scanner to collect image data for producing one or more image slices through the selected object with minimized radiation exposure and data acquisition time.Type: GrantFiled: September 28, 1998Date of Patent: May 15, 2001Assignee: Advanced Research & Technology InstituteInventor: Pingyu Liu
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Patent number: 6225075Abstract: The invention provides an isolated and purified nucleic acid molecule encoding a Candida albicans sterol methyltransferase (ERG6). Also provided is a C. albicans strain or isolate that has reduced levels of sterol methyltransferase as a result of the disruption of at least one sterol methyltransferase gene. Preferred isolates are more susceptible to a number of sterol synthesis and metabolic inhibitors relative to wild type isolates. Further provided are methods to identify sterol methyltransferase inhibitors and methods to screen for antifungals or metabolic inhibitors which are not normally permeable to the fungal cell.Type: GrantFiled: March 13, 1998Date of Patent: May 1, 2001Assignee: Advanced Research and Technology Institute, Inc.Inventor: Martin Bard
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Patent number: 6213976Abstract: A guide catheter includes a body and a centering mechanism. The body has an elongatable section and a lumen with a stop. The centering mechanism is a plurality of bias elements that forms a self-expanding basket attached to the body so that the elongatable section is within the basket. A straightening catheter engages the stop to stretch the elongatable section and to flatten the basket against the body. The guide catheter can be inserted into a vessel and the centering mechanism can be positioned at a desired treatment site by means of an over-the-wire guidewire system. The straightening catheter can be removed to allow the self-expanding basket to center the guide catheter in the vessel. A dosing device can then be inserted into the guide catheter and located at the centered basket to deliver the brachytherapy to prevent restenosis.Type: GrantFiled: July 22, 1999Date of Patent: April 10, 2001Assignee: Advanced Research and Technology Institute, Inc.Inventor: Scott O. Trerotola
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Patent number: 6200302Abstract: Devices and methods are disclosed for the percutaneous administration of a composition to a desired in vivo location. The composition comprises a biologically active substance and a pharmaceutically acceptable carrier. The pharmaceutically acceptable carrier is preferably non-solid and a polymer, which is preferably capable of being transformed into a gel, thus allowing timed-released delivery of the substance. A preferred use for this invention is to provide local delivery of biologically active substances for the prevention of restenosis following angioplasty or other blood vessel injury.Type: GrantFiled: March 17, 1999Date of Patent: March 13, 2001Assignee: Advanced Research and Technology Institute, Inc.Inventor: Matthew S. Johnson
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Patent number: 6190661Abstract: Disclosed are methods and compositions for identifying, monitoring and treating premalignant and malignant conditions in a human subject. The present invention further discloses methods and compositions for determining cells undergoing apoptosis, and for increasing the efficacy of a cancer therapy. The methods involve the use of apurinic/apyrimidinic endonuclease (APE), independently, as a marker for (pre)malignant conditions and for apoptosis. Also described are polyclonal antibody preparations for use in methods for detecting APE and methods for modulating expression susceptibility of cells to apoptosis.Type: GrantFiled: June 18, 1999Date of Patent: February 20, 2001Assignee: Advanced Research & Technology InstituteInventors: Mark R. Kelley, John Duquid, John Eble
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Patent number: 6187044Abstract: Compositions and methods are disclosed for filling prostheses for implantation into human soft tissue. The compositions comprise at least one nonionic surfactant, such as a polysorbate, which can be provided to fill a physiologically compatible shell or containment sac of the prosthesis. The liquid compositions of the present invention have a relatively high viscosity and are quickly absorbed from body tissues, metabolized and excreted with no known adverse effect. The compositions can be injected into the physiologically compatible shell either before, during or after the surgical implantation procedure.Type: GrantFiled: January 7, 1998Date of Patent: February 13, 2001Assignee: Advanced Research and Technology Institute, Inc.Inventor: Barry L. Eppley
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Patent number: 6184435Abstract: Methods for screening for risk of Alzheimer's disease involve assaying for a guanine to thymine substitution at position 1924 of the gene encoding the human amyloid precursor protein. Also described are transgenic non-human mammals, especially transgenic mice, harboring an expressable gene sequence encoding human amyloid precursor protein having a phenyalanine for valine amino acid substitution in the transmembrane domain of the amyloid precursor protein.Type: GrantFiled: June 7, 1995Date of Patent: February 6, 2001Assignee: Advanced Research and Technology InstituteInventors: Merrill D. Benson, Jill Murrell, Martin Farlow, Bernardino Ghetti
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Patent number: 6132440Abstract: The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane. The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patient's skin is also disclosed.Type: GrantFiled: September 22, 1998Date of Patent: October 17, 2000Assignee: Advanced Research & Technology InstituteInventors: David Hathaway, Brian Patton, Keith March
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Patent number: 6120287Abstract: An orthodontic force measuring apparatus includes a dental replica which includes a first tooth replica and a second tooth replica. The first tooth replica is moveable relative to the second tooth replica. The apparatus also includes an orthodontic appliance secured to both the first tooth replica and the second tooth replica of the dental replica. The apparatus further includes a force measuring device operatively coupled to the first tooth replica. The force measuring device is configured so as to measure force exerted on the first tooth replica by the orthodontic appliance. A method of measuring orthodontic force is also disclosed.Type: GrantFiled: August 6, 1999Date of Patent: September 19, 2000Assignee: Advanced Research and Technology Institute, Inc.Inventor: Jie Chen
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Patent number: 6117988Abstract: Analogues of RNA and DNA compounds contain a neutral, stereoregular linking group based on replacement of the phosphoryl with a sulfonyl group. Precursors to the analogues are also described, as are methods for preparing the precursors and analogues.Type: GrantFiled: January 31, 1997Date of Patent: September 12, 2000Assignee: Advanced Research & Technology InstituteInventor: Theodore S. Widlanski
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Patent number: 6116070Abstract: Described are unique prosthesis systems including superplastically-formed prosthetic elements, and methods and an apparatus for forming such elements. A preferred dental prosthesis system includes at least two osseointegrated fixtures, abutments attached to the fixtures, a bar member interconnecting the abutments, and a prosthesis detachably connected to the bar member, wherein the prosthesis includes a superplastically-formed metal element having a surface conforming to the bar member and abutments, a resin denture base attached to the metal element, and artificial teeth mounted on the resin denture base. The preferred prosthetic components are prepared by superplastic forming under temperature conditions which are repeatedly cycled above and below the transformation temperature of the metal being formed.Type: GrantFiled: November 11, 1998Date of Patent: September 12, 2000Assignee: Advanced Research and Technology InstituteInventors: Yoshiki Oshida, Martin Thomas Barco, II
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Patent number: 6096300Abstract: The present invention provides purified and isolated chemokine protein, fragments and polypeptide analogs thereof, antibodies thereto, and materials and methods for the recombinant production thereof. These products are useful in therapeutics, such as the treatment of myeloproliferative diseases, as well as in diagnostic and medical imaging applications.Type: GrantFiled: November 14, 1997Date of Patent: August 1, 2000Assignee: Advanced Research and Technology InstituteInventor: Robert Hromas
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Patent number: 6090590Abstract: Non-template 3' nucleotide addition to a transcript is reduced by transcribing a transcript from a template comprising an ultimate and/or penultimate 5' ribose having a C'2 substituent such as methoxy, which reduces non-template 3' nucleotide addition to the transcript. The methods are shown to be applicable to a wide variety of polymerases, including Taq, T7 RNA polymerase, etc.Type: GrantFiled: August 10, 1999Date of Patent: July 18, 2000Assignees: The Regents of the University of California, Advanced Research and Technology, Inc.Inventor: C. Cheng Kao
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Patent number: 6080419Abstract: The present invention provides a method to prevent, inhibit, or reduce dental calculus deposits or formation on the teeth of a dental calculus forming animal comprising exposing the teeth to a food product comprising an acidulent amount of phosphoric acid, wherein said food product further comprises an amount of a polycarboxylic acid sequestering agent effective to prevent, inhibit, or reduce dental calculus deposits or formation. The present invention further provides the food products and the method of preparing the food products of said method.Type: GrantFiled: May 22, 1998Date of Patent: June 27, 2000Assignee: Advanced Research and Technology Institute, Inc.Inventor: George K. Stookey