Patents Assigned to Agency for Science, Technology and Research
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Patent number: 11701657Abstract: A column-based device and method for retrieving cells of interest were enclosed. The said device comprises a column comprising (i) an inner wall defining an inner chamber with inlet and outlet openings, (ii) a perforated plug disposed adjacent to the outlet opening, (iii) a sleeve insert with a channel and disposed within the chamber and adjacent to the perforated plug, and (iv) a filtering means housed within sleeve insert sandwiched between two sealing means. In particular, Tumor-derived endothelial cell clusters (TECCs) as characterized multiple nuclei, expression of endothelial markers (PECAM1, VWF and CDH5), and non-expression of leukocyte, megakaryocyte and platelets markers, may be retrieved using the disclosed device. Also encompassed are methods, reagents and kits for the diagnosis and prognosis of cancers by detecting for the presence of TECCs isolated from blood samples using the claimed device.Type: GrantFiled: October 22, 2020Date of Patent: July 18, 2023Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Jackie Y. Ying, Min-Han Tan, Yoke San Daniel Lee, Igor Cima, Yeon Joon Park, Wai Min Phyo
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Patent number: 11702425Abstract: The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.Type: GrantFiled: July 23, 2019Date of Patent: July 18, 2023Assignee: Agency for Science, Technology and ResearchInventor: Vikrant Arun Adsool
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Patent number: 11702541Abstract: Disclosed is a vesicular system comprising a surface with a vesicle immobilized thereon. The immobilized vesicle has a circumferential membrane of an amphiphilic polymer. The vesicle is coupled to a surface by means of a molecule with a non-polar moiety. The non-polar moiety comprises a main chain of 3 to about 30 carbon atoms and 0 to about 12 heteroatoms selected from Si, O, S, and Se. The molecule with the non-polar moiety is coupled to the surface via a covalent or non-covalent bond. A portion of the non-polar moiety is integrated in the circumferential membrane.Type: GrantFiled: June 28, 2019Date of Patent: July 18, 2023Assignee: Agency for Science, Technology and ResearchInventors: Madhavan Nallani, Eva-Kathrin Ehmoser, Madanagopal Kunnavakkam
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Patent number: 11697681Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYSITSGYSWH; a VHCDR2 having the amino acid sequence YIHYSGSTKYNPSLKS and a VHCDR3 having the amino acid sequence GSNYGFDY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLYSNDQKNYLA, a VLCDR2 having the amino acid sequence WASIRES, and a VLCDR3 having the amino acid sequence QQYYIYPLT.Type: GrantFiled: April 14, 2020Date of Patent: July 11, 2023Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Simeon Cua, Andre Boon Hwa Choo, Heng Liang Tan, Wey Jia Fong, Vanessa Mei Yee Ding, Leonard Wen Yan Leong
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Patent number: 11692116Abstract: The present disclosure relates to a phase change material (PCM) composition and a process for preparation thereof, wherein said composition comprising a phase change material, glass fibers and xanthan gum. In a preferred embodiment, the phase change material is water (or ice) and the g lass fibers are glass wool. The disclosure also relates to a stackable and sealable package enclosing the PCM composition. In a particular embodiment, the PCM composition is used to prepare a cold box that may be used in cold chain transportation.Type: GrantFiled: March 23, 2018Date of Patent: July 4, 2023Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Qiang Zhu, Tao Tang, Ying Ying Lesley Low, Xiang Yun Debbie Soo, Jian Wei Xu
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Patent number: 11690380Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.Type: GrantFiled: November 16, 2019Date of Patent: July 4, 2023Assignees: Coral Bay II, LLC, Agency For Science, Technology And ResearchInventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
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Publication number: 20230201345Abstract: Anti-PD-L1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.Type: ApplicationFiled: November 23, 2022Publication date: June 29, 2023Applicant: Agency for Science, Technology and ResearchInventors: Cheng-I Wang, Hsueh Ling Janice Oh, Siok Ping Yeo
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Patent number: 11688826Abstract: A light emitting device, a method of fabricating a light emitting device and a method of controlling light emission. The light emitting device includes a plasmonic structure. The plasmonic structure is configured to have a plurality of localized surface plasmon resonances. The light emitting device also includes a broadband light emitting layer having an emission spectrum substantially overlapping wavelengths of the localized surface plasmon resonances. A spacer layer is disposed between the plasmonic structure and the broadband light emitting layer. A color of light emitted by the broadband light emitting layer is tunable by the localized surface plasmon resonances of the plasmonic structure.Type: GrantFiled: June 5, 2018Date of Patent: June 27, 2023Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Ee Jin Teo, Yi Shi, Chengyuan Yang, Qing Yang Steve Wu, Yin Thai Chan, Yang Xu, Chi Jin Darren Neo
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Patent number: 11680298Abstract: There is provided a method of identifying risk of cancer in a human subject, the method comprising: determining in a biological sample of the subject, whether a copy number amplification of at least one continuous genomic region specific to human chromosome 1q21 is present, wherein the presence of a copy number amplification of the region specific to human chromosome 1q21 represents an elevated risk of cancer in the subject and the at least one continuous genomic region is selected from the group consisting of: a human TUFT 1 gene or a gene from the human S100 family. It is also provided a method of treating cancer in a subject determined to have a copy number amplification of a region specific to human chromosome 1q21, the method comprising administering a therapeutic agent capable of suppressing IRAK1, IRAK4 or a S100 family member, such as Pacritinib. There are also provided a method of treating cancer, related polynucleotides, kits, therapeutic agents and use of the therapeutic agents.Type: GrantFiled: September 7, 2017Date of Patent: June 20, 2023Assignees: Agency for Science, Technology and Research, Tan Tock Seng Hospital Pte. Ltd.Inventors: Qiang Yu, Jian Yuan Goh, Min Feng, Ern Yu Tan
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Patent number: 11680256Abstract: A bacterial strain comprising one or more vectors encoding a) one or more enzymes to produce one or more terpene precursors; and b) a fungal terpene synthase (FTPS). The present invention also relates to a method of producing a terpenoid comprising a) culturing the bacterial strain described herein in an expression medium; and b) isolating the terpenoid from said expression medium.Type: GrantFiled: September 2, 2019Date of Patent: June 20, 2023Assignees: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, JUSTUS-LIEBIG-UNIVERSITAET GIESSENInventors: Congqiang Zhang, Xixian Chen, Ruehl Martin, Heng-Phon Too
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Patent number: 11672455Abstract: Described is a computer system for establishing an electroencephalogram (EEG) model for discriminating between alert and fatigue states. The computer system comprises a receiver module for receiving an alert state segment illustrative of an alert state of at least one subject, and one or more EEG fatigue data segments illustrative of a fatigue state of the at least one subject. The computer system further comprises a segment selector for selecting one of the one or more fatigue data segments and setting it to be an assumed maximum fatigue segment, an EEG classifier trainer for training an EEG classifier by extracting an EEG feature space from the alert state segment and assumed maximum fatigue segment, and a maximum fatigue identifier module for identifying a segment of maximum fatigue by applying the EEG classifier to each of the fatigue data segments.Type: GrantFiled: December 29, 2017Date of Patent: June 13, 2023Assignee: Agency for Science Technology And ResearchInventors: Zhuo Zhang, Aung Aung Phyo Wai, Cuntai Guan, Hai Hong Zhang
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Publication number: 20230174533Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.Type: ApplicationFiled: December 8, 2022Publication date: June 8, 2023Applicant: Agency for Science, Technology and ResearchInventors: Soo Yei HO, Stephanie Eliane BLANCHARD, Athisayamani Jeyaraj DURAISWAMY, Jenefer ALAM, Vikrant Arun ADSOOL
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Patent number: 11670078Abstract: This disclosure relates to method and system for visual inspection of rotating components. The method includes representing rotation cycles of a rotating component as spatial features based on video or image frames, ascertaining and/or evolving Hidden Markov Model (HMM) chains for the cycles, ascertaining a count of the rotating component in the frames and/or labelling the frames with ascertained states of the HMM chains.Type: GrantFiled: March 27, 2020Date of Patent: June 6, 2023Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Wei Xiong, Wenyu Chen, Jierong Cheng, Jia Du
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Publication number: 20230159990Abstract: The present invention relates to signalling catalytic nucleic acid nanostructures that are responsive to polymerase activity, methods of their use, devices and kits comprising the same. More specifically, the present invention provides a catalytic signalling nanostructure comprising a DNAzyme/RNAzyme, such as G-quadruplex hemin, and a polymerase—responsive element. Polymerase elongation of the polymerase-responsive element eliminates catalytic activity of the DNAzyme/RNAzyme. The catalytic nucleic acid nanostructure can be used alone or paired with a target recognition nanostructure which can transduce molecular signals into polymerase activity, in an integrated circuit.Type: ApplicationFiled: April 7, 2021Publication date: May 25, 2023Applicants: National University of Singapore, Agency for Science, Technology and ResearchInventors: Huilin Shao, Yuan Chen, Noah Riandiputra Sundah, Rui Yuan Nicholas Ho
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Patent number: 11657270Abstract: A method, a computer-readable medium, and an apparatus for feature learning are provided. The apparatus may receive a data sample as an input to a feature learning model. The apparatus may calculate a reconstruction error based on the data sample and a plurality of features of the feature learning model. The apparatus may determine whether the reconstruction error satisfies a first threshold. The apparatus may add a feature into the feature learning model to represent the data sample if the data sample satisfies the first threshold. The apparatus may determine whether the reconstruction error satisfies a second threshold. The apparatus may ignore the data sample if the reconstruction error satisfies the second threshold. The apparatus may update the weights associated with the plurality of features of the feature learning model if the reconstruction error satisfies neither the first threshold nor the second threshold.Type: GrantFiled: September 28, 2017Date of Patent: May 23, 2023Assignee: Agency for Science, Technology and ResearchInventors: Savitha Ramasamy, Rajaraman Kanagasabai
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Patent number: 11659779Abstract: Various embodiments may provide a memory cell. The memory cell may include an active electrode including an active electrode material. The memory cell may also include a first noble electrode contact with the active electrode, the first noble electrode being a patterned electrode including a noble electrode material. The memory cell may further include a resistive switching layer in contact with the active electrode and the first noble electrode. The memory cell may additionally include a second noble electrode including a noble electrode material, the second noble electrode in contact with the resistive switching layer.Type: GrantFiled: March 8, 2019Date of Patent: May 23, 2023Assignees: Agency for Science, Technology and Research, National University of SingaporeInventors: Wen Xiao, Wendong Song, Jun Ding, Ernult Franck Gerard
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Patent number: 11649505Abstract: The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, comprising a primer pair capable of amplifying a PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion. Also disclosed is a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, comprising detecting the PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion with a primer pair.Type: GrantFiled: December 21, 2017Date of Patent: May 16, 2023Assignee: Agency for Science, Technology and ResearchInventors: Bong Hwa Gan, Masafumi Inoue, Veronica Diermayr
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Patent number: 11646418Abstract: According to the present disclosure, a method of fabricating a metal-carbon fibrous structure is provided. The method comprises the steps of: (a) forming a fibrous support structure comprising composite nanocrystals and polymeric fibers, wherein each of the composite nanocrystals comprises metal ions connected by organic ligands; (b) growing the composite nanocrystals on the fibrous support structure; and (c) subjecting the fibrous support structure of step (b) to carbonization to form the metal-carbon fibrous structure, wherein the metal-carbon fibrous structure comprises metal nanoparticles derived from the composite nanocrystals. A metal-carbon fibrous structure comprising carbon based fibers arranged to form a porous network and the carbon based fibers are doped with metal nanoparticles, wherein the carbon based fibers have surfaces which comprise graphitic carbon, is also disclosed herein.Type: GrantFiled: April 6, 2021Date of Patent: May 9, 2023Assignee: Agency for Science, Technology and ResearchInventors: Suxi Wang, Xu Li, Andy Hor, Zhongxing Zhang, Kia Jia Benny Chew
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Patent number: 11635327Abstract: Provided is an optical probe, and a Raman spectroscopy system using such, including excitation and detection optics coupled to a sampling optics via a beam splitter, in confocal arrangement with a sample focal plane of the sampling optics. The detection optics is arranged to receive Raman signal from the sample focal plane and direct it onto a tip of a detection optical fiber. The optical probe may further include a positioning device mechanically coupled to the sampling optics and configured to control a position of the sample focal plane. In the Raman spectroscopy system a light source is coupled to the excitation optics via an excitation optical fiber, and a spectrometer is coupled to a detection optics via a detection optical fiber. Provided is further a method for measuring Raman signal depth profile in a sample, wherein sample's Raman spectra is measured and stored at different focal plane positions.Type: GrantFiled: March 29, 2018Date of Patent: April 25, 2023Assignee: Agency for Science, Technology and ResearchInventors: Malini Olivo, Gurpreet Singh, Renzhe Bi, Kapil Dev, Dinish Unnimadhava Kurup Soudamini Amma, Chris Jun Hui Ho
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Patent number: 11634437Abstract: The present invention provides fluorescent compounds of formula (I) as disclosed herein or pharmaceutically acceptable salts thereof. Further provided are uses of said fluorescent compounds in methods of determining, in a sample, the presence and/or amount of pluripotent stem cells or cells undergoing reprogramming to become induced pluripotent stem cells.Type: GrantFiled: July 4, 2018Date of Patent: April 25, 2023Assignee: Agency for Science, Technology and ResearchInventors: Sandhya Sriram, Shigeki Sugii, Young Tae Chang, Nam-Young Kang