Abstract: A method of diagnosing patients suspected of having a neurological disorder is disclosed and includes monitoring movement of a patient in order to obtain movement data that is representative of the movement of the patient. Another step of the method includes processing the movement data in order to obtain an input pattern that is representative of the movement data. The method also includes the step of processing the input pattern with a computational intelligence system that has been trained to classify movement based upon a predetermined group of neurological disorder classifications. Furthermore, the method includes generating with the computational intelligence system an output that is indicative of an appropriate neurological disorder classification for the patient. An analysis system for diagnosing patients suspected of having a neurological disorder is also disclosed.

Abstract: An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. In one embodiment, the ion source includes a molecule separation instrument operable to separate ions in time according to a molecular characteristic such as ion retention time. The resultant instrument is thus operable to provide molecular information separated in time as functions of retention time, ion mobility and ion mass/charge. In another embodiment, the ion separation instrument includes first and second ion mobility instruments disposed in a cascade arrangement between the ion source and mass spectrometer, wherein the two ion mobility instruments are operable to separate ions in time each according to different ion mobility functions.

Abstract: A method and apparatus for prediction of system reliability is disclosed. The method comprises the steps of: (a) identifying the minimal path set of components which must function for the system to function; (b) constructing a minimal path set matrix by representing the minimal path sets as binary numbers in the matrix; (c) constructing a design matrix from OR operations on sets of columns of the minimal path set matrix whose results are appended to the original minimal path set matrix; (d) constructing a vector of ones having signs related to the position in the vector; and (e) calculating the system reliability from the design matrix, vector of ones and the reliabilities of each of the components of the system. The method of the present invention also determines the structure function of the system from the design matrix, vector of ones, and the states of the components of the system. The apparatus for performing the method of the present invention comprises a programmable processor.

Abstract: The present invention relates to an apparatus and method for voxelizing geometric and volumetric models of objects in 3D space, i.e. converting these 3D models into a voxel-based volume representation. Based on an unconventional way of using the 3D graphics hardware in modern graphics workstations, the present invention generates slices of the model as frame buffer images, and then stores the slices in a 3D texture memory for interactive volume rendering. Since most of the computation is carried out directly by hardware, the voxelization algorithms of the present invention are much faster than existing algorithms, and are able to achieve interactive volume rendering and manipulation of complex 3D scenes consisting of intermixed geometric models and sampled volume data sets (e.g. CT and MRI scans).

Abstract: The present invention relates to the use of collagen and MHC-like compounds to down regulate immune responses. Methods for administration of such compounds that induce immune tolerance are described. The invention is important in the context of allograft rejection, transplantation, graft rejection, pleural disease and immunotolerance.

Abstract: The invention relates generally to compositions of and methods for obtaining mu opioid receptor polypeptides. The invention relates as well to polynucleotides encoding mu opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant opioid receptor polypeptides. The invention includes as well, methods for using the isolated, recombinant receptor polypeptide in assays designed to select and improve substances capable of interacting with mu opioid receptor polypeptides for use in diagnostic, drug design and therapeutic applications.

Abstract: The invention includes an isolated bacterium and a consortium of microorganisms including an isolated bacterium of the invention, which is capable of utilizing as a sole carbon source a polychlorinated biphenyl. The invention also includes a recombinant microorganism, such as a bacterium, a yeast or a bacteriophage, transfected with nucleic acid from an isolated bacterium of the invention, which is capable of utilizing as a sole carbon source a polychlorinated biphenyl. The invention also includes an isolated bacterium, which is capable of utilizing as a sole carbon source a chlorobenzoate. In addition, the invention includes an isolated nucleic acid and recombinant enzymes useful in the degradation of a polychlorinated biphenyl. The invention also includes methods for the bioremediation or enhancement of the bioremediation of a PCB-contaminated environment using the bacteria or microorganisms of the invention.

Abstract: A multi-channel combustion device is provided. The device includes an inlet port, at least one radially partitioned inlet zone within the inlet port, and a plurality of circumferentially spaced combustion chambers in which deflagrative or detonative combustion occurs. The inlet port may have a plurality of separate, circumferentially partitioned inlet zones for supplying fuel and air mixtures to the inlet end of the combustion chambers. Each inlet zone is capable of introducing a different combustible mixture sequentially to a given combustion chamber as the chamber communicates with the inlet zones. The inlet of at least one combustion chamber is radially partitioned. At least one inlet zone is radially partitioned to permit radial stratification within the combustion chambers. The multi-channel combustion device may be a combustion wave rotor or a valved combustor.

Abstract: Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammalian LHRH comprises a hydrophilic N-acyl moiety, a dipolar moiety, a sulfonium moiety, a receptor-modifying moiety or a small polar moiety.

Abstract: A polymer-micelle complex is disclosed. The polymer-micelle complex includes a micelle having a negative charge. The negatively charged micelle is bound electrostatically to a polymer bearing a positive charge. The complex can be in turn electrostatically bound to a siliceous material so that the complex is immobilized on the siliceous material. In addition, a composition comprising a negatively charged micelle, a positively charged polymer, and an aqueous carrier is disclosed. The aqueous carrier can exhibit salinity. In the composition, the micelle and polymer can electrostatically interact so as to form a polymer-micelle complex (which can either be soluble in the aqueous carrier or in the form of a precipitate or coacervate), or, alternatively, the polymer and micelle can remain separate such that a complex is not formed therebetween.

Abstract: The present invention is directed to a recombinant adenovirus vector comprising two inverted terminal repeats (ITRs) each of which comprises a D-sequence having (i) from 5 to 15 native nucleotides and (ii) one or more deletions or substitutions therein.

Abstract: The present invention relates to mammalian Lhx3 nucleic acids and proteins encoded thereby. More specifically, the invention discloses novel porcine and human Lhx3 genes and isoforms thereof. The invention further relates to genomic mapping of the human Lhx3 coding region to the subtelomeric region of Chromosome 9. The invention also relates to methods and kits relating to the nucleic and amino acids encoding Lhx3 and uses therefor.

Abstract: The invention provides novel tetradentate enediyne ligands that are themselves thermally stable, yet react at about room temperature or slightly higher upon addition of metal ions or under photothermal conditions. In another aspect of the invention, a method of treating a disorder in a mammal comprising administering a therapeutically effective amount of a compound or composition is provided. In addition, the free ligand can be delivered to the mammal prior to complexation to metals, such that the ligand is exposed to a metal in the body and forms a metal complex in vivo. Furthermore, a metal complex of the invention can be administered to the mammal such that the complex exchanges the first metal center with another endogenous metal in order to form a second metal complex in vivo. The second metal complex is capable of forming a benzenoid diradical under physiological conditions and/or under photothermal conditions.

Abstract: A method of evolving a neural network that includes a plurality of processing elements interconnected by a plurality of weighted connections includes the step of obtaining a definition for the neural network by evolving a plurality of weights for the plurality of weighted connections, and evolving a plurality of activation function parameters associated with the plurality of processing elements. Another step of the method includes determining whether the definition for the neural network may be simplified based upon at least one activation function parameter of the plurality of activation function parameters. Yet another step of the method includes updating the definition for the neural network in response to determining that the definition for the neural network may be simplified. The method utilizes particle swarm optimization techniques to evolve the plurality of weights and the plurality of activation parameters.

Abstract: An aortic stent-graft model is provided. A hollow Y-frame is cast from polyurethane to form a core. After silicone aortic wall thickness and aneurysmal segments are applied to the contour of the core, the polyurethane core is removed to leave a hollow aortic model of silicone. Marking indicia are applied to the aortic model to effect selected dimensional measurements. The model can be utilized to calibrate the equipment of testing modalities such as contrast aortography (CA), spiral computed tomography (CT), magnetic resonance imaging (MRI), and intravascular ultrasonography (IVUS). Dimensional measurements from the marking indicia are compared to corresponding images of the model to detect any variation needed for calibration. An aortic stent-graft model can also be utilized to simulate introduction of a guidewire and catheter for deployment of a stent for repair of an abdominal aortic aneurysm (AAA).

Abstract: A system and method for case study instruction, comprising a host server, a database associated with the host server, at least one client computer, and a network operably connecting the host server and the client computer(s). Client computers are operated by learners or facilitators. Case studies according to the present invention comprise episodes. Each episode comprises events on timelines, character profiles, and, optionally, resources. Each event optionally comprises activities. Information about a case study is retrievably stored on the host server and in the database. Case studies are executed by one or more learners using a client computer to retrieve case study information through the network. Learners may be organized into teams. Where the network comprises a global computer network, learners may execute a case study from substantially any place in the world, at substantially any time of the day. Facilitators assist learners during execution of a case study.

Abstract: The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present invention provides a method of obtaining a luminescent quantum dot, a method of making a biomolecular conjugate thereof, and methods of using a biomolecular conjugate for ultrasensitive nonisotopic detection in vitro and in vivo.

Abstract: The invention provides antiviral compounds and compositions comprising a viral specific oligonucleotide. Also provided are methods to inhibit or treat viral infections with the compounds or compositions of the invention.

Abstract: An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. In one embodiment, the ion source includes a molecule separation instrument operable to separate ions in time according to a molecular characteristic such as ion retention time. The resultant instrument is thus operable to provide molecular information separated in time as functions of retention time, ion mobility and ion mass/charge. In another embodiment, the ion separation instrument includes first and second ion mobility instruments disposed in a cascade arrangement between the ion source and mass spectrometer, wherein the two ion mobility instruments are operable to separate ions in time each according to different ion mobility functions.

Abstract: Described are preferred myocardial grafts of skeletal myoblasts or cardiomyocytes, and cellular compositions and methods useful in obtaining the grafts. The myocardial grafts are stable and can be used, for example, to deliver recombinant proteins directly to the heart.