Abstract: The present invention relates to an induced pluripotent stem cell (iPSC) model of Noonan syndrome, a preparation method thereof, and uses to study of the pathogenesis of Noonan syndrome and a therapeutic agent screening method. Particularly, induced pluripotent stem cells from dermal fibroblasts of a Noonan syndrome-patient (NS-iPSCs) were generated, and differentiated into embryoid bodies (EBs), neural rosettes and neural cells. These iPSCs exhibited the normal morphology while showed reduced differentiation potency compare to control cell lines. NS-iPSCs were developed into embryoid bodies and neural rosettes by naturally and chemically directed differentiation. Interestingly, embryoid bodies and neural rosettes induced via chemically directed differentiation exhibited normal morphology and expressed ectoderm, neural rosettes and neural marker genes similar to normal cells.

Abstract: The present disclosure relates to a process for forming substantially dust-free additive granules, comprising the steps of. a) extruding or otherwise processing an additive or blend of additives to provide an substrate; b) cooling the substrate; c) conveying the substrate onto a profiled surface; and d) fragmenting the substrate into granules by means of a first rotating roller bearing on the substrate on the profiled surface.

Abstract: An exemplary sound processor 1) identifies at least one frequency bin, included in a plurality of frequency bins included in a frequency spectrum of an audio signal that is presented to a cochlear implant patient, that contains spectral energy above a modified spectral envelope, 2) identifies each frequency bin that contains spectral energy below the modified spectral envelope, 3) enhances the spectral energy contained in the at least one frequency bin identified as containing spectral energy above the modified spectral envelope, and 4) compresses the spectral energy contained in each frequency bin identified as containing spectral energy below the modified spectral envelope.

Abstract: Provided are an image restoration method and device. The method comprises: processing image blocks, which are initially registered, to acquire connection curves among the image blocks; constructing an ambient field of images to be restored by means of the connection curve; by minimizing energy of the connection curve in the ambient field, registering the image blocks; and performing image filling on the registered image blocks to acquire a restored image. The device comprises: a processing unit used for processing the image blocks, which are initially registered, to acquire the connection curve among the image blocks; an ambient field construction unit used for constructing the ambient field of the image to be restored by means of the connection curve; a registering unit used for registering the image blocks by minimizing the energy of the connection curve in the ambient field; and a filling unit used for performing image filling on the registered image blocks to acquire the restored image.

Abstract: Compositions useful for the selective removal of titanium nitride and/or photoresist etch residue materials relative to metal conducting, e.g., tungsten, and insulating materials from a microelectronic device having same thereon. The removal compositions contain at least one oxidant and one etchant, may contain various corrosion inhibitors to ensure selectivity.

Abstract: A time-temperature indicator (TTI) uses polymer hardening properties to “set” or retain indications of temperature history. The TTI includes a mesh layer affixed to a thermo-conductive adhesive layer and a photonic crystal patterned film affixed to the mesh layer. The photonic crystal shows a property of bandgap shift vs temperature and responds to a predetermined range of temperatures to provide a visible indication of the range of temperatures. A hardener pouch is affixed to one end of the mesh layer and releases hardener in response to an initiating event, so that the photonic crystal material responds to the hardener by presenting a fixed state.

Abstract: A fault detection apparatus coupling with a lamp module includes a current detector and a controlling module. The controlling module is coupled with the current detector. A fault detection method of a fault detection apparatus is also provided in the present disclose. The method includes providing a current detector to detect a current variation of one lamp of a lamp module in a period, and provide a controlling module to compare the current variation with a reference value stored in the controlling module to determine a state of the lamp module.

Abstract: Sensor coupled to the ultrasound probe provides position information related to an ultrasound imaging position in the object. A processor performs first registration between the medical image and the ultrasound image based on the anatomical feature in the ultrasound image and a medical image of the object acquired by imaging modality different from the ultrasound apparatus, obtains first registration information which provides a relationship between a coordinate system of the medical image and a coordinate system of the ultrasound image based on the first registration, performs second registration between the sensor and the medical image based on the position information and the first registration information, and obtains second registration information based on the second registration. A display may display a portion of the medical image corresponding to the ultrasound imaging position based on the second registration information. The medical image includes one of SPECT, PET, MR, PET-CT, and PET-MR image.

Abstract: In various embodiments, an illumination apparatus includes an air gap between a sub-assembly and a waveguide attached thereto at a plurality of discrete attachment points, as well as a bare-die light-emitting diode encapsulated by the waveguide.

Abstract: Provided are a plant derived plastic blend and a manufacturing method thereof in which high density polyethylene and polylactic acid are microscopically mixed to improve the mechanical properties of the plant derived plastic blend. The plant derived plastic blend comprises 10 wt % or more and 90 wt % or less of a plant derived polyethylene and 10 wt % or more and 90 wt % or less of a plant derived polylactic acid to achieve a total of 100 wt %, and further contains 1 wt % or more and 20 wt % or less of a compatibilizing agent. The manufacturing method of the plant derived plastic blend is carried out in a cylinder by applying a shear flow field and a stretching field and melt-kneading raw material containing the plant derived polyethylene, the polylactic acid and the compatibilizing agent.

Abstract: An emergency alert system, method and device are disclosed. The invention employs an emergency alert message, which directs end users to take some particular action like evacuating an identified geographic area. The invention further employs a geographic area message, which is based on a particular geographic area within which all persons should receive the emergency alert message. The invention utilizes an emergency alert enabled device that receives both the emergency alert message and the geographic area message. The emergency alert enabled device determines whether it is located within the geographic area of concern, and if so, presents the emergency alert message to the end user.

Abstract: A method of and apparatus for changing lesion classification data, the method including determining whether at least one mass is included in an image of an object, determining whether the at least one mass corresponds to a lesion by using first data including at least one first information, selecting a false negative (FN) mass which has been determined as not corresponding to the lesion among the at least one mass, based on a first input, and changing the first data to second data by using second information of the selected FN mass.

Abstract: Described herein are embodiments of systems, methods, apparatus and computer program products that accept student input and use a computer to process its mathematical meaning. The input can then be algorithmically tested for certain mathematical criteria. Those test results then allow the system to output immediate assessment, grades, and feedback.

Abstract: Disclosed are a method and system for dividing a plant organ point cloud. According to information about lamina point cloud blocks and stem point cloud blocks in a previous adjacent point cloud frame of a point cloud frame to be divided and a flatness feature of a data point of the point cloud frame to be divided, a point cloud of the point cloud frame to be divided is divided into lamina point cloud blocks and stem point cloud blocks; taking the adjacent point cloud frame as a reference to divide the point cloud frame facilitates the divided organ in maintaining the consistency of time and space between adjacent point cloud frames, and improves the accuracy of plant organ division.

Abstract: The present application describes embodiments of an interface for coupling flash memory and dynamic random access memory (DRAM) in a processing system. Some embodiments include a dedicated interface between a flash memory and DRAM. The dedicated interface is to provide access to the flash memory in response to instructions received over a DRAM interface between the DRAM and a processing device. Some embodiments of a method include accessing a flash memory via a dedicated interface between the flash memory and a dynamic random access memory (DRAM) in response to an instruction received over a DRAM interface between the DRAM and a processing device.

Abstract: A microfluidic device having a substrate with an electrically conductive element made using a conductive ink layer underlying a hydrophobic layer.

Abstract: The present invention relates to the formation of protein conjugates from proteins chemically modified for linkage to (1) anticancer drug pharmacophores, (2) ligands to biomarkers on cancer cell surfaces, (3) and/or another protein molecule. It provides and specifies new compositions, methods and combinations for tumor, and tumor vasculature targeting and cancer treatment.

Abstract: A microfluidic device having a substrate with an electrically conductive element made using a conductive ink layer underlying a hydrophobic layer.

Abstract: The present disclosure relates to a semiconductor substrate, a semiconductor module and a method for manufacturing the same. The semiconductor substrate includes a first dielectric structure, a second dielectric structure, a first patterned conductive layer and a second patterned conductive layer. The first dielectric structure has a first surface and a second surface opposite the first surface. The second dielectric structure has a third surface and a fourth surface opposite the third surface, where the fourth surface is adjacent to the first surface. The second dielectric structure defines a through hole extending from the third surface to the fourth surface. A cavity is defined by the through hole and the first dielectric structure. The first patterned conductive layer is disposed on the first surface of the first dielectric structure. The second patterned conductive layer is disposed on the second surface of the first dielectric structure.