Patents Assigned to Agilent Technologies
  • Metal components with inert vapor phase coating on internal surfaces
    Patent number: 10895009
    Abstract: The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: January 19, 2021
    Assignee: Agilent Technologies, Inc.
    Inventors: Elizabeth Carr, Karen L. Seaward, Kevin P. Killeen
  • COUPLED-AMPLIFIER MULTI-FREQUENCY CIRCUIT TOPOLOGIES APPLICABLE TO MASS SPECTROMETER RADIO-FREQUENCY DRIVE SYSTEMS
    Publication number: 20210013915
    Abstract: A circuit and method for providing high-voltage radio-frequency (RF) energy to an instrument at multiple frequencies includes a plurality of inputs each configured to receive an RF voltage signal oscillating at a corresponding frequency, and a step-up circuit for generating magnified RF voltage signals based on the received RF voltage signals. The step-up circuit includes an LC network operable to isolate the RF voltage signals at the plurality inputs from one another while preserving a voltage magnification from each input to a common output at each of the corresponding frequencies.
    Type: Application
    Filed: July 10, 2020
    Publication date: January 14, 2021
    Applicant: Agilent Technologies, Inc.
    Inventor: Michael J. Schoessow
  • Multi-temperature optical spectrometer modules, systems and methods of using the same
    Patent number: 10890523
    Abstract: An optical spectrometer module for analysing samples. The optical spectrometer module comprises two or more sample holders. Each sample holder is adapted to receive and reproducibly position a sample in fixed locations within the optical spectrometer module. Each sample holder is also adapted to receive a light beam to thereby enable a sample contained in the sample holder to be exposed to the received light beam. Each sample holder is further adapted to enable light transmitted through the sample holder to exit the sample holder. The optical spectrometer module also comprises two or more electro-thermal components. Each electro-thermal component is thermally coupled to a respective sample holder to control the temperature of the sample holder.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: January 12, 2021
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventor: Hugh Charles Stevenson
  • Method and device for calibration of biological flux
    Patent number: 10883978
    Abstract: An apparatus for calibrating a flux analyzer comprises a first frame; a second frame; and a permeable membrane. The first frame and the second frame are connected or integrally formed. A method for calibrating a flux analyzer is provided which uses an artificial standard rather than a biological standard.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: January 5, 2021
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventor: Andrew C. Neilson
  • Full field visual-mid-infrared imaging system
    Patent number: 10887532
    Abstract: An apparatus and method for generating images of specimens is disclosed. The apparatus includes an imaging system, controller, and user interface. The imaging system generates a plurality of component images of a specimen, each component image corresponding to a different viewing condition. Each image is represented by an intensity as a function of location on the specimen. The controller stores the component images and generates a compound image from a plurality of the component images. The compound image includes a weighted sum of first and second ones of the component images, the controller displaying the compound image on a display controlled by the controller. The user interface is adapted to control a weighting factor used in generating the weighted sum in response to user input. The controller redisplays the compound image after the weighting factor is changed in response to user input.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: January 5, 2021
    Assignee: Agilent Technologies, Inc.
    Inventor: Andrew Ghetler
  • Precision high voltage power supply utilizing feedback through return side output
    Patent number: 10872753
    Abstract: In one embodiment, a high voltage power supply includes a DC voltage input, a converter for converting a DC voltage at the DC voltage input to an AC voltage, a booster for boosting the AC voltage to a boosted AC voltage, a rectifier in DC isolation from the DC voltage input, the rectifier operable to convert the boosted AC voltage to a high DC voltage at an isolated rectifier output, a high voltage DC output for outputting the high DC voltage, a voltage control input, and an error circuit coupled to the voltage control input and operable to reduce variation in the high DC voltage by driving a return side of the isolated rectifier output in response to feedback based on the high DC voltage.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: December 22, 2020
    Assignee: Agilent Technologies, Inc.
    Inventor: David Deford
  • Inductively coupled plasma mass spectrometry (ICP-MS) with improved signal-to-noise and signal-to-background ratios
    Patent number: 10854438
    Abstract: In an inductively coupled plasma-mass spectrometry (ICP-MS) system, ions are transmitted into a collision/reaction cell. A DC potential is applied at an exit of the cell at a first magnitude to generate a DC potential barrier effective to prevent the ions from exiting the cell. The DC potential barrier is maintained during a confinement period to perform an interaction. After the confinement period, analyte ions or product ions are transmitted to a mass spectrometer by switching the exit DC potential to a second magnitude effective to allow the analyte ions or product ions to pass through the cell exit as a pulse. The analyte ions or product ions are then counted during a measurement period. The interaction may be ion-molecule reactions or ion-molecule collisions.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: December 1, 2020
    Assignee: Agilent Technologies, Inc.
    Inventors: Noriyuki Yamada, Erina Shimizu
  • Use of Tri- and Tetra- Hydroxyl Quaternary Ammonium Compounds As Resolving Agents for Electrophoretic Separations
    Publication number: 20200371063
    Abstract: The present disclosure provides methods of improving the resolution of analytes by in electrophoretic separations using a gel by incorporating into the gel an effective amount of one or more tri- or tetra-hydroxyl quaternary ammonium compounds, or a mixture of such compounds.
    Type: Application
    Filed: January 11, 2019
    Publication date: November 26, 2020
    Applicant: Agilent Technologies, Inc.
    Inventors: Michael J. KIMZEY, Fielito U. LIMJAP, Francis T. HAXO, Sergey VLASENKO
  • Temporary storage of sample portions for artefact-preventing fluid processing
    Patent number: 10830739
    Abstract: In a method for processing successive fluidic sample portions provided by a sample source, sample reception volumes are filled successively temporarily with at least a respective one of the sample sections, and the sample sections are emptied successively out of the sample reception volumes in such a way, that, while emptying, it is avoided to bring two respective ones of the sample sections, which have not left the sample source directly adjacent to one another, in contact with one another.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: November 10, 2020
    Assignee: Agilent Technologies, Inc.
    Inventors: Herbert Anderer, Konstantin Shoykhet, Klaus Witt, Stephan Buckenmaier
  • Systems and methods for tracking and providing workflow information
    Patent number: 10832199
    Abstract: A tangible computer-readable storage device storing computer-executable program instructions that generate a user interface for displaying workflow information associated with a tissue specimen in a pathology laboratory. The program instructions may perform a method including displaying a virtual laboratory component representing a physical pathology laboratory having one or more laboratory stations for processing the tissue specimen according to a workflow, and displaying a specimen indicator that indicates a current specimen state based on a current relationship of the tissue specimen to the workflow.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: November 10, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Laura Chirica, Mats Grahn, Stephen Jones
  • METHODS, DEVICES, AND KITS TO IMPROVE REDUCTION OR LABELING OF CARBOHYDRATES
    Publication number: 20200346214
    Abstract: The present invention provides methods, devices, and kits to improve procedures for reducing carbohydrates, such as glycans released from glycoconjugates, or for labeling carbohydrates by reductive amination.
    Type: Application
    Filed: September 17, 2019
    Publication date: November 5, 2020
    Applicant: Agilent Technologies, Inc.
    Inventor: Andres GUERRERO NAVARRO
  • Multi Frequency LC Resonator Topologies Applicable to Mass Spectrometer Radio Frequency Drive Systems
    Publication number: 20200328070
    Abstract: In one embodiment, a power source for providing high-voltage radio-frequency (RF) energy to an instrument such as a mass spectrometer includes an RF power amplifier having an output, an oscillating RF signal generator configured to provide first and second RF signals respectively oscillating at first and second frequencies to the RF power amplifier, and a step-up circuit for magnifying the RF power amplifier output. The step-up circuit includes an LC resonator network tuned to the first and second frequencies, and an output for providing the magnified voltage to a rod assembly of the mass spectrometer.
    Type: Application
    Filed: April 8, 2020
    Publication date: October 15, 2020
    Applicant: Agilent Technologies, Inc.
    Inventor: Michael Schoessow
  • Mid-Infrared Scanning System for Analyzing Particulates
    Publication number: 20200309669
    Abstract: An apparatus and method for analyzing particulates in a sample is disclosed. The method includes placing the sample on a moveable stage in an apparatus having a tunable MIR light scanner and a visible imaging system, the stage moving between the MIR light scanner and the visible imaging system, providing a visible image of the sample, and receiving user input as to a region of the sample that is to be analyzed. The sample is then moved to the MIR light scanner, the MIR light scanner generating an MIR light beam that is focused to a point on the specimen and measuring light reflected from the specimen. The specimen is then scanned at a first MIR wavelength by moving the specimen relative to the MIR light beam, and particles are identified that meet a selection criterion. The MIR absorption spectrum of each of the identified particle is then automatically measured.
    Type: Application
    Filed: January 30, 2020
    Publication date: October 1, 2020
    Applicant: Agilent Technologies, Inc.
    Inventors: Christopher Ryan Moon, Andrew Ghetler, Matthew Kole
  • Method of oligonucleotide analysis
    Patent number: 10781484
    Abstract: Described herein, among other things, is a method of estimating efficiency of an oligonucleotide synthesis reaction. In some embodiments, the method comprises subjecting the products of one or more oligonucleotide synthesis reactions to LC-MS to produce a series of mass spectra, analyzing the mass spectra, and estimating the overall efficiency of an oligonucleotide synthesis reaction and/or the efficiency of addition of one or more of G, A, T or C individually in an oligonucleotide synthesis reaction.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: September 22, 2020
    Assignee: Agilent Technologies, Inc.
    Inventor: Joel Myerson
  • High specificity genome editing using chemically modified guide RNAs
    Patent number: 10767175
    Abstract: The present invention relates to guide RNAs having chemical modifications and their use in CRISPR-Cas systems. The chemically modified guide RNAs have enhanced specificity for target polynucleotide sequences. The present invention also relates to methods of using chemically modified guide RNAs for cleaving or nicking polynucleotides, and for high specificity genome editing.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: September 8, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Douglas J Dellinger, Daniel E Ryan, Subhadeep Roy, Jeffrey R Sampson
  • Components with an atomic layer deposition coating and methods of producing the same
    Patent number: 10767259
    Abstract: Liquid chromatography and gas chromatography components with a conformal protective coating on internal surfaces thereof and methods for producing the same are provided. The conformal protective coating is formed via an atomic layer deposition (ALD) process. The components and methods of the present disclosure find use in providing protective coatings for liquid chromatography and gas chromatography components that are compatible with bioanalytical separations and sensitive trace analyses.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: September 8, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Elizabeth Carr, Kevin P. Killeen
  • Artifact compensation due to different properties of fluid accommodation volumes in sample separation apparatus
    Patent number: 10761071
    Abstract: A control device for controlling at least part of a sample separation apparatus for separating a fluidic sample, the sample separation apparatus including at least two fluid accommodation volumes having different flow through properties and each being configured for temporarily accommodating fluidic sample, wherein the control device is configured for controlling operation of at least part of the sample separation apparatus for at least partially compensating sample separation artifacts resulting from the different flow through properties of the fluid accommodation volumes.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: September 1, 2020
    Assignee: Agilent Technologies, Inc.
    Inventors: Dwight Robert Stoll, Konstantin Shoykhet, Klaus Witt, Stephan Buckenmaier
  • Systems and methods for automated alignment, calibration and standardization of electrophoresis data
    Patent number: 10761054
    Abstract: Systems and methods are provided for improving the analysis of analytes by using electrophoresis apparatus. Exemplary methods provide an increase in the yield of useful results, e.g., quantity and quality of useable data, in automated peak detection, in connection with an electrophoretic separation, e.g., capillary electrophoresis. In various embodiments, the system virtualizes the raw data, transforming the migration time into virtual units thereby allowing the visual comparison of analyte electropherograms and the reliable measurement of unknown analytes. The analytes can be, for example, any organic or inorganic molecules, including but not limited to nucleic acids (DNA, RNA), proteins, peptides, glycans, metabolites, secondary metabolites, lipids, or any combination thereof. Analyte detection can be performed by any method including, but not limited to, fluorescence detection or UV absorption.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: September 1, 2020
    Assignee: Agilent Technologies, Inc.
    Inventors: Bruce DeSimas, Boris Belopolski
  • Systems and methods for transferring liquids
    Patent number: 10761104
    Abstract: One or more liquids are transferred from a source array to one or more remotely positioned destination sites such as chambers by utilizing one or more movable transfer elements, such as contact pins or capillaries. The source array may include a predetermined organization of addresses at which materials are positioned. One or more materials may be selected for transfer. Based on the selection, one or more addresses may be accessed by the transfer element(s). The addresses may correspond to spots on a surface of the source array. Each spot may be a feature containing one or more (bio)chemical compounds. At the chamber(s), the material(s) may be processed, such by reaction with one or more reagents. The reaction(s) may entail synthesis of one or more desired products. Alternatively, reaction(s) may be performed at the source array, and the product(s) then transferred to the chamber(s).
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: September 1, 2020
    Assignee: Agilent Technologies, Inc.
    Inventors: Reid A. Brennen, Bo Curry, Joel Myerson, Paige Anderson, Arthur Schleifer, Rolfe Anderson
  • Conical heater assembly for a gas chromatography column
    Patent number: 10764964
    Abstract: A heating apparatus for a gas chromatography column is described. The GC column heating apparatus includes a conical heater assembly comprising a heating element between an inner layer and an outer layer. The apparatus can also include optionally an outer cowl and/or an inner cowl surrounding the conical heater assembly. The conical heater assembly rapidly increases the temperature of the column by conductive heating. The selection of shape (in particular, the cone angle of a conical heater) and materials allows the GC column to adapt to expansion that occurs upon heating. A gas chromatography (GC) column heating and cooling apparatus is also described, in which the heater and outer cowl define a flowpath through which a cooling fluid can pass and cool the GC column.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: September 1, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Thomas Harrison, Sammye Elizabeth Traudt, William H Wilson