Abstract: Devices and methods are disclosed for the percutaneous administration of a composition to a desired in vivo location. The composition comprises a biologically active substance and a pharmaceutically acceptable carrier. The pharmaceutically acceptable carrier is preferably non-solid and a polymer, which is preferably capable of being transformed into a gel, thus allowing timed-released delivery of the substance. A preferred use for this invention is to provide local delivery of biologically active substances for the prevention of restenosis following angioplasty or other blood vessel injury.
Type:
Grant
Filed:
March 17, 1999
Date of Patent:
March 13, 2001
Assignee:
Advanced Research and Technology Institute, Inc.
Abstract: Compositions and methods are disclosed for filling prostheses for implantation into human soft tissue. The compositions comprise at least one nonionic surfactant, such as a polysorbate, which can be provided to fill a physiologically compatible shell or containment sac of the prosthesis. The liquid compositions of the present invention have a relatively high viscosity and are quickly absorbed from body tissues, metabolized and excreted with no known adverse effect. The compositions can be injected into the physiologically compatible shell either before, during or after the surgical implantation procedure.
Type:
Grant
Filed:
January 7, 1998
Date of Patent:
February 13, 2001
Assignee:
Advanced Research and Technology Institute, Inc.
Abstract: Methods for screening for risk of Alzheimer's disease involve assaying for a guanine to thymine substitution at position 1924 of the gene encoding the human amyloid precursor protein. Also described are transgenic non-human mammals, especially transgenic mice, harboring an expressable gene sequence encoding human amyloid precursor protein having a phenyalanine for valine amino acid substitution in the transmembrane domain of the amyloid precursor protein.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
February 6, 2001
Assignee:
Advanced Research and Technology Institute
Inventors:
Merrill D. Benson, Jill Murrell, Martin Farlow, Bernardino Ghetti
Abstract: An orthodontic force measuring apparatus includes a dental replica which includes a first tooth replica and a second tooth replica. The first tooth replica is moveable relative to the second tooth replica. The apparatus also includes an orthodontic appliance secured to both the first tooth replica and the second tooth replica of the dental replica. The apparatus further includes a force measuring device operatively coupled to the first tooth replica. The force measuring device is configured so as to measure force exerted on the first tooth replica by the orthodontic appliance. A method of measuring orthodontic force is also disclosed.
Type:
Grant
Filed:
August 6, 1999
Date of Patent:
September 19, 2000
Assignee:
Advanced Research and Technology Institute, Inc.
Abstract: Described are unique prosthesis systems including superplastically-formed prosthetic elements, and methods and an apparatus for forming such elements. A preferred dental prosthesis system includes at least two osseointegrated fixtures, abutments attached to the fixtures, a bar member interconnecting the abutments, and a prosthesis detachably connected to the bar member, wherein the prosthesis includes a superplastically-formed metal element having a surface conforming to the bar member and abutments, a resin denture base attached to the metal element, and artificial teeth mounted on the resin denture base. The preferred prosthetic components are prepared by superplastic forming under temperature conditions which are repeatedly cycled above and below the transformation temperature of the metal being formed.
Type:
Grant
Filed:
November 11, 1998
Date of Patent:
September 12, 2000
Assignee:
Advanced Research and Technology Institute
Inventors:
Yoshiki Oshida, Martin Thomas Barco, II
Abstract: The present invention provides purified and isolated chemokine protein, fragments and polypeptide analogs thereof, antibodies thereto, and materials and methods for the recombinant production thereof. These products are useful in therapeutics, such as the treatment of myeloproliferative diseases, as well as in diagnostic and medical imaging applications.
Type:
Grant
Filed:
November 14, 1997
Date of Patent:
August 1, 2000
Assignee:
Advanced Research and Technology Institute
Abstract: Non-template 3' nucleotide addition to a transcript is reduced by transcribing a transcript from a template comprising an ultimate and/or penultimate 5' ribose having a C'2 substituent such as methoxy, which reduces non-template 3' nucleotide addition to the transcript. The methods are shown to be applicable to a wide variety of polymerases, including Taq, T7 RNA polymerase, etc.
Type:
Grant
Filed:
August 10, 1999
Date of Patent:
July 18, 2000
Assignees:
The Regents of the University of California, Advanced Research and Technology, Inc.
Abstract: The present invention provides a method to prevent, inhibit, or reduce dental calculus deposits or formation on the teeth of a dental calculus forming animal comprising exposing the teeth to a food product comprising an acidulent amount of phosphoric acid, wherein said food product further comprises an amount of a polycarboxylic acid sequestering agent effective to prevent, inhibit, or reduce dental calculus deposits or formation. The present invention further provides the food products and the method of preparing the food products of said method.
Type:
Grant
Filed:
May 22, 1998
Date of Patent:
June 27, 2000
Assignee:
Advanced Research and Technology Institute, Inc.
Abstract: Described are DNA-repair fusion proteins of multiple, complementary DNA repair proteins and having the activity of each protein, and related polynucleotides and vectors. The proteins, when expressed in cells, e.g., hematopoietic cells, increase the survival rate of the cells when contacted with chemotherapeutic agents. Also described are transgenic animal models wherein these proteins are expressed in essentially all cells of the animal. Such animal models are useful for instance in testing chemotherapeutic agents.
Type:
Grant
Filed:
October 24, 1997
Date of Patent:
April 4, 2000
Assignee:
Advanced Research and Technology Institute
Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
Type:
Grant
Filed:
May 1, 1997
Date of Patent:
October 12, 1999
Assignees:
Advanced Research and Technology Institute, Inc., The Board of Governors of Wayne State University, Purdue Reseach Foundation
Inventors:
Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
Abstract: Materials and methods for selectively adsorbing proteins are disclosed. Under the invention, controlled pore glass is treated with a polyelectrolyte layer which comprises at least one polymer having a cationic portion which is electrostatically attracted to the porous outer surface of the glass. The constituents of the polyelectrolyte are preferably selected to have an affinity for the predetermined protein to facilitate adsorption thereof on the polyelectrolyte treated glass. Advantageously, the materials of the present invention can be utilized to immobilize enzymes and also to separate proteins from other components in a medium.
Abstract: Devices and methods are disclosed for the percutaneous administration of a composition to a desired in vivo location. The composition comprises a biologically active substance and a pharmaceutically acceptable carrier. The pharmaceutically acceptable carrier is preferably non-solid and a polymer, which is preferably capable of being transformed into a gel, thus allowing timed-released delivery of the substance. A preferred use for this invention is to provide local delivery of biologically active substances for the prevention of restenosis following angioplasty or other blood vessel injury.
Type:
Grant
Filed:
March 13, 1997
Date of Patent:
April 13, 1999
Assignee:
Advanced Research And Technology Institute, Inc.
Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
Type:
Grant
Filed:
June 13, 1997
Date of Patent:
December 15, 1998
Assignee:
Advanced Research and Technology Institute, Inc.
Inventors:
Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
Abstract: Described are unique preferred enzyme coacervate compositions and their use in catalyzing the reaction of substrates to which the enzyme is specific. Preferred coacervates of the invention are complex coacervates formed by complexing enzymes with polyelectrolytes.
Type:
Grant
Filed:
June 21, 1994
Date of Patent:
November 10, 1998
Assignee:
Advanced Research and Technology Institute, Inc.
Inventors:
Paul L. Dubin, Barry B. Muhoberac, Jiulin Xia
Abstract: There is disclosed a method for increasing retinal and optic nerve head blood velocity by topical application of carbonic anhydrase inhibitors to the eye.
Type:
Grant
Filed:
May 22, 1995
Date of Patent:
August 4, 1998
Assignee:
Advanced Research and Technology Institute