Abstract: A method of inducing apoptosis in apoptosis-inducible cancer cells by administering thereto an apoptosis-inducing effective amount of the compound benzamide riboside or salts thereof.
Type:
Grant
Filed:
May 22, 1997
Date of Patent:
May 11, 1999
Assignee:
Advanced Research & Technology Institute
Abstract: Devices and methods are disclosed for the percutaneous administration of a composition to a desired in vivo location. The composition comprises a biologically active substance and a pharmaceutically acceptable carrier. The pharmaceutically acceptable carrier is preferably non-solid and a polymer, which is preferably capable of being transformed into a gel, thus allowing timed-released delivery of the substance. A preferred use for this invention is to provide local delivery of biologically active substances for the prevention of restenosis following angioplasty or other blood vessel injury.
Type:
Grant
Filed:
March 13, 1997
Date of Patent:
April 13, 1999
Assignee:
Advanced Research And Technology Institute, Inc.
Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
Type:
Grant
Filed:
June 13, 1997
Date of Patent:
December 15, 1998
Assignee:
Advanced Research and Technology Institute, Inc.
Inventors:
Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
Abstract: Described are unique preferred enzyme coacervate compositions and their use in catalyzing the reaction of substrates to which the enzyme is specific. Preferred coacervates of the invention are complex coacervates formed by complexing enzymes with polyelectrolytes.
Type:
Grant
Filed:
June 21, 1994
Date of Patent:
November 10, 1998
Assignee:
Advanced Research and Technology Institute, Inc.
Inventors:
Paul L. Dubin, Barry B. Muhoberac, Jiulin Xia
Abstract: There is disclosed a method for increasing retinal and optic nerve head blood velocity by topical application of carbonic anhydrase inhibitors to the eye.
Type:
Grant
Filed:
May 22, 1995
Date of Patent:
August 4, 1998
Assignee:
Advanced Research and Technology Institute
Abstract: The present invention combines detection and identification of H. capsulatum in one step, eliminating the need to use DNA probes to react with PCR products in order to distinguish different types of fungi. The purpose of the invention is to provide compounds and methods to directly and specifically identify H. capsulatum in clinical specimens. Specifically, we provide a unique nucleotide sequence from the rRNA gene internal transcribed spacer region I (ITSI) of H. capsulatum and a PCR method which amplifies the unique sequence of H. capsulatum.
Type:
Grant
Filed:
March 8, 1995
Date of Patent:
December 2, 1997
Assignee:
Indiana University Advanced Research & Technology Institute