Patents Assigned to Agilent Technologies
  • Spectrophotometer calibration methods and systems
    Patent number: 11181422
    Abstract: A method of calibrating a spectrophotometer comprising a flash lamp. The method comprises receiving light from the flash lamp at a monochromator of the spectrometer, wherein the flash lamp is a short arc noble gas flash lamp with transverse or axially aligned electrodes; configuring the monochromator to progressively transmit the received light at each of a plurality wavelengths of a selected range of wavelengths, wherein the range of wavelengths is associated with a wavelength feature according to a known spectral profile of the flash lamp, and wherein the wavelength feature is a self-absorption feature; and determining a spectrum of the flash lamp, wherein the spectrum comprises a corresponding power or intensity value for each of the plurality of wavelengths.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: November 23, 2021
    Assignee: Agilent Technologies, Inc.
    Inventors: David Death, Philip Valmont Wilson
  • Mid-infrared scanning system for analyzing particulates
    Patent number: 11175212
    Abstract: An apparatus and method for analyzing particulates in a sample is disclosed. The method includes placing the sample on a moveable stage in an apparatus having a tunable MIR light scanner and a visible imaging system, the stage moving between the MIR light scanner and the visible imaging system, providing a visible image of the sample, and receiving user input as to a region of the sample that is to be analyzed. The sample is then moved to the MIR light scanner, the MIR light scanner generating an MIR light beam that is focused to a point on the specimen and measuring light reflected from the specimen. The specimen is then scanned at a first MIR wavelength by moving the specimen relative to the MIR light beam, and particles are identified that meet a selection criterion. The MIR absorption spectrum of each of the identified particle is then automatically measured.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: November 16, 2021
    Assignee: Agilent Technologies, Inc.
    Inventors: Christopher Ryan Moon, Andrew Ghetler, Matthew Kole
  • Kits for Using Bispyridines to Improve Labeling of Nucleophiles
    Publication number: 20210333269
    Abstract: Bispyridines improve the labeling of nucleophiles, including amines and thiols and are particularly useful for improving labeling with acidic and basic labels. Use of bispyridines with such labels dramatically increases labeling compared to protocols without a bispyridine. The labeled nucleophile can then be subjected to standard analytical methods.
    Type: Application
    Filed: July 7, 2021
    Publication date: October 28, 2021
    Applicant: Agilent Technologies, Inc.
    Inventors: Francis T. Haxo, Michael J. Kimzey
  • Method and system for estimating a gender of a foetus of a pregnant female
    Patent number: 11155854
    Abstract: A method for estimating a gender of a foetus of a pregnant female, said method comprising measuring allele presences (DX) for a first plurality of genetic markers of the X-chromosome and allele presences (DR) for a second plurality of genetic markers of at least one reference chromosome, different from the X and Y chromosome, in a sample of cell-free DNA from a pregnant female; based on said measured allele presences for said first plurality, determining a first fraction thereof which is associated with purely homozygous genetic markers; based on said measured allele presences for said second plurality, determining a second fraction thereof which is associated with purely homozygous genetic markers; and estimating a gender of said foetus based on said first and second fraction.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: October 26, 2021
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Paul Vauterin, Michaël Vyverman, Joachim De Schrijver
  • Multipole ion optic assembly
    Patent number: 11152199
    Abstract: An ion optic assembly includes a set of conductive rods, a first insulator, and a second insulator. The rods are inserted into through-holes of the first insulator, which are arranged about an axis along which the rods are elongated. The rods are then inserted through a bore of the second insulator and become located in notches of the bore, which are arranged about the axis. Accordingly, the first insulator positions one end of the rods at a first distance from the axis, and the second insulator positions the other end of the rods at a second distance from the axis, which may equal to or different from the first distance. The rods contact, and may be spring-biased against, the notches. The assembly may include an electrical contact with fingers spring-biased into contact with the rods. Each insulator may include both through-holes and notches for additional rods.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: October 19, 2021
    Assignee: Agilent Technologies, Inc.
    Inventors: Robert M. Roberts, James L. Bertsch
  • Filters for liquid flow based devices and systems
    Patent number: 11150225
    Abstract: A filter includes an inlet side, an outlet side, and a body. The body includes a first substrate that includes an array of inlet holes passing through the first substrate, and a second substrate that includes an array of outlet holes passing through the second substrate. The body further includes an intermediate region that includes a plurality of channels extending along a plane that is transverse or at an angle to a main axis of the filter. Each channel communicates directly or indirectly with at least one of the inlet holes and at least one of the outlet holes. The filter provides a plurality of fluid flow paths through the body from the inlet side to the outlet side.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: October 19, 2021
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Qing Bai, Ares Geovanos, Hongfeng Yin, Thor Miller Wilbanks
  • Interface device between sample separation device and mass spectrometer having multiple sample capillaries
    Patent number: 11152200
    Abstract: An interface device, for providing a fluidic interface between a sample separation device and a mass spectrometer, includes an emitter capillary and a plurality of sample capillaries. The sample capillaries are movably arranged within the emitter capillary for transferring fluidic sample from the sample separation device to the mass spectrometer.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: October 19, 2021
    Assignee: Agilent Technologies, Inc.
    Inventor: Hans-Peter Zimmermann
  • User interface configured to facilitate user annotation for instance segmentation within biological samples
    Patent number: 11145058
    Abstract: Novel tools and techniques are provided for implementing digital microscopy imaging using deep learning-based segmentation via multiple regression layers, implementing instance segmentation based on partial annotations, and/or implementing user interface configured to facilitate user annotation for instance segmentation. In various embodiments, a computing system might generate a user interface configured to collect training data for predicting instance segmentation within biological samples, and might display, within a display portion of the user interface, the first image comprising a field of view of a biological sample. The computing system might receive, from a user via the user interface, first user input indicating a centroid for each of a first plurality of objects of interest and second user input indicating a border around each of the first plurality of objects of interest.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: October 12, 2021
    Assignee: Agilent Technologies, Inc.
    Inventors: Elad Arbel, Itay Remer, Amir Ben-Dor
  • Quick lock connector for connecting a capillary to a fluidic conduit of a fluidic component
    Patent number: 11137378
    Abstract: A fitting for providing a fluid connection between a capillary and a fluidic conduit of a fluidic component, wherein the fitting comprises a capillary reception configured for receiving the capillary, a force applicator configured for being operable to apply a fixing force for fixing the capillary within the fitting, a force limitation mechanism configured for limiting the fixing force being applicable by the force applicator to the capillary, a force splitter configured for splitting the fixing force into an advance force component for advancing the capillary received in the capillary reception towards the fluidic component and into a clamping force component for clamping the capillary received in the capillary reception within the fitting, and a biasing mechanism particularly arranged between the force applicator and the force splitter and configured for biasing the force splitter against the capillary.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: October 5, 2021
    Assignee: Agilent Technologies, Inc.
    Inventors: Darijo Zeko, Jose-Angel Mora-Fillat
  • Hybridization compositions and methods
    Patent number: 11118226
    Abstract: The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, utilize a of cyclic and/or non-cyclic solvent that is non-toxic and may eliminate or reduce the amount of formamide in the hybridization composition.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: September 14, 2021
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventor: Steen Hauge Matthiesen
  • Hybridization compositions and methods
    Patent number: 11118214
    Abstract: The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: September 14, 2021
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Steen Hauge Matthiesen, Kenneth H. Petersen, Tim Svenstrup Poulsen, Charles M. Hansen
  • Methods, kits and compositions pertaining to the suppression of the detectable probe binding to randomly distributed repeat sequences genomic nucleic acid
    Patent number: 11111525
    Abstract: This invention is directed to methods, kits, non-nucleotide probes as well as other compositions pertaining to the suppression of binding of detectable nucleic acid probes to undesired nucleotide sequences of genomic nucleic acid in assays designed to determine target genomic nucleic acid.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: September 7, 2021
    Assignees: Applied Biosystems, LLC, Agilent Technologies, Inc.
    Inventors: Kirsten Vang Nielsen, Jens Hyldig-Nielsen, Brett F. Williams
  • Use of quaternary and tertiary ammonium cations to denature proteins
    Patent number: 11111268
    Abstract: Ammonium cation detergents comprising a quaternary or tertiary ammonium cation can be used as detergents to denature proteins and are particularly useful in denaturing glycoproteins or glycopeptides prior to enzymatic deglycosylation. Ammonium cation detergents with sulfate or sulfonate anions are particularly useful.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: September 7, 2021
    Assignee: Agilent Technologies, Inc.
    Inventors: Michael J. Kimzey, Francis T. Haxo, Vaishali Sharma
  • Phosphorous protecting groups and methods of preparation and use thereof
    Patent number: 11104699
    Abstract: Aspects of the present disclosure include compositions that make use of phosphorus and/or nucleobase protecting groups which find use in the synthesis of long polynucleotides. Phosphorus protecting groups are provided that help increase the stepwise coupling yield and/or phosphorous protecting groups that can be removed during the oxidation step. Amidine nucleobase protecting groups are provided that find use in the subject compositions and methods which provides for e.g., increased resistance to depurination during polynucleotide synthesis. In some instances, the methods and compositions disclosed herein utilize a combination of the phosphorus and amidine nucleobase protecting groups in the synthesis of polynucleotides having a sequence of 200 or more monomeric units in length. Also provided are methods for synthesizing a polynucleotide (e.g., a DNA) using one or more compounds disclosed herein.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: August 31, 2021
    Assignees: Agilent Technologies, Inc., University of Colorado Boulder
    Inventors: Douglas J. Dellinger, Luca Monfregola, Marvin Caruthers, Mithun Roy
  • Use of Mild Electrophiles to Reduce Artifacts in Analyzing Glycans Released from Glycoproteins or Glycopeptides
    Publication number: 20210263043
    Abstract: The presence of mild electrophiles, such as aldehydes, during the denaturation of glycoproteins or glycopeptides and subsequent enzymatic deglycosylation reduces artifacts in subsequent analyses of the glycans released from the glycoproteins or gly-copeptides.
    Type: Application
    Filed: May 13, 2021
    Publication date: August 26, 2021
    Applicant: Agilent Technologies, Inc.
    Inventor: Michael J. Kimzey
  • Use of bispyridines to improve labeling of nucleophiles
    Patent number: 11092595
    Abstract: Bispyridines improve the labeling of nucleophiles, including amines and thiols and are particularly useful for improving labeling with acidic and basic labels. Use of bispyridines with such labels dramatically increases labeling compared to protocols without a bispyridine. The labeled nucleophile can then be subjected to standard analytical methods.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: August 17, 2021
    Assignee: Agilent Technologies, Inc.
    Inventors: Francis T. Haxo, Michael J. Kimzey
  • ICP spectroscopy torch with removable one-piece injector
    Patent number: 11089669
    Abstract: A torch for use in analytic instruments includes a tube subassembly with substantially cylindrical nested inner and outer tubes with coincident central axes, the inner tube having a terminus. The torch also includes a removable injector extending at least partially in the inner tube and having an alignment feature, an inlet, an outlet, and a central axis that is coincident with the central axes of the inner and outer tubes, a seal having a channel for accommodating a portion of the injector, and a base for supporting the tube subassembly, injector, and seal. The seal has a complementary feature to engage the alignment feature of the injector to prevent axial misalignment of the injector and maintain a fixed gap between the terminus of the inner tube and the outlet of the injector.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: August 10, 2021
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventor: Luke Sparkes
  • Methods and apparatus to facilitate gravitational cell extraction
    Patent number: 11077440
    Abstract: The invention relates generally to methods and apparatus that gravitationally transfer cells from a first medium to a second medium. More specifically, the invention relates to a novel microfluidic device. The microfluidic device includes a cell transfer region, a cell settling channel, a waste channel, a cell output channel, and an input medium channel. The cell settling channel, the waste channel, and the cell output channel extend from, are in fluid communication with, and are smaller in cross section than the cell transfer region. The cell output channel is substantially perpendicular to the cell settling channel and to the waste channel. The input medium channel extends from and is in fluid communication with the cell output channel.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: August 3, 2021
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Curt A. Flory, Dustin Chang, Pallevi Srivastva, Rolfe Anderson
  • Methods for non-invasive detection of transplant health or rejection
    Patent number: 11072829
    Abstract: The present invention relates to the technical field of organ and tissue transplantation and specifically to methods allowing rejection of transplanted organs and tissues by a transplant patient. The present invention provides methods for non-invasive and ex vivo or in vitro detection of the presence or absence of transplant rejection, i.e. transplant health or rejection. The present methods allow for effective and continuous monitoring of transplant status with a minimal or absent discomfort for a transplant patent.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: July 27, 2021
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Dirk Goossens, Joachim De Schrijver, Jurgen Del Favero
  • Spectrophotometer
    Patent number: D929881
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: September 7, 2021
    Assignee: Agilent Technologies, Inc.
    Inventors: Dale Hathaway, Daniela Loraing, Maximilian Schneider, Craig Peters, Stuart Bonthron, Scott Harwood