Abstract: A method for metering two or more liquids in controlled proportions in a liquid supply system and for supplying a resultant mixture, in which the liquid supply system includes a plurality of solvent supply lines, a proportioning valve interposed between the solvent supply lines and an inlet of a pumping unit, the method includes drawing in a first liquid into the pumping unit via a first solvent supply line; determining one or more switching points of time for switching between different solvent supply lines, the switching points of time being determined in a way that at said switching points of time, the liquid supplied to the pumping unit is in a predefined pressure range; switching from the first solvent supply line to a second solvent supply line at one of said switching points of time; drawing in a second liquid into the pumping unit via the second solvent supply line.

Abstract: A column assembly for gas chromatography, which is coolable by a fluid, includes a capillary column, a heating element for heating at least a portion of the capillary column, and a tube having a lumen and in contact with at least one of the capillary column and the heating element. When energized, the heating element raises the temperature of the capillary column. To lower the temperature of the capillary column, a fluid flows through the tube, and heat is transferred from the capillary column to the fluid in the tube.

Abstract: The present invention provides, inter alia, methods of analyzing mass spectral data based on charge states of analyte ions. In some embodiments, the methods can be used for differential profiling of samples, such as comparing a sample comprising a given compound and a sample comprising metabolites of the same compound. The methods can also be used to identify and isolate biomarkers. Systems for performing the methods, as well as computer-readable media for performing the methods, are also described.

Abstract: An apparatus for providing multiple collimated light beams from optical fibers and the method for producing such beams. The apparatus includes first and second optical fibers that carry light of first and second wavelengths, respectively, a fixture that maintains the fibers in a fixed relationship to one another, and a collimating lens. Light from each of the first and second optical fibers diverges from a face of the fixture. The collimating lens produces first and second collimated light beams that are displaced relative to one another from the light leaving the face. The face of the fixture is positioned to correct for chromatic aberration in the lens.

Abstract: GC-MS analysis apparatus has an interface section between GC and MS sections, which is located with respect to the direction of an analyte flow downstream of the GC section and upstream of the MS section. The interface section comprises at least one membrane with at least one orifice capable of establishing a molecular flow condition in the analyte passing between the GC and MS sections through the membrane. The membrane is subjected to a pressure differential such that the pressure pa in a region located upstream of the membrane is higher than the pressure pb in a region located downstream of the membrane.

Abstract: Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.

Abstract: A device for driving a switch in a digital-to-analog converter (DAC) includes first and second latches, and a logic gate. The first latch is configured to store a digital input data signal according to a clock signal, and to output a first latch signal corresponding to the stored digital input data signal. The second latch is configured to store the first latch signal output by the first latch according to a logical inverse of the clock signal, and to output a second latch signal corresponding to the stored first latch signal. The logic gate is configured to perform an OR logic operation on the first latch signal and the second latch signal, the logic gate outputting a drive signal for driving a switch in the DAC connected to a current source.

Abstract: A mass analyzer comprises a pair of planar electrode structures. The electrode structures are disposed opposite one another, parallel to one another, and axially offset from one another. One of the pair of planar electrodes comprises an opening. The mass analyzer comprises an ion mirror disposed between the pair of planar electrodes. A mass spectrometer and a mass spectrometry method are also described.

Abstract: Comparative genomic hybridization assays and compositions for use in practicing the same are provided. A characteristic of the subject comparative genomic hybridization assays is that solid support immobilized oligonucleotide feature elements, e.g., in the form of an array, are employed. Specifically, at least first and second nucleic acid populations prepared from genomic templates are contacted with a plurality of distinct oligonucleotide feature elements immobilized on a solid support surface and the binding of the at least first and second populations is then evaluated. Also provided are kits for use in practicing the subject methods.

Abstract: A nucleoside monomer that is protected by a thionocarbamate protecting group and contains one or more 2H, 13C, or 15N isotopes in the ribose and/or base part is provided, as well as a method for making a polynucleotide that uses the same. Also provided is a polynucleotide synthesis method that employs a diamine to deprotect a protected polynucleotide.

Abstract: A hierarchical test executive system comprising and including Procedure, Test, Measurement and Datapoint levels. A Procedure is an ordered list of Tests; a Test is a group of Measurements in a Procedure that share the same test algorithm, and thus the same software code; a Measurement is a configuration or setup for a Test, and provides parameters to a Test; and a Datapoint is a subset of a Measurement containing additional parameters that select a result when one Measurement generates multiple results. When initiated, the test executive system presents a list of models and the user selects a model to be tested. The program then uploads the test software corresponding to the selected model and presents a list and descriptions of Procedures to the user. The user selects one of the Procedures, and the program retrieves the selected procedure from the test software and expands it into Tests, Measurements and Datapoints as determined by the Procedure.

Abstract: A vector modulator calibration system (“VMCS”) for obtaining a calibrated modulated output signal while minimizing spurious output signals from a vector modulator is shown. The VMCS may include a power sensor in signal communication with the vector modulator and a digitizer in signal communication with the power sensor.

Abstract: A method of selecting a set of normalization probes for use on a comparative genome hybridization array is provided. In certain embodiments, the method includes: a) selecting a first region of a genome to be evaluated by comparative genome hybridization to produce data; b) selecting a second region of the genome for normalization of the data, and c) selecting from a set of candidate probes a sub-set of normalization probes that detect the second region.

Abstract: A phase-locked loop includes: a voltage-controlled oscillator (VCO) system receiving one or more control signals and in response thereto generating a PLL output signal; a plurality of phase detectors for comparing a reference signal having a reference frequency to a PLL feedback signal having a PLL feedback frequency derived from the PLL output signal, and in response thereto to output a comparison signal; and a plurality of signal processing paths each connected to an output of a corresponding one of the phase detectors for outputting a phase detection output signal. The signal processing paths have different frequency responses from each other. In operation only one of the phase detectors is activated, and a switching arrangement selectively switches between outputs of the signal processing paths to select the phase detection output signal from the activated phase detector to generate the control signal(s) for the VCO system.

Abstract: A system for filtering a data signal includes an input configured to receive the data signal through a transmission medium and a filter configured to remove distortion from the received data signal using equalization coefficients. The system further includes a processing unit configured to determine dynamically the equalization coefficients of the filter without using a predetermined training pattern in the received data signal.

Abstract: A device includes a first substrate having a principal surface having a plurality of sample sites having a corresponding sample; a second substrate having a principal surface facing and spaced apart from the principal surface of the first substrate, the second substrate having a plurality of ultraviolet emission sites corresponding to the sample sites of the first substrate, each of the ultraviolet emission sites being spaced apart from and facing a corresponding one of the sample sites of the first substrate, each of the ultraviolet emission sites being configured to emit ultraviolet light to a corresponding one of the sample sites on the first substrate, and to ionize at least a portion of a sample provided at each sample site; and an ion extraction device configured to extract ions from a gap between the first substrate and the structure.

Abstract: A sensor for sensing an angular position of an instrument relative to a static magnetic field includes a flexible beam, an electromagnetic device, and a measuring device. The beam at one end may be coupled to the instrument, and lies along a sensor axis when the beam is in a non -flexed state. The electromagnetic device is coupled to the beam and is configured for generating a magnetic sensor field aligned with the sensor axis. The measuring device communicates with the beam and is configured for measuring a property of the beam related to an amount of flexure of the beam. The sensor may be utilized to set the instrument at a desired angle prior to operating the instrument, and to determine whether the instrument has deviated from the desired angle during operation. The instrument may include a probe spinning module such as may be utilized in magnetic resonance experiments.

Abstract: An integrated flow cell, the flow cell comprising a semiconductor substrate, and a fluidic conduit having an at least partially transparent semiconductor oxide tubing, wherein the semiconductor oxide tubing is formed with the semiconductor substrate.

Abstract: A detector in a gas chromatograph includes a detector inlet configured to receive a chromatographic column, the chromatographic column having a column entrance and a column exit, the column exit coupled to the detector inlet, a restriction integrated within the detector, the restriction located to receive an output of the chromatographic column, at least one pressure regulated gas source provided for normal gas chromatograph operation and arranged to provide at least one gas to a location between the integrated restriction and the column exit, and a backflush controller coupled to the pressure regulated gas source, the backflush controller configured to control a pressure differential between the column exit and the column entrance such that the at least one gas backflushes the chromatographic column when a pressure at the column exit exceeds a pressure at the column entrance.

Abstract: A lens stage for use in a scanning system is provided. In certain embodiments, the lens stage comprises: a) a support comprising a first rail and a second rail, in which the first rail and the second rail are mounted to the support in parallel; and b) a linearly moveable lens assembly comprising: i) a voice coil comprising a moving coil that moves in a direction parallel to the rails; ii) a lens; iii) a bracket that is attached to: a) the moving coil and b) the lens, and moveably engaged with the rails via a set of bearing cars; and iv) means to reduce force exerted on the set of bearing cars due to thermal expansion of the moving coil.