Abstract: The invention provides exemplary methods and apparatus for dispensing liquids as an atomized spray. In one particularly preferably method, a liquid is dispensed as an atomized spray from a vibratable member having a front surface and a rear surface, with the member having at least one tapered hole between the surfaces for dispensing the liquid. The tapered hole has a larger cross-sectional area at the rear surface than at the front surface. The liquid is delivered from a supply container to the rear surface of the vibratable member in an amount sufficient to cover the hole with liquid. The vibratable member is then vibrated to dispense at least a portion of the liquid through the hole and from the front surface. Additional liquid is delivered from the supply container and to the rear surface in volumes that are substantially equal to the volumes dispensed.

Abstract: A fluid injection device for ejecting fluid droplets in response to electrical signals comprises an oscillating surface that has one or more tapered apertures, each aperture having a first and second opening. The first opening of each aperture is larger than the second opening. The first opening is in surface tension contact with the fluid to be ejected. The fluid interaction with the tapered aperture wall creates cycles of fluid compression and decompression inside the aperture, causing fluid to be drawn from the large opening and ejected out the small opening of the aperture. The device includes a fluid supply nozzle that transports fluid to the oscillating surface at the large opening of the apertures. A discharge valve controls the fluid supply. An electronic wave generator induces oscillation in the tapered aperture containing surface. The device is used to great advantage for fluid atomization and fluid spray.

Abstract: The invention provides methods and apparatus for nebulizing liquids. In one exemplary embodiment, an apparatus is provided which comprises a thin shell member having a front surface, a rear surface, and a plurality of apertures extending therebetween. The apertures are tapered to narrow from the rear surface to the front surface. A liquid supplier is further provided which delivers a predetermined unit volume of liquid to the rear surface. A vibrator vibrates the thin shell member to eject liquid droplets from the front surface of the thin shell member.

Abstract: A fluid injection device for ejecting fluid droplets in response to electrical signals comprises an oscillating surface that has one or more tapered apertures, each aperture having a first and second opening. The first opening of each aperture is larger than the second opening. The first opening is in surface tension contact with the fluid to be ejected. The fluid interaction with the tapered aperture wall creates cycles of fluid compression and decompression inside the aperture, causing fluid to be drawn from the large opening and ejected out the small opening of the aperture. The device includes a fluid supply nozzle that transports fluid to the oscillating surface at the large opening of the apertures. A discharge valve controls the fluid supply. An electronic wave generator induces oscillation in the tapered aperture containing surface. The device is used to great advantage for fluid atomization and fluid spray.

Abstract: An apparatus for delivery of a medicament to the respiratory system comprises a reservoir that is adapted to hold a liquid medicament that is to be delivered to a respiratory system. An aerosol generator is provided that is adapted to aerosolize the liquid medicament. A liquid supplier is used to deliver the liquid medicament from the reservoir to the aerosol generator. A connector is operably coupled to the aerosol generator and comprises a gas conduit having an inlet, and an outlet, and an aerosol supply conduit. The aerosol generator is configured to provide the aerosolized liquid medicament into the gas conduit through the aerosol supply conduit, and the gas conduit is adapted to pass gases to entrain the aerosolized liquid medicament.

Abstract: Apparatus and methods are provided for delivery of a medicament to a respiratory system. A reservoir is provided for a liquid medicament with the reservoir having a liquid medicament inlet port and a medicament outlet. An aerosol generator is provided at the medicament outlet of the reservoir for aerosolizing the liquid medicament. A connector entrains the aerosolized medicament from the aerosol generator with a gas.

Abstract: A nebulizer comprising an aerosol generator and a titration mechanism comprising a dosing mechanism, a screw assembly, a plunger and an actuator, wherein the dosing mechanism is rotatably mounted in the nebulizer and the plunger is mounted in the nebulizer to travel along a longitudinal axis substantially perpendicular to the plane of rotation of the dosing mechanism. The actuator is mounted to the nebulizer to travel in the direction of the longitudinal axis. The screw mechanism allows the rotation of the dosing mechanism to fix a variable distance of travel of the plunger based on the selected dose, without moving the plunger longitudinally. This allows the user to verify and if necessary correct the selected dose prior to any drug being released from the vial. Operation of the actuator causes longitudinal movement, through the screw mechanism, to the plunger.

Abstract: A nebule comprising at least one identification marker or label can be coupled an aerosol generator. The identification marker can be sensed by a sensing device on the aerosol generator so as to identify the liquid in the nebule to the controller of the aerosol generator. The controller of the aerosol generator can control the aerosol generator based on the information read from the identification marker.

Abstract: An aerosolization device comprises a housing having a mouthpiece, an aerosol generator, a flow sensor and a controller. The controller is configured to begin operation of the aerosol generator upon receipt of a signal from the flow sensor indicating that a threshold flow rate has been achieved by a user when inhaling a tidal breath through the mouthpiece, and to stop operation after the passage of an operation time period that is selected such that continuation of the tidal breath delivers substantially all of the aerosol to the lungs.

Abstract: Devices and methods for nebulizing a fluid are described. A replaceable fluid assembly may include a reservoir and a fluid cartridge. The reservoir may be detachable from the fluid cartridge and may be assembled by the prior prior to loading into the nebulizing device.

Abstract: A method for producing an aerosol generator utilizes a vibratable member having a plurality of apertures for producing liquid droplets upon vibration of the vibratable member. A support member is injection molded about the vibratable member, and a vibratable element is placed in vibrational communication with the vibratable member.

Abstract: A device for nebulizing a fluid is supplied which has a flow director. The flow director helps to direct any bubbles formed by the nebulizing device away from the nebulizing device. The nebulizing device has a vibrating element with apertures through which the fluid is dispensed. A dispensing chamber is defined between the flow director and the vibrating element. The dispensing chamber has an inlet which is positioned below an outlet so that bubbles naturally migrate up and away from the vibrating element.

Abstract: A method for aerosolizing a liquid comprises providing an aerosol generator having a plate with a plurality of apertures and a piezoelectric element to vibrate the plate. Liquid is supplied to the plate, and the piezoelectric element is energized to vibrate the plate at an initial frequency. The energy level is adjusted to vibrate the plate at its instantaneous resonant frequency during aerosolization of the liquid.

Abstract: A nebulizing device having two or more nebulizing elements. The nebulizing device may be used to deliver two or more fluids to the patient or may be used for enhanced fluid flow of a single fluid. The nebulizing elements are preferably vibrating elements with holes therein through which the fluid is expelled when the vibrating elements are vibrated.

Abstract: The invention provides exemplary methods and apparatus for dispensing liquids as an atomized spray. In one particularly preferably method, a liquid is dispensed as an atomized spray from a vibratable member having a front surface and a rear surface, with the member having at least one tapered hole between the surfaces for dispensing the liquid. The tapered hole has a larger cross-sectional area at the rear surface than at the front surface. The liquid is delivered from a supply container to the rear surface of the vibratable member in an amount sufficient to cover the hole with liquid. The vibratable member is then vibrated to dispense at least a portion of the liquid through the hole and from the front surface. Additional liquid is delivered from the supply container and to the rear surface in volumes that are substantially equal to the volumes dispensed.

Abstract: A method for controlling the supply of liquid to an aerosol generator comprises operating a liquid supply system to supply a liquid to a vibratable aperture plate of an aerosol generator which senses an amount of liquid adhering to the vibratable aperture plate, and controls operation of the liquid supply system to adjust the amount of liquid adhering to the vibratable aperture plate.

Abstract: An aerosol generator comprises a vibratable member having a front, a rear, an outer periphery and a plurality of apertures extending between the front and the rear. A support element is disposed about the outer periphery of the vibratable member, and a vibratable element is coupled to the support element. The vibratable element is configured to vibrate the vibratable member at ultrasonic frequencies. An isolating structure is coupled to the support element and is configured to couple the aerosol generator to a support structure. The isolating structure has a mechanical vibrational impedance that is sufficient to substantially vibrationally isolate the aerosol generator from the support structure.