Patents Assigned to Agilent Technology, Inc.
  • Sample processing apparatus with integrated heater, shaker and magnet
    Patent number: 10399048
    Abstract: Samples in an array of containers are processed by mounting the containers on a sample stage, moving magnets into proximity with bottoms of the containers of a first column of containers to apply a magnetic field, moving the magnets into proximity with bottoms of the containers of a second column, and moving heater elements into proximity with the container bottoms of the first column. While the magnetic field is applied to the containers of the second column, heat energy may be applied to the containers of the first column. The process may be repeated for additional columns. The containers may also be shaken to agitate the samples. A single apparatus may perform heating, shaking, and magnetic field application, without needing to transport the containers to different stations.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: September 3, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Chai Siong Siow, Thuan-Khim Khor, David Knorr
  • Method for Finding Species Peaks in Mass Spectrometry
    Publication number: 20190259592
    Abstract: A method for operating a data processing system to find peaks in a mass spectrum that includes an ordered set of measurements of the abundances of species as a function of the mass/charge ratio of the species is disclosed. The method includes selecting a candidate blob that has a plurality of blob peaks from the mass spectrum. The data processing system selects a candidate blob peak for characterization. The candidate blob peak is approximated by a first species peak using a species peak model having a plurality of parameters by fitting the species peak model to a portion of the blob that has values that are substantially free of contributions from other species peaks that overlap with the first species peak and that are not represented by the species peak model. The first species peak is then subtracted from the candidate blob.
    Type: Application
    Filed: December 18, 2018
    Publication date: August 22, 2019
    Applicant: Agilent Technologies, Inc.
    Inventor: Daniel Y. Abramovitch
  • Ion transfer device for mass spectrometry with selectable bores
    Patent number: 10388501
    Abstract: An ion transfer device for transferring ions from a first chamber to a second, reduced-pressure chamber includes a tube and a bore selector. The tube includes a plurality of tube bores. The bore selector is positioned at an inlet end of the tube and includes an inlet port. The tube is movable relative to the bore selector, and/or the bore selector is movable relative to the tube, to align the inlet port with a selected one of the tube bores while blocking the other tube bores. Alignment of the inlet port with the selected tube bore defines an ion transfer path from the first chamber, through the selected tube bore, and to the second chamber. The ion transfer device may be utilized, for example, in an atmospheric-pressure interface of a mass spectrometer.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: August 20, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Maozi Liu, Nigel P. Gore
  • Rigid piston-actuator-assembly supported for performing a pendulum-type tolerance compensation motion
    Patent number: 10385847
    Abstract: A pump for pumping fluid, wherein the pump includes a working chamber, a piston assembly configured for reciprocating within the working chamber to thereby displace fluid, a piston actuator being rigidly assembled with the piston assembly at least in a working mode of the pump to thereby transmit drive energy to the piston assembly to reciprocate along a common rigid axis of the piston-actuator-assembly, and a bearing arrangement bearing the piston assembly and the piston actuator in the pump so that the piston-actuator-assembly provided by the piston assembly and the piston actuator is capable of performing a pendulum-type compensation motion around a pendulum point at the piston actuator on the common rigid axis.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: August 20, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Arne Kurz, Bernhard Dehmer, Lothar Mitzlaff
  • Experimental chamber with computer-controlled display wall
    Patent number: 10379607
    Abstract: An environmental chamber having an interior compartment, an augmented display, and a controller is disclosed. The interior compartment is adapted for isolating an experimental setup from an environment external to the interior compartment. The augmented display is positioned to allow a user in the external environment to view the interior compartment and an image generated on the augmented display. The controller generates the image. The image includes information about a component within the interior compartment. The augment display can include a touch-enabled display screen that allows the user to interact with controller.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: August 13, 2019
    Assignee: Agilent Technologies, Inc.
    Inventor: Robert H. Kincaid
  • Impact centrifugal separator and associated methods for fraction collection in supercritical fluid systems
    Patent number: 10376814
    Abstract: A separator (e.g. an impact centrifugal separator) is for use in collection of liquid portions of a bi-phasic flowstream in a supercritical fluid system. A separator chamber defines an interior space, surrounded by a spiral channel and that has an exit at a lower portion of the separator chamber. A flowstream director (e.g. an entry lube) focuses the flowstream so that the flowstream impacts a wail of the spiral channel at an angle that promotes coalescence of the liquid component. The spiral channel may promote further coalescence of the liquid portions within the constraining spiral channel after impact. A central director may be included in the interior space of the separator chamber to promote flow of the gaseous component toward the exit. A dripper may be included in fluid communication with the spiral channel, for example, in the exit and to direct the coalesced liquid into a collection vessel.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: August 13, 2019
    Assignee: Agilent Technologies, Inc.
    Inventor: Edwin E. Wikfors
  • Method for enhancing electrospray
    Patent number: 10373816
    Abstract: Provided herein, among other things, is a method of ionizing a first stream of liquid by an electrospray ion source having a nebulizer, wherein the first stream of liquid may comprise an analyte. In some embodiments, the method may comprise: a) providing the first stream of liquid to the nebulizer; b) adding a second stream of liquid to the first stream of liquid, wherein the second stream of liquid comprises a co-solvent that has a relatively high boiling point and an enhancement solvent that a relatively high boiling; and c) nebulizing and ionizing the resulting liquid.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: August 6, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Steven M. Fischer, Justin R. Cross
  • Branching off fluidic sample with low influence on source flow path
    Patent number: 10371671
    Abstract: A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured to adjust a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: August 6, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Thomas Ortmann, Daniel Thielsch
  • Full Field Visual-Mid-Infrared Imaging System
    Publication number: 20190238763
    Abstract: An apparatus and method for generating images of specimens is disclosed. The apparatus includes an imaging system, controller, and user interface. The imaging system generates a plurality of component images of a specimen, each component image corresponding to a different viewing condition. Each image is represented by an intensity as a function of location on the specimen. The controller stores the component images and generates a compound image from a plurality of the component images. The compound image includes a weighted sum of first and second ones of the component images, the controller displaying the compound image on a display controlled by the controller. The user interface is adapted to control a weighting factor used in generating the weighted sum in response to user input. The controller redisplays the compound image after the weighting factor is changed in response to user input.
    Type: Application
    Filed: April 3, 2019
    Publication date: August 1, 2019
    Applicant: Agilent Technologies, Inc.
    Inventor: Andrew Ghetler
  • Full field visual-mid-infrared imaging system
    Patent number: 10341583
    Abstract: An apparatus and method for generating images of specimens is disclosed. The apparatus includes an imaging system, controller, and user interface. The imaging system generates a plurality of component images of a specimen, each component image corresponding to a different viewing condition. Each image is represented by an intensity as a function of location on the specimen. The controller stores the component images and generates a compound image from a plurality of the component images. The compound image includes a weighted sum of first and second ones of the component images, the controller displaying the compound image on a display controlled by the controller. The user interface is adapted to control a weighting factor used in generating the weighted sum in response to user input. The controller redisplays the compound image after the weighting factor is changed in response to user input.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: July 2, 2019
    Assignee: Agilent Technologies, Inc.
    Inventor: Andrew Ghetler
  • Fluidic valve with contactless force transmission for pressing together stator and rotor
    Patent number: 10302213
    Abstract: A fluidic valve for switching between different fluid coupling states includes a stator having at least one fluidic stator interface, a rotor having at least one fluidic rotor interface, wherein the rotor is rotatable relative to the stator to thereby switch the fluidic valve between a plurality of different fluid coupling states between the at least one fluidic stator interface and the at least one fluidic rotor interface, and a force transmission mechanism configured for pressing the stator and the rotor together by a contactless force transmission to provide for a fluid tight sealing between the stator and the rotor.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: May 28, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Tony Ziegler, Manfred Berndt
  • Sealing configuration with metal-coated structure
    Patent number: 10300403
    Abstract: A sealing configuration is configured for sealingly coupling a first fluid flow path of a first device to a second fluid flow path of a second device. The sealing configuration comprises a contact surface comprising a structure configured for increasing a surface pressure when coupling the first device to the second device. The contact surface comprises a metal coating configured for increasing sealing.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: May 28, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Hans-Georg Haertl, Joachim-Richard Wagner
  • Angular synchronization of stationary and orbiting plate scroll blades in a scroll pump using a metallic bellows
    Patent number: 10294939
    Abstract: Parts of a pump head of a scroll pump facilitate an assembly process in which the stationary and orbiting scroll blades of the pump are angularly aligned or synchronized with one another. A metallic bellows of the pump head provides a primary means of synchronizing the stationary and orbiting scroll blades. The assembly process may be carried out using a fixture configured to be mountable to an assemblage including the bellows and the orbiting plate scroll. The fixture has a reference feature, and the orbiting plate scroll or the frame has another reference feature that can be aligned with the reference feature of the fixture, in the circumferential direction of the bellows, during the course of the assembly process.
    Type: Grant
    Filed: March 19, 2016
    Date of Patent: May 21, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: John Calhoun, George Galica, Vannie (Yucong) Lu, James Pierce
  • Plurality of transposase adapters for DNA manipulations
    Patent number: 10287622
    Abstract: The present invention relates to transposase adapters and uses thereof, including uses in preparing DNA molecules, in vitro amplification, sequencing of nucleic acids, and screening of DNA libraries for sequences of interest as well as nucleic acid delivery.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: May 14, 2019
    Assignee: Agilent Technologies, Inc.
    Inventor: Alexander S. Belyaev
  • Tandem collision/reaction cell for inductively coupled plasma-mass spectrometry (ICP-MS)
    Patent number: 10290482
    Abstract: A tandem collision/reaction cell for an inductively coupled plasma-mass spectrometry (ICP-MS) system includes a first ion guide, a second ion guide, and an intermediate electrode in the vicinity of an exit end of the first ion guide. A DC potential barrier is applied to the intermediate electrode. The cell may provide two or more stages of an ion-molecule collision process.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: May 14, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Noriyuki Yamada, Erina Shimizu, Yu Okamoto
  • Quantum cascade laser with serially configured gain sections
    Patent number: 10283936
    Abstract: An apparatus that includes a gain chip assembly, an external cavity, and a controller is disclosed. The gain chip assembly includes first and second gain chips that are coupled optically such that light travels serially between the first gain chip and the second gain chip, each gain chip is electrically biased. The electrical bias of the first gain chip is independent of the electrical bias of the second gain chip. The external cavity has a tunable wavelength selective filter that is changed in response to a control signal. Light in the external cavity passes through the gain chip assembly. The controller determines the tunable wavelength selective filter, and the electrical bias of each of the gain chips so as to cause the apparatus to lase at a wavelength specified by a control signal to the controller.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: May 7, 2019
    Assignee: Agilent Technologies, Inc.
    Inventor: Guthrie Partridge
  • System and method for generating high-voltage radio frequency signals using an electronically tuned resonator
    Patent number: 10284154
    Abstract: A system for generating a radio frequency (RF) signal at a drive frequency and a high voltage. The system includes a RF amplifier to amplify the voltage of a drive signal having a selected RF frequency. The amplified drive signal is used to drive a resonator to generate the RF signal such that the resonant frequency is the same or substantially the same as the drive frequency. A resonance tuning controller compares the drive frequency and the resonant frequency. If the resonant frequency and drive frequency are different, a temperature changing element is controlled to either increase heat or decrease heat radiating toward a tuning component with a resonance parameter that varies with temperature. For example, the heat may change the capacitance of the tuning capacitor causing a change in the resonant frequency of the resonator.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: May 7, 2019
    Assignee: Agilent Technologies, Inc.
    Inventor: Michael Schoessow
  • Self cleaning gas-liquid separator for serial or parallel collection of liquid fractions
    Patent number: 10279294
    Abstract: An apparatus, process, and system are disclosed that effectively provide separation of a combined gas/liquid flow stream into its separated gas and liquid factions. The invention is primarily directed to the fields of preparative supercritical fluid chromatography (SFC) and supercritical fluid extraction (SFE), but will have other utilization and applicability where phases of dramatically different density, viscosity and volumetric flow require separation.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: May 7, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Kimber D Fogelman, Terry A Berger, Edwin E Wikfors
  • Wideband isolation directed by ion mobility separation for analyzing compounds
    Patent number: 10267765
    Abstract: In an ion mobility-mass spectrometry (IM-MS) system, an ion mass-isolated data set is acquired by operating a mass filter to apply a mass isolation window having an m/z width such that the mass isolation window moves through a sequence of window positions, each window position being defined by an IM drift time value and an m/z ratio value. The m/z width of the mass isolation window and the sequence of window positions are determined such that the mass isolation window captures ions in a region of interest of a larger all-ions data set. The isolation window may be a wideband isolation window. In comparison to the all-ions data set, the mass-isolated data set may yield reduced ion signal interference and increased selectivity for analytes of interest.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: April 23, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Jun Wang, Ruwan T. Kurulugama, George Stafford, Gregor T. Overney
  • System and method for facilitating manual sorting of objects
    Patent number: 10265733
    Abstract: An apparatus that facilitates the manual sorting of objects is disclosed. The apparatus includes a display surface having a surface that can be selectively illuminated and that is adapted for receiving the objects. An identification reader reads identification information stored on the objects. A controller causes an area on the display surface corresponding to one of the objects to be illuminated based on the identification information and indicates a location to which the illuminated object is to be moved. In one aspect of the invention, the display surface includes an area adapted for positioning a receiver for the objects. The display surface provides an indication of a position in the receiver at which the one of the objects is to be placed.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: April 23, 2019
    Assignee: Agilent Technologies, Inc.
    Inventors: Robert Kincaid, Melanie Tory, Joachim Schmid